rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.47360/1995-4484-2024-162-167rsp-3545Research ArticleФОРУМ МОЛОДЫХ УЧЕНЫХYOUNG SCIENTISTS FORUMМеханизмы повреждения хряща при подагре и гиперурикемииMechanisms of cartilage damage in gout and hyperuricemiahttps://orcid.org/0000-0002-4383-9872ПанинаЕ. В.PaninaE. V.

Панина Елена Владимировна – младший научный сотрудник лаборатории микрокристалических артритов

115522, Москва, Каширское шоссе, 34а

Elena V. Panina

115522, Moscow, Kashirskoye Highway, 34A

buipvybho@gmail.comФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation202428042024622162167Copyright © Панина Е.В., 20242024Панина Е.В.Panina E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/3545

Распространенность гиперурикемии (ГУ), которую можно считать первой стадией развития подагры, различается в разных странах и имеет тенденцию к нарастанию. Мочевая кислота (МК) даже в растворенной форме активирует повреждение и потенцирует гибель клеток суставного хряща за счет прямой цитотоксичности и ряда других механизмов. Возможная ассоциация ГУ и остеоартрита (ОА) может быть следствием ряда общих патогенетических механизмов, однако направление этой связи до сих пор остается дискуссионным вопросом. Накопленные данные предполагают необходимость более глубокого изучения взаимосвязи подагры и ГУ с патологическими процессами, приводящими к развитию и прогрессированию ОА и нарушений костного метаболизма.

The prevalence of hyperuricemia (HU), which can be considered the first stage of gout formation, varies in different countries and tends to increase. Uric acid (UA), even in its dissolved form, activates damage and potentiates the death of articular cartilage cells through direct cytotoxicity and a number of other pathogenetic mechanisms. The possible association of HU and osteoarthritis may be due to a number of common pathogenetic mechanisms, but the direction of this relationship is still a debatable issue. The accumulated data suggest the need for a deeper study of the relationship between gout and HU with pathological processes leading to the development and progression of osteoarthritis and bone metabolism disorders.

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The authors declare that there are no conflicts of interest present.