rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.47360/1995-4484-2025-246-252rsp-3764Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESМенопауза и ревматоидный артрит. Что мы знаем на сегодняшний день?Menopause and rheumatoid arthritis (up to date)https://orcid.org/0000-0002-5290-156XПаневинТ. С.PanevinT. S.

Паневин Тарас Сергеевич.

115522, Москва, Каширское шоссе, 34а; 680000, Хабаровск, ул. Муравьева-Амурского, 35

Taras S. Panevin.

115522, Moscow, Kashirskoye Highway, 34A; 680000, Khabarovsk, Muravyova-Amurskogo str., 35

tarasel@list.ruhttps://orcid.org/0000-0002-0627-3902СметникА. А.SmetnikA. A.

117997, Москва, ул. Академика Опарина, 4

Antonina A. Smetnik.

117997, Moscow, Akademika Oparina str., 4

https://orcid.org/0000-0002-4579-2836ЗоткинЕ. Г.ZotkinE. G.

115522, Москва, Каширское шоссе, 34а

Evgeniy G. Zotkin.

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0002-1598-8360НасоновЕ. Л.NasonovE. L.

115522, Москва, Каширское шоссе, 34а

Evgeny L. Nasonov.

115522, Moscow, Kashirskoye Highway, 34A

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГБОУ ВО «Дальневосточный государственный медицинский университет» Минздрава РоссииРоссияV.A. Nasonova Research Institute of Rheumatology; Far Eastern State Medical UniversityRussian FederationФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Минздрава РоссииРоссияNational Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. KulakovRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation202502072025633246252Copyright © Паневин Т.С., Сметник А.А., Зоткин Е.Г., Насонов Е.Л., 20252025Паневин Т.С., Сметник А.А., Зоткин Е.Г., Насонов Е.Л.Panevin T.S., Smetnik A.A., Zotkin E.G., Nasonov E.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/3764

Ревматоидным артритом (РА) наиболее часто страдают женщины, а дебют РА часто приходится на средний возраст наступления менопаузы. РА у женщин в сравнении с мужчинами протекает тяжелее, характеризуется трудностями достижения ремиссии и более негативным прогнозом. Результаты исследований говорят о наличии взаимосвязи между менопаузой, уровнем эстрогенов и РА. Раннее наступление менопаузы характеризуется увеличением риска развития РА, а также трудностями достижения ремиссии и более низким качеством жизни. Менопаузальная гормонотерапия (МГТ) может оказывать влияние как на риск развития РА, так и на его течение. С учетом взаимосвязи менопаузы и других состояний, таких как ожирение, сердечно-сосудистые заболевания, остеопороз и фибромиалгия, назначение МГТ, согласно зарегистрированным показаниям, может быть одним из возможных путей преодоления резистентности к терапии РА.

Rheumatoid arthritis (RA) most often affects women, and the onset of RA often occurs around the middle age of menopause. RA in women, compared to men, is more severe, characterized by difficulties in achieving remission and a more negative prognosis. Research results indicate a relationship between menopause, estrogen levels and RA. Early menopause is characterized by an increased risk of developing RA, as well as difficulty achieving remission and a lower quality of life. Menopausal hormone therapy (MHT) may influence both the risk of developing RA and its course. Given the relationship between menopause and other conditions such as obesity, cardiovascular disease, osteoporosis and fibromyalgia, off-label MHT may be one of the possible ways to overcome treatment resistance in RA.

ревматоидный артритменопаузаклимактерический синдромрезистентностьrheumatoid arthritismenopausemenopausal syndromeresistanceОбзор литературы выполнен в рамках государственного задания по теме № 125020301268-4 «Персонализация лечения ревматоидного артрита, направленного на поддержание стойкой ремиссии с учетом клинических и молекулярно-биологических предикторов ответа на базисную терапию».ReferencesKlareskog L, Stolt P, Lundberg K, Källberg H, Bengtsson C, Grunewald J, et al. A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum. 2006;54(1):38-46. doi: 10.1002/art.21575Klareskog L, Stolt P, Lundberg K, Källberg H, Bengtsson C, Grunewald J, et al. A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum. 2006;54(1):38-46. doi: 10.1002/art.21575Nagy G, Roodenrijs NMT, Welsing PM, Kedves M, Hamar A, van der Goes MC, et al. EULAR definition of difficult-to-treat rheumatoid arthritis. Ann Rheum Dis. 2021;80(1):31-35. doi: 10.1136/annrheumdis-2020-217344Nagy G, Roodenrijs NMT, Welsing PM, Kedves M, Hamar A, van der Goes MC, et al. EULAR definition of difficult-to-treat rheumatoid arthritis. Ann Rheum Dis. 2021;80(1):31-35. doi: 10.1136/annrheumdis-2020-217344Насонов ЕЛ. Фармакотерапия ревматоидного артрита: новая стратегия, новые мишени. Научно-практическая ревматология. 2017;55(4):409-419. doi: 10.14412/1995-4484-2017-409-419Nasonov EL. Pharmacotherapy for rheumatoid arthritis: New strategy, new targets. Nauchno-Prakticheskaya Revmatologia = Rheumatology Science and Practice. 2017;55(4):409-419 (In Russ.). doi: 10.14412/1995-4484-2017-409-419Насонов ЕЛ, Олюнин ЮА, Лила АМ. Ревматоидный артрит: проблемы ремиссии и резистентности к терапии. Научно-практическая ревматология. 2018;56(3):263-271. doi: 10.14412/1995-4484-2018-263-271Nasonov EL, Olyunin YuA, Lila AM. Rheumatoid arthritis: The problems of remission and therapy resistance. Nauchno-Prakticheskaya Revmatologia = Rheumatology Science and Practice. 2018;56(3):363-271 (In Russ.). doi: 10.14412/1995-4484-2018-263-271Kvien TK, Uhlig T, Ødegård S, Heiberg MS. Epidemiological aspects of rheumatoid arthritis: The sex ratio. Ann N Y Acad Sci. 2006;1069:212-222. doi: 10.1196/annals.1351.019Kvien TK, Uhlig T, Ødegård S, Heiberg MS. Epidemiological aspects of rheumatoid arthritis: The sex ratio. Ann N Y Acad Sci. 2006;1069:212-222. doi: 10.1196/annals.1351.019Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW, et al. Executive summary of the Stages of Reproductive Aging Workshop + 10: Addressing the unfinished agenda of staging reproductive aging. J Clin Endocrinol Metab. 2012;97(4):1159-1168. doi: 10.1210/jc.2011-3362Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW, et al. Executive summary of the Stages of Reproductive Aging Workshop + 10: Addressing the unfinished agenda of staging reproductive aging. J Clin Endocrinol Metab. 2012;97(4):1159-1168. doi: 10.1210/jc.2011-3362Jawaheer D, Maranian P, Park G, Lahiff M, Amjadi SS, Paulus HE. Disease progression and treatment responses in a prospective DMARD-naive seropositive early rheumatoid arthritis cohort: Does gender matter? J Rheumatol. 2010;37(12):2475-2485. doi: 10.3899/jrheum.091432Jawaheer D, Maranian P, Park G, Lahiff M, Amjadi SS, Paulus HE. Disease progression and treatment responses in a prospective DMARD-naive seropositive early rheumatoid arthritis cohort: Does gender matter? J Rheumatol. 2010;37(12):2475-2485. doi: 10.3899/jrheum.091432Kuiper S, van Gestel AM, Swinkels HL, de Boo TM, da Silva JA, van Riel PL. Influence of sex, age, and menopausal state on the course of early rheumatoid arthritis. J Rheumatol. 2001;28(8):1809-1816.Kuiper S, van Gestel AM, Swinkels HL, de Boo TM, da Silva JA, van Riel PL. Influence of sex, age, and menopausal state on the course of early rheumatoid arthritis. J Rheumatol. 2001;28(8):1809-1816.Alpizar-Rodriguez D, Förger F, Courvoisier DS, Gabay C, Finckh A. Role of reproductive and menopausal factors in functional and structural progression of rheumatoid arthritis: Results from the SCQM cohort. Rheumatology (Oxford). 2019;58(3):432-440. doi: 10.1093/rheumatology/key311Alpizar-Rodriguez D, Förger F, Courvoisier DS, Gabay C, Finckh A. Role of reproductive and menopausal factors in functional and structural progression of rheumatoid arthritis: Results from the SCQM cohort. Rheumatology (Oxford). 2019;58(3):432-440. doi: 10.1093/rheumatology/key311Cutolo M, Gotelli E. Complex role of oestrogens in the risk and severity of rheumatoid arthritis in menopause. RMD Open. 2023;9(2):e003176. doi: 10.1136/rmdopen-2023-003176Cutolo M, Gotelli E. Complex role of oestrogens in the risk and severity of rheumatoid arthritis in menopause. RMD Open. 2023;9(2):e003176. doi: 10.1136/rmdopen-2023-003176Cutolo M, Straub RH. Sex steroids and autoimmune rheumatic diseases: State of the art. Nat Rev Rheumatol. 2020;16(11):628-644. doi: 10.1038/s41584-020-0503-4Cutolo M, Straub RH. Sex steroids and autoimmune rheumatic diseases: State of the art. Nat Rev Rheumatol. 2020;16(11):628-644. doi: 10.1038/s41584-020-0503-4Straub RH. The complex role of estrogens in inflammation. Endocr Rev. 2007;28(5):521-574. doi: 10.1210/er.2007-0001Straub RH. The complex role of estrogens in inflammation. Endocr Rev. 2007;28(5):521-574. doi: 10.1210/er.2007-0001Islander U, Jochems C, Lagerquist MK, Forsblad-d’Elia H, Carlsten H. Estrogens in rheumatoid arthritis; the immune system and bone. Mol Cell Endocrinol. 2011;335(1):14-29. doi: 10.1016/j.mce.2010.05.018Islander U, Jochems C, Lagerquist MK, Forsblad-d’Elia H, Carlsten H. Estrogens in rheumatoid arthritis; the immune system and bone. Mol Cell Endocrinol. 2011;335(1):14-29. doi: 10.1016/j.mce.2010.05.018Kim OY, Chae JS, Paik JK, Seo HS, Jang Y, Cavaillon JM, et al. Effects of aging and menopause on serum interleukin-6 levels and peripheral blood mononuclear cell cytokine production in healthy nonobese women. Age (Dordr). 2012;34(2):415-425. doi: 10.1007/s11357-011-9244-2Kim OY, Chae JS, Paik JK, Seo HS, Jang Y, Cavaillon JM, et al. Effects of aging and menopause on serum interleukin-6 levels and peripheral blood mononuclear cell cytokine production in healthy nonobese women. Age (Dordr). 2012;34(2):415-425. doi: 10.1007/s11357-011-9244-2Al-Salman H. 17β-estradiol hormone and interleukin 1-beta change related to menopause in the women with rheumatoid arthritis. Asian J Pharm. 2019;13(02). doi: 10.22377/ajp.v13i02.31066Al-Salman H. 17β-estradiol hormone and interleukin 1-beta change related to menopause in the women with rheumatoid arthritis. Asian J Pharm. 2019;13(02). doi: 10.22377/ajp.v13i02.31066Engdahl C, Bondt A, Harre U, Raufer J, Pfeifle R, Camponeschi A, et al. Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: A potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women. Arthritis Res Ther. 2018;20(1):84. doi: 10.1186/s13075-018-1586-zEngdahl C, Bondt A, Harre U, Raufer J, Pfeifle R, Camponeschi A, et al. Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: A potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women. Arthritis Res Ther. 2018;20(1):84. doi: 10.1186/s13075-018-1586-zOhmi Y, Ise W, Harazono A, Takakura D, Fukuyama H, Baba Y, et al. Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis. Nat Commun. 2016;7:11205. doi: 10.1038/ncomms11205Ohmi Y, Ise W, Harazono A, Takakura D, Fukuyama H, Baba Y, et al. Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis. Nat Commun. 2016;7:11205. doi: 10.1038/ncomms11205Gupta P, Sághy T, Nordqvist J, Nilsson J, Carlsten H, Horkeby K, et al. Impact of estrogen on IgG glycosylation and serum protein glycosylation in a murine model of healthy postmenopause. Front Endocrinol (Lausanne). 2023;14:1243942. doi: 10.3389/fendo.2023.1243942Gupta P, Sághy T, Nordqvist J, Nilsson J, Carlsten H, Horkeby K, et al. Impact of estrogen on IgG glycosylation and serum protein glycosylation in a murine model of healthy postmenopause. Front Endocrinol (Lausanne). 2023;14:1243942. doi: 10.3389/fendo.2023.1243942Zhang X, Qiao P, Guo Q, Liang Z, Pan J, Wu F, et al. High follicle-stimulating hormone level associated with risk of rheumatoid arthritis and disease activity. Front Endocrinol (Lausanne). 2022;13:862849. doi: 10.3389/fendo.2022.862849Zhang X, Qiao P, Guo Q, Liang Z, Pan J, Wu F, et al. High follicle-stimulating hormone level associated with risk of rheumatoid arthritis and disease activity. Front Endocrinol (Lausanne). 2022;13:862849. doi: 10.3389/fendo.2022.862849Qian H, Jia J, Yang Y, Bian Z, Ji Y. A follicle-stimulating hormone exacerbates the progression of periapical inflammation through modulating the cytokine release in periodontal tissue. Inflammation. 2020;43(4):1572-1585. doi: 10.1007/s10753-020-01234-9Qian H, Jia J, Yang Y, Bian Z, Ji Y. A follicle-stimulating hormone exacerbates the progression of periapical inflammation through modulating the cytokine release in periodontal tissue. Inflammation. 2020;43(4):1572-1585. doi: 10.1007/s10753-020-01234-9Mumusoglu S, Yildiz BO. Metabolic syndrome during menopause. Curr Vasc Pharmacol. 2019;17(6):595-603. doi: 10.2174/1570161116666180904094149Mumusoglu S, Yildiz BO. Metabolic syndrome during menopause. Curr Vasc Pharmacol. 2019;17(6):595-603. doi: 10.2174/1570161116666180904094149Pamuk ON, Dönmez S, Cakir N. Increased frequencies of hysterectomy and early menopause in fibromyalgia patients: A comparative study. Clin Rheumatol. 2009;28(5):561-564. doi: 10.1007/s10067-009-1087-1Pamuk ON, Dönmez S, Cakir N. Increased frequencies of hysterectomy and early menopause in fibromyalgia patients: A comparative study. Clin Rheumatol. 2009;28(5):561-564. doi: 10.1007/s10067-009-1087-1Eisenberger NI, Inagaki TK, Rameson LT, Mashal NM, Irwin MR. An fMRI study of cytokine-induced depressed mood and social pain: The role of sex differences. Neuroimage. 2009;47(3):881-890. doi: 10.1016/j.neuroimage.2009.04.040Eisenberger NI, Inagaki TK, Rameson LT, Mashal NM, Irwin MR. An fMRI study of cytokine-induced depressed mood and social pain: The role of sex differences. Neuroimage. 2009;47(3):881-890. doi: 10.1016/j.neuroimage.2009.04.040Каратеев АЕ, Насонов ЕЛ. Хроническая боль и центральная сенситизация при иммуновоспалительных ревматических заболеваниях: патогенез, клинические проявления, возможность применения таргетных базисных противовоспалительных препаратов. Научно-практическая ревматология. 2019;57(2):197-209 doi: 10.14412/1995-4484-2019-197-209Karateev AE, Nasonov EL. Chronic pain and central sensitization in immuno-inflammatory rheumatic diseases: Pathogenesis, clinical manifestations, the possibility of using targeted disease modifying antirheumatic drugs. Nauchno-Prakticheskaya Revmatologia = Rheumatology Science and Practice. 2019;57(2):197-209 (In Russ.). doi: 10.14412/1995-4484-2019-197-209Паневин ТС, Бобкова АО, Каратеев АЕ, Зоткин ЕГ. Дефицит эндогенных эстрогенов и развитие хронической скелетно-мышечной боли. Терапевтический архив. 2022;94(5):683-688. doi: 10.26442/00403660.2022.05.201490Panevin TS, Bobkova AO, Karateev AE, Zotkin EG. Endogenous estrogen deficiency and the development of chronic musculoskeletal pain: A review. Terapevticheskii arkhiv. 2022;94(5):683-688 (In Russ.). doi: 10.26442/00403660.2022.05.201490Круглый ЛБ, Фомичева ОА, Карпов ЮА, Попкова ТВ, Новикова ДС, Насонов ЕЛ. Сердечно-сосудистые осложнения ревматоидного артрита: распространенность и патогенез. Кардиология. 2016;6:89-95. doi: 10.18565/cardio.2016.6.89-95Krougly LB, Fomicheva OA, Karpov YA, Popkova TV, Novikova DS, Nasonov EL. Cardiovascular complications of rheumatoid arthritis: Prevalence and pathogenesis. Kardiologiia. 2016;6:89-95 (In Russ.). doi: 10.18565/cardio.2016.6.89-95Lee E, Anselmo M, Tahsin CT, Vanden Noven M, Stokes W, Carter JR, et al. Vasomotor symptoms of menopause, autonomic dysfunction, and cardiovascular disease. Am J Physiol Heart Circ Physiol. 2022;323(6):H1270-H1280. doi: 10.1152/ajpheart.00477.2022Lee E, Anselmo M, Tahsin CT, Vanden Noven M, Stokes W, Carter JR, et al. Vasomotor symptoms of menopause, autonomic dysfunction, and cardiovascular disease. Am J Physiol Heart Circ Physiol. 2022;323(6):H1270-H1280. doi: 10.1152/ajpheart.00477.2022Осипова ИВ, Стародубова ЮН. Прогнозирование сердечно-сосудистых заболеваний у женщин с ревматоидным артритом. Кардиология. 2024;64(1):67-79. doi: 10.18087/cardio.2024.1.n2616Osipova IV, Starodubova YN. Prediction of cardiovascular diseases in women with rheumatoid arthritis. Kardiologiia. 2024;64(1):67-79 (In Russ.). doi: 10.18087/cardio.2024.1.n2616Gomez-Ramirez EE, Ramirez-Villafaña M, Gamez-Nava JI, Cons-Molina F, Rodriguez Jimenez NA, Saldaña-Cruz AM, et al. Risk factors of muscle wasting in women with rheumatoid arthritis: Relevance of the persistent failure of conventional combination therapy. Healthcare (Basel). 2022;10(10):2004. doi: 10.3390/healthcare10102004Gomez-Ramirez EE, Ramirez-Villafaña M, Gamez-Nava JI, Cons-Molina F, Rodriguez Jimenez NA, Saldaña-Cruz AM, et al. Risk factors of muscle wasting in women with rheumatoid arthritis: Relevance of the persistent failure of conventional combination therapy. Healthcare (Basel). 2022;10(10):2004. doi: 10.3390/healthcare10102004Российское общество акушеров-гинекологов. Менопауза и климактерическое состояние у женщины: клинические рекомендации. М.;2021.Russian Society of Obstetricians and Gynecologists. Menopause and climacteric state in women: Clinical guidelines. Moscow;2021 (In Russ.).Паневин ТС, Ледина АВ, Зоткин ЕГ. Менопауза и преждевременная недостаточность яичников при ревматических заболеваниях. Гинекология. 2023;25(4):428-434. doi: 10.26442/20795696.2023.4.202366Panevin TS, Ledina AV, Zotkin EG. Menopause and premature ovarian insufficiency in rheumatic diseases: A review. Gynecology. 2023;25(4):428-434 (In Russ.). doi: 10.26442/20795696.2023.4.202366Brouwer J, Laven JS, Hazes JM, Schipper I, Dolhain RJ. Levels of serum anti-Müllerian hormone, a marker for ovarian reserve, in women with rheumatoid arthritis. Arthritis Care Res (Hoboken). 2013;65(9):1534-1538. doi: 10.1002/acr.22013Brouwer J, Laven JS, Hazes JM, Schipper I, Dolhain RJ. Levels of serum anti-Müllerian hormone, a marker for ovarian reserve, in women with rheumatoid arthritis. Arthritis Care Res (Hoboken). 2013;65(9):1534-1538. doi: 10.1002/acr.22013Brouwer J, Dolhain RJEM, Hazes JMW, Visser JA, Laven JSE. Reduced ovarian function in female rheumatoid arthritis patients trying to conceive. ACR Open Rheumatol. 2019;1(5):327-335. doi: 10.1002/acr2.11043Brouwer J, Dolhain RJEM, Hazes JMW, Visser JA, Laven JSE. Reduced ovarian function in female rheumatoid arthritis patients trying to conceive. ACR Open Rheumatol. 2019;1(5):327-335. doi: 10.1002/acr2.11043Eudy AM, McDaniel G, Hurd WW, Clowse MEB. Fertility and ovarian reserve among women with rheumatoid arthritis. J Rheumatol. 2019;46(5):455-459. doi: 10.3899/jrheum.180176Eudy AM, McDaniel G, Hurd WW, Clowse MEB. Fertility and ovarian reserve among women with rheumatoid arthritis. J Rheumatol. 2019;46(5):455-459. doi: 10.3899/jrheum.180176Jiang LQ, Zhang RD, Musonye HA, Zhao HY, He YS, Zhao CN, et al. Hormonal and reproductive factors in relation to the risk of rheumatoid arthritis in women: A prospective cohort study with 223 526 participants. RMD Open. 2024;10(1):e003338. doi: 10.1136/rmdopen-2023-003338Jiang LQ, Zhang RD, Musonye HA, Zhao HY, He YS, Zhao CN, et al. Hormonal and reproductive factors in relation to the risk of rheumatoid arthritis in women: A prospective cohort study with 223 526 participants. RMD Open. 2024;10(1):e003338. doi: 10.1136/rmdopen-2023-003338Beydoun HA, el-Amin R, McNeal M, Perry C, Archer DF. Reproductive history and postmenopausal rheumatoid arthritis among women 60 years or older: Third National Health and Nutrition Examination Survey. Menopause. 2013;20(9):930-935. doi: 10.1097/GME.0b013e3182a14372Beydoun HA, el-Amin R, McNeal M, Perry C, Archer DF. Reproductive history and postmenopausal rheumatoid arthritis among women 60 years or older: Third National Health and Nutrition Examination Survey. Menopause. 2013;20(9):930-935. doi: 10.1097/GME.0b013e3182a14372Banas T, Hajdyla-Banas I, Pitynski K, Niewegłowska D, Juszczyk G, Ludwin A, et al. Age at natural menopause in women on long-term methotrexate therapy for rheumatoid arthritis. Menopause. 2016;23(10):1130-1138. doi: 10.1097/GME.0000000000000674Banas T, Hajdyla-Banas I, Pitynski K, Niewegłowska D, Juszczyk G, Ludwin A, et al. Age at natural menopause in women on long-term methotrexate therapy for rheumatoid arthritis. Menopause. 2016;23(10):1130-1138. doi: 10.1097/GME.0000000000000674Park EH, Kang EH, Lee YJ, Ha YJ. Impact of early age at menopause on disease outcomes in postmenopausal women with rheumatoid arthritis: A large observational cohort study of Korean patients with rheumatoid arthritis. RMD Open. 2023;9(1):e002722. doi: 10.1136/rmdopen-2022-002722Park EH, Kang EH, Lee YJ, Ha YJ. Impact of early age at menopause on disease outcomes in postmenopausal women with rheumatoid arthritis: A large observational cohort study of Korean patients with rheumatoid arthritis. RMD Open. 2023;9(1):e002722. doi: 10.1136/rmdopen-2022-002722Wong LE, Huang WT, Pope JE, Haraoui B, Boire G, Thorne JC, et al. Effect of age at menopause on disease presentation in early rheumatoid arthritis: Results from the Canadian Early Arthritis Cohort. Arthritis Care Res (Hoboken). 2015;67(5):616-623. doi: 10.1002/acr.22494Wong LE, Huang WT, Pope JE, Haraoui B, Boire G, Thorne JC, et al. Effect of age at menopause on disease presentation in early rheumatoid arthritis: Results from the Canadian Early Arthritis Cohort. Arthritis Care Res (Hoboken). 2015;67(5):616-623. doi: 10.1002/acr.22494Salliot C, Nguyen Y, Gelot A, Mariette X, Boutron-Ruault MC, Seror R. Lifetime female hormonal exposure and risk of rheumatoid arthritis in postmenopausal women: Results from the French E3N cohort. Joint Bone Spine. 2022;89(5):105374. doi: 10.1016/j.jbspin.2022.105374Salliot C, Nguyen Y, Gelot A, Mariette X, Boutron-Ruault MC, Seror R. Lifetime female hormonal exposure and risk of rheumatoid arthritis in postmenopausal women: Results from the French E3N cohort. Joint Bone Spine. 2022;89(5):105374. doi: 10.1016/j.jbspin.2022.105374Walitt B, Pettinger M, Weinstein A, Katz J, Torner J, Wasko MC, et al. Effects of postmenopausal hormone therapy on rheumatoid arthritis: The women’s health initiative randomized controlled trials. Arthritis Rheum. 2008;59(3):302-310. doi: 10.1002/art.23325Walitt B, Pettinger M, Weinstein A, Katz J, Torner J, Wasko MC, et al. Effects of postmenopausal hormone therapy on rheumatoid arthritis: The women’s health initiative randomized controlled trials. Arthritis Rheum. 2008;59(3):302-310. doi: 10.1002/art.23325Jeong HS, Hong SJ, Choi SJ, Kim JH, Song GG, Jung JH. Effects of oral contraceptives on rheumatoid arthritis in Korean menopausal women: A nationwide cross-sectional study. Maturitas. 2018;112:24-28. doi: 10.1016/j.maturitas.2018.03.017Jeong HS, Hong SJ, Choi SJ, Kim JH, Song GG, Jung JH. Effects of oral contraceptives on rheumatoid arthritis in Korean menopausal women: A nationwide cross-sectional study. Maturitas. 2018;112:24-28. doi: 10.1016/j.maturitas.2018.03.017Orellana C, Saevarsdottir S, Klareskog L, Karlson EW, Alfredsson L, Bengtsson C. Postmenopausal hormone therapy and the risk of rheumatoid arthritis: Results from the Swedish EIRA population-based case-control study. Eur J Epidemiol. 2015;30(5):449-457. doi: 10.1007/s10654-015-0004-yOrellana C, Saevarsdottir S, Klareskog L, Karlson EW, Alfredsson L, Bengtsson C. Postmenopausal hormone therapy and the risk of rheumatoid arthritis: Results from the Swedish EIRA population-based case-control study. Eur J Epidemiol. 2015;30(5):449-457. doi: 10.1007/s10654-015-0004-yYuk JS, Seo YS, Im YH, Kim JH. Menopausal hormone therapy and risk of seropositive rheumatoid arthritis: A nationwide cohort study in Korea. Semin Arthritis Rheum. 2023;63:152280. doi: 10.1016/j.semarthrit.2023.152280Yuk JS, Seo YS, Im YH, Kim JH. Menopausal hormone therapy and risk of seropositive rheumatoid arthritis: A nationwide cohort study in Korea. Semin Arthritis Rheum. 2023;63:152280. doi: 10.1016/j.semarthrit.2023.152280Eun Y, Jeon KH, Han K, Kim D, Kim H, Lee J, et al. Menopausal factors and risk of seropositive rheumatoid arthritis in postmenopausal women: A nationwide cohort study of 1.36 million women. Sci Rep. 2020;10(1):20793. doi: 10.1038/s41598-020-77841-1Eun Y, Jeon KH, Han K, Kim D, Kim H, Lee J, et al. Menopausal factors and risk of seropositive rheumatoid arthritis in postmenopausal women: A nationwide cohort study of 1.36 million women. Sci Rep. 2020;10(1):20793. doi: 10.1038/s41598-020-77841-1Hadizadeh F, Johansson T, Johansson Å, Karlsson T, Ek WE. Effects of oral contraceptives and menopausal hormone therapy on the risk of rheumatoid arthritis: A prospective cohort study. Rheumatology (Oxford). 2024;63(8):2101-2108. doi: 10.1093/rheumatology/kead513Hadizadeh F, Johansson T, Johansson Å, Karlsson T, Ek WE. Effects of oral contraceptives and menopausal hormone therapy on the risk of rheumatoid arthritis: A prospective cohort study. Rheumatology (Oxford). 2024;63(8):2101-2108. doi: 10.1093/rheumatology/kead513Diaz-Ruano AB, Martinez-Alarcon N, Perán M, Benabdellah K, Garcia-Martinez MLÁ, Preda O, et al. Estradiol and estrone have different biological functions to induce NF-κB-driven inflammation, EMT and stemness in ER+ cancer cells. Int J Mol Sci. 2023;24(2):1221. doi: 10.3390/ijms24021221Diaz-Ruano AB, Martinez-Alarcon N, Perán M, Benabdellah K, Garcia-Martinez MLÁ, Preda O, et al. Estradiol and estrone have different biological functions to induce NF-κB-driven inflammation, EMT and stemness in ER+ cancer cells. Int J Mol Sci. 2023;24(2):1221. doi: 10.3390/ijms24021221Паневин ТС, Юренева СВ, Зоткин ЕГ, Кошелева НМ. Менопаузальная гормонотерапия при ревматоидном артрите. Проблемы репродукции. 2022;28(1):149-158 doi: 10.17116/repro20222801114Panevin TS, Yureneva SV, Zotkin EG, Kosheleva NM. Morphological structure of the placenta as a result of its increment. Russian Journal of Human Reproduction. 2022;28(1):149-158 (In Russ.). doi: 10.17116/repro20222801114Daraghmeh DN, Hopkins AM, King C, Abuhelwa AY, Wechalekar MD, Proudman SM, et al. Female reproductive status and exogenous sex hormone use in rheumatoid arthritis patients treated with tocilizumab and csDMARDs. Rheumatology (Oxford). 2023;62(2):583-595. doi: 10.1093/rheumatology/keac357Daraghmeh DN, Hopkins AM, King C, Abuhelwa AY, Wechalekar MD, Proudman SM, et al. Female reproductive status and exogenous sex hormone use in rheumatoid arthritis patients treated with tocilizumab and csDMARDs. Rheumatology (Oxford). 2023;62(2):583-595. doi: 10.1093/rheumatology/keac357Safiri S, Kolahi AA, Hoy D, Smith E, Bettampadi D, Mansournia MA, et al. Global, regional and national burden of rheumatoid arthritis 1990–2017: A systematic analysis of the Global Burden of Disease study 2017. Ann Rheum Dis. 2019;78(11):1463-1471. doi: 10.1136/annrheumdis-2019-215920Safiri S, Kolahi AA, Hoy D, Smith E, Bettampadi D, Mansournia MA, et al. Global, regional and national burden of rheumatoid arthritis 1990–2017: A systematic analysis of the Global Burden of Disease study 2017. Ann Rheum Dis. 2019;78(11):1463-1471. doi: 10.1136/annrheumdis-2019-215920

The authors declare that there are no conflicts of interest present.