rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.47360/1995-4484-2023-728-734rsp-3479Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHОстеопоротический фенотип состава тела: взаимосвязь с нутритивным статусом и физическим состоянием у женщин с ревматоидным артритомOsteoporotic phenotype of body composition: Relationship with nutritional status and physical condition in women with rheumatoid arthritishttps://orcid.org/0000-0002-2809-0197ДобровольскаяО. В.DobrovolskayaO. V.

Добровольская Ольга Валерьевна.

115522, Москва, Каширское шоссе, 34а

Olga V. Dobrovolskaya.

115522, Moscow, Kashirskoye Highway, 34A

olgavdobr@mail.ruhttps://orcid.org/0000-0002-7661-3124ФеклистовА. Ю.FeklistovA. Yu.

115522, Москва, Каширское шоссе, 34а

Alexey Yu. Feklistov.

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0003-0560-3495КозыреваМ. В.KozyrevaM. V.

115522, Москва, Каширское шоссе, 34а

Maria V. Kozyreva.

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0003-4739-4302ТоропцоваН. В.ToroptsovaN. V.

115522, Москва, Каширское шоссе, 34а

Natalia V. Toroptsova.

115522, Moscow, Kashirskoye Highway, 34A

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation202301012024616728734Copyright © Добровольская О.В., Феклистов А.Ю., Козырева М.В., Торопцова Н.В., 20242024Добровольская О.В., Феклистов А.Ю., Козырева М.В., Торопцова Н.В.Dobrovolskaya O.V., Feklistov A.Y., Kozyreva M.V., Toroptsova N.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/3479

Цель исследования – оценить связь остеопоротического фенотипа (ОПФ) состава тела с нутритивным статусом (НС) и уровнем физической активности (ФА) у женщин с ревматоидным артритом (РА).

Материал и методы

Материал и методы. В исследование включены 104 женщины (средний возраст – 59,5±8,7 года) с достоверным диагнозом РА. Проводилось клиническое, лабораторное и инструментальное (двуэнергетическая рентгеновская абсорбциометрия) обследование. Статус питания и физическое состояние изучали с помощью опросников Mini Nutricial Assessment (MNA-SF), International Physical Activity Questionnaire (IPAQ), тестов оценки мышечной силы и физической работоспособности.

Результаты

Результаты. По данным денситометрии 40 (38,5%) пациенток имели ОПФ. Нормальный НС по MNA-SF имели 51,0%, сниженный – 49,0% женщин. Низкая и умеренная ФА по IPAQ выявлена у 51,9% больных РА. В многофакторном логистическом регрессионном анализе определены независимые факторы, связанные с ОПФ: пешие прогулки <30 минут в день (отношение шансов (ОШ) – 1,34; 95%-й доверительный интервал (95% ДИ): 0,11–17,32)); низкая мышечная сила верхних (кистевая динамометрия менее 16 кг; ОШ=7,12; 95% ДИ: 1,02–49,57) и нижних конечностей (тест «Встать со стула» более 15 с; ОШ=4,45; 95% ДИ: 1,08–18,42); индекс массы тела <25 кг/м2 (ОШ=1,39; 95% ДИ=1,04–1,85)

Заключение

Заключение. Выявлена высокая частота ОПФ у пациентов с РА, среди которых почти в половине случаев встречалось недостаточное питание и/или сниженный физический статус. Пешие прогулки <30 минут в день, низкая мышечная сила верхних и нижних конечностей и ИМТ<25 кг/м2 ассоциировались с ОПФ.

Aim of the study – to assess the relationship of the osteoporotic phenotype of body composition with nutritional and physical status in women with rheumatoid arthritis (RA).

Material and methods

Material and methods. 104 women (average age 59.5±8.7 years) with RA were enrolled. The examination included clinical, laboratory and instrumental (dual-energy X-ray absorptiometry) methods. Nutritional status was assessed using the Mini Nutrition Assessment-Short Form (MNA-SF), physical status – using the International Physical Activity Questionnaire (IPAQ), “Chair stand test”, handgrip strength, “Timed Up and Go test” and gait speed.

Results

Results. Osteoporotic phenotype was diagnosed in 38.5% of patients. Malnutrition and risk of malnutrition according to MNA-SF had 51.0% of women. Low and moderate level of physical activity according to IPAQ – 51.9% of patients. In multivariate logistic regression analysis, independent factors associated with osteoporotic phenotype were determined: walking <30 minutes a day (odds ratio (OR) – 1.34; 95% confidence interval (95% CI): 0.11–17.32), low muscle strength of the upper extremities (handgrip strength less than 16 kg) (OR=7.12; 95% CI: 1.02–49.57) and lower extremities (“Chair stand test” more than 15 seconds) (OR=4.45; 95% CI: 1.08–18.42), body mass index (BMI) less than 25 kg/m2 (OR=1.39; 95% CI: 1.04–1.85).

Conclusion

Conclusion. A high frequency of the osteoporotic phenotype of body composition was revealed in patients with RA, among whom almost half of the examined individuals had insufficient nutrition and/or reduced physical activity. Walking <30 minutes a day, low upper and lower limb muscle strength, and BMI<25 kg/m2 were associated with the osteoporotic phenotype.

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The authors declare that there are no conflicts of interest present.