rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.47360/1995-4484-2023-165-180rsp-3319Research ArticleПРОГРЕСС В РЕВМАТОЛОГИИ В XXI ВЕКЕPROGRESS IN RHEUMATOLOGY IN THE XXI CENTURYРоль интерлейкина 17 в патогенезе ревматоидного артрита. Есть ли перспективы применения ингибиторов ИЛ-17?The role of interleukin 17 in the pathogenesis of rheumatoid arthritis. Are there any prospects for the use of IL-17 inhibitors?https://orcid.org/0000-0002-1598-8360НасоновЕ. Л.NasonovE. L.

дмн, профессор, академик РАН, научный руководитель ФГБНУ НИИР им В.А. Насоновой; профессор, кафедра внутренних профессиональных болезней и ревматологии Первого МГМУ им. Сеченова

115522, Москва, Каширское шоссе, 34а; 119991, Москва, ул. Трубецкая, 8, стр. 2

115522, Moscow, Kashirskoye Highway, 34A; 119991, Moscow, Trubetskaya str., 8, building 2

nasonov@irramn.ruhttps://orcid.org/0000-0003-3057-9175АвдееваА. С.AvdeevaA. S.

дмн, старший научный сотрудник лаборатории иммунологии и молекулярной биологии ревматических заболеваний 

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A 

https://orcid.org/0000-0003-0579-1131КоротаеваТ. В.KorotaevaT. V.

дмн, начальник отдела спондилоартритов, заведующий лаборатории псориатического артрита 

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A 

https://orcid.org/0000-0002-1771-6246ДубининаТ. В.DubininaT. V.

кмн, заведующий лабораторией аксиального спондилоартрита

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A 

https://orcid.org/0000-0002-3377-7700УсачеваЮ. В.UsachevaJu. V.

старший федеральный советник компании «Биокад»

198515, Санкт-Петербург, пос. Стрельна, ул. Связи, 38, стр. 1

198515, Strelna Settlement, Svyazi str., 38, building 1

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияV.A. Nasonova Research Institute of Rheumatology; I.M. Sechenov First Moscow State Medical University of the Ministry of Health Care of Russian Federation (Sechenov University)Russian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian FederationАО «БИОКАД»РоссияBIOCADRussian Federation202328042023612165180Copyright © Насонов Е.Л., Авдеева А.С., Коротаева Т.В., Дубинина Т.В., Усачева Ю.В., 20232023Насонов Е.Л., Авдеева А.С., Коротаева Т.В., Дубинина Т.В., Усачева Ю.В.Nasonov E.L., Avdeeva A.S., Korotaeva T.V., Dubinina T.V., Usacheva J.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/3319

Ревматоидный артрит (РА) – иммуновоспалительное ревматическое заболевание (ИВРЗ), характеризующееся хроническим эрозивным артритом и системным поражением внутренних органов, приводящее к ранней инвалидности и сокращению продолжительности жизни пациентов. Благодаря прогрессу в изучении механизмов развития ИВРЗ и промышленной биотехнологии были созданы новые противовоспалительные лекарственные средства, применение которых позволило существенно повысить эффективность фармакотерапии РА. Тем не менее, возможности фармакотерапии РА ограничены. Парадоксально, но все генно-инженерные биологические препараты (ГИБП) независимо от механизма действия обладают примерно одинаковой эффективностью в отношении достижения ремиссии. Полагают, что относительно не удовлетворительные результаты терапии РА обусловлены гетерогенностью механизмов воспаления и боли. Обсуждаются значение Th17-типа иммунного ответа в патогенезе РА, результаты контролируемых исследований ингибиторов интерлейкина (ИЛ) 17 и целесообразность дальнейшего изучения эффективности этих препаратов у пациентов с определенными фенотипами РА.

Rheumatoid arthritis (RA) is an immunoinflammatory rheumatic disease (IMRI) characterized by chronic erosive arthritis and systemic damage to internal organs, leading to early disability and reduced life expectancy in patients. Thanks to the progress in the study of the mechanisms of the development of the IVRI and industrial biotechnology, new anti-inflammatory drugs have been created, the use of which has significantly increased the effectiveness of the pharmacotherapy of RA. However, the possibilities of pharmacotherapy for RA are limited, since all biologics, regardless of the mechanism of action, have approximately the same effectiveness in achieving remission. It is believed that the relatively unsatisfactory results of RA therapy are due to the heterogeneity of the mechanisms of inflammation and pain. The significance of the Th17 type of immune response in the pathogenesis of RA, the results of controlled studies of IL-17 inhibitors, and the advisability of further studying the effectiveness of these drugs in patients with certain RA phenotypes are discussed.

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The authors declare that there are no conflicts of interest present.