rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.47360/1995-4484-2024-622-626rsp-3658Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHЕсть ли связь между остеопорозом и мочевой кислотой?Is there an association between osteoporosis and uric acid?https://orcid.org/0000-0003-4739-4302ТоропцоваН. В.ToroptsovaN. V.

115522, Москва, Каширское шоссе, 34а

Natalia V. Toroptsova 

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0002-2809-0197ДобровольскаяО. В.DobrovolskayaO. V.

Добровольская Ольга Валерьевна 

115522, Москва, Каширское шоссе, 34а

Olga V. Dobrovolskaya 

115522, Moscow, Kashirskoye Highway, 34A

olgavdobr@mail.ruhttps://orcid.org/0000-0003-0560-3495КозыреваМ. В.KozyrevaM. V.

115522, Москва, Каширское шоссе, 34а

Maria V. Kozyreva 

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0003-0961-9785ДеминН. В.DeminN. V.

115522, Москва, Каширское шоссе, 34а

Nikolay V. Demin 

115522, Moscow, Kashirskoye Highway, 34A

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation202427122024626622626Copyright © Торопцова Н.В., Добровольская О.В., Козырева М.В., Демин Н.В., 20242024Торопцова Н.В., Добровольская О.В., Козырева М.В., Демин Н.В.Toroptsova N.V., Dobrovolskaya O.V., Kozyreva M.V., Demin N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/3658

Цель исследования – изучить связь между уровнем мочевой кислоты (МК) сыворотки крови, минеральной плотностью кости (МПК) и наличием остеопороза (ОП) у женщин в постменопаузе.

Материал и методы

Материал и методы. Обследованы 394 женщины в постменопаузе (медиана возраста – 62 [56; 68] года). Проведены опрос, антропометрические измерения, биохимическое исследование крови, двухэнергетическая рентгеновская денситометрия с определением МПК в поясничном отделе позвоночника (L1–L4), шейке бедра (ШБ) и проксимальном отделе бедра (ПОБ) в целом.

Результаты

Результаты. У женщин с ОП уровень урикемии и частота гиперурикемии были меньше, чем у лиц без ОП (р=0,005 и р=0,019 соответственно). Содержание МК слабо позитивно коррелировало с МПК в L1–L4 (r=0,20; р<0,001), ШБ (r=0,12; р=0,021) и ПОБ (r=0,17; р=0,001). Слабая обратная корреляция выявлена между уровнем МК и наличием ОП (r=–0,13; р=0,008). Множественный логистический регрессионный анализ показал, что независимыми факторами, связанными с ОП у женщин в постменопаузе, были возраст (отношение шансов (ОШ) – 1,06; 95%-й доверительный интервал (95% ДИ): 1,02–1,10; р=0,003) и индекс массы тела (ОШ=0,83 (95% ДИ: 0,77–0,89); р<0,001). Статистически значимой связи между уровнем МК и ОП не выявлено.

Заключение

Заключение. Таким образом, у женщин в постменопаузе не выявлено влияния МК на риск развития ОП.

The aim – to study the association between serum uric acid (SUA) level, bone mineral density (BMD) and osteoporosis (OP) in postmenopausal women.

Materials and methods

Materials and methods. 394 postmenopausal women were examined (median age – 62 [56; 68] years). Examination and anthropometric measurements, a biochemical blood test, including level of SUA, dual-energy X-ray absorptiometry of the lumbar spine (L1–L4), femoral neck (FN) and total hip (TH) were carried out.

Results

Results. In women with OP, the level of SUA and the frequency of hyperuricemia were lower than in those without OP (p=0.005 and p=0.019, respectively). SUA was weakly positively correlated with BMD in L1–L4 (r=0.20; p<0.001), FN (r=0.12; p=0.021) and TH (r=0.17; p=0.001). A weak negative correlation was found between the level of SUA and the presence of OP (r=–0.13; p=0.008). Multiple logistic regression analysis showed that the independent factors associated with OP in postmenopausal women were age (odds ratio (OR) – 1.06 (95% confidence interval (95% CI): 1.02–1.10); p=0.003) and body mass index (OR=0.83 (95% CI: 0.77–0.89); p<0.001). There was no significant relationship between the level of SUA and OP.

Conclusion

Conclusion. Thus, in postmenopausal women, the effect of SUA on the risk of OP was not revealed.

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The authors declare that there are no conflicts of interest present.