rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.47360/1995-4484-2023-531-536rsp-3347Research ArticleМЕЖДУНАРОДНЫЕ И РОССИЙСКИЕ РЕКОМЕНДАЦИИ ПО ЛЕЧЕНИЮ РЕВМАТИЧЕСКИХ ЗАБОЛЕВАНИЙINTERNATIONAL AND RUSSIAN GUIDELINES FOR THE TREATMENT OF RHEUMATIC DISEASESНовые классификационные критерии АНЦА-ассоциированных системных васкулитов ACR/EULAR 2022New ACR/EULAR 2022 classification criteria for ANCA-associated vasculitishttps://orcid.org/0000-0003-2641-9785БекетоваТ. В.BeketovaT. V.

121356, Москва, ул. Маршала Тимошенко, 15;115522, Москва, Каширское шоссе, 34а;107023, Москва, ул. Большая Семёновская, 38

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tvbek@rambler.ruФГБУ «Центральная клиническая больница с поликлиникой» Управления делами Президента Российской Федерации; ФГБНУ «Научноисследовательский институт ревматологии им. В.А. Насоновой»; ФГАОУ ВО «Московский политехнический университет»РоссияCentral State Medical Academy of the Administrative Directorate of the President of the Russian Federation; V.A. Nasonova Research Institute of Rheumatology; Moscow Polytechnic UniversityRussian Federation202327102023615531536Copyright © Бекетова Т.В., 20232023Бекетова Т.В.Beketova T.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/3347

Важным этапом в развитии учения о системных васкулитах (СВ) в 2022 г. стали новые классификационные критерии СВ, ассоциированных с антинейтрофильными цитоплазматическими антителами (АНЦА), предложенные экспертами Американской коллегии ревматологов (ACR, American College of Rheumatology) и Европейского альянса ревматологических ассоциаций (EULAR, European Alliance of Associations for Rheumatology). На основании анализа крупных международных когорт были пересмотрены критерии гранулематоза с полиангиитом и эозинофильного гранулематоза с полиангиитом, а также впервые предложены классификационные критерии микроскопического полиангиита. Обсуждается история создания классификационных критериев АНЦА-СВ за последние три десятилетия, рассматриваются их ограничения. Следует принимать во внимание, что критерии ACR/EULAR 2022 г. разрабатывались для создания однородных групп пациентов в научных исследованиях и не могут широко применяться в клинической практике для диагностики различных нозологических форм АНЦА-СВ – прежде всего на ранней стадии заболевания, при поражении одного органа (например, почек). По-прежнему решающее значение в диагностике АНЦА-СВ принадлежит детальному клиническому анализу течения заболевания и подробному обследованию пациентов с выявлением патогномоничных признаков, в том числе асимптомных.

The new 2022 classification criteria for antineutrophil cytoplasmic antibodies associated vasculitis (AAV), proposed by the American College of Rheumatology (ACR) and the European Alliance of Associations for Rheumatology (EULAR), was an important stage in the development of the doctrine of systemic vasculitis. Based on the analysis of large international cohorts, the criteria for granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis were revised, and classification criteria for microscopic polyangiitis were proposed for the first time. The creation’s history of the AAV classification criteria is discussed over the past three decades, and their limitations are considered. It should be noted, the ACR/EULAR 2022 criteria were developed for creating homogeneous groups of patients for scientific studies and cannot be widely used in clinical practice for the various AAV nosological forms diagnosis, primarily at early stage of the disease or mono organ damage (for example, kidneys). As before, decisive importance in AVV diagnostic belong to a detailed clinical analysis and a complete examination of patients to identify pathognomonic symptoms, including asymptomatic ones.

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The authors declare that there are no conflicts of interest present.