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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rsp</journal-id><journal-title-group><journal-title xml:lang="ru">Научно-практическая ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Rheumatology Science and Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-4484</issn><issn pub-type="epub">1995-4492</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.47360/1995-4484-2025-576-591</article-id><article-id custom-type="elpub" pub-id-type="custom">rsp-3833</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕЖДУНАРОДНЫЕ И РОССИЙСКИЕ РЕКОМЕНДАЦИИ ПО ЛЕЧЕНИЮ РЕВМАТИЧЕСКИХ ЗАБОЛЕВАНИЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INTERNATIONAL AND RUSSIAN GUIDELINES FOR THE TREATMENT OF RHEUMATIC DISEASES</subject></subj-group></article-categories><title-group><article-title>Рекомендации EULAR 2024 года по применению противоревматических препаратов в репродуктивном периоде, во время беременности и лактации, комментарии к ним</article-title><trans-title-group xml:lang="en"><trans-title>EULAR 2024 recommendations on the use of antirheumatic drugs in reproduction, pregnancy and lactation and comments on them</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6018-3895</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кошелева</surname><given-names>Н. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kosheleva</surname><given-names>N. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кошелева Надежда Михайловна,</p><p>115522, Москва, Каширское шоссе, 34а</p></bio><bio xml:lang="en"><p>Nadezhda M. Kosheleva</p><p>115522, Moscow, Kashirskoye Highway, 34A</p></bio><email xlink:type="simple">nadkosheleva@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3552-2522</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Решетняк</surname><given-names>Т. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Reshetnyak</surname><given-names>T. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34а; 125993, Москва, ул. Баррикадная, 2/1, стр. 1</p></bio><bio xml:lang="en"><p>Tatiana M. Reshetnyak</p><p>115522, Moscow, Kashirskoye Highway, 34A; 125993, Moscow, Barrikadnaya str., 2/1, building 1</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9901-225X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Клименченко</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Klimenchenko</surname><given-names>N. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>117997, Москва, ул. Академика Опарина, 4</p></bio><bio xml:lang="en"><p>Natalia I. Klimenchenko</p><p>117997, Москва, ул. Академика Опарина, 4</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1598-8360</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Насонов</surname><given-names>Е. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Nasonov</surname><given-names>E. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34а</p></bio><bio xml:lang="en"><p>Evgeny L. Nasonov</p><p>115522, Moscow, Kashirskoye Highway, 34A</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology; Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of Ministry of Health of Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2025</year></pub-date><volume>63</volume><issue>6</issue><fpage>576</fpage><lpage>591</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кошелева Н.М., Решетняк Т.М., Клименченко Н.И., Насонов Е.Л., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Кошелева Н.М., Решетняк Т.М., Клименченко Н.И., Насонов Е.Л.</copyright-holder><copyright-holder xml:lang="en">Kosheleva N.M., Reshetnyak T.M., Klimenchenko N.I., Nasonov E.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://rsp.mediar-press.net/rsp/article/view/3833">https://rsp.mediar-press.net/rsp/article/view/3833</self-uri><abstract><p>В статье представлена обновленная в 2024 г. версия рекомендаций по применению противоревматических препаратов в репродуктивном периоде, во время беременности и лактации, разработанных Европейским альянсом ревматологических ассоциаций, и комментарии к ним.</p></abstract><trans-abstract xml:lang="en"><p>The article presents an updated version of the recommendations on the use of antirheumatic drugs in reproduction, pregnancy and lactation developed by the European Alliance of Rheumatology Associations in 2024 and commenting on them.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>клинические рекомендации</kwd><kwd>противоревматические препараты</kwd><kwd>репродукция</kwd><kwd>беременность</kwd><kwd>лактация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>clinical recommendations</kwd><kwd>antirheumatic drugs</kwd><kwd>reproduction</kwd><kwd>pregnancy</kwd><kwd>lactation</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование не имело спонсорской поддержки</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Насонов ЕЛ (ред.). Ревматология. Российские клинические рекомендации. М.:ГЭОТАР-Медиа;2017.</mixed-citation><mixed-citation xml:lang="en">Nasonov EL (ed.). Rheumatology. Russian clinical recommendations. Moscow:GEOTAR-Media;2017 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Gotestam Skorpen C, Hoeltzenbein M, Tincani A, FischerBetz R, Elefant E, Chambers C, et al. The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation. Ann Rheum Dis. 2016;75(5):795-810. doi: 10.1136/annrheumdis-2015-208840</mixed-citation><mixed-citation xml:lang="en">Gotestam Skorpen C, Hoeltzenbein M, Tincani A, FischerBetz R, Elefant E, Chambers C, et al. The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation. Ann Rheum Dis. 2016;75(5):795-810. doi: 10.1136/annrheumdis-2015-208840</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Flint J, Panchal S, Hurrell A, van de Venne M, Gayed M, Schreiber K, et al. BSR and BHPR guideline on prescribing drugs in pregnancy and breastfeeding – Part I: Standard and biologic disease modifying anti-rheumatic drugs and corticosteroids. Rheumatology (Oxford) 2016;55(9):1693-1697. doi: 10.1093/rheumatology/kev404</mixed-citation><mixed-citation xml:lang="en">Flint J, Panchal S, Hurrell A, van de Venne M, Gayed M, Schreiber K, et al. BSR and BHPR guideline on prescribing drugs in pregnancy and breastfeeding – Part I: Standard and biologic disease modifying anti-rheumatic drugs and corticosteroids. Rheumatology (Oxford) 2016;55(9):1693-1697. doi: 10.1093/rheumatology/kev404</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Flint J, Panchal S, Hurrell A, van de Venne M, Gayed M, Schreiber K, et al. BSR and BHPR guideline rheumatology practice on prescribing drugs in pregnancy and breastfeeding – Part II: Analgesics and other drugs used in rheumatology practice. Rheumatology (Oxford) 2016;55(9):1698-1702. doi: 10.1093/rheumatology/kev405</mixed-citation><mixed-citation xml:lang="en">Flint J, Panchal S, Hurrell A, van de Venne M, Gayed M, Schreiber K, et al. BSR and BHPR guideline rheumatology practice on prescribing drugs in pregnancy and breastfeeding – Part II: Analgesics and other drugs used in rheumatology practice. Rheumatology (Oxford) 2016;55(9):1698-1702. doi: 10.1093/rheumatology/kev405</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Andreoli L, Chighizola CB, Iaccarino L, Botta A, Gerosa M, Ramoni V, et al. Immunology of pregnancy and reproductive health in autoimmune rheumatic diseases. Update from the 11th International Conference on Reproduction, Pregnancy and Rheumatic Diseases. Autoimmun Rev. 2023;22(3):103259. doi: 10.1016/j.autrev.2022.103259</mixed-citation><mixed-citation xml:lang="en">Andreoli L, Chighizola CB, Iaccarino L, Botta A, Gerosa M, Ramoni V, et al. Immunology of pregnancy and reproductive health in autoimmune rheumatic diseases. Update from the 11th International Conference on Reproduction, Pregnancy and Rheumatic Diseases. Autoimmun Rev. 2023;22(3):103259. doi: 10.1016/j.autrev.2022.103259</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ruegg L, Pluma A, Hamroun S, Cecchi I, Perez-Garcia LF, Anderson PO, et al. EULAR recommendations for use of antirheumatic drugs in reproduction, pregnancy, and lactation: 2024 update. Ann Rheum Dis. 2025;00:1-17. doi: 10.1016/j.ard.2025.02.023</mixed-citation><mixed-citation xml:lang="en">Ruegg L, Pluma A, Hamroun S, Cecchi I, Perez-Garcia LF, Anderson PO, et al. EULAR recommendations for use of antirheumatic drugs in reproduction, pregnancy, and lactation: 2024 update. Ann Rheum Dis. 2025;00:1-17. doi: 10.1016/j.ard.2025.02.023</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">European Alliance of Associations for Rheumatology. EULAR SOPs – standard operating procedures for task forces, version 52. URL: https://www.eular.org/web/static/lib/pdfjs/web/viewer.html?file=https://www.eular.org/document/download/680/b9eb08d0-faca-4606-8ed9-d0539b3f312a/660 (Accessed: 19th September 2024).</mixed-citation><mixed-citation xml:lang="en">European Alliance of Associations for Rheumatology. EULAR SOPs – standard operating procedures for task forces, version 52. URL: https://www.eular.org/web/static/lib/pdfjs/web/viewer.html?file=https://www.eular.org/document/download/680/b9eb08d0-faca-4606-8ed9-d0539b3f312a/660 (Accessed: 19th September 2024).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Oxford Centre for Evidence-Based Medicine: Levels of evidence (March 2009). URL: https://www.cebm.ox.ac.uk/resources/levelsof-evidence/oxford-centre-for-evidence-based-medicine-levelsof-evidence-march-2009 (Accessed: 1st June 2024).</mixed-citation><mixed-citation xml:lang="en">Oxford Centre for Evidence-Based Medicine: Levels of evidence (March 2009). URL: https://www.cebm.ox.ac.uk/resources/levelsof-evidence/oxford-centre-for-evidence-based-medicine-levelsof-evidence-march-2009 (Accessed: 1st June 2024).</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Singh M, Wambua S, Lee SI, Okoth K, Wang Z, Fazla F, et al. Autoimmune diseases and adverse pregnancy outcomes: An umbrella review. Lancet. 2023;402(Suppl 1):84. doi: 10.1016/s0140-6736(23)02128-1</mixed-citation><mixed-citation xml:lang="en">Singh M, Wambua S, Lee SI, Okoth K, Wang Z, Fazla F, et al. Autoimmune diseases and adverse pregnancy outcomes: An umbrella review. Lancet. 2023;402(Suppl 1):84. doi: 10.1016/s0140-6736(23)02128-1</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Meek JY, Noble L. Technical report: Breastfeeding and the use of human milk. Pediatrics. 2022;150(1):e2022057989. doi: 10.1542/peds.2022-057989</mixed-citation><mixed-citation xml:lang="en">Meek JY, Noble L. Technical report: Breastfeeding and the use of human milk. Pediatrics. 2022;150(1):e2022057989. doi: 10.1542/peds.2022-057989</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">World Health Organization. Breastfeeding. URL: https://www.who.int/health-topics/breastfeeding#tab=tab_2 (Accessed: 1st June 2024).</mixed-citation><mixed-citation xml:lang="en">World Health Organization. Breastfeeding. URL: https://www.who.int/health-topics/breastfeeding#tab=tab_2 (Accessed: 1st June 2024).</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Schreiber K, Graversgaard C, Parodis I, Agmon-Levin N, Aguilera S, Antovic A, et al. Impact of conflicting information on the use of antirheumatic drugs in pregnancy and breastfeeding: perspectives of healthcare providers from the global PRAISE survey. Ther Adv Musculoskelet Dis. 2025;17:1-17. doi: 10.1177/1759720X251350087</mixed-citation><mixed-citation xml:lang="en">Schreiber K, Graversgaard C, Parodis I, Agmon-Levin N, Aguilera S, Antovic A, et al. Impact of conflicting information on the use of antirheumatic drugs in pregnancy and breastfeeding: perspectives of healthcare providers from the global PRAISE survey. Ther Adv Musculoskelet Dis. 2025;17:1-17. doi: 10.1177/1759720X251350087</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Sammaritano LR, Bermas BL, Chakravarty EE, Chambers C, Clowse MEB, Lockshin MD, et al. 2020 American College of Rheumatology guideline for the management of reproductive health in rheumatic and musculoskeletal diseases. Arthritis Rheumatol 2020;72(4):529-556. doi: 10.1002/art.41191</mixed-citation><mixed-citation xml:lang="en">Sammaritano LR, Bermas BL, Chakravarty EE, Chambers C, Clowse MEB, Lockshin MD, et al. 2020 American College of Rheumatology guideline for the management of reproductive health in rheumatic and musculoskeletal diseases. Arthritis Rheumatol 2020;72(4):529-556. doi: 10.1002/art.41191</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Russell MD, Dey M, Flint J, Davie P, Allen A, Crossley A, et al. Executive summary: British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: Immunomodulatory anti-rheumatic drugs and corticosteroids. Rheumatology (Oxford). 2023;62(4):1370-1387. doi: 10.1093/rheumatology/ keac558</mixed-citation><mixed-citation xml:lang="en">Russell MD, Dey M, Flint J, Davie P, Allen A, Crossley A, et al. Executive summary: British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: Immunomodulatory anti-rheumatic drugs and corticosteroids. Rheumatology (Oxford). 2023;62(4):1370-1387. doi: 10.1093/rheumatology/ keac558</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Chambers CD, Johnson DL, Xu R, Luo Y, Felix R, Fine M, et al. Birth outcomes in women who have taken hydroxycholoroquine during pregnancy: A prospective cohort study. Arthritis Rheumatol. 2022;74(4):711-724. doi: 10.1002/art.42015.</mixed-citation><mixed-citation xml:lang="en">Chambers CD, Johnson DL, Xu R, Luo Y, Felix R, Fine M, et al. Birth outcomes in women who have taken hydroxycholoroquine during pregnancy: A prospective cohort study. Arthritis Rheumatol. 2022;74(4):711-724. doi: 10.1002/art.42015.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Andersson NW, Skov L, Andersen JT. Fetal safety of chloroquine and hydroxychloroquine use during pregnancy: A nationwide cohort study. Rheumatology (Oxford). 2021;60(5):2317-2326. doi: 10.1093/rheumatology/keaa592</mixed-citation><mixed-citation xml:lang="en">Andersson NW, Skov L, Andersen JT. Fetal safety of chloroquine and hydroxychloroquine use during pregnancy: A nationwide cohort study. Rheumatology (Oxford). 2021;60(5):2317-2326. doi: 10.1093/rheumatology/keaa592</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Huybrechts KF, Bateman BT, Zhu Y, Straub L, Mogun H, Kim SC, et al. Hydroxychloroquine early in pregnancy and risk of birth defects. Am J Obstet Gynecol. 2021;224(3):290.e1-22. doi: 10.1016/j.ajog.2020.09.007</mixed-citation><mixed-citation xml:lang="en">Huybrechts KF, Bateman BT, Zhu Y, Straub L, Mogun H, Kim SC, et al. Hydroxychloroquine early in pregnancy and risk of birth defects. Am J Obstet Gynecol. 2021;224(3):290.e1-22. doi: 10.1016/j.ajog.2020.09.007</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Schreiber K, Giles I, Costedoat-Chalumeau N, Nelson-Piercy C, Dolhain RJ, Mosca M, et al. Global comment on the use of hydroxychloroquine during the periconception period and pregnancy in women with autoimmune diseases. Lancet Rheumatol. 2023;5(9):501-506. doi: 10.1016/S2665-9913(23)00215-1</mixed-citation><mixed-citation xml:lang="en">Schreiber K, Giles I, Costedoat-Chalumeau N, Nelson-Piercy C, Dolhain RJ, Mosca M, et al. Global comment on the use of hydroxychloroquine during the periconception period and pregnancy in women with autoimmune diseases. Lancet Rheumatol. 2023;5(9):501-506. doi: 10.1016/S2665-9913(23)00215-1</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Indraratna PL, Virk S, Gurram D, Day RO. Use of colchicine in pregnancy: A systematic review and meta-analysis. Rheumatology (Oxford). 2018;57(2):382-387. doi: 10.1093/rheumatology/kex353</mixed-citation><mixed-citation xml:lang="en">Indraratna PL, Virk S, Gurram D, Day RO. Use of colchicine in pregnancy: A systematic review and meta-analysis. Rheumatology (Oxford). 2018;57(2):382-387. doi: 10.1093/rheumatology/kex353</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Norgard BM, Friedman S, Kjeldsen J, Nielsen J. The safety of paternal and maternal use of 5-aminosalicylic acid during conception and pregnancy: A nationwide cohort study. Aliment Pharmacol Ther. 2022;56(9):1349-1360. doi: 10.1111/apt.17189</mixed-citation><mixed-citation xml:lang="en">Norgard BM, Friedman S, Kjeldsen J, Nielsen J. The safety of paternal and maternal use of 5-aminosalicylic acid during conception and pregnancy: A nationwide cohort study. Aliment Pharmacol Ther. 2022;56(9):1349-1360. doi: 10.1111/apt.17189</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Torres J, Chaparro M, Julsgaard M, Katsanos K, Zelinkova Z, Agrawal M, et al. European Crohn’s and colitis guidelines on sexuality, fertility, pregnancy, and lactation. J Crohns Colitis. 2023;17(1):1-27. doi: 10.1093/ecco-jcc/jjac115</mixed-citation><mixed-citation xml:lang="en">Torres J, Chaparro M, Julsgaard M, Katsanos K, Zelinkova Z, Agrawal M, et al. European Crohn’s and colitis guidelines on sexuality, fertility, pregnancy, and lactation. J Crohns Colitis. 2023;17(1):1-27. doi: 10.1093/ecco-jcc/jjac115</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Peterson EA, Lynton J, Bernard A, Santillan MK, Bettendorf B. Rheumatologic medication use during pregnancy. Obstet Gynecol. 2020;135(5):1161-1176. doi: 10.1097/AOG.0000000000003755</mixed-citation><mixed-citation xml:lang="en">Peterson EA, Lynton J, Bernard A, Santillan MK, Bettendorf B. Rheumatologic medication use during pregnancy. Obstet Gynecol. 2020;135(5):1161-1176. doi: 10.1097/AOG.0000000000003755</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Hernandez-Díaz S, Werler MM, Walker AM, Mitchell AA. Folic acid antagonists during pregnancy and the risk of birth defects. N Engl J Med. 2000;343(22):1608-1614. doi: 10.1056/ NEJM200011303432204</mixed-citation><mixed-citation xml:lang="en">Hernandez-Díaz S, Werler MM, Walker AM, Mitchell AA. Folic acid antagonists during pregnancy and the risk of birth defects. N Engl J Med. 2000;343(22):1608-1614. doi: 10.1056/ NEJM200011303432204</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">De-Regil LM, Peña-Rosas JP, Fernández-Gaxiola AC, RaycoSolon P. Effects and safety of periconceptional oral folate supplementation for preventing birth defects. Cochrane Database Syst Rev. 2015;12:CD007950. doi: 10.1002/14651858.CD007950.pub3</mixed-citation><mixed-citation xml:lang="en">De-Regil LM, Peña-Rosas JP, Fernández-Gaxiola AC, RaycoSolon P. Effects and safety of periconceptional oral folate supplementation for preventing birth defects. Cochrane Database Syst Rev. 2015;12:CD007950. doi: 10.1002/14651858.CD007950.pub3</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Genetics Committee, Wilson RD, Audibert F, Brock JA, Carroll J, Gagnon A. et al. Pre-conception folic acid and multivitamin supplementation for the primary and secondary prevention of neural tube defects and other folic acid-sensitive congenital anomalies. J Obstet Gynaecol Can. 2015;37(6):534-352. doi: 10.1016/s17012163(15)30230-9</mixed-citation><mixed-citation xml:lang="en">Genetics Committee, Wilson RD, Audibert F, Brock JA, Carroll J, Gagnon A. et al. Pre-conception folic acid and multivitamin supplementation for the primary and secondary prevention of neural tube defects and other folic acid-sensitive congenital anomalies. J Obstet Gynaecol Can. 2015;37(6):534-352. doi: 10.1016/s17012163(15)30230-9</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Guideline: Daily iron and folic acid supplementation in pregnant women: WHO guidelines approved by the Guidelines Review Committee. Geneva:World Health Organization;2012.</mixed-citation><mixed-citation xml:lang="en">Guideline: Daily iron and folic acid supplementation in pregnant women: WHO guidelines approved by the Guidelines Review Committee. Geneva:World Health Organization;2012.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Cordero AM, Crider KS, Rogers LM, Cannon MJ, Berry RJ. Optimal serum and red blood cell folate concentrations in women of reproductive age for prevention of neural tube defects: World Health Organization guidelines. MMWR Morb Mortal Wkly Rep. 2015;64(15):421-423.</mixed-citation><mixed-citation xml:lang="en">Cordero AM, Crider KS, Rogers LM, Cannon MJ, Berry RJ. Optimal serum and red blood cell folate concentrations in women of reproductive age for prevention of neural tube defects: World Health Organization guidelines. MMWR Morb Mortal Wkly Rep. 2015;64(15):421-423.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Нормальная беременность: Клинические рекомендации Минздрава России 2023–2024–2025. М.;2024.</mixed-citation><mixed-citation xml:lang="en">Нормальная беременность: Клинические рекомендации Минздрава России 2023–2024–2025. М.;2024.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Perez-Aytes A, Marin-Reina P, Boso V, Ledo A, Carey JC, Vento M. Mycophenolate mofetil embryopathy: A newly recognized teratogenic syndrome. Eur J Med Genet. 2017;60(1):16-21. doi: 10.1016/j.ejmg.2016.09.014</mixed-citation><mixed-citation xml:lang="en">Perez-Aytes A, Marin-Reina P, Boso V, Ledo A, Carey JC, Vento M. Mycophenolate mofetil embryopathy: A newly recognized teratogenic syndrome. Eur J Med Genet. 2017;60(1):16-21. doi: 10.1016/j.ejmg.2016.09.014</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Weber-Schoendorfer C, Chambers C, Wacker E, Beghin D, Bernard N, Centers Network of French Pharmacovigilance, et al. Pregnancy outcome after methotrexate treatment for rheumatic disease prior to or during early pregnancy: A prospective multicenter cohort study. Arthritis Rheumatol. 2014;66(5):1101-1110. doi: 10.1002/art.38368</mixed-citation><mixed-citation xml:lang="en">Weber-Schoendorfer C, Chambers C, Wacker E, Beghin D, Bernard N, Centers Network of French Pharmacovigilance, et al. Pregnancy outcome after methotrexate treatment for rheumatic disease prior to or during early pregnancy: A prospective multicenter cohort study. Arthritis Rheumatol. 2014;66(5):1101-1110. doi: 10.1002/art.38368</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Zanetti A, Zambon A, Scire CA, Bortoluzzi A. Impact of rheumatoid arthritis and methotrexate on pregnancy outcomes: Retrospective cohort study of the Italian Society for Rheumatology. RMD Open. 2022;8(2):e002412. doi: 10.1136/rmdopen-2022-002412</mixed-citation><mixed-citation xml:lang="en">Zanetti A, Zambon A, Scire CA, Bortoluzzi A. Impact of rheumatoid arthritis and methotrexate on pregnancy outcomes: Retrospective cohort study of the Italian Society for Rheumatology. RMD Open. 2022;8(2):e002412. doi: 10.1136/rmdopen-2022-002412</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">McInerney KA, Hatch EE, Wesselink AK, Rothman KJ, Mikkelsen EM, Wise LA. Preconception use of pain-relievers and timeto-pregnancy: A prospective cohort study. Hum Reprod. 2017;32(1):103-111. doi: 10.1093/humrep/dew272</mixed-citation><mixed-citation xml:lang="en">McInerney KA, Hatch EE, Wesselink AK, Rothman KJ, Mikkelsen EM, Wise LA. Preconception use of pain-relievers and timeto-pregnancy: A prospective cohort study. Hum Reprod. 2017;32(1):103-111. doi: 10.1093/humrep/dew272</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Micu MC, Micu R, Ostensen M. Luteinized unruptured follicle syndrome increased by inactive disease and selective cyclooxygenase 2 inhibitors in women with inflammatory arthropathies. Arthritis Care Res (Hoboken). 2011;63(9):1334-1338. doi: 10.1002/acr.20510</mixed-citation><mixed-citation xml:lang="en">Micu MC, Micu R, Ostensen M. Luteinized unruptured follicle syndrome increased by inactive disease and selective cyclooxygenase 2 inhibitors in women with inflammatory arthropathies. Arthritis Care Res (Hoboken). 2011;63(9):1334-1338. doi: 10.1002/acr.20510</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Odufalu FD, Long M, Lin K, Mahadevan U. Exposure to corticosteroids in pregnancy is associated with adverse perinatal outcomes among infants of mothers with inflammatory bowel disease: Results from the PIANO registry. Gut. 2022;71(9):1766-1772. doi: 10.1136/gutjnl-2021-325317</mixed-citation><mixed-citation xml:lang="en">Odufalu FD, Long M, Lin K, Mahadevan U. Exposure to corticosteroids in pregnancy is associated with adverse perinatal outcomes among infants of mothers with inflammatory bowel disease: Results from the PIANO registry. Gut. 2022;71(9):1766-1772. doi: 10.1136/gutjnl-2021-325317</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Jølving LR, Nielsen J, Andersen ML, Friedman S, Nørgrd BM. Adverse birth outcomes and early-life infections after in utero exposure to corticosteroids for inflammatory bowel disease: A Danish nationwide cohort study. BMC Med. 2023;21(1):140. doi: 10.1186/s12916-023-02817-7</mixed-citation><mixed-citation xml:lang="en">Jølving LR, Nielsen J, Andersen ML, Friedman S, Nørgrd BM. Adverse birth outcomes and early-life infections after in utero exposure to corticosteroids for inflammatory bowel disease: A Danish nationwide cohort study. BMC Med. 2023;21(1):140. doi: 10.1186/s12916-023-02817-7</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Gur C, Diav-Citrin O, Shechtman S, Arnon J, Ornoy A. Pregnancy outcome after first trimester exposure to corticosteroids: A prospective controlled study. Reprod Toxicol. 2004;18(1):93-101. doi: 10.1016/j.reprotox.2003.10.007</mixed-citation><mixed-citation xml:lang="en">Gur C, Diav-Citrin O, Shechtman S, Arnon J, Ornoy A. Pregnancy outcome after first trimester exposure to corticosteroids: A prospective controlled study. Reprod Toxicol. 2004;18(1):93-101. doi: 10.1016/j.reprotox.2003.10.007</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Bandoli G, Palmsten K, Forbess Smith CJ, Chambers CD. A review of systemic corticosteroid use in pregnancy and the risk of select pregnancy and birth outcomes. Rheum Dis Clin North Am. 2017;43(3):489-502. doi: 10.1016/j.rdc.2017.04.013</mixed-citation><mixed-citation xml:lang="en">Bandoli G, Palmsten K, Forbess Smith CJ, Chambers CD. A review of systemic corticosteroid use in pregnancy and the risk of select pregnancy and birth outcomes. Rheum Dis Clin North Am. 2017;43(3):489-502. doi: 10.1016/j.rdc.2017.04.013</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Desai RJ, Bateman BT, Huybrechts KF, Patorno E, HernandezDiaz S, Park Y, et al. Risk of serious infections associated with use of immunosuppressive agents in pregnant women with autoimmune inflammatory conditions: Cohort study. BMJ 2017;356:j895. doi: 10.1136/bmj.j895</mixed-citation><mixed-citation xml:lang="en">Desai RJ, Bateman BT, Huybrechts KF, Patorno E, HernandezDiaz S, Park Y, et al. Risk of serious infections associated with use of immunosuppressive agents in pregnant women with autoimmune inflammatory conditions: Cohort study. BMJ 2017;356:j895. doi: 10.1136/bmj.j895</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Carsote M, Turturea MR, Valea A, Buescu C, Nistor C, Turturea IF. Bridging the gap: Pregnancyand lactation-associated osteoporosis. Diagnostics (Basel). 2023;13(9):1615. doi: 10.3390/diagnostics13091615</mixed-citation><mixed-citation xml:lang="en">Carsote M, Turturea MR, Valea A, Buescu C, Nistor C, Turturea IF. Bridging the gap: Pregnancyand lactation-associated osteoporosis. Diagnostics (Basel). 2023;13(9):1615. doi: 10.3390/diagnostics13091615</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Palmsten K, Bandoli G, Vazquez-Benitez G, Xi M, Johnson DL, Xu R, et al. Oral corticosteroid use during pregnancy and risk of preterm birth. Rheumatology (Oxford). 2020;59(6):1262-1271. doi: 10.1093/rheumatology/kez405</mixed-citation><mixed-citation xml:lang="en">Palmsten K, Bandoli G, Vazquez-Benitez G, Xi M, Johnson DL, Xu R, et al. Oral corticosteroid use during pregnancy and risk of preterm birth. Rheumatology (Oxford). 2020;59(6):1262-1271. doi: 10.1093/rheumatology/kez405</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Smith CJF, Bandoli G, Kavanaugh A, Chambers CD. Birth outcomes and disease activity during pregnancy in a prospective cohort of women with psoriatic arthritis and ankylosing spondylitis. Arthritis Care Res (Hoboken). 2020;72(7):1029-1037. doi: 10.1002/ acr.23924</mixed-citation><mixed-citation xml:lang="en">Smith CJF, Bandoli G, Kavanaugh A, Chambers CD. Birth outcomes and disease activity during pregnancy in a prospective cohort of women with psoriatic arthritis and ankylosing spondylitis. Arthritis Care Res (Hoboken). 2020;72(7):1029-1037. doi: 10.1002/ acr.23924</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Palmsten K, Rolland M, Hebert MF, Clowse MEB, Schatz M, Xu R, et al. Patterns of prednisone use during pregnancy in women with rheumatoid arthritis: Daily and cumulative dose. Pharmacoepidemiol Drug Saf. 2018;27(4):430-438. doi: 10.1002/pds.4410</mixed-citation><mixed-citation xml:lang="en">Palmsten K, Rolland M, Hebert MF, Clowse MEB, Schatz M, Xu R, et al. Patterns of prednisone use during pregnancy in women with rheumatoid arthritis: Daily and cumulative dose. Pharmacoepidemiol Drug Saf. 2018;27(4):430-438. doi: 10.1002/pds.4410</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">de Steenwinkel FDO, Dolhain RJEM, Hazes JMW, HokkenKoelega ACS. Does prednisone use in pregnant women with rheumatoid arthritis induce insulin resistance in the offspring? Clin Rheumatol. 2023;42(1):47-54. doi: 10.1007/s10067-022-06347-0</mixed-citation><mixed-citation xml:lang="en">de Steenwinkel FDO, Dolhain RJEM, Hazes JMW, HokkenKoelega ACS. Does prednisone use in pregnant women with rheumatoid arthritis induce insulin resistance in the offspring? Clin Rheumatol. 2023;42(1):47-54. doi: 10.1007/s10067-022-06347-0</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Dunn L, Greer R, Flenady V, Kumar S. Sildenafil in pregnancy: A systematic review of maternal tolerance and obstetric and perinatal outcomes. Fetal Diagn Ther. 2017;41(2):81-88. doi: 10.1159/000453062</mixed-citation><mixed-citation xml:lang="en">Dunn L, Greer R, Flenady V, Kumar S. Sildenafil in pregnancy: A systematic review of maternal tolerance and obstetric and perinatal outcomes. Fetal Diagn Ther. 2017;41(2):81-88. doi: 10.1159/000453062</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Ferreira RDDS, Negrini R, Bernardo WM, Simoes R, Piato S. The effects of sildenafil in maternal and fetal outcomes in pregnancy: A systematic review and meta-analysis. PLoS One. 2019;14(7):e0219732. doi: 10.1371/journal.pone.0219732</mixed-citation><mixed-citation xml:lang="en">Ferreira RDDS, Negrini R, Bernardo WM, Simoes R, Piato S. The effects of sildenafil in maternal and fetal outcomes in pregnancy: A systematic review and meta-analysis. PLoS One. 2019;14(7):e0219732. doi: 10.1371/journal.pone.0219732</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Tektonidou MG, Andreoli L, Limper M, Amoura Z, Cervera R, Costedoat-Chalumeau N, et al. EULAR recommendations for the management of antiphospholipid syndrome in adults. Ann Rheum Dis. 2019;78(10):1296-1304. doi: 10.1136/annrheumdis-2019-215213</mixed-citation><mixed-citation xml:lang="en">Tektonidou MG, Andreoli L, Limper M, Amoura Z, Cervera R, Costedoat-Chalumeau N, et al. EULAR recommendations for the management of antiphospholipid syndrome in adults. Ann Rheum Dis. 2019;78(10):1296-1304. doi: 10.1136/annrheumdis-2019-215213</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Andreoli L, Bertsias GK, Agmon-Levin N, Brown S, Cervera R, Costedoat Chalumeau N, et al. EULAR recommendations for women’s health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome. Ann Rheum Dis. 2017;76(3):476-485. doi: 10.1136/annrheumdis-2016-209770</mixed-citation><mixed-citation xml:lang="en">Andreoli L, Bertsias GK, Agmon-Levin N, Brown S, Cervera R, Costedoat Chalumeau N, et al. EULAR recommendations for women’s health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome. Ann Rheum Dis. 2017;76(3):476-485. doi: 10.1136/annrheumdis-2016-209770</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Nelson-Piercy C, Agarwal S, Lams B. Lesson of the month: Selective use of cyclophosphamide in pregnancy for severe autoimmune respiratory disease. Thorax. 2016;71(7):667-668.</mixed-citation><mixed-citation xml:lang="en">Nelson-Piercy C, Agarwal S, Lams B. Lesson of the month: Selective use of cyclophosphamide in pregnancy for severe autoimmune respiratory disease. Thorax. 2016;71(7):667-668.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Orozco-Guillen AO, Abraham VS, Moguel Gonzalez B, Valdez Ortiz R, Ibarguengoitia F, Del Carmen ZM, et al. Kidney-limited full-house lupus-like membranous nephropathy and membranoproliferative glomerulonephritis in pregnancy. Kidney Int Rep. 2023;8(4):932-938. doi: 10.1136/thoraxjnl-2016-208441</mixed-citation><mixed-citation xml:lang="en">Orozco-Guillen AO, Abraham VS, Moguel Gonzalez B, Valdez Ortiz R, Ibarguengoitia F, Del Carmen ZM, et al. Kidney-limited full-house lupus-like membranous nephropathy and membranoproliferative glomerulonephritis in pregnancy. Kidney Int Rep. 2023;8(4):932-938. doi: 10.1136/thoraxjnl-2016-208441</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Clowse MEB, Richeson RL, Pieper C, Merkel PA, Vasculitis Clinical Research Consortium. Pregnancy outcomes among patients with vasculitis. Arthritis Care Res (Hoboken). 2013;65(8):1370-1374. doi: 10.1002/acr.21983</mixed-citation><mixed-citation xml:lang="en">Clowse MEB, Richeson RL, Pieper C, Merkel PA, Vasculitis Clinical Research Consortium. Pregnancy outcomes among patients with vasculitis. Arthritis Care Res (Hoboken). 2013;65(8):1370-1374. doi: 10.1002/acr.21983</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Le HL, Francke MI, Andrews LM, de Winter BCM, van Gelder T, Hesselink DA. Usage of tacrolimus and mycophenolic acid during conception, pregnancy, and lactation, and its implications for therapeutic drug monitoring: A systematic critical review. Ther Drug Monit. 2020;42(4):518-531. doi: 10.1097/FTD.0000000000000769</mixed-citation><mixed-citation xml:lang="en">Le HL, Francke MI, Andrews LM, de Winter BCM, van Gelder T, Hesselink DA. Usage of tacrolimus and mycophenolic acid during conception, pregnancy, and lactation, and its implications for therapeutic drug monitoring: A systematic critical review. Ther Drug Monit. 2020;42(4):518-531. doi: 10.1097/FTD.0000000000000769</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Malek A, Sager R, Kuhn P, Nicolaides KH, Schneider H. Evolution of maternofetal transport of immunoglobulins during human pregnancy. Am J Reprod Immunol. 1996;36(5):248-255. doi: 10.1111/j.1600-0897.1996.tb00172.x</mixed-citation><mixed-citation xml:lang="en">Malek A, Sager R, Kuhn P, Nicolaides KH, Schneider H. Evolution of maternofetal transport of immunoglobulins during human pregnancy. Am J Reprod Immunol. 1996;36(5):248-255. doi: 10.1111/j.1600-0897.1996.tb00172.x</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Porter C, Armstrong-Fisher S, Kopotsha T, Smith B, Baker T, Kevorkian L, et al. Certolizumab pegol does not bind the neonatal Fc receptor (FcRn): consequences for FcRn-mediated in vitro transcytosis and ex vivo human placental transfer. J Reprod Immunol. 2016;116:7-12. doi: 10.1016/j.jri.2016.04.284</mixed-citation><mixed-citation xml:lang="en">Porter C, Armstrong-Fisher S, Kopotsha T, Smith B, Baker T, Kevorkian L, et al. Certolizumab pegol does not bind the neonatal Fc receptor (FcRn): consequences for FcRn-mediated in vitro transcytosis and ex vivo human placental transfer. J Reprod Immunol. 2016;116:7-12. doi: 10.1016/j.jri.2016.04.284</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Murashima A, Watanabe N, Ozawa N, Saito H, Yamaguchi K. Etanercept during pregnancy and lactation in a patient with rheumatoid arthritis: Drug levels in maternal serum, cord blood, breast milk and the infant’s serum. Ann Rheum Dis. 2009;68(11):1793-1794. doi: 10.1136/ard.2008.105924</mixed-citation><mixed-citation xml:lang="en">Murashima A, Watanabe N, Ozawa N, Saito H, Yamaguchi K. Etanercept during pregnancy and lactation in a patient with rheumatoid arthritis: Drug levels in maternal serum, cord blood, breast milk and the infant’s serum. Ann Rheum Dis. 2009;68(11):1793-1794. doi: 10.1136/ard.2008.105924</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Mariette X, Forger F, Abraham B, Flynn AD, Molto A, Flipo RM, et al. Lack of placental transfer of certolizumab pegol during pregnancy: Results from CRIB, a prospective, postmarketing, pharmacokinetic study. Ann Rheum Dis. 2018;77(2):228-233. doi: 10.1136/annrheumdis-2017-212196</mixed-citation><mixed-citation xml:lang="en">Mariette X, Forger F, Abraham B, Flynn AD, Molto A, Flipo RM, et al. Lack of placental transfer of certolizumab pegol during pregnancy: Results from CRIB, a prospective, postmarketing, pharmacokinetic study. Ann Rheum Dis. 2018;77(2):228-233. doi: 10.1136/annrheumdis-2017-212196</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Julsgaard M, Christensen LA, Gibson PR, Gearry RB, Fallingborg J, Hvas CL, et al. Concentrations of adalimumab and infliximab in mothers and newborns, and effects on infection. Gastroenterology. 2016;151(1):110-119. doi: 10.1053/j.gastro.2016.04.002</mixed-citation><mixed-citation xml:lang="en">Julsgaard M, Christensen LA, Gibson PR, Gearry RB, Fallingborg J, Hvas CL, et al. Concentrations of adalimumab and infliximab in mothers and newborns, and effects on infection. Gastroenterology. 2016;151(1):110-119. doi: 10.1053/j.gastro.2016.04.002</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Ghalandari N, Kemper E, Crijns IH, Wolbink G, Rispens T, Smeele HT, et al. Analysing cord blood levels of TNF inhibitors to validate the EULAR points to consider for TNF inhibitor use during pregnancy. Ann Rheum Dis. 2022;81(3):402-405. doi: 10.1136/annrheumdis-2021-221036</mixed-citation><mixed-citation xml:lang="en">Ghalandari N, Kemper E, Crijns IH, Wolbink G, Rispens T, Smeele HT, et al. Analysing cord blood levels of TNF inhibitors to validate the EULAR points to consider for TNF inhibitor use during pregnancy. Ann Rheum Dis. 2022;81(3):402-405. doi: 10.1136/annrheumdis-2021-221036</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Nielsen OH, Gubatan JM, Juhl CB, Streett SE, Maxwell C. Biologics for inflammatory bowel disease and their safety in pregnancy: A systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2022;20(1):74-87.e3. doi: 10.1016/j.cgh.2020.07.047</mixed-citation><mixed-citation xml:lang="en">Nielsen OH, Gubatan JM, Juhl CB, Streett SE, Maxwell C. Biologics for inflammatory bowel disease and their safety in pregnancy: A systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2022;20(1):74-87.e3. doi: 10.1016/j.cgh.2020.07.047</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">O’Byrne LJ, Alqatari SG, Maher GM, O’Sullivan AM, Khashan AS, Murphy GP, et al. Fetal and maternal outcomes after maternal biologic use during conception and pregnancy: A systematic review and meta-analysis. BJOG. 2022;129(8):1236-1246. doi: 10.1111/1471-0528.17093</mixed-citation><mixed-citation xml:lang="en">O’Byrne LJ, Alqatari SG, Maher GM, O’Sullivan AM, Khashan AS, Murphy GP, et al. Fetal and maternal outcomes after maternal biologic use during conception and pregnancy: A systematic review and meta-analysis. BJOG. 2022;129(8):1236-1246. doi: 10.1111/1471-0528.17093</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Tsao NW, Rebic N, Lynd LD, De Vera MA. Maternal and neonatal outcomes associated with biologic exposure before and during pregnancy in women with inflammatory systemic diseases: A systematic review and meta-analysis of observational studies. Rheumatology (Oxford). 2020;59(8):1808-1817. doi: 10.1093/rheumatology/keaa064</mixed-citation><mixed-citation xml:lang="en">Tsao NW, Rebic N, Lynd LD, De Vera MA. Maternal and neonatal outcomes associated with biologic exposure before and during pregnancy in women with inflammatory systemic diseases: A systematic review and meta-analysis of observational studies. Rheumatology (Oxford). 2020;59(8):1808-1817. doi: 10.1093/rheumatology/keaa064</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Nguyen H, Ahmed K, Luo W, Flint J, Giles I. A systematic review of the safety of non-TNF inhibitor biologic and targeted synthetic drugs in rheumatic disease in pregnancy. Semin Arthritis Rheum. 2021;51(6):1205-1217. doi: 10.1016/j.semarthrit.2021.09.004</mixed-citation><mixed-citation xml:lang="en">Nguyen H, Ahmed K, Luo W, Flint J, Giles I. A systematic review of the safety of non-TNF inhibitor biologic and targeted synthetic drugs in rheumatic disease in pregnancy. Semin Arthritis Rheum. 2021;51(6):1205-1217. doi: 10.1016/j.semarthrit.2021.09.004</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Das G, Damotte V, Gelfand JM, Bevan C, Cree BAC, Do L, et al. Rituximab before and during pregnancy: A systematic review, and a case series in MS and NMOSD. Neurol Neuroimmunol Neuroinflamm. 2018;5(3):e453. doi: 10.1212/NXI.0000000000000453</mixed-citation><mixed-citation xml:lang="en">Das G, Damotte V, Gelfand JM, Bevan C, Cree BAC, Do L, et al. Rituximab before and during pregnancy: A systematic review, and a case series in MS and NMOSD. Neurol Neuroimmunol Neuroinflamm. 2018;5(3):e453. doi: 10.1212/NXI.0000000000000453</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Youngstein T, Hoffmann P, Gul A, Lane T, Williams R, Rowczenio DM, et al. International multi-centre study of pregnancy outcomes with interleukin-1 inhibitors. Rheumatology (Oxford). 2017;56(12):2102-2108. doi: 10.1093/rheumatology/kex305</mixed-citation><mixed-citation xml:lang="en">Youngstein T, Hoffmann P, Gul A, Lane T, Williams R, Rowczenio DM, et al. International multi-centre study of pregnancy outcomes with interleukin-1 inhibitors. Rheumatology (Oxford). 2017;56(12):2102-2108. doi: 10.1093/rheumatology/kex305</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Kao JH, Lan TY, Lu CH, Cheng CF, Huang YM, Shen CY, et al. Pregnancy outcomes in patients treated with belimumab: Report from real-world experience. Semin Arthritis Rheum. 2021;51(5):963-968.</mixed-citation><mixed-citation xml:lang="en">Kao JH, Lan TY, Lu CH, Cheng CF, Huang YM, Shen CY, et al.  Pregnancy outcomes in patients treated with belimumab: Report from real-world experience. Semin Arthritis Rheum. 2021;51(5):963-968.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Chakravarty EF, Murray ER, Kelman A, Farmer P. Pregnancy outcomes after maternal exposure to rituximab. Blood 2011;117(5):1499-1506. doi: 10.1182/blood-2010-07-295444</mixed-citation><mixed-citation xml:lang="en">Chakravarty EF, Murray ER, Kelman A, Farmer P. Pregnancy outcomes after maternal exposure to rituximab. Blood 2011;117(5):1499-1506. doi: 10.1182/blood-2010-07-295444</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Avni-Biron I, Mishael T, Zittan E, Livne-Margolin M, Zinger A, Tzadok R, et al. Ustekinumab during pregnancy in patients with inflammatory bowel disease: A prospective multicentre cohort study. Aliment Pharmacol Ther. 2022;56(9):1361-1369. doi: 10.1111/apt.17224</mixed-citation><mixed-citation xml:lang="en">Avni-Biron I, Mishael T, Zittan E, Livne-Margolin M, Zinger A, Tzadok R, et al. Ustekinumab during pregnancy in patients with inflammatory bowel disease: A prospective multicentre cohort study. Aliment Pharmacol Ther. 2022;56(9):1361-1369. doi: 10.1111/apt.17224</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Gall B, Yee A, Berry B, Bircham D, Hayashi A, Dansereau J, et al. Rituximab for management of refractory pregnancy-associated immune thrombocytopenic purpura. J Obstet Gynaecol Can. 2010;32(12):1167-1171. doi: 10.1016/S1701-2163(16)34741-7</mixed-citation><mixed-citation xml:lang="en">Gall B, Yee A, Berry B, Bircham D, Hayashi A, Dansereau J, et al. Rituximab for management of refractory pregnancy-associated immune thrombocytopenic purpura. J Obstet Gynaecol Can. 2010;32(12):1167-1171. doi: 10.1016/S1701-2163(16)34741-7</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Klink DT, van Elburg RM, Schreurs MW, van Well GT. Rituximab administration in third trimester of pregnancy suppresses neonatal B-cell development. Clin Dev Immunol. 2008;2008:271363. doi: 10.1155/2008/271363</mixed-citation><mixed-citation xml:lang="en">Klink DT, van Elburg RM, Schreurs MW, van Well GT. Rituximab administration in third trimester of pregnancy suppresses neonatal B-cell development. Clin Dev Immunol. 2008;2008:271363. doi: 10.1155/2008/271363</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Bitter H, Bendvold AN, Østensen ME. Lymphocyte changes and vaccination response in a child exposed to belimumab during pregnancy. Ann Rheum Dis. 2018;77(11):1692-1693. doi: 10.1136/annrheumdis-2018-213004</mixed-citation><mixed-citation xml:lang="en">Bitter H, Bendvold AN, Østensen ME. Lymphocyte changes and vaccination response in a child exposed to belimumab during pregnancy. Ann Rheum Dis. 2018;77(11):1692-1693. doi: 10.1136/annrheumdis-2018-213004</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Vittorakis SK, Giannakopoulou G, Samitas K, Zervas E. Successful and safe treatment of severe steroid depended eosinophilic asthma with mepolizumab in a woman during pregnancy. Respir Med Case Rep. 2023;41:101785. doi: 10.1016/j.rmcr.2022.101785</mixed-citation><mixed-citation xml:lang="en">Vittorakis SK, Giannakopoulou G, Samitas K, Zervas E. Successful and safe treatment of severe steroid depended eosinophilic asthma with mepolizumab in a woman during pregnancy. Respir Med Case Rep. 2023;41:101785. doi: 10.1016/j.rmcr.2022.101785</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Ozden G, Pinar Deniz P. May mepolizumab used in asthma correct subfertility? Ann Med. 2021;53(1):456-458. doi: 10.1080/07853 890.2021.1900591</mixed-citation><mixed-citation xml:lang="en">Ozden G, Pinar Deniz P. May mepolizumab used in asthma correct subfertility? Ann Med. 2021;53(1):456-458. doi: 10.1080/07853 890.2021.1900591</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Miyasaka N, Miura O, Kawaguchi T, Arima N, Morishita E, Usuki K, et al. Pregnancy outcomes of patients with paroxysmal nocturnal hemoglobinuria treated with eculizumab: A Japanese experience and updated review. Int J Hematol. 2016;103(6):703-712. doi: 10.1007/s12185-016-1946-x</mixed-citation><mixed-citation xml:lang="en">Miyasaka N, Miura O, Kawaguchi T, Arima N, Morishita E, Usuki K, et al. Pregnancy outcomes of patients with paroxysmal nocturnal hemoglobinuria treated with eculizumab: A Japanese experience and updated review. Int J Hematol. 2016;103(6):703-712. doi: 10.1007/s12185-016-1946-x</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Kelly R, Arnold L, Richards S, Hill A, Bomken C, Hanley J, et al. The management of pregnancy in paroxysmal nocturnal haemoglobinuria on long term eculizumab. Br J Haematol. 2010;149(3):446-450. doi: 10.1111/j.1365-2141.2010.08099.x</mixed-citation><mixed-citation xml:lang="en">Kelly R, Arnold L, Richards S, Hill A, Bomken C, Hanley J, et al. The management of pregnancy in paroxysmal nocturnal haemoglobinuria on long term eculizumab. Br J Haematol. 2010;149(3):446-450. doi: 10.1111/j.1365-2141.2010.08099.x</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">European Medicine Agency. URL: https://www.ema.europa.eu/en/homepage (Accessed: 1st June 2024).</mixed-citation><mixed-citation xml:lang="en">European Medicine Agency. URL: https://www.ema.europa.eu/en/homepage (Accessed: 1st June 2024).</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Beaulieu DB, Ananthakrishnan AN, Martin C, Cohen RD, Kane SV, Mahadevan U. Use of biologic therapy by pregnant women with inflammatory bowel disease does not affect infant response to vaccines. Clin Gastroenterol Hepatol. 2018;16(1):99-105. doi: 10.1016/j.cgh.2017.08.041</mixed-citation><mixed-citation xml:lang="en">Beaulieu DB, Ananthakrishnan AN, Martin C, Cohen RD, Kane SV, Mahadevan U. Use of biologic therapy by pregnant women with inflammatory bowel disease does not affect infant response to vaccines. Clin Gastroenterol Hepatol. 2018;16(1):99-105. doi: 10.1016/j.cgh.2017.08.041</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Goulden B, Chua N, Parker E, Giles I. A systematic review of live vaccine outcomes in infants exposed to biologic disease modifying anti-rheumatic drugs in utero. Rheumatology (Oxford). 2022;61(10):3902-3906. doi: 10.1093/rheumatology/keac141</mixed-citation><mixed-citation xml:lang="en">Goulden B, Chua N, Parker E, Giles I. A systematic review of live vaccine outcomes in infants exposed to biologic disease modifying anti-rheumatic drugs in utero. Rheumatology (Oxford). 2022;61(10):3902-3906. doi: 10.1093/rheumatology/keac141</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Cheent K, Nolan J, Shariq S, Kiho L, Pal A, Arnold J. Case report: Fatal case of disseminated BCG infection in an infant born to a mother taking infliximab for Crohn’s disease. J Crohns Colitis. 2010;4(5):603-605. doi: 10.1016/j.crohns.2010.05.001</mixed-citation><mixed-citation xml:lang="en">Cheent K, Nolan J, Shariq S, Kiho L, Pal A, Arnold J. Case report: Fatal case of disseminated BCG infection in an infant born to a mother taking infliximab for Crohn’s disease. J Crohns Colitis. 2010;4(5):603-605. doi: 10.1016/j.crohns.2010.05.001</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Fitzpatrick T, Alsager K, Sadarangani M, Pham-Huy A, Murguía-Favela L, Morris SK, et al. Immunological effects and safety of live rotavirus vaccination after antenatal exposure to immunomodulatory biologic agents: A prospective cohort study from the Canadian Immunization Research Network. Lancet Child Adolesc Health. 2023;7(9):648-656. doi: 10.1016/S23524642(23)00136-0</mixed-citation><mixed-citation xml:lang="en">Fitzpatrick T, Alsager K, Sadarangani M, Pham-Huy A, Murguía-Favela L, Morris SK, et al. Immunological effects and safety of live rotavirus vaccination after antenatal exposure to immunomodulatory biologic agents: A prospective cohort study from the Canadian Immunization Research Network. Lancet Child Adolesc Health. 2023;7(9):648-656. doi: 10.1016/S23524642(23)00136-0</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Zerbo O, Modaressi S, Goddard K, Lewis E, Getahun D, Palmsten KK, et al. Safety of live-attenuated vaccines in children exposed to biologic response modifiers in utero. Pediatrics. 2022;150(1):e2021056021. doi: 10.1542/peds.2021-056021</mixed-citation><mixed-citation xml:lang="en">Zerbo O, Modaressi S, Goddard K, Lewis E, Getahun D, Palmsten KK, et al. Safety of live-attenuated vaccines in children exposed to biologic response modifiers in utero. Pediatrics. 2022;150(1):e2021056021. doi: 10.1542/peds.2021-056021</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Weber-Schoendorfer C, Beck E, Tissen-Diabate T, Schaefer C. Leflunomide – a human teratogen? A still not answered question. An evaluation of the German Embryotox pharmacovigilance database. Reprod Toxicol. 2017;71:101-107. doi: 10.1016/j.reprotox.2017.04.007</mixed-citation><mixed-citation xml:lang="en">Weber-Schoendorfer C, Beck E, Tissen-Diabate T, Schaefer C. Leflunomide – a human teratogen? A still not answered question. An evaluation of the German Embryotox pharmacovigilance database. Reprod Toxicol. 2017;71:101-107. doi: 10.1016/j.reprotox.2017.04.007</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Henson LJ, Afsar S, Davenport L, Purvis A, Poole EM, Truffinet P. Pregnancy outcomes in patients treated with leflunomide, the parent compound of the multiple sclerosis drug teriflunomide. Reprod Toxicol. 2020;95:45-50. doi: 10.1016/j.reprotox.2020.04.073</mixed-citation><mixed-citation xml:lang="en">Henson LJ, Afsar S, Davenport L, Purvis A, Poole EM, Truffinet P. Pregnancy outcomes in patients treated with leflunomide, the parent compound of the multiple sclerosis drug teriflunomide. Reprod Toxicol. 2020;95:45-50. doi: 10.1016/j.reprotox.2020.04.073</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">Chambers CD, Johnson DL, Robinson LK, Braddock SR, Xu R, Lopez-Jimenez J, et al. Birth outcomes in women who have taken leflunomide during pregnancy. Arthritis Rheum. 2010;62(5):1494-1503. doi: 10.1002/art.27358</mixed-citation><mixed-citation xml:lang="en">Chambers CD, Johnson DL, Robinson LK, Braddock SR, Xu R, Lopez-Jimenez J, et al. Birth outcomes in women who have taken leflunomide during pregnancy. Arthritis Rheum. 2010;62(5):1494-1503. doi: 10.1002/art.27358</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">Andersen JB, Wandall-Holm MF, Magyari M. Pregnancy outcomes following maternal or paternal exposure to teriflunomide in the Danish MS population. Mult Scler Relat Disord. 2022;59:103529.</mixed-citation><mixed-citation xml:lang="en">Andersen JB, Wandall-Holm MF, Magyari M. Pregnancy outcomes following maternal or paternal exposure to teriflunomide in the Danish MS population. Mult Scler Relat Disord. 2022;59:103529.</mixed-citation></citation-alternatives></ref><ref id="cit84"><label>84</label><citation-alternatives><mixed-citation xml:lang="ru">Vukusic S, Coyle PK, Jurgensen S, Truffinet P, Benamor M, Afsar S, et al. Pregnancy outcomes in patients with multiple sclerosis treated with teriflunomide: Clinical study data and 5 years of post-marketing experience. Mult Scler. 2020;26(7):829-836. doi: 10.1016/j.msard.2022.103529</mixed-citation><mixed-citation xml:lang="en">Vukusic S, Coyle PK, Jurgensen S, Truffinet P, Benamor M, Afsar S, et al. Pregnancy outcomes in patients with multiple sclerosis treated with teriflunomide: Clinical study data and 5 years of post-marketing experience. Mult Scler. 2020;26(7):829-836. doi: 10.1016/j.msard.2022.103529</mixed-citation></citation-alternatives></ref><ref id="cit85"><label>85</label><citation-alternatives><mixed-citation xml:lang="ru">Drugs and Lactation Database (LactMed). URL: https://www.ncbi.nlm.nih.gov/books/NBK501922 (Accessed: 1st June 2024).</mixed-citation><mixed-citation xml:lang="en">Drugs and Lactation Database (LactMed). URL: https://www. ncbi.nlm.nih.gov/books/NBK501922 (Accessed: 1st June 2024).</mixed-citation></citation-alternatives></ref><ref id="cit86"><label>86</label><citation-alternatives><mixed-citation xml:lang="ru">Boz C, Terzi M, Zengin Karahan S, Sen S, Sarac Y, Emrah Mavis M. Safety of IV pulse methylprednisolone therapy during breastfeeding in patients with multiple sclerosis. Mult Scler. 2018;24(9):1205-1211. doi: 10.1177/1352458517717806</mixed-citation><mixed-citation xml:lang="en">Boz C, Terzi M, Zengin Karahan S, Sen S, Sarac Y, Emrah Mavis M. Safety of IV pulse methylprednisolone therapy during breastfeeding in patients with multiple sclerosis. Mult Scler. 2018;24(9):1205-1211. doi: 10.1177/1352458517717806</mixed-citation></citation-alternatives></ref><ref id="cit87"><label>87</label><citation-alternatives><mixed-citation xml:lang="ru">Zengin Karahan S, Boz C, Terzi M, Aktoz G, Sen S, Ozbudun B, et al. Methylprednisolone concentrations in breast milk and serum of patients with multiple sclerosis treated with IV pulse methylprednisolone. Clin Neurol Neurosurg. 2020;197:106118. doi: 10.1016/j.clineuro.2020.106118</mixed-citation><mixed-citation xml:lang="en">Zengin Karahan S, Boz C, Terzi M, Aktoz G, Sen S, Ozbudun B, et al. Methylprednisolone concentrations in breast milk and serum of patients with multiple sclerosis treated with IV pulse methylprednisolone. Clin Neurol Neurosurg. 2020;197:106118. doi: 10.1016/j.clineuro.2020.106118</mixed-citation></citation-alternatives></ref><ref id="cit88"><label>88</label><citation-alternatives><mixed-citation xml:lang="ru">Aluko A, Ranganathan P. Pharmacogenetics of drug therapies in rheumatoid arthritis. Methods Mol Biol. 2022;2547:527-567. doi: 10.1007/978-1-0716-2573-6_19</mixed-citation><mixed-citation xml:lang="en">Aluko A, Ranganathan P. Pharmacogenetics of drug therapies in rheumatoid arthritis. Methods Mol Biol. 2022;2547:527-567. doi: 10.1007/978-1-0716-2573-6_19</mixed-citation></citation-alternatives></ref><ref id="cit89"><label>89</label><citation-alternatives><mixed-citation xml:lang="ru">Datta P, Baker T, Hale TW. Balancing the use of medications while maintaining breastfeeding. Clin Perinatol. 2019;46(2):367-382. doi: 10.1016/j.clp.2019.02.007</mixed-citation><mixed-citation xml:lang="en">Datta P, Baker T, Hale TW. Balancing the use of medications while maintaining breastfeeding. Clin Perinatol. 2019;46(2):367-382. doi: 10.1016/j.clp.2019.02.007</mixed-citation></citation-alternatives></ref><ref id="cit90"><label>90</label><citation-alternatives><mixed-citation xml:lang="ru">Anderson PO. Monoclonal antibodies during breastfeeding. Breastfeed Med. 2021;16(8):591-593. doi: 10.1089/bfm.2021.0110</mixed-citation><mixed-citation xml:lang="en">Anderson PO. Monoclonal antibodies during breastfeeding. Breastfeed Med. 2021;16(8):591-593. doi: 10.1089/bfm.2021.0110</mixed-citation></citation-alternatives></ref><ref id="cit91"><label>91</label><citation-alternatives><mixed-citation xml:lang="ru">Rød BE, Torkildsen Ø, Myhr KM, Bø L, Wergeland S. Safety of breast feeding during rituximab treatment in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2022;94(1):38-41. doi: 10.1136/jnnp-2022-329545</mixed-citation><mixed-citation xml:lang="en">Rød BE, Torkildsen Ø, Myhr KM, Bø L, Wergeland S. Safety of breast feeding during rituximab treatment in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2022;94(1):38-41. doi: 10.1136/jnnp-2022-329545</mixed-citation></citation-alternatives></ref><ref id="cit92"><label>92</label><citation-alternatives><mixed-citation xml:lang="ru">Bosshard N, Zbinden A, Eriksson KK, Forger F. Rituximab and canakinumab use during lactation: No detectable serum levels in breastfed infants. Rheumatol Ther. 2021;8(2):1043-1048. doi: 10.1007/s40744-021-00313-z</mixed-citation><mixed-citation xml:lang="en">Bosshard N, Zbinden A, Eriksson KK, Forger F. Rituximab and canakinumab use during lactation: No detectable serum levels in breastfed infants. Rheumatol Ther. 2021;8(2):1043-1048. doi: 10.1007/s40744-021-00313-z</mixed-citation></citation-alternatives></ref><ref id="cit93"><label>93</label><citation-alternatives><mixed-citation xml:lang="ru">Clowse ME, Forger F, Hwang C, Thorp J, Dolhain RJ, van Tubergen A, et al. Minimal to no transfer of certolizumab pegol into breast milk: Results from CRADLE, a prospective, postmarketing, multicentre, pharmacokinetic study. Ann Rheum Dis. 2017;76(11):1890-1896. doi: 10.1136/annrheumdis-2017-211384</mixed-citation><mixed-citation xml:lang="en">Clowse ME, Forger F, Hwang C, Thorp J, Dolhain RJ, van Tubergen A, et al. Minimal to no transfer of certolizumab pegol into breast milk: Results from CRADLE, a prospective, postmarketing, multicentre, pharmacokinetic study. Ann Rheum Dis. 2017;76(11):1890-1896. doi: 10.1136/annrheumdis-2017-211384</mixed-citation></citation-alternatives></ref><ref id="cit94"><label>94</label><citation-alternatives><mixed-citation xml:lang="ru">Perez-Garcia LF, Roder E, Smeele HTW, Goekoop R, Hazes JMW, Kok MR, et al. Paternal inflammatory arthritis is associated with a higher risk of miscarriage: Results of a large multicentre study (iFAME-Fertility). Rheumatology (Oxford). 2022;61(8):3390-3395. doi: 10.1093/rheumatology/keab910</mixed-citation><mixed-citation xml:lang="en">Perez-Garcia LF, Roder E, Smeele HTW, Goekoop R, Hazes JMW, Kok MR, et al. Paternal inflammatory arthritis is associated with a higher risk of miscarriage: Results of a large multicentre study (iFAME-Fertility). Rheumatology (Oxford). 2022;61(8):3390-3395. doi: 10.1093/rheumatology/keab910</mixed-citation></citation-alternatives></ref><ref id="cit95"><label>95</label><citation-alternatives><mixed-citation xml:lang="ru">Villiger PM, Caliezi G, Cottin V, Forger F, Senn A, Østensen M. Effects of TNF antagonists on sperm characteristics in patients with spondyloarthritis. Ann Rheum Dis. 2010;69(10):1842-1844. doi: 10.1093/rheumatology/keab910</mixed-citation><mixed-citation xml:lang="en">Villiger PM, Caliezi G, Cottin V, Forger F, Senn A, Østensen M. Effects of TNF antagonists on sperm characteristics in patients with spondyloarthritis. Ann Rheum Dis. 2010;69(10):1842-1844. doi: 10.1093/rheumatology/keab910</mixed-citation></citation-alternatives></ref><ref id="cit96"><label>96</label><citation-alternatives><mixed-citation xml:lang="ru">Grosen A, Bungum M, Christensen LA, Cordelli E, Larsen OH, Leter G, et al. Semen quality and sperm DNA integrity in patients with severe active inflammatory bowel disease and effects of tumour necrosis factor-alpha inhibitors. J Crohns Colitis. 2019;13(5):564-571. doi: 10.1093/ecco-jcc/jjy198</mixed-citation><mixed-citation xml:lang="en">Grosen A, Bungum M, Christensen LA, Cordelli E, Larsen OH, Leter G, et al. Semen quality and sperm DNA integrity in patients with severe active inflammatory bowel disease and effects of tumour necrosis factor-alpha inhibitors. J Crohns Colitis. 2019;13(5):564-571. doi: 10.1093/ecco-jcc/jjy198</mixed-citation></citation-alternatives></ref><ref id="cit97"><label>97</label><citation-alternatives><mixed-citation xml:lang="ru">Tiseo BC, Cocuzza M, Bonfa E, Srougi M, Silva CA. Male fertility potential alteration in rheumatic diseases: A systematic review. Int Braz J Urol. 2016;42(1):11-21. doi: 10.1590/S1677-5538.IBJU.2014.0595</mixed-citation><mixed-citation xml:lang="en">Tiseo BC, Cocuzza M, Bonfa E, Srougi M, Silva CA. Male fertility potential alteration in rheumatic diseases: A systematic review. Int Braz J Urol. 2016;42(1):11-21. doi: 10.1590/S1677-5538.IBJU.2014.0595</mixed-citation></citation-alternatives></ref><ref id="cit98"><label>98</label><citation-alternatives><mixed-citation xml:lang="ru">Perez-Garcia LF, Dolhain RJEM, Vorstenbosch S, Bramer W, van Puijenbroek E, Hazes JMW, et al. The effect of paternal exposure to immunosuppressive drugs on sexual function, reproductive hormones, fertility, pregnancy and offspring outcomes: A systematic review. Hum Reprod Update. 2020;26(6):961-1001. doi: 10.1093/humupd/dmaa022</mixed-citation><mixed-citation xml:lang="en">Perez-Garcia LF, Dolhain RJEM, Vorstenbosch S, Bramer W, van Puijenbroek E, Hazes JMW, et al. The effect of paternal exposure to immunosuppressive drugs on sexual function, reproductive hormones, fertility, pregnancy and offspring outcomes: A systematic review. Hum Reprod Update. 2020;26(6):961-1001. doi: 10.1093/humupd/dmaa022</mixed-citation></citation-alternatives></ref><ref id="cit99"><label>99</label><citation-alternatives><mixed-citation xml:lang="ru">Mouyis M, Flint JD, Giles IP. Safety of anti-rheumatic drugs in men trying to conceive: A systematic review and analysis of published evidence. Semin Arthritis Rheum. 2019;48(5):911-920. doi: 10.1016/j.semarthrit.2018.07.011</mixed-citation><mixed-citation xml:lang="en">Mouyis M, Flint JD, Giles IP. Safety of anti-rheumatic drugs in men trying to conceive: A systematic review and analysis of published evidence. Semin Arthritis Rheum. 2019;48(5):911-920. doi: 10.1016/j.semarthrit.2018.07.011</mixed-citation></citation-alternatives></ref><ref id="cit100"><label>100</label><citation-alternatives><mixed-citation xml:lang="ru">Grosen A, Bellaguarda E, Nersting J, Hvas CL, Liljeqvist-Soltic I, Stein A, et al. Low-dose methotrexate therapy does not affect semen parameters and sperm DNA. Inflamm Bowel Dis. 2022;28(7):1012-1018. doi: 10.1093/ibd/izab205</mixed-citation><mixed-citation xml:lang="en">Grosen A, Bellaguarda E, Nersting J, Hvas CL, Liljeqvist-Soltic I, Stein A, et al. Low-dose methotrexate therapy does not affect semen parameters and sperm DNA. Inflamm Bowel Dis. 2022;28(7):1012-1018. doi: 10.1093/ibd/izab205</mixed-citation></citation-alternatives></ref><ref id="cit101"><label>101</label><citation-alternatives><mixed-citation xml:lang="ru">Perez-Garcia LF, Roder E, Krijthe BP, Kranenburg-van Koppen LJ, van Adrichem R, Zirkzee E, et al. Is methotrexate safe for men with an immunemediated inflammatory disease and an active desire to become a father? Results of a prospective cohort study (iFAME-MTX). Ann Rheum Dis. 2023;82(8):1068-1075. doi: 10.1136/ard-2023-224032</mixed-citation><mixed-citation xml:lang="en">Perez-Garcia LF, Roder E, Krijthe BP, Kranenburg-van Koppen LJ, van Adrichem R, Zirkzee E, et al. Is methotrexate safe for men with an immunemediated inflammatory disease and an active desire to become a father? Results of a prospective cohort study (iFAME-MTX). Ann Rheum Dis. 2023;82(8):1068-1075. doi: 10.1136/ard-2023-224032</mixed-citation></citation-alternatives></ref><ref id="cit102"><label>102</label><citation-alternatives><mixed-citation xml:lang="ru">Meserve J, Luo J, Zhu W, Veeravalli N, Bandoli G, Chambers CD, et al. Paternal exposure to immunosuppressive and/ or biologic agents and birth outcomes in patients with immunemediated inflammatory diseases. Gastroenterology. 2021;161(1):107-115.e3. doi: 10.1053/j.gastro.2021.03.020</mixed-citation><mixed-citation xml:lang="en">Meserve J, Luo J, Zhu W, Veeravalli N, Bandoli G, Chambers CD, et al. Paternal exposure to immunosuppressive and/ or biologic agents and birth outcomes in patients with immunemediated inflammatory diseases. Gastroenterology. 2021;161(1):107-115.e3. doi: 10.1053/j.gastro.2021.03.020</mixed-citation></citation-alternatives></ref><ref id="cit103"><label>103</label><citation-alternatives><mixed-citation xml:lang="ru">EMA. Teriflunomide (Aubagio). Summary of product characteristics. URL: https://www.ema.europa.eu/en/documents/productinformation/aubagio-epar-product-information_en.pdf (Accessed: 1st June 2024).</mixed-citation><mixed-citation xml:lang="en">EMA. Teriflunomide (Aubagio). Summary of product characteristics. URL: https://www.ema.europa.eu/en/documents/productinformation/aubagio-epar-product-information_en.pdf (Accessed: 1st June 2024).</mixed-citation></citation-alternatives></ref><ref id="cit104"><label>104</label><citation-alternatives><mixed-citation xml:lang="ru">Barbonetti A, Tienforti D, Castellini C, Giulio FD, Muselli M, Pizzocaro A, et al. Effect of antioxidants on semen parameters in men with oligoastheno-teratozoospermia: A network metaanalysis. Andrology. 2024;12(3):538-552. doi: 10.1111/andr.13498</mixed-citation><mixed-citation xml:lang="en">Barbonetti A, Tienforti D, Castellini C, Giulio FD, Muselli M, Pizzocaro A, et al. Effect of antioxidants on semen parameters in men with oligoastheno-teratozoospermia: A network metaanalysis. Andrology. 2024;12(3):538-552. doi: 10.1111/andr.13498</mixed-citation></citation-alternatives></ref><ref id="cit105"><label>105</label><citation-alternatives><mixed-citation xml:lang="ru">Mulder RL, Font-Gonzalez A, Green DM, Loeffen EAH, Hudson MM, Loonen J, et al. Fertility preservation for male patients with childhood, adolescent, and young adult cancer: Recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group. Lancet Oncol. 2021;22(2):e57-е67. doi: 10.1016/S14702045(20)30582-9</mixed-citation><mixed-citation xml:lang="en">Mulder RL, Font-Gonzalez A, Green DM, Loeffen EAH, Hudson MM, Loonen J, et al. Fertility preservation for male patients with childhood, adolescent, and young adult cancer: Recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group. Lancet Oncol. 2021;22(2):e57-е67. doi: 10.1016/S14702045(20)30582-9</mixed-citation></citation-alternatives></ref><ref id="cit106"><label>106</label><citation-alternatives><mixed-citation xml:lang="ru">Reinisch W, Hellstrom W, Dolhain RJEM, Sikka S, Westhovens R, Mehta R, et al. Effects of filgotinib on semen parameters and sex hormones in male patients with inflammatory diseases: Results from the phase 2, randomised, double-blind, placebocontrolled MANTA and MANTA-RAy studies. Ann Rheum Dis. 2023;82(8):1049-1058. doi: 10.1136/ard-2023-224017</mixed-citation><mixed-citation xml:lang="en">Reinisch W, Hellstrom W, Dolhain RJEM, Sikka S, Westhovens R, Mehta R, et al. Effects of filgotinib on semen parameters and sex hormones in male patients with inflammatory diseases: Results from the phase 2, randomised, double-blind, placebocontrolled MANTA and MANTA-RAy studies. Ann Rheum Dis. 2023;82(8):1049-1058. doi: 10.1136/ard-2023-224017</mixed-citation></citation-alternatives></ref><ref id="cit107"><label>107</label><citation-alternatives><mixed-citation xml:lang="ru">Mahadevan U, Dubinsky MC, Su C, Lawendy N, Jones TV, Marren A, et al. Outcomes of pregnancies with maternal/paternal exposure in the tofacitinib safety databases for ulcerative colitis. Inflamm Bowel Dis. 2018;24(12):2494-2500. doi: 10.1093/ibd/izy160</mixed-citation><mixed-citation xml:lang="en">Mahadevan U, Dubinsky MC, Su C, Lawendy N, Jones TV, Marren A, et al. Outcomes of pregnancies with maternal/paternal exposure in the tofacitinib safety databases for ulcerative colitis. Inflamm Bowel Dis. 2018;24(12):2494-2500. doi: 10.1093/ibd/izy160</mixed-citation></citation-alternatives></ref><ref id="cit108"><label>108</label><citation-alternatives><mixed-citation xml:lang="ru">Giles I, Yee CS, Gordon C. Stratifying management of rheumatic disease for pregnancy and breastfeeding. Nat Rev Rheumatol. 2019;15:391-402. doi: 10.1038/s41584-019-0240-8</mixed-citation><mixed-citation xml:lang="en">Giles I, Yee CS, Gordon C. Stratifying management of rheumatic disease for pregnancy and breastfeeding. Nat Rev Rheumatol. 2019;15:391-402. doi: 10.1038/s41584-019-0240-8</mixed-citation></citation-alternatives></ref><ref id="cit109"><label>109</label><citation-alternatives><mixed-citation xml:lang="ru">Giles I, Thorne I, Schmidt NS, Reid C, Crossley A, Panca M, et al. The time of equipoise on the use of biological DMARDs in for inflammatory arthritis during pregnancy is finally over: A reappraisal of evidence to optimise pregnancy management. Lancet Rheumatol. 2024;6:e546-e559. doi: 10.1016/S26659913(24)00097-3</mixed-citation><mixed-citation xml:lang="en">Giles I, Thorne I, Schmidt NS, Reid C, Crossley A, Panca M, et al. The time of equipoise on the use of biological DMARDs in for inflammatory arthritis during pregnancy is finally over: A reappraisal of evidence to optimise pregnancy management. Lancet Rheumatol. 2024;6:e546-e559. doi: 10.1016/S26659913(24)00097-3</mixed-citation></citation-alternatives></ref><ref id="cit110"><label>110</label><citation-alternatives><mixed-citation xml:lang="ru">Bermas BL, Tassinari M, Clowse M, Chakravarty E. The new FDA labeling rule: Impact on prescribing rheumatological medications during pregnancy. Rheumatology. 2018;57(Suppl 5):2-8. doi: 10.1093/rheumatology/key010</mixed-citation><mixed-citation xml:lang="en">Bermas BL, Tassinari M, Clowse M, Chakravarty E. The new FDA labeling rule: Impact on prescribing rheumatological medications during pregnancy. Rheumatology. 2018;57(Suppl 5):2-8. doi: 10.1093/rheumatology/key010</mixed-citation></citation-alternatives></ref><ref id="cit111"><label>111</label><citation-alternatives><mixed-citation xml:lang="ru">Andreoli L, Crisafulli F, Tincani A. Pregnancy and reproductive aspects of systemic lupus erythematosus. Curr Opin Rheumatol. 2017;29:473-479. doi: 10.1097/BOR.0000000000000415</mixed-citation><mixed-citation xml:lang="en">Andreoli L, Crisafulli F, Tincani A. Pregnancy and reproductive aspects of systemic lupus erythematosus. Curr Opin Rheumatol. 2017;29:473-479. doi: 10.1097/BOR.0000000000000415</mixed-citation></citation-alternatives></ref><ref id="cit112"><label>112</label><citation-alternatives><mixed-citation xml:lang="ru">Rosta K, Binder J, Kuczwara V, Horvath M, Heinzl F, Hörhager C, et al. Periconceptional counselling in women with autoimmune inflammatory rheumatic diseases. J Clin Med. 2024;13:2483. doi: 10.3390/jcm13092483</mixed-citation><mixed-citation xml:lang="en">Rosta K, Binder J, Kuczwara V, Horvath M, Heinzl F, Hörhager C, et al. Periconceptional counselling in women with autoimmune inflammatory rheumatic diseases. J Clin Med. 2024;13:2483. doi: 10.3390/jcm13092483</mixed-citation></citation-alternatives></ref><ref id="cit113"><label>113</label><citation-alternatives><mixed-citation xml:lang="ru">Schreiber K, Frishman M, Russell MD, Dey M, Flint J, Allen A, et al. British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: Comorbidity medications used in rheumatology practice. Rheumatology (Oxford). 2023;62(4):e89-e104. doi: 10.1093/rheumatology/keac552</mixed-citation><mixed-citation xml:lang="en">Schreiber K, Frishman M, Russell MD, Dey M, Flint J, Allen A, et al. British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: Comorbidity medications used in rheumatology practice. Rheumatology (Oxford). 2023;62(4):e89-e104. doi: 10.1093/rheumatology/keac552</mixed-citation></citation-alternatives></ref><ref id="cit114"><label>114</label><citation-alternatives><mixed-citation xml:lang="ru">Sammaritano LR. Contraception and preconception counseling in women with autoimmune disease. Best Pract Res Clin Obstet Gynaecol. 2020;64:11-23. doi: 10.1016/j.bpobgyn.2019.09.003</mixed-citation><mixed-citation xml:lang="en">Sammaritano LR. Contraception and preconception counseling in women with autoimmune disease. Best Pract Res Clin Obstet Gynaecol. 2020;64:11-23. doi: 10.1016/j.bpobgyn.2019.09.003</mixed-citation></citation-alternatives></ref><ref id="cit115"><label>115</label><citation-alternatives><mixed-citation xml:lang="ru">Yeung CHT, Houle SKD, Anderson PO, Best BM, Dubinsky S, Edginton AN. Addressing maternal medication use during breastfeeding using clinical resources and a novel physiologically based pharmacokinetic model-derived metric: A qualitative study. Front Pediatr. 2023;11:1147566. doi: 10.3389/fped.2023.1147566</mixed-citation><mixed-citation xml:lang="en">Yeung CHT, Houle SKD, Anderson PO, Best BM, Dubinsky S, Edginton AN. Addressing maternal medication use during breastfeeding using clinical resources and a novel physiologically based pharmacokinetic model-derived metric: A qualitative study. Front Pediatr. 2023;11:1147566. doi: 10.3389/fped.2023.1147566</mixed-citation></citation-alternatives></ref><ref id="cit116"><label>116</label><citation-alternatives><mixed-citation xml:lang="ru">Schreiber K, Graversgaard C, Hunt BJ, Wason JMS, CostedoatChalumeau N, Aguilera S, et al. Challenges of designing and conducting cohort studies and clinical trials in populations of pregnant people. Lancet Rheumatol. 2024;6(8):e560-e572. doi: 10.1016/S2665-9913(24)00118-8</mixed-citation><mixed-citation xml:lang="en">Schreiber K, Graversgaard C, Hunt BJ, Wason JMS, CostedoatChalumeau N, Aguilera S, et al. Challenges of designing and conducting cohort studies and clinical trials in populations of pregnant people. Lancet Rheumatol. 2024;6(8):e560-e572. doi: 10.1016/S2665-9913(24)00118-8</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
