rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.47360/1995-4484-2025-338-347rsp-3780Research ArticleПРОГРЕСС В РЕВМАТОЛОГИИ В XXI ВЕКЕPROGRESS IN RHEUMATOLOGY IN THE XXI CENTURYНейтрофилы при АНЦА-ассоциированном системном васкулите: патогенетическое значение и возможные терапевтические стратегииNeutrophils in ANCA-associated vasculitis: The role in the pathogenesis and promising therapeutic strategieshttps://orcid.org/0000-0003-2641-9785БекетоваТ. В.BeketovaT. V.

Бекетова Татьяна Валентиновна

115522, Москва, Каширское шоссе, 34а; 121356, Москва, ул. Маршала Тимошенко, 15; 107023, Москва, ул. Большая Семеновская, 38

Tatiana V. Beketova

115522, Kashirskoye Highway, 34A; 121359, Moscow, Marshala Timoshenko str., 19, building 1A; 107023, Moscow, Bolshaya Semyonovskaya str., 38

doc@tvbek.ruhttps://orcid.org/0000-0002-1598-8360НасоновЕ. Л.NasonovE. I.

115522, Москва, Каширское шоссе, 34а

Evgeny L. Nasonov

115522, Kashirskoye Highway, 34A

https://orcid.org/0000-0002-6373-332XПоповИ. Ю.PopovI. Yu.

115522, Москва, Каширское шоссе, 34а

Ivan Yu. Popov

115522, Kashirskoye Highway, 34A

https://orcid.org/0000-0001-7004-0903СоколовА. А.SokolovA. A.

198015, Санкт-Петербург, ул. Кирочная, 41

Alexey A. Sokolov

191015, Saint-Petersburg, Kirochnaya str., 41

https://orcid.org/0000-0002-6068-3080ЛилаА. М.LilaA. M.

115522, Москва, Каширское шоссе, 34а; 125993, Москва, ул. Баррикадная, 2/1, стр. 1»

Aleksander M. Lila

115522, Kashirskoye Highway, 34A; 125993, Moscow, Barrikadnaya str., 2/1, building 1

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГБУ «Центральная клиническая больница с поликлиникой» Управления делами Президента Российской Федерации; ФГАОУ ВО «Московский политехнический университет»РоссияV.A. Nasonova Research Institute of Rheumatology; Central State Medical Academy of the Administrative Directorate of the President of the Russian Federation; Moscow Polytechnic UniversityRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian FederationФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава РоссииРоссияNorth-Western State Medical University named after I.I. MechnikovRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияV.A. Nasonova Research Institute of Rheumatology; Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian FederationRussian Federation202531082025634338347Copyright © Бекетова Т.В., Насонов Е.Л., Попов И.Ю., Соколов А.А., Лила А.М., 20252025Бекетова Т.В., Насонов Е.Л., Попов И.Ю., Соколов А.А., Лила А.М.Beketova T.V., Nasonov E.I., Popov I.Y., Sokolov A.A., Lila A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/3780

Обзор посвящен современным представлениям о значении нейтрофилов в патогенезе ассоциированного с антинейтрофильными цитоплазматическими антителами (АНЦА) системного васкулита (СВ). Обсуждаются многочисленные сигнальные пути регуляции функции нейтрофилов в ходе развития АНЦА-СВ, включая роль нейтрофильных протеаз, внеклеточных ловушек нейтрофилов, компонентов комплемента, особенностей межклеточного взаимодействия. Анализируется влияние экстракорпоральных методов лечения. Рассматриваются перспективные цели терапевтических стратегий.

The review focuses on the latest data on the role of neutrophils in the pathogenesis of ANCA-associated systemic vasculitis (AAV). Numerous signaling pathways for the regulation of neutrophil function during AAV development are discussed, including the role of neutrophil proteases, neutrophil extracellular traps, the influence of complement components and intercellular interactions. The impact of extracorporeal treatments is discussed. The perspective goals of therapy are considered.

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The authors declare that there are no conflicts of interest present.