rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.47360/1995-4484-2025-374-379rsp-3784Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHМочевая кислота и состояние костной и мышечной ткани у больных ревматоидным артритомUric acid and the bone and muscle status in patients with rheumatoid arthritishttps://orcid.org/0000-0002-2809-0197ДобровольскаяО. В.DobrovolskayaO. V.

Добровольская Ольга Валерьевна

115522, Москва, Каширское шоссе, 34а

Olga V. Dobrovolskaya

115522, Moscow, Kashirskoye Highway, 34A

olgavdobr@mail.ruhttps://orcid.org/0000-0003-0961-9785ДеминН. В.DeminN. V.

115522, Москва, Каширское шоссе, 34а

Nikolay V. Demin

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0003-0560-3495КозыреваМ. В.KozyrevaM. V.

115522, Москва, Каширское шоссе, 34а

Maria V. Kozyreva

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0003-4739-4302ТоропцоваН. В.ToroptsovaN. V.

115522, Москва, Каширское шоссе, 34а

Natalia V. Toroptsova

115522, Moscow, Kashirskoye Highway, 34A

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation202531082025634374379Copyright © Добровольская О.В., Демин Н.В., Козырева М.В., Торопцова Н.В., 20252025Добровольская О.В., Демин Н.В., Козырева М.В., Торопцова Н.В.Dobrovolskaya O.V., Demin N.V., Kozyreva M.V., Toroptsova N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/3784

Цель исследования – оценить взаимосвязь минеральной плотности кости (МПК) и мышечной массы с уровнем мочевой кислоты (МК) у женщин с ревматоидным артритом (РА).

Материал и методы

Материал и методы. Обследованы 182 женщины с подтвержденным диагнозом РА (медиана возраста – 61 [53; 66] год). Проведены клинико-лабораторное обследование, включая определение МК в сыворотке крови, и двухэнергетическая рентгеновская абсорбциометрия в стандартных областях измерения и всего тела.

Результаты

Результаты. Медиана уровня МК в обследованной группе составила 258,5 [198,0; 309,5] мкмоль/л. При сравнительном анализе в зависимости от квартиля уровня МК выявлены статистически значимые различия между группами по возрасту, индексу массы тела, аппендикулярному мышечному индексу (АМИ), общей мышечной массе (ОММ) и общему мышечному индексу (ОМИ). Методом прямой пошаговой регрессии установлено, что уровень МК у женщин с РА не связан с величиной МПК во всех областях измерения (р>0,05), но коррелировал со всеми количественными показателями мышечной массы (АМИ – β=0,29; ОММ – β=0,37; ОМИ – β=0,35; р<0,001).

Заключение

Заключение. У женщин с РА не выявлено независимой связи между уровнем МК и МПК в стандартных областях измерения. Показана статистически значимая позитивная корреляция уровня МК с аппендикулярной и общей мышечной массой.

The aim – to evaluate the relationship between bone mineral density (BMD) and muscle mass with uric acid (UA) level in women with rheumatoid arthritis (RA).

Materials and methods

Materials and methods. A total of 182 women with confirmed RA (median age 61 [53; 66] years) were examined. Clinical and laboratory examination was performed, including blood serum UA testing, dual-energy X-ray absorptiometry in standard measurement areas and the whole body.

Results

Results. The UA level in the examined group was 258.5 [198.0; 309.5] μmol/l. A comparative analysis depending on the UA level quartile revealed significant differences between the groups in age, body mass index, appendicular muscle index (AMI), total muscle mass (TMM), and total muscle index (TMI). The direct stepwise regression method showed that the UA level in women with RA was not associated with the BMD value in all measurement areas (p>0.05), but was associated with all quantitative indices of muscle mass (with AMI – β=0.29; with TMM – β=0.37; with TMI – β=0.35; p<0.001).

Conclusion

Conclusion. In women with RA, no independent association was found between UA level and BMD in standard measurement areas. A significant positive association between UA and appendicular and total muscle mass was revealed.

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The authors declare that there are no conflicts of interest present.