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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rsp</journal-id><journal-title-group><journal-title xml:lang="ru">Научно-практическая ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Rheumatology Science and Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-4484</issn><issn pub-type="epub">1995-4492</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.47360/1995-4484-2024-494-500</article-id><article-id custom-type="elpub" pub-id-type="custom">rsp-3635</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФОРУМ МОЛОДЫХ УЧЕНЫХ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>YOUNG SCIENTISTS FORUM</subject></subj-group></article-categories><title-group><article-title>Ревматоидный артрит с дебютом в пожилом возрасте: от иммунного старения до организации специализированной помощи</article-title><trans-title-group xml:lang="en"><trans-title>Rheumatoid arthritis with onset in old age: From immune aging to the organization of specialized care</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3431-5580</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аболешина</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Aboleshina</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аболешина Александра Вадимовна</p><p>115522, Москва, Каширское шоссе, 34а</p></bio><bio xml:lang="en"><p>Aleksandra Aboleshina</p><p>115522, Moscow, Kashirskoye Highway, 34A</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>31</day><month>10</month><year>2024</year></pub-date><volume>62</volume><issue>5</issue><fpage>494</fpage><lpage>500</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Аболешина А.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Аболешина А.В.</copyright-holder><copyright-holder xml:lang="en">Aboleshina A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://rsp.mediar-press.net/rsp/article/view/3635">https://rsp.mediar-press.net/rsp/article/view/3635</self-uri><abstract><p>Ревматоидный артрит (РА), начавшийся у пожилых пациентов, отличается от РА с дебютом в более раннем возрасте тяжестью течения, активностью, ответом на терапию и исходами, что позволяет предполагать наличие особого фенотипа РА с началом болезни в пожилом возрасте. Однако трудности ведения пожилого пациента с РА обусловлены не только особенностями основного заболевания, но и другими факторами: мультиморбидностью, полипрагмазией и гериатрическими синдромами (саркопения, старческая астения, падения, когнитивный дефицит, инконтиненция). Такое сочетание клинических состояний не только значимо отягощает течение основного заболевания, но и усложняет выбор тактики ведения пациента в целом. Имеющиеся сложности курации пожилых пациентов с РА пока не послужили поводом к формированию общепринятого подхода, однако для решения данного вопроса была предложена комплексная гериатрическая оценка (КГО). КГО представляет собой диагностический процесс, включающий оценку физического, психоэмоционального статуса, функциональных возможностей и социальных проблем пожилого человека с целью сохранения его независимости, общего функционирования, а также оптимизации медицинской и социальной помощи.</p></abstract><trans-abstract xml:lang="en"><p>The onset of rheumatoid arthritis (RA) in the old age differs from that at an earlier age in terms of severity of course, disease activity, response to therapy, and outcomes, which has led to the suggestion of a specific phenotype of RA with onset in old age. However, the difficulties of managing the elderly patient with RA are not only due to the specific features of the main disease, but also due to other factors: multimorbidity, polypharmacy and geriatric syndromes (sarcopenia, senile asthenia, falls, cognitive deficit, incontinence). Such a combination of clinical conditions significantly exacerbates not only the course of the main disease, but also complicates the decision-making process regarding the optimal tactics for the overall patient management. The existing difficulties of managing elderly patients with RA have not yet led to the formation of a generally accepted approach; however, to solve this problem, a comprehensive geriatric assessment (CGA) has been proposed. CGA is a diagnostic process aimed at evaluating the physical, psycho-emotional status, functional abilities and social problems of the elderly person in order to keep their independence, general functioning, as well as to optimize medical and social care.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ревматоидный артрит</kwd><kwd>пожилой возраст</kwd><kwd>мультиморбидность</kwd><kwd>полипрагмазия</kwd><kwd>гериатрические синдромы</kwd><kwd>комплексная гериатрическая оценка</kwd></kwd-group><kwd-group xml:lang="en"><kwd>rheumatoid arthritis</kwd><kwd>elderly age</kwd><kwd>multimorbidity</kwd><kwd>polypharmacy</kwd><kwd>geriatric syndromes</kwd><kwd>comprehensive geriatric assessment</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена в рамках фундаментальной научной тематики FURS-2022-008 «Разработка персонализированной программы лечения рефрактерного ревматоидного артрита на основе изучения молекулярно-генетических и молекулярно-биологических предикторов. Создание и апробация регистра пациентов с ревматоидным артритом, резистентных к базисной противовоспалительной терапии» (номер государственного задания 1021051503137-7).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Насонов ЕЛ (ред.). Ревматология. Российские клинические рекомендации. М.:ГЭОТАР-Медиа;2020.</mixed-citation><mixed-citation xml:lang="en">Nasonov EL (ed.). Rheumatology. Russian clinical recommendations. Moscow:GEOTAR-Media;2020 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">GBD 2021 Rheumatoid Arthritis Collaborators. Global, regional, and national burden of rheumatoid arthritis, 1990–2020, and projections to 2050: A systematic analysis of the Global Burden of Disease Study 2021. 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