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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rsp</journal-id><journal-title-group><journal-title xml:lang="ru">Научно-практическая ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Rheumatology Science and Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-4484</issn><issn pub-type="epub">1995-4492</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.47360/1995-4484-2024-13-23</article-id><article-id custom-type="elpub" pub-id-type="custom">rsp-3510</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕЖДУНАРОДНЫЕ И РОССИЙСКИЕ РЕКОМЕНДАЦИИ ПО ЛЕЧЕНИЮ РЕВМАТИЧЕСКИХ ЗАБОЛЕВАНИЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INTERNATIONAL AND RUSSIAN GUIDELINES FOR THE TREATMENT OF RHEUMATIC DISEASES</subject></subj-group></article-categories><title-group><article-title>Контрацепция при антифосфолипидном синдроме и системной красной волчанке (по рекомендациям Европейского альянса ревматологических ассоциаций/Американской коллегии ревматологов, EULAR/АCR)</article-title><trans-title-group xml:lang="en"><trans-title>Contraception for antiphospholipid syndrome and systemic lupus erythematosus (according to the recommendations of the European Alliance of Associations for Rheumatology/American College of Rheumatology, EULAR/ACR)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3552-2522</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Решетняк</surname><given-names>Т. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Reshetnyak</surname><given-names>T. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Решетняк Татьяна Магомедалиевна – д.м.н., профессор, зав. лабораторией тромбовоспаления</p><p>115522, Москва, Каширское шоссе, 34;</p><p>125993, Москва, ул. Баррикадная, 2/1, стр. 1</p></bio><bio xml:lang="en"><p>Tatiana M. Reshetnyak</p><p>115522, Moscow, Kashirskoye Highway, 34A;</p><p>125993, Moscow, Barrikadnaya str., 2/1, building 1</p></bio><email xlink:type="simple">t_reshetnyak@yahoo.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4411-4478</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Керчелаева</surname><given-names>С. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Kertchelaeva</surname><given-names>S. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор кафедры акушерства и гинекологии лечебного факультета</p><p>117997, Москва, ул. Островитянова, 1</p></bio><bio xml:lang="en"><p>Svetlana B. Kertchelaeva</p><p>117997, Moscow, Ostrovitianova str., 1</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6018-3895</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кошелева</surname><given-names>Н. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kosheleva</surname><given-names>N. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., старший научный сотрудник лаборатории тромбовоспаления</p><p>115522, Москва, Каширское шоссе, 34</p></bio><bio xml:lang="en"><p>Nadezhda M. Kosheleva</p><p>115522, Moscow, Kashirskoye Highway, 34A</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»;&#13;
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России<country>Россия</country></aff><aff xml:lang="en">V.A. Nasonova Research Institute of Rheumatology;&#13;
Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России<country>Россия</country></aff><aff xml:lang="en">N.I. Pirogov Russian National Research Medical University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»<country>Россия</country></aff><aff xml:lang="en">V.A. Nasonova Research Institute of Rheumatology<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>29</day><month>02</month><year>2024</year></pub-date><volume>62</volume><issue>1</issue><fpage>13</fpage><lpage>23</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Решетняк Т.М., Керчелаева С.Б., Кошелева Н.М., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Решетняк Т.М., Керчелаева С.Б., Кошелева Н.М.</copyright-holder><copyright-holder xml:lang="en">Reshetnyak T.M., Kertchelaeva S.B., Kosheleva N.M.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://rsp.mediar-press.net/rsp/article/view/3510">https://rsp.mediar-press.net/rsp/article/view/3510</self-uri><abstract><p>Одной из первостепенных задач общества является сохранение и укрепление здоровья нации. Недостаточное понимание важности вопросов контрацепции медицинским сообществом и ее применения социумом может привести к нарушению репродуктивного здоровья населения. Базовые знания об эффективных и безопасных методах контрацепции важны для каждого ревматолога, поскольку репродуктивное здоровье влияет как на общее состояние больных, так и на течение основного ревматического заболевания (РЗ). Это особенно касается больных, позитивных по антифосфолипидным антителам (аФЛ), пациентов с антифосфолипидным синдромом (АФС) и системной красной волчанкой (СКВ). Наличие аФЛ/АФС, как и активность СКВ, является наиболее важным фактором, определяющим выбор метода контрацепции и риск применения гормональных контрацептивов при РЗ. Между тем, использование адекватной (высокоэффективной и безопасной) контрацепции у данной категории пациентов позволяет не только планировать рождение ребенка, но и избежать нежелательной беременности в активной фазе болезни, приема эмбриотоксических и тератогенных препаратов, а также проводить оптимальное лечение сопутствующей патологии, о чем должен быть хорошо осведомлен курирующий врач-ревматолог. Рассмотрению основных вопросов контрацепции у наиболее «ранимой» категории больных РЗ, имеющих аФЛ, АФС и СКВ, посвящена данная публикация.</p></abstract><trans-abstract xml:lang="en"><p>Maintaining and strengthening the health of the population is one of the primary functions of society. Inadequate understanding of the importance of contraception by the medical community and its application by society can lead to the population’s reproductive health becoming compromised. Basic knowledge of effective and safe contraceptive methods is important for every rheumatologist, as reproductive health affects both the general condition of patients and the course of the main rheumatic diseases (RH). This is particularly true for patients with antiphospholipid antibody (aPL) positivity, antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). The presence of aPL/APS, as well as the activity of SLE, are the main factors determining the choice of contraceptive method and the risk of hormonal contraception in patients with RH. Meanwhile, the use of appropriate (highly effective and safe) contraceptive therapy in this category of patients allows not only to plan the birth of a child, but also to avoid unwanted pregnancy in cases of disease activity, the use of embryotoxic and teratogenic drugs, as well as to carry out optimal treatment of concomitant pathology, which the supervising rheumatologist should be well aware of. This publication is devoted to the consideration of the main issues of contraception in the most “vulnerable” category of patients with RH – with positive aPL, APS and SLE.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>контрацепция</kwd><kwd>методы контрацепции</kwd><kwd>гормональные контрацептивы</kwd><kwd>антифосфолипидный синдром</kwd><kwd>системная красная волчанка</kwd></kwd-group><kwd-group xml:lang="en"><kwd>contraception</kwd><kwd>contraceptive methods</kwd><kwd>hormonal contraceptives</kwd><kwd>antiphospholipid syndrome</kwd><kwd>systemic lupus erythematosus</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>Статья подготовлена в рамках темы ФГБНУ НИИР им. В.А. Насоновой FURS-2022-003 (№ 122040400024-7).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Обоскалова ТА (ред). Методы контрацепции и критерии их применения. Учебное пособие. Екатеринбург;2019.</mixed-citation><mixed-citation xml:lang="en">Oboskalova TA (ed.). Methods of contraception and criteria for their use. Textbook. Ekaterinburg;2019 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Национальные медицинские критерии приемлемости методов контрацепции. Адаптированный документ «Медицинские критерии приемлемости использования методов контрацепции ВОЗ, 5-е издание, 2015». М.;2023.</mixed-citation><mixed-citation xml:lang="en">National medical criteria for the acceptability of contraceptive methods. Adapted document “Medical eligibility criteria for the use of WHO contraceptive methods, 5th edition, 2015”. Moscow;2023 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Сухих ГТ, Прилепская ВН, Аганезова НВ, Андреева ЕН, Баранов ИИ, Долгушина НВ, и др. Контрацепция у женщин репродуктивного возраста. Учебное пособие. М.:Бином;2019.</mixed-citation><mixed-citation xml:lang="en">Sukhikh GT, Prilepskaya VN, Aganezova NV, Andreeva EN, Baranov II, Dolgushina NV, et al. Contraception in women of reproductive age. Textbook. Moscow:Binom;2019 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Сумятина ЛВ. Современные гормональные контрацептивы: новые возможности выбора. Проблемы репродукции. 2014;(6): 46-48.</mixed-citation><mixed-citation xml:lang="en">Sumiatina LV. Modern hormonal contraceptives: new options. Russian Journal of Human Reproduction. 2014;(6):46-48 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Trussell J. Contraceptive failure in the United States. Contraception. 2011;83(5):397-404. doi: 10.1016/j.contraception.2011.01.021</mixed-citation><mixed-citation xml:lang="en">Trussell J. Contraceptive failure in the United States. Contraception. 2011;83(5):397-404. doi: 10.1016/j.contraception.2011.01.021</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Kestelman P, Trussell J. Efficacy of the simultaneous use of condoms and spermicides. Fam Plan Perspect. 1991;23(5):226-227,232.</mixed-citation><mixed-citation xml:lang="en">Kestelman P, Trussell J. Efficacy of the simultaneous use of condoms and spermicides. Fam Plan Perspect. 1991;23(5):226-227,232.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Назарова НМ, Прилепская ВН. Эстроген-гестагенные рилизинг-системы: новый взгляд на контрацепцию (обзор литературы). Фарматека. 2009;(14):10-16.</mixed-citation><mixed-citation xml:lang="en">Nazarova NM, Prilepskaya VN. Estrogen-progestogen releasing systems: A new look at contraception (literature review). Pharmateka. 2009;(14):10-16 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Williams WV. Hormonal contraception and the development of autoimmunity: A review of the literature. Linacre Q. 2017;84(3): 275-295. doi: 10.1080/00243639.2017.1360065</mixed-citation><mixed-citation xml:lang="en">Williams WV. Hormonal contraception and the development of autoimmunity: A review of the literature. Linacre Q. 2017;84(3): 275-295. doi: 10.1080/00243639.2017.1360065</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Iwata M, Oikawa Y, Shimizu Y, Sakashita N, Shoji A, Igarashi A, et al. Efficacy of low-dose estrogen-progestins and progestins in Japanese women with dysmenorrhea: A systematic review and network meta-analysis. Adv Ther. 2022;39(11):4892-4909. doi: 10.1007/s12325-022-02298-9</mixed-citation><mixed-citation xml:lang="en">Iwata M, Oikawa Y, Shimizu Y, Sakashita N, Shoji A, Igarashi A, et al. Efficacy of low-dose estrogen-progestins and progestins in Japanese women with dysmenorrhea: A systematic review and network meta-analysis. Adv Ther. 2022;39(11):4892-4909. doi: 10.1007/s12325-022-02298-9</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Прилепская ВН. Новаринг – контрацепция, анатомия, сексология. Гинекология. 2004;6(6):306-308.</mixed-citation><mixed-citation xml:lang="en">Prilepskaya VN. Novaring – contraception, anatomy, sexology. Gynecology. 2004;6(6):306-308 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Прилепская ВН, Назарова НМ. Новые технологии в контрацепции: гормональные рилизинг-системы. Гинекология. 2005;7(1):41-44.</mixed-citation><mixed-citation xml:lang="en">Prilepskaya VN, Nazarova NM. New technologies in contraception: Hormonal releasing systems. Gynecology. 2005;7(1):41-44 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Khialani D, Rosendaal F, Vlieg AVH. Hormonal contraceptives and the risk of venous thrombosis. Semin Thromb Hemost. 2020;46(8):865-871. doi: 10.1055/s-0040-1715793</mixed-citation><mixed-citation xml:lang="en">Khialani D, Rosendaal F, Vlieg AVH. Hormonal contraceptives and the risk of venous thrombosis. Semin Thromb Hemost. 2020;46(8):865-871. doi: 10.1055/s-0040-1715793</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Medical Eligibility Criteria for Contraceptive Use. 5th ed. Geneva: World Health Organization; 2015. https://ww.who.int/reproductivehealth/publications/family_planning/Ex-Summ-MEC-5/en/</mixed-citation><mixed-citation xml:lang="en">Medical Eligibility Criteria for Contraceptive Use. 5th ed. Geneva: World Health Organization; 2015. https://ww.who.int/reproductivehealth/publications/family_planning/Ex-Summ-MEC-5/en/</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Amy JJ, Tripathi V. Contraception for women: An evidence-based overview. BMJ. 2009;339:b2895. doi: 10.1136/bmj.b2895</mixed-citation><mixed-citation xml:lang="en">Amy JJ, Tripathi V. Contraception for women: An evidence-based overview. BMJ. 2009;339:b2895. doi: 10.1136/bmj.b2895</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Winner B, Peipert JF, Zhao Q, Buckel C, Madden T, Allsworth JE, et al. Effectiveness of long-acting reversible contraception. N Engl J Med. 2012;366(21):1998-2007. doi: 10.1056/NEJMoa1110855</mixed-citation><mixed-citation xml:lang="en">Winner B, Peipert JF, Zhao Q, Buckel C, Madden T, Allsworth JE, et al. Effectiveness of long-acting reversible contraception. N Engl J Med. 2012;366(21):1998-2007. doi: 10.1056/NEJMoa1110855</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Kavanaugh ML, Pliskin E. Use of contraception among reproductive-aged women in the United States, 2014 and 2016. F S Rep. 2020;1(2):83-93. doi: 10.1016/j.xfre.2020.06.006</mixed-citation><mixed-citation xml:lang="en">Kavanaugh ML, Pliskin E. Use of contraception among reproductive-aged women in the United States, 2014 and 2016. F S Rep. 2020;1(2):83-93. doi: 10.1016/j.xfre.2020.06.006</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Sammaritano LR, Bermas BL, Chakravarty EE, Chambers C, Clowse MEB, Lockshin MD, et al. 2020 American College of Rheumatology guideline for the management of reproductive health in rheumatic and musculoskeletal diseases. Arthritis Care Res (Hoboken). 2020;72(4):461-488. doi: 10.1002/acr.24130</mixed-citation><mixed-citation xml:lang="en">Sammaritano LR, Bermas BL, Chakravarty EE, Chambers C, Clowse MEB, Lockshin MD, et al. 2020 American College of Rheumatology guideline for the management of reproductive health in rheumatic and musculoskeletal diseases. Arthritis Care Res (Hoboken). 2020;72(4):461-488. doi: 10.1002/acr.24130</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Насонов ЕЛ (ред.). Антифосфолипидный синдром. М.:Литтерра;2004.</mixed-citation><mixed-citation xml:lang="en">Nasonov EL (ed.). Antiphospholipid syndrome. Moscow:Litterra;2004 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Решетняк ТМ. Антифосфолипидный синдром: диагностика и клинические проявления (лекция). Научно-практическая ревматология. 2014;52(1):56-71. doi: 10.14412/1995-4484-2014-56-71</mixed-citation><mixed-citation xml:lang="en">Reshetnyak TM. Antiphospholipid syndrome: Diagnosis and clinical manifestations (a lecture). NauchnoPrakticheskaya Revmatologia = Rheumatology Science and Practice. 2014;52(1):56-71 (In Russ.) doi: 10.14412/1995-4484-2014-56-71</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4(2):295-306. doi: 10.1111/j.1538-7836.2006.01753.x</mixed-citation><mixed-citation xml:lang="en">Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4(2):295-306. doi: 10.1111/j.1538-7836.2006.01753.x</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Schwarz EB, Manzi S. Risk of unintended pregnancy among women with systemic lupus erythematosus. Arthritis Rheum. 2008;59(6):863-866. doi: 10.1002/art.23712</mixed-citation><mixed-citation xml:lang="en">Schwarz EB, Manzi S. Risk of unintended pregnancy among women with systemic lupus erythematosus. Arthritis Rheum. 2008;59(6):863-866. doi: 10.1002/art.23712</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Yazdany J, Trupin L, Kaiser R, Schmajuk G, Gillis JZ, Chakravarty E, et al. Contraceptive counseling and use among women with systemic lupus erythematosus: A gap in health care quality? Arthritis Care Res (Hoboken). 2011;63(3):358-365. doi: 10.1002/acr.20402</mixed-citation><mixed-citation xml:lang="en">Yazdany J, Trupin L, Kaiser R, Schmajuk G, Gillis JZ, Chakravarty E, et al. Contraceptive counseling and use among women with systemic lupus erythematosus: A gap in health care quality? Arthritis Care Res (Hoboken). 2011;63(3):358-365. doi: 10.1002/acr.20402</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Brunson MR, Klein DA, Olsen CH, Weir LF, Roberts TA. Postpartum contraception: Initiation and effectiveness in a large universal healthcare system. Am J Obstet Gynecol. 2017;217(1): 55.e1-55.e9. doi: 10.1016/j.ajog.2017.02.036</mixed-citation><mixed-citation xml:lang="en">Brunson MR, Klein DA, Olsen CH, Weir LF, Roberts TA. Postpartum contraception: Initiation and effectiveness in a large universal healthcare system. Am J Obstet Gynecol. 2017;217(1): 55.e1-55.e9. doi: 10.1016/j.ajog.2017.02.036</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Mendel A, Bernatsky S, Pineau CA, St-Pierre Y, Hanly JG, Urowitz MB, et al. Use of combined hormonal contraceptives among women with systemic lupus erythematosus with and without medical contraindications to oestrogen. Rheumatology (Oxford). 2019;58(7):1259-1267. doi: 10.1093/rheumatology/kez014</mixed-citation><mixed-citation xml:lang="en">Mendel A, Bernatsky S, Pineau CA, St-Pierre Y, Hanly JG, Urowitz MB, et al. Use of combined hormonal contraceptives among women with systemic lupus erythematosus with and without medical contraindications to oestrogen. Rheumatology (Oxford). 2019;58(7):1259-1267. doi: 10.1093/rheumatology/kez014</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">DeNoble AE, Hall KS, Xu X, Zochowski MK, Piehl K, Dalton VK. Receipt of prescription contraception by commercially insured women with chronic medical conditions. Obstet Gynecol. 2014;123(6):1213-1220. doi: 10.1097/AOG.0000000000000279</mixed-citation><mixed-citation xml:lang="en">DeNoble AE, Hall KS, Xu X, Zochowski MK, Piehl K, Dalton VK. Receipt of prescription contraception by commercially insured women with chronic medical conditions. Obstet Gynecol. 2014;123(6):1213-1220. doi: 10.1097/AOG.0000000000000279</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Champaloux SW, Tepper NK, Curtis KM, Zapata LB, Whiteman MK, Marchbanks PA, et al. Contraceptive use among women with medical conditions in a nationwide privately insured population. Obstet Gynecol. 2015;126(6):1151-1159. doi: 10.1097/AOG.0000000000001134</mixed-citation><mixed-citation xml:lang="en">Champaloux SW, Tepper NK, Curtis KM, Zapata LB, Whiteman MK, Marchbanks PA, et al. Contraceptive use among women with medical conditions in a nationwide privately insured population. Obstet Gynecol. 2015;126(6):1151-1159. doi: 10.1097/AOG.0000000000001134</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Birru Talabi M, Clowse MEB, Blalock SJ, Moreland L, Siripong N, Borrero S. Contraception use among reproductive-age women with rheumatic diseases. Arthritis Care Res (Hoboken). 2019;71(8):1132-1140. doi: 10.1002/acr.23724</mixed-citation><mixed-citation xml:lang="en">Birru Talabi M, Clowse MEB, Blalock SJ, Moreland L, Siripong N, Borrero S. Contraception use among reproductive-age women with rheumatic diseases. Arthritis Care Res (Hoboken). 2019;71(8):1132-1140. doi: 10.1002/acr.23724</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Danowski A, de Azevedo MN, de Souza Papi JA, Petri M. Determinants of risk for venous and arterial thrombosis in primary antiphospholipid syndrome and in antiphospholipid syndrome with systemic lupus erythematosus. J Rheumatol. 2009;36(6):1195-1199. doi: 10.3899/jrheum.081194</mixed-citation><mixed-citation xml:lang="en">Danowski A, de Azevedo MN, de Souza Papi JA, Petri M. Determinants of risk for venous and arterial thrombosis in primary antiphospholipid syndrome and in antiphospholipid syndrome with systemic lupus erythematosus. J Rheumatol. 2009;36(6):1195-1199. doi: 10.3899/jrheum.081194</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Erkan D, Harrison MJ, Levy R, Peterson M, Petri M, Sammaritano L, et al. Aspirin for primary thrombosis prevention in the antiphospholipid syndrome: A randomized, double-blind, placebo-controlled trial in asymptomatic antiphospholipid antibody-positive individuals. Arthritis Rheum. 2007;56(7):2382-2391. doi: 10.1002/art.22663</mixed-citation><mixed-citation xml:lang="en">Erkan D, Harrison MJ, Levy R, Peterson M, Petri M, Sammaritano L, et al. Aspirin for primary thrombosis prevention in the antiphospholipid syndrome: A randomized, double-blind, placebo-controlled trial in asymptomatic antiphospholipid antibody-positive individuals. Arthritis Rheum. 2007;56(7):2382-2391. doi: 10.1002/art.22663</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Brouwer JL, Bijl M, Veeger NJ, Kluin-Nelemans HC, van der Meer J. The contribution of inherited and acquired thrombophilic defects, alone or combined with antiphospholipid antibodies, to venous and arterial thromboembolism in patients with systemic lupus erythematosus. Blood. 2004;104(1):143-148. doi: 10.1182/blood-2003-11-4085</mixed-citation><mixed-citation xml:lang="en">Brouwer JL, Bijl M, Veeger NJ, Kluin-Nelemans HC, van der Meer J. The contribution of inherited and acquired thrombophilic defects, alone or combined with antiphospholipid antibodies, to venous and arterial thromboembolism in patients with systemic lupus erythematosus. Blood. 2004;104(1):143-148. doi: 10.1182/blood-2003-11-4085</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Girolami A, Zanon E, Zanardi S, Saracino MA, Simioni P. Thromboembolic disease developing during oral contraceptive therapy in young females with antiphospholipid antibodies. Blood Coagul Fibrinolysis. 1996;7(4):497-501. doi: 10.1097/00001721-199606000-00011</mixed-citation><mixed-citation xml:lang="en">Girolami A, Zanon E, Zanardi S, Saracino MA, Simioni P. Thromboembolic disease developing during oral contraceptive therapy in young females with antiphospholipid antibodies. Blood Coagul Fibrinolysis. 1996;7(4):497-501. doi: 10.1097/00001721-199606000-00011</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Bacci S, Urquiola G, del Médico P, Sanabria JA, Bacci JC, Guzmán M, et al. Síndrome de Budd-Chiari, tromboembolismo pulmonar y trombosis venosa profunda, asociado con “anticoagulante lúpico” y uso reciente de anticonceptivos orales [Budd-Chiari syndrome, pulmonary thromboembolism, and deep venous thrombosis associated with “lupus anticoagulant” and recent use of oral contraceptives]. G E N. 1990;44(3):237-242 (In Spanish).</mixed-citation><mixed-citation xml:lang="en">Bacci S, Urquiola G, del Médico P, Sanabria JA, Bacci JC, Guzmán M, et al. Síndrome de Budd-Chiari, tromboembolismo pulmonar y trombosis venosa profunda, asociado con “anticoagulante lúpico” y uso reciente de anticonceptivos orales [Budd-Chiari syndrome, pulmonary thromboembolism, and deep venous thrombosis associated with “lupus anticoagulant” and recent use of oral contraceptives]. G E N. 1990;44(3):237-242 (In Spanish).</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Urbanus RT, Siegerink B, Roest M, Rosendaal FR, de Groot PG, Algra A. Antiphospholipid antibodies and risk of myocardial infarction and ischaemic stroke in young women in the RATIO study: A case-control study. Lancet Neurol. 2009;8(11):998-1005. doi: 10.1016/S1474-4422(09)70239-X</mixed-citation><mixed-citation xml:lang="en">Urbanus RT, Siegerink B, Roest M, Rosendaal FR, de Groot PG, Algra A. Antiphospholipid antibodies and risk of myocardial infarction and ischaemic stroke in young women in the RATIO study: A case-control study. Lancet Neurol. 2009;8(11):998-1005. doi: 10.1016/S1474-4422(09)70239-X</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Sammaritano LR.Which hormones and contraception for women with APS? Exogenous hormone use in women with APS. Curr Rheumatol Rep. 2021;23(6):44. doi: 10.1007/s11926-021-01006-w</mixed-citation><mixed-citation xml:lang="en">Sammaritano LR.Which hormones and contraception for women with APS? Exogenous hormone use in women with APS. Curr Rheumatol Rep. 2021;23(6):44. doi: 10.1007/s11926-021-01006-w</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Iskander MK, Khan M. Chorea as the initial presentation of oral contraceptive related systemic lupus erythematosus. J Rheumatol. 1989;16(6):850-851.</mixed-citation><mixed-citation xml:lang="en">Iskander MK, Khan M. Chorea as the initial presentation of oral contraceptive related systemic lupus erythematosus. J Rheumatol. 1989;16(6):850-851.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Yamakami LY, de Araujo DB, Silva CA, Baracat EC, de Carvalho JF. Severe hemorrhagic corpus luteum complicating anticoagulation in antiphospholipid syndrome. Lupus. 2011;20(5):523-526. doi: 10.1177/0961203310383300</mixed-citation><mixed-citation xml:lang="en">Yamakami LY, de Araujo DB, Silva CA, Baracat EC, de Carvalho JF. Severe hemorrhagic corpus luteum complicating anticoagulation in antiphospholipid syndrome. Lupus. 2011;20(5):523-526. doi: 10.1177/0961203310383300</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Crétel E, Cacoub P, Huong DL, Gompel A, Amoura Z, Piette JC. Massive ovarian haemorrhage complicating oral anticoagulation in the antiphospholipid syndrome: A report of three cases. Lupus. 1999;8(6):482-485. doi: 10.1177/096120339900800614</mixed-citation><mixed-citation xml:lang="en">Crétel E, Cacoub P, Huong DL, Gompel A, Amoura Z, Piette JC. Massive ovarian haemorrhage complicating oral anticoagulation in the antiphospholipid syndrome: A report of three cases. Lupus. 1999;8(6):482-485. doi: 10.1177/096120339900800614</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">ACOG Committee on Practice Bulletins-Gynecology. ACOG practice bulletin. No. 73: Use of hormonal contraception in women with coexisting medical conditions. Obstet Gynecol. 2006;107(6):1453-1472. doi: 10.1097/00006250-200606000-00055</mixed-citation><mixed-citation xml:lang="en">ACOG Committee on Practice Bulletins-Gynecology. ACOG practice bulletin. No. 73: Use of hormonal contraception in women with coexisting medical conditions. Obstet Gynecol. 2006;107(6):1453-1472. doi: 10.1097/00006250-200606000-00055</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Pisoni CN, Cuadrado MJ, Khamashta MA, Hunt BJ. Treatment of menorrhagia associated with oral anticoagulation: Efficacy and safety of the levonorgestrel releasing intrauterine device (Mirena coil). Lupus. 2006;15(12):877-880. doi: 10.1177/0961203306071706</mixed-citation><mixed-citation xml:lang="en">Pisoni CN, Cuadrado MJ, Khamashta MA, Hunt BJ. Treatment of menorrhagia associated with oral anticoagulation: Efficacy and safety of the levonorgestrel releasing intrauterine device (Mirena coil). Lupus. 2006;15(12):877-880. doi: 10.1177/0961203306071706</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Rebelo RC, Pignaton E, Valeria Bahamondes M, Costallat LTL, Appenzeller S, Bahamondes L, et al. Disease activity and thromboembolic events in women with systemic lupus erythematosus with and without anti-phospholipid syndrome: Users of the 52-mg levonorgestrel-releasing intrauterine system. Arch Gynecol Obstet. 2019;299(6):1597-1605. doi: 10.1007/s00404-019-05131-x</mixed-citation><mixed-citation xml:lang="en">Rebelo RC, Pignaton E, Valeria Bahamondes M, Costallat LTL, Appenzeller S, Bahamondes L, et al. Disease activity and thromboembolic events in women with systemic lupus erythematosus with and without anti-phospholipid syndrome: Users of the 52-mg levonorgestrel-releasing intrauterine system. Arch Gynecol Obstet. 2019;299(6):1597-1605. doi: 10.1007/s00404-019-05131-x</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">van Vlijmen EF, Veeger NJ, Middeldorp S, Hamulyák K, Prins MH, Büller HR, et al. Thrombotic risk during oral contraceptive use and pregnancy in women with factor V Leiden or prothrombin mutation: A rational approach to contraception. Blood. 2011;118(8):2055-2061;quiz 2375. doi: 10.1182/blood-2011-03-345678</mixed-citation><mixed-citation xml:lang="en">van Vlijmen EF, Veeger NJ, Middeldorp S, Hamulyák K, Prins MH, Büller HR, et al. Thrombotic risk during oral contraceptive use and pregnancy in women with factor V Leiden or prothrombin mutation: A rational approach to contraception. Blood. 2011;118(8):2055-2061;quiz 2375. doi: 10.1182/blood-2011-03-345678</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Klok FA, Barco S. Optimal management of hormonal contraceptives after an episode of venous thromboembolism. Thromb Res. 2019;181(Suppl 1):1-5. doi: 10.1016/S0049-3848(19)30357-3</mixed-citation><mixed-citation xml:lang="en">Klok FA, Barco S. Optimal management of hormonal contraceptives after an episode of venous thromboembolism. Thromb Res. 2019;181(Suppl 1):1-5. doi: 10.1016/S0049-3848(19)30357-3</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Martinelli I, Lensing AW, Middeldorp S, Levi M, Beyer-Westendorf J, van Bellen B, et al. Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use. Blood. 2016;127(11):1417-1425. doi: 10.1182/blood2015-08-665927</mixed-citation><mixed-citation xml:lang="en">Martinelli I, Lensing AW, Middeldorp S, Levi M, Beyer-Westendorf J, van Bellen B, et al. Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use. Blood. 2016;127(11):1417-1425. doi: 10.1182/blood2015-08-665927</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Паневин ТС, Попкова ТВ, Решетняк ТМ, Кошелева НМ, Ледина АВ. Менопаузальная гормонотерапия при системной красной волчанке: Pro et contra. Научно-практическая ревматология. 2023;61(1):70-76. doi: 10.47360/1995-4484-2023-70-76</mixed-citation><mixed-citation xml:lang="en">Panevin TS, Popkova TV, Reshetnyak TM, Kosheleva NM, Ledina AV. Menopausal hormone therapy for systemic lupus erythematosus: Pro et contra.  Nauchno-Prakticheskaya Revmatologia = Rheumatology Science and Practice. 2023;61(1):70-76 (In Russ.) doi: 10.47360/1995-4484-2023-70-76</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">The NAMS 2017 Hormone Therapy Position Statement Advisory Panel. The 2017 hormone therapy position statement of The North American Menopause Society. Menopause. 2017;24(7):728-753. doi: 10.1097/GME.0000000000000921</mixed-citation><mixed-citation xml:lang="en">The NAMS 2017 Hormone Therapy Position Statement Advisory Panel. The 2017 hormone therapy position statement of The North American Menopause Society. Menopause. 2017;24(7):728-753. doi: 10.1097/GME.0000000000000921</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">U.S. Preventive Services Task Force. Hormone therapy for the prevention of chronic conditions in postmenopausal women: Recommendations from the U.S. Preventive Services Task Force. Ann Intern Med. 2005;142(10):855-860.</mixed-citation><mixed-citation xml:lang="en">U.S. Preventive Services Task Force. Hormone therapy for the prevention of chronic conditions in postmenopausal women: Recommendations from the U.S. Preventive Services Task Force. Ann Intern Med. 2005;142(10):855-860.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Beral V; Million Women Study Collaborators. Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet. 2003;362(9382):419-427. doi: 10.1016/s0140-6736(03)14065-2</mixed-citation><mixed-citation xml:lang="en">Beral V; Million Women Study Collaborators. Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet. 2003;362(9382):419-427. doi: 10.1016/s0140-6736(03)14065-2</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Менопауза и климактерическое состояние у женщин: Клинические рекомендации МЗ РФ. М.;2021. [Menopause and climacteric condition in women. Clinical recommendations of the Ministry of Health of the Russian Federation. Moscow;2021 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Менопауза и климактерическое состояние у женщин: Клинические рекомендации МЗ РФ. М.;2021. [Menopause and climacteric condition in women. Clinical recommendations of the Ministry of Health of the Russian Federation. Moscow;2021 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Cushman M, Kuller LH, Prentice R, Rodabough RJ, Psaty BM, Stafford RS, et al.; Women’s Health Initiative Investigators. Estrogen plus progestin and risk of venous thrombosis. JAMA. 2004;292(13):1573-1580. doi: 10.1001/jama.292.13.1573</mixed-citation><mixed-citation xml:lang="en">Cushman M, Kuller LH, Prentice R, Rodabough RJ, Psaty BM, Stafford RS, et al.; Women’s Health Initiative Investigators. Estrogen plus progestin and risk of venous thrombosis. JAMA. 2004;292(13):1573-1580. doi: 10.1001/jama.292.13.1573</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Marjoribanks J, Farquhar C, Roberts H, Lethaby A. Long term hormone therapy for perimenopausal and postmenopausal women. Cochrane Database Syst Rev. 2012;(7):CD004143. doi: 10.1002/14651858</mixed-citation><mixed-citation xml:lang="en">Marjoribanks J, Farquhar C, Roberts H, Lethaby A. Long term hormone therapy for perimenopausal and postmenopausal women. Cochrane Database Syst Rev. 2012;(7):CD004143. doi: 10.1002/14651858</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Smith NL, Heckbert SR, Lemaitre RN, Reiner AP, Lumley T, Weiss NS, et al. Esterified estrogens and conjugated equine estrogens and the risk of venous thrombosis. JAMA. 2004;292(13):1581-1587. doi: 10.1001/jama.292.13.1581</mixed-citation><mixed-citation xml:lang="en">Smith NL, Heckbert SR, Lemaitre RN, Reiner AP, Lumley T, Weiss NS, et al. Esterified estrogens and conjugated equine estrogens and the risk of venous thrombosis. JAMA. 2004;292(13):1581-1587. doi: 10.1001/jama.292.13.1581</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Sweetland S, Beral V, Balkwill A, Liu B, Benson VS, Canonico M, et al.; Million Women Study Collaborators. Venous thromboembolism risk in relation to use of different types of postmenopausal hormone therapy in a large prospective study. J Thromb Haemost. 2012;10(11):2277-2286. doi: 10.1111/j.1538-7836.2012.04919.x</mixed-citation><mixed-citation xml:lang="en">Sweetland S, Beral V, Balkwill A, Liu B, Benson VS, Canonico M, et al.; Million Women Study Collaborators. Venous thromboembolism risk in relation to use of different types of postmenopausal hormone therapy in a large prospective study. J Thromb Haemost. 2012;10(11):2277-2286. doi: 10.1111/j.1538-7836.2012.04919.x</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Straczek C, Oger E, Yon de Jonage-Canonico MB, Plu-Bureau G, Conard J, Meyer G, et al.; Estrogen and Thromboembolism Risk (ESTHER) Study Group. Prothrombotic mutations, hormone therapy, and venous thromboembolism among postmenopausal women: Impact of the route of estrogen administration. Circulation. 2005; 112(22):3495-3500. doi: 10.1161/CIRCULATIONAHA.105.565556</mixed-citation><mixed-citation xml:lang="en">Straczek C, Oger E, Yon de Jonage-Canonico MB, Plu-Bureau G, Conard J, Meyer G, et al.; Estrogen and Thromboembolism Risk (ESTHER) Study Group. Prothrombotic mutations, hormone therapy, and venous thromboembolism among postmenopausal women: Impact of the route of estrogen administration. Circulation. 2005; 112(22):3495-3500. doi: 10.1161/CIRCULATIONAHA.105.565556</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Rosendaal FR, Vessey M, Rumley A, Daly E, Woodward M, Helmerhorst FM, et al. Hormonal replacement therapy, prothrombotic mutations and the risk of venous thrombosis. Br J Haematol. 2002;116(4):851-854. doi: 10.1046/j.0007-1048.2002.03356.x</mixed-citation><mixed-citation xml:lang="en">Rosendaal FR, Vessey M, Rumley A, Daly E, Woodward M, Helmerhorst FM, et al. Hormonal replacement therapy, prothrombotic mutations and the risk of venous thrombosis. Br J Haematol. 2002;116(4):851-854. doi: 10.1046/j.0007-1048.2002.03356.x</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Canonico M, Oger E, Plu-Bureau G, Conard J, Meyer G, Lévesque H, et al.; Estrogen and Thromboembolism Risk (ESTHER) Study Group. Hormone therapy and venous thromboembolism among postmenopausal women: Impact of the route of estrogen administration and progestogens: The ESTHER study. Circulation. 2007;115(7):840-845. doi: 10.1161/CIRCULATIONAHA.106.642280</mixed-citation><mixed-citation xml:lang="en">Canonico M, Oger E, Plu-Bureau G, Conard J, Meyer G, Lévesque H, et al.; Estrogen and Thromboembolism Risk (ESTHER) Study Group. Hormone therapy and venous thromboembolism among postmenopausal women: Impact of the route of estrogen administration and progestogens: The ESTHER study. Circulation. 2007;115(7):840-845. doi: 10.1161/CIRCULATIONAHA.106.642280</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Rovinski D, Ramos RB, Fighera TM, Casanova GK, Spritzer PM. Risk of venous thromboembolism events in postmenopausal women using oral versus non-oral hormone therapy: A systematic review and meta-analysis. Thromb Res. 2018;168:83-95. doi: 10.1016/j.thromres.2018.06.014</mixed-citation><mixed-citation xml:lang="en">Rovinski D, Ramos RB, Fighera TM, Casanova GK, Spritzer PM. Risk of venous thromboembolism events in postmenopausal women using oral versus non-oral hormone therapy: A systematic review and meta-analysis. Thromb Res. 2018;168:83-95. doi: 10.1016/j.thromres.2018.06.014</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Canonico M, Plu-Bureau G, Lowe GD, Scarabin PY. Hormone replacement therapy and risk of venous thromboembolism in postmenopausal women: Systematic review and meta-analysis. BMJ. 2008;336(7655):1227-1231. doi: 10.1136/bmj.39555.441944.BE</mixed-citation><mixed-citation xml:lang="en">Canonico M, Plu-Bureau G, Lowe GD, Scarabin PY. Hormone replacement therapy and risk of venous thromboembolism in postmenopausal women: Systematic review and meta-analysis. BMJ. 2008;336(7655):1227-1231. doi: 10.1136/bmj.39555.441944.BE</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Pinkerton JV, James AH. Management of menopausal symptoms for women who are at high risk of thrombosis. Clin Obstet Gynecol. 2018;61(2):260-268. doi: 10.1097/GRF.0000000000000358</mixed-citation><mixed-citation xml:lang="en">Pinkerton JV, James AH. Management of menopausal symptoms for women who are at high risk of thrombosis. Clin Obstet Gynecol. 2018;61(2):260-268. doi: 10.1097/GRF.0000000000000358</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Krause MS, Nakajima ST. Hormonal and nonhormonal treatment of vasomotor symptoms. Obstet Gynecol Clin North Am. 2015;42(1):163-179. doi: 10.1016/j.ogc.2014.09.008</mixed-citation><mixed-citation xml:lang="en">Krause MS, Nakajima ST. Hormonal and nonhormonal treatment of vasomotor symptoms. Obstet Gynecol Clin North Am. 2015;42(1):163-179. doi: 10.1016/j.ogc.2014.09.008</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Nelson HD, Vesco KK, Haney E, Fu R, Nedrow A, Miller J, et al. Nonhormonal therapies for menopausal hot flashes: Systematic review and meta-analysis. JAMA. 2006;295(17):2057-2071. doi: 10.1001/jama.295.17.2057</mixed-citation><mixed-citation xml:lang="en">Nelson HD, Vesco KK, Haney E, Fu R, Nedrow A, Miller J, et al. Nonhormonal therapies for menopausal hot flashes: Systematic review and meta-analysis. JAMA. 2006;295(17):2057-2071. doi: 10.1001/jama.295.17.2057</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Management of symptomatic vulvovaginal atrophy: 2013 position statement of The North American Menopause Society. Menopause. 2013;20(9):888-902;quiz 903-904. doi: 10.1097/GME.0b013e3182a122c2</mixed-citation><mixed-citation xml:lang="en">Management of symptomatic vulvovaginal atrophy: 2013 position statement of The North American Menopause Society. Menopause. 2013;20(9):888-902;quiz 903-904. doi: 10.1097/GME.0b013e3182a122c2</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Bhupathiraju SN, Grodstein F, Stampfer MJ, Willett WC, Crandall CJ, Shifren JL, et al. Vaginal estrogen use and chronic disease risk in the Nurses’ Health Study. Menopause. 2018;26(6):603-610. doi: 10.1097/GME.0000000000001284</mixed-citation><mixed-citation xml:lang="en">Bhupathiraju SN, Grodstein F, Stampfer MJ, Willett WC, Crandall CJ, Shifren JL, et al. Vaginal estrogen use and chronic disease risk in the Nurses’ Health Study. Menopause. 2018;26(6):603-610. doi: 10.1097/GME.0000000000001284</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">de Melo AS, Dos Reis RM, Ferriani RA, Vieira CS. Hormonal contraception in women with polycystic ovary syndrome: Choices, challenges, and noncontraceptive benefits. Open Access J Contracept. 2017;8:13-23. doi: 10.2147/OAJC.S85543</mixed-citation><mixed-citation xml:lang="en">de Melo AS, Dos Reis RM, Ferriani RA, Vieira CS. Hormonal contraception in women with polycystic ovary syndrome: Choices, challenges, and noncontraceptive benefits. Open Access J Contracept. 2017;8:13-23. doi: 10.2147/OAJC.S85543</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Vercellini P, Buggio L, Frattaruolo MP, Borghi A, Dridi D, Somigliana E. Medical treatment of endometriosis-related pain. Best Pract Res Clin Obstet Gynaecol. 2018;51:68-91. doi: 10.1016/j.bpobgyn.2018.01.015</mixed-citation><mixed-citation xml:lang="en">Vercellini P, Buggio L, Frattaruolo MP, Borghi A, Dridi D, Somigliana E. Medical treatment of endometriosis-related pain. Best Pract Res Clin Obstet Gynaecol. 2018;51:68-91. doi: 10.1016/j.bpobgyn.2018.01.015</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Yuk JS, Song JY, Lee JH, Park WI, Ahn HS, Kim HJ. Levonorgestrel-releasing intrauterine systems versus oral cyclic medroxyprogesterone acetate in endometrial hyperplasia therapy: A meta-analysis. Ann Surg Oncol. 2017;24(5):1322-1329. doi: 10.1245/s10434-016-5699-9</mixed-citation><mixed-citation xml:lang="en">Yuk JS, Song JY, Lee JH, Park WI, Ahn HS, Kim HJ. Levonorgestrel-releasing intrauterine systems versus oral cyclic medroxyprogesterone acetate in endometrial hyperplasia therapy: A meta-analysis. Ann Surg Oncol. 2017;24(5):1322-1329. doi: 10.1245/s10434-016-5699-9</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Grandone E, Di Micco PP, Villani M, Colaizzo D, FernándezCapitán C, Del Toro J, et al.; RIETE Investigators. Venous thromboembolism in women undergoing assisted reproductive technologies: Data from the RIETE registry. Thromb Haemost. 2018;118(11):1962-1968. doi: 10.1055/s-0038-1673402</mixed-citation><mixed-citation xml:lang="en">Grandone E, Di Micco PP, Villani M, Colaizzo D, FernándezCapitán C, Del Toro J, et al.; RIETE Investigators. Venous thromboembolism in women undergoing assisted reproductive technologies: Data from the RIETE registry. Thromb Haemost. 2018;118(11):1962-1968. doi: 10.1055/s-0038-1673402</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Machin N, Ragni MV. Hormones and thrombosis: Risk across the reproductive years and beyond. Transl Res. 2020;225:9-19. doi: 10.1016/j.trsl.2020.06.011</mixed-citation><mixed-citation xml:lang="en">Machin N, Ragni MV. Hormones and thrombosis: Risk across the reproductive years and beyond. Transl Res. 2020;225:9-19. doi: 10.1016/j.trsl.2020.06.011</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Xu X, Chlebowski RT, Shi J, Barac A, Haque R. Aromatase inhibitor and tamoxifen use and the risk of venous thromboembolism in breast cancer survivors. Breast Cancer Res Treat. 2019;174(3):785-794. doi: 10.1007/s10549-018-05086-8</mixed-citation><mixed-citation xml:lang="en">Xu X, Chlebowski RT, Shi J, Barac A, Haque R. Aromatase inhibitor and tamoxifen use and the risk of venous thromboembolism in breast cancer survivors. Breast Cancer Res Treat. 2019;174(3):785-794. doi: 10.1007/s10549-018-05086-8</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Getahun D, Nash R, Flanders WD, Baird TC, Becerra-Culqui TA, Cromwell L, et al. Cross-sex hormones and acute cardiovascular events in transgender persons: A cohort study. Ann Intern Med. 2018;169(4):205-213. doi: 10.7326/M17-2785</mixed-citation><mixed-citation xml:lang="en">Getahun D, Nash R, Flanders WD, Baird TC, Becerra-Culqui TA, Cromwell L, et al. Cross-sex hormones and acute cardiovascular events in transgender persons: A cohort study. Ann Intern Med. 2018;169(4):205-213. doi: 10.7326/M17-2785</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Goldstein Z, Khan M, Reisman T, Safer JD. Managing the risk of venous thromboembolism in transgender adults undergoing hormone therapy. J Blood Med. 2019;10:209-216. doi: 10.2147/JBM.S166780</mixed-citation><mixed-citation xml:lang="en">Goldstein Z, Khan M, Reisman T, Safer JD. Managing the risk of venous thromboembolism in transgender adults undergoing hormone therapy. J Blood Med. 2019;10:209-216. doi: 10.2147/JBM.S166780</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Duan B, Zhang Y, Wang X, Zhang Y, Hou Y, Bai J, et al. Effect of megestrol acetate combined with oral nutrition supplement in malnourished lung cancer patients: A single-center prospective cohort study. Front Nutr. 2021;8:654194. doi: 10.3389/fnut.2021.654194</mixed-citation><mixed-citation xml:lang="en">Duan B, Zhang Y, Wang X, Zhang Y, Hou Y, Bai J, et al. Effect of megestrol acetate combined with oral nutrition supplement in malnourished lung cancer patients: A single-center prospective cohort study. Front Nutr. 2021;8:654194. doi: 10.3389/fnut.2021.654194</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Poulter NR, Chang CL, Farley TM, Meirik O. Risk of cardiovascular diseases associated with oral progestagen preparations with therapeutic indications. Lancet. 1999;354(9190):1610. doi: 10.1016/s0140-6736(99)03132-3</mixed-citation><mixed-citation xml:lang="en">Poulter NR, Chang CL, Farley TM, Meirik O. Risk of cardiovascular diseases associated with oral progestagen preparations with therapeutic indications. Lancet. 1999;354(9190):1610. doi: 10.1016/s0140-6736(99)03132-3</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Аномальные маточные кровотечения. Клинические рекомендации МЗ РФ. М.;2021. [Abnormal uterine bleeding. Clinical recommendations of the Ministry of Health of the Russian Federation. Moscow;2021 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Аномальные маточные кровотечения. Клинические рекомендации МЗ РФ. М.;2021. [Abnormal uterine bleeding. Clinical recommendations of the Ministry of Health of the Russian Federation. Moscow;2021 (In Russ.)].</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
