rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.47360/1995-4484-2023-220-235rsp-3325Research ArticleРЕВМООРТОПЕДИЯ И РЕАБИЛИТАЦИЯORTHOPEDIC RHEUMATOLOGY AND REHABILITATIONАваскулярный некроз костной ткани: определение, эпидемиология, виды, факторы риска, патогенез заболевания. Аналитический обзор литературыAvascular necrosis of bone tissue: Definition, epidemiology, types, risk factors, pathogenesis of the disease. Analytical review of the literaturehttps://orcid.org/0000-0002-3745-0924БяликВ. Е.BialikV. E.

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A

DoctorBjalik@yandex.ruhttps://orcid.org/0000-0002-5626-7404МакаровМ. А.MakarovM. A.

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0001-7938-1536БяликЕ. И.ByalikE. I.

115522, Москва, Каширское шоссе, 34а;125993, Москва, ул. Баррикадная, 2/1, стр. 1

115522, Moscow, Kashirskoye Highway, 34A;125993, Moscow, Barrikadnaya str., 2/1, building 1

https://orcid.org/0000-0001-8563-0631МакаровС. А.MakarovS. A.

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0002-1391-0711КаратеевА. Е.KarateevA. E.

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0002-7179-8174НестеренкоВ. А.NesterenkoV. A.

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0002-5256-7346ЧерниковаА. А.ChernikovaA. A.

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0002-0454-0974КапитоновД. В.KapitonovD. V.

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0009-0009-5068-3536ГореловаА. И.GorelovaA. I.

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияV.A. Nasonova Research Institute of Rheumatology; Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian FederationRussian Federation202328042023612220235Copyright © Бялик В.Е., Макаров М.А., Бялик Е.И., Макаров С.А., Каратеев А.Е., Нестеренко В.А., Черникова А.А., Капитонов Д.В., Горелова А.И., 20232023Бялик В.Е., Макаров М.А., Бялик Е.И., Макаров С.А., Каратеев А.Е., Нестеренко В.А., Черникова А.А., Капитонов Д.В., Горелова А.И.Bialik V.E., Makarov M.A., Byalik E.I., Makarov S.A., Karateev A.E., Nesterenko V.A., Chernikova A.A., Kapitonov D.V., Gorelova A.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/3325

Аваскулярный некроз (АН) костной ткани является распространенной патологией, которой страдают люди любого возраста, чаще молодые и трудоспособные. Заболевание приводит к быстрому разрушению субхондральной кости и коллапсу с последующим развитием вторичного остеоартрита (ОА) пораженного сустава.

Целью данной обзорной статьи является представление накопленных знаний о распространенности АН, наиболее частых его локализациях, факторах риска и патогенезе заболевания. Поскольку в большинстве мировых источников литературы представлены знания об отдельных звеньях патогенеза АН, в этой статье выполнен анализ всех известных путей развития заболевания – от начала ишемии до коллапса и развития вторичного ОА, и патогенез представлен в хронологическом порядке. По результатам статьи предложено определение термина АН и выделены стадии развития заболевания, наиболее перспективные для консервативных методов лечения.

Avascular necrosis (AN) of bone tissue is a common pathology that affects people of any age, more often young and able-bodied. The disease leads to rapid destruction of the subchondral bone and collapse, followed by the development of secondary osteoarthritis (OA) of the affected joint.

The purpose of this review article is to present the accumulated knowledge about the prevalence of AN, the most commonly affected joints, risk factors and pathogenesis of the disease. Since most of the world’s literature sources present knowledge about the individual parts and facts that make up the pathogenesis of AN, this article analyzes all known paths of the development of the disease from the onset of ischemia to collapse and the development of secondary OA and the pathogenesis is presented in chronological order. Based on the results of the article, a definition of the term AN was proposed, and the stages of the disease within the pathogenesis, the most promising for conservative methods of treatment, were identified.

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The authors declare that there are no conflicts of interest present.