rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.47360/1995-4484-2023-513-530rsp-3434Research ArticleПЕРЕДОВАЯLEADING ARTICLEРоль нетоза в патогенезе иммуновоспалительных ревматических заболеванийThe role of NETosis in the pathogenesis of immunoinflammatory rheumatic diseaseshttps://orcid.org/0000-0002-1598-8360НасоновЕ. Л.NasonovE. L.

115522, Москва, Каширское шоссе, 34а;119991, Москва, ул. Трубецкая, 8, стр. 2

115522, Moscow, Kashirskoye Highway, 34A;119991, Moscow, Trubetskaya str., 8, building 2

nasonov@irramn.ruhttps://orcid.org/0000-0003-3057-9175АвдееваА. С.AvdeevaA. S.

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0003-3552-2522РешетнякТ. М.ReshetnyakT. M.

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0001-6686-0896АлексанкинА. П.AleksankinA. P.

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0001-9175-3013РубцовЮ. П.RubtsovYu. P.

117997, Москва, ул. Миклухо-Маклая, 16/10;115522, Москва, Каширское шоссе, 23

117997, Moscow, Miklukho-Maklaya str., 16/10;115522, Moscow, Kashirskoye Highway, 23

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияV.A. Nasonova Research Institute of Rheumatology; I.M. Sechenov First Moscow State Medical University of the Ministry of Health Care of Russian Federation (Sechenov University)Russian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian FederationФГБУН Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН; ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииРоссияShemyakin–Ovchinnikov Institute of Bioorganic Chemitry of the Russian Academy of Sciences; National Medical Research Center for Oncology named after N.N. BlokhinRussian Federation202327102023615513530Copyright © Насонов Е.Л., Авдеева А.С., Решетняк Т.М., Алексанкин А.П., Рубцов Ю.П., 20232023Насонов Е.Л., Авдеева А.С., Решетняк Т.М., Алексанкин А.П., Рубцов Ю.П.Nasonov E.L., Avdeeva A.S., Reshetnyak T.M., Aleksankin A.P., Rubtsov Y.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/3434

Неконтролируемая активация нейтрофилов рассматривается как важный механизм тромбовоспаления и фиброза при иммуновоспалительных ревматических заболеваниях (ИВРЗ), злокачественных новообразованиях, атеросклерозе, COVID-19 и многих других острых и хронических воспалительных болезнях человека. Особое внимание привлечено к способности нейтрофилов формировать «сетевые» (web-like) структуры, получившие название «нейтрофильные внеклеточные ловушки», или NETs (neutrophil extracellular traps). Процесс, связанный с образованием NETs и ослаблением их деградации, получил название нетоз (NETosis). В статье суммированы данные о роли нетоза в патогенезе ИВРЗ, обсуждаются перспективы фармакотерапии, направленной на предотвращение формирования и разрушение NETs. 

Uncontrolled activation of neutrophils is considered an important mechanism of thromboinflammation and fibrosis in immunemediated rheumatic diseases (IMRD), malignant neoplasms, atherosclerosis, COVID-19 and many other acute and chronic inflammatory diseases of humans. Particular attention has been drawn to the ability of neutrophils to form “network” (web-like) structures, called “neutrophil extracellular traps” NETs. The process associated with the formation of NETs and the weakening of their degradation is called “NETosis”. The publication summarizes data on the role of NETosis in the pathogenesis of IMRD and discusses the prospects for pharmacotherapy aimed at preventing the formation and destruction of NETs.

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The authors declare that there are no conflicts of interest present.