rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.47360/1995-4484-2024-582-589rsp-3653Research ArticleПРОГРЕСС В РЕВМАТОЛОГИИ В XXI ВЕКЕPROGRESS IN RHEUMATOLOGY IN THE XXI CENTURYРоль интерлейкина 17 в патогенезе гигантоклеточного артериита: новые возможности фармакотерапииThe role of interleukin 17 in the pathogenesis of giant cell arteritis: new possibilities for pharmacotherapyhttps://orcid.org/0000-0002-1598-8360НасоновЕ. Л.NasonovE. L.

Евгений Львович Насонов, д.м.н., профессор, академик РАН, научный руководитель

115522, Москва, Каширское шоссе, 34а

119991, Москва, ул. Трубецкая, 8, стр. 2

Evgeny L. Nasonov 

115522, Moscow, Kashirskoye Highway, 34A

119991, Moscow, Trubetskaya str., 8, building 2

nasonov@irramn.ruhttps://orcid.org/0000-0003-2641-9785БекетоваТ. В.BeketovaT. V.

д.м.н., заведующая ревматологическим отделением (с нефрологическими койками и кабинетом терапии генно-инженерными биологическими препаратами); ведущий научный сотрудник лаборатории системного склероза

115522, Москва, Каширское шоссе, 34а

121356, Москва, ул. Маршала Тимошенко, 15

107023, Москва, ул. Большая Семёновская, 38

Tatiana V. Beketova 

115522, Moscow, Kashirskoye Highway, 34A

121359, Moscow, Marshala Timoshenko str., 19, building 1A

107023, Moscow, Bolshaya Semyonovskaya str., 38

https://orcid.org/0000-0002-1508-0854СатыбалдыевА. М.SatybaldyevA. M.

д.м.н., ведущий научный сотрудник лаборатории эволюции ревматоидного артрита

115522, Москва, Каширское шоссе, 34а

Azamat M. Satybaldyev 

115522, Moscow, Kashirskoye Highway, 34A

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой» ; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияV.A. Nasonova Research Institute of Rheumatology ; I.M. Sechenov First Moscow State Medical University of the Ministry of Health Care of Russian Federation (Sechenov University)Russian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой» ; ФГБУ «Центральная клиническая больница с поликлиникой» Управления делами Президента Российской Федерации ; ФГАОУ ВО «Московский политехнический университет»РоссияI.M. Sechenov First Moscow State Medical University of the Ministry of Health Care of Russian Federation (Sechenov University) ; Central State Medical Academy of the Administrative Directorate of the President of the Russian Federation ; Moscow Polytechnic UniversityRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation202426122024626582589Copyright © Насонов Е.Л., Бекетова Т.В., Сатыбалдыев А.М., 20242024Насонов Е.Л., Бекетова Т.В., Сатыбалдыев А.М.Nasonov E.L., Beketova T.V., Satybaldyev A.M.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/3653

Гигантоклеточный артериит (ГКА) относится к иммуновоспалительным ревматическим заболеваниям (ИВРЗ). Обращается внимание на парадоксальным несоответствием между высокой эффективностью глюкокортикоидов (ГК) в краткосрочной перспективе и нарастанием тяжести патологии, связанной с сохраняющейся воспалительной активностью и накоплением органных повреждений, индуцированных ГК, в отдаленной перспективе, что свидетельствует о необходимости совершенствования терапии, в первую очередь в направлении оптимизацией применения ГК. Новые возможности фармакотерапии ГКА связаны с применением моноклональных антител (мАТ), блокирующих активность цитокинов, участвующих в иммунопатогенезе ИВРЗ. Среди фармакологических «мишеней» особое внимание привлекает интерлейкин (ИЛ) 6, а также ИЛ-17. В настоящее время разработано несколько мАТ, специфичных в отношении ИЛ-17. В статье суммированы данные, касающиеся патогенетического значения ИЛ-17 при ГКА и перспективы фармакотерапии ГКА с использованием мАТ к ИЛ-17.

Giant cell arteritis (GCA) characterized by the paradoxical discrepancy between the high effectiveness of glucocorticoid (GCs) in the short term and the increase in signs associated with the persistence of inflammatory activity and the accumulation of organ damage induced by GCs in the long term, which indicates the need for the use of therapy, primarily in the direction of optimizing the use of GCs. New opportunities for pharmacotherapy of GCA are associated with the use of monoclonal antibodies (mAbs) that block the activity of cytokines involved in the immunopathogenesis of IMIRDs. Among pharmacological “targets”, interleukin (IL) 6, as well as IL-17, attracts special attention. Currently, several mAbs specific for IL-17 have been developed. The article summarizes data regarding the pathogenetic significance of IL-17 in GCA and the prospects for pharmacotherapy of GCA using mAbs to IL-17.

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The authors declare that there are no conflicts of interest present.