rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.47360/1995-4484-2026-223-226rsp-3940Research ArticleПЕРЕДОВАЯLEADING ARTICLEГлюкокортикоиды в ревматологии: к 130-летию со дня рождения Филипа Шоуолтера ХенчаGlucocorticoids in rheumatology: 130th anniversary of the birth of Philip Showalter Henchhttps://orcid.org/0000-0002-1598-8360НасоновЕ. Л.NasonovE. L.

Насонов Евгений Львович

115522, Москва, Каширское шоссе, 34а; 117997, Москва, ул. Островитянова, 1

Evgeny Nasonov

115522, Moscow, Kashirskoye Highway, 34A;117997, Moscow, Ostrovitianova str., 1

nasonov@irramn.ruФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииРоссияV.A. Nasonova Research Institute of Rheumatology; N.I. Pirogov Russian National Research Medical UniversityRussian Federation202630062026643223226Copyright © Насонов Е.Л., 20262026Насонов Е.Л.Nasonov E.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/3940

В 2026 году исполняется 130 лет со дня рождения выдающегося американского ревматолога Филипа Шоултера Хенча, который в 1950 году (вместе с биохимиками Эдуардом Кендаллом и Тадеушом Рейнстеном) был удостоен Нобелевской премии по физиологии и медицине за «открытие, касающееся гормонов коры надпочечников, их структуры и биологических эффектов». В статье суммированы данные, связанные с историей изучения и вкладом Ф. Хенча в разработку глюкокортикоидов; рассмотрены перспективы глюкокортикоидной терапии при иммуновоспалительных ревматических заболеваниях.

The year 2026 marks the 130th anniversary of the birth of the eminent American rheumatologist Philip Showalter Hench, who in 1950 (along with biochemists Edward Kendall and Tadeusz Reichstein) was awarded the Nobel Prize in Physiology or Medicine “for their discoveries relating to the hormones of the adrenal cortex, their structure and biological effects”. The article summarizes data concerning the history of the study and contribution of P. Hench to the development of glucocorticoids, and examines the prospects of glucocorticoid therapy in immune-mediated rheumatic diseases.

Филип ХенчНобелевская премияглюкокортикоидыPhilip HenchNobel PrizeglucocorticoidsИсследование не имело спонсорской поддержки. Автор не получал гонорар за статью.ReferencesLloyd M. Philip Showalter Hench, 1896–1965. Rheumatology (Oxford). 2002;41(5):582-584. doi: 10.1093/rheumatology/41.5.582Lloyd M. Philip Showalter Hench, 1896–1965. Rheumatology (Oxford). 2002;41(5):582-584. doi: 10.1093/rheumatology/41.5.582Le Fanu J. 1949: Cortisone. In: Le Fanu J (ed). The rise and fall of modern medicine. NY:Carroll & Graff Publishers, Inc; 2000: 16-25.Le Fanu J. 1949: Cortisone. In: Le Fanu J (ed). The rise and fall of modern medicine. NY:Carroll & Graff Publishers, Inc; 2000: 16-25.Glyn J. The discovery and early use of cortisone. J R Soc Med. 1998;91(10):513-517. doi: 10.1177/014107689809101004Glyn J. The discovery and early use of cortisone. J R Soc Med. 1998;91(10):513-517. doi: 10.1177/014107689809101004Hench PS. Analgesia accompanying hepatitis and jaundice in cases of chronic arthritis, fibrositis and sciatic pain. Proceedings of the Staff Meetings of the Mayo Clinic. 1933;8:433-437.Hench PS. Analgesia accompanying hepatitis and jaundice in cases of chronic arthritis, fibrositis and sciatic pain. Proceedings of the Staff Meetings of the Mayo Clinic. 1933;8:433-437.Selye H. A syndrome produced by diverse nocuous agents. Nature. 1936;138:32.Selye H. A syndrome produced by diverse nocuous agents. Nature. 1936;138:32.Hetenyi G Jr, Karsh J. Cortisone therapy: A challenge to academic medicine in 1949–1952. Perspect Biol Med. 1997;40(3):426-439. doi: 10.1353/pbm.1997.0006Hetenyi G Jr, Karsh J. Cortisone therapy: A challenge to academic medicine in 1949–1952. Perspect Biol Med. 1997;40(3):426-439. doi: 10.1353/pbm.1997.0006Hench PS, Kendall EC, Slocumb CH, Polley HF. Effects of cortisone acetate and pituitary ACTH on rheumatoid arthritis, rheumatic fever and certain other conditions. Arch Intern Med (Chic). 1950;85(4):545-666. doi: 10.1001/archinte.1950.00230100002001Hench PS, Kendall EC, Slocumb CH, Polley HF. Effects of cortisone acetate and pituitary ACTH on rheumatoid arthritis, rheumatic fever and certain other conditions. Arch Intern Med (Chic). 1950;85(4):545-666. doi: 10.1001/archinte.1950.00230100002001Cushing H. The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism). Bulletin of the Johns Hopkins Hospital. 1932;50:137-195.Cushing H. The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism). Bulletin of the Johns Hopkins Hospital. 1932;50:137-195.The Joint Committee of the Medical Research Council and Nuffield Foundation on Clinical Trials of Cortisone, A.C.T.H., and Other Therapeutic Measures in Chronic Rheumatic Diseases. A comparison of cortisone and aspirin in the treatment of early cases of rheumatoid arthritis; A report by the Joint Committee of the Medical Research Council and Nuffield Foundation on Clinical Trials of Cortisone, A.C.T.H., and Other Therapeutic Measures in Chronic Rheumatic Diseases. Br Med J. 1954;1(4873):1223-1227.The Joint Committee of the Medical Research Council and Nuffield Foundation on Clinical Trials of Cortisone, A.C.T.H., and Other Therapeutic Measures in Chronic Rheumatic Diseases. A comparison of cortisone and aspirin in the treatment of early cases of rheumatoid arthritis; A report by the Joint Committee of the Medical Research Council and Nuffield Foundation on Clinical Trials of Cortisone, A.C.T.H., and Other Therapeutic Measures in Chronic Rheumatic Diseases. Br Med J. 1954;1(4873):1223-1227.The Joint Committee of the Medical Research Council and Nuffield Foundation. A Comparison of cortisone and aspirin in the treatment of early cases of rheumatoid arthritis; A second report by the Joint Committee of the Medical Research Council and Nuffield Foundation on clinical trials of cortisone, A.C.T.H., and other therapeutic measures in chronic rheumatic diseases. Br Med J. 1955;2(4941):695-700.The Joint Committee of the Medical Research Council and Nuffield Foundation. A Comparison of cortisone and aspirin in the treatment of early cases of rheumatoid arthritis; A second report by the Joint Committee of the Medical Research Council and Nuffield Foundation on clinical trials of cortisone, A.C.T.H., and other therapeutic measures in chronic rheumatic diseases. Br Med J. 1955;2(4941):695-700.The Joint Committee of the Medical Research Council and Nuffield Foundation; Kellgren JH. Long-term results in early cases of rheumatoid arthritis treated with either cortisone or aspirin. Br Med J. 1957;1(5023):847-850.The Joint Committee of the Medical Research Council and Nuffield Foundation; Kellgren JH. Long-term results in early cases of rheumatoid arthritis treated with either cortisone or aspirin. Br Med J. 1957;1(5023):847-850.EMPIRE Rheumatism Council. Multi-centre controlled trial comparing cortisone acetate and acetyl salicylic acid in the long-term treatment of rheumatoid arthritis; results up to one year. Ann Rheum Dis. 1955;14(4):353-370. doi: 10.1136/ard.14.4.353EMPIRE Rheumatism Council. Multi-centre controlled trial comparing cortisone acetate and acetyl salicylic acid in the long-term treatment of rheumatoid arthritis; results up to one year. Ann Rheum Dis. 1955;14(4):353-370. doi: 10.1136/ard.14.4.353A comparison of prednisolone with aspirin on other analgesics in the treatment of rheumatold arthritis. Ann Rheum Dis. 1959;18(3):173-188.A comparison of prednisolone with aspirin on other analgesics in the treatment of rheumatold arthritis. Ann Rheum Dis. 1959;18(3):173-188.Lundberg IE, Grundtman C, Larsson E, Klareskog L. Corticosteroids – from an idea to clinical use. Best Pract Res Clin Rheumatol. 2004;18(1):7-19. doi: 10.1016/j.berh.2003.10.003Lundberg IE, Grundtman C, Larsson E, Klareskog L. Corticosteroids – from an idea to clinical use. Best Pract Res Clin Rheumatol. 2004;18(1):7-19. doi: 10.1016/j.berh.2003.10.003Glyn JH. The discovery of cortisone: A personal memory. BMJ. 1998;317(7161):822A. doi: 10.1136/bmj.317.7161.822aGlyn JH. The discovery of cortisone: A personal memory. BMJ. 1998;317(7161):822A. doi: 10.1136/bmj.317.7161.822aHollander JL, Brown EM, Jessar RA, Brown CY. Hydrocortisone and cortisone injected into arthritic joints; comparative effects of and use of hydrocortisone as a local antiarthritic agent. J Am Med Assoc. 195;147(17):1629-1635. doi: 10.1001/jama.1951.03670340019005Hollander JL, Brown EM, Jessar RA, Brown CY. Hydrocortisone and cortisone injected into arthritic joints; comparative effects of and use of hydrocortisone as a local antiarthritic agent. J Am Med Assoc. 195;147(17):1629-1635. doi: 10.1001/jama.1951.03670340019005Cain DW, Cidlowski JA. Immune regulation by glucocorticoids. Nat Rev Immunol. 2017;17(4):233-247. doi: 10.1038/nri.2017.1Cain DW, Cidlowski JA. Immune regulation by glucocorticoids. Nat Rev Immunol. 2017;17(4):233-247. doi: 10.1038/nri.2017.1Насонов ЕЛ, Чичасова НВ, Ковалев ВЮ. Глюкокортикоиды в ревматологии. М.;1998.Nasonov EL, Chichasova NV, Kovalev VYu. Glucocorticoids in rheumatology. Moscow; 1998 (In Russ.)Buttgereit F, Tam LS. Glucocorticoid treatment in patients with inflammatory rheumatic diseases: Current practice and open questions. Lancet Rheumatol. 2026;8(5):e389-e400. doi: 10.1016/S2665-9913(26)00072-XButtgereit F, Tam LS. Glucocorticoid treatment in patients with inflammatory rheumatic diseases: Current practice and open questions. Lancet Rheumatol. 2026;8(5):e389-e400. doi: 10.1016/S2665-9913(26)00072-XButtgereit F. Views on glucocorticoid therapy in rheumatology: The age of convergence. Nat Rev Rheumatol. 2020;16(4):239-246. doi: 10.1038/s41584-020-0370-zButtgereit F. Views on glucocorticoid therapy in rheumatology: The age of convergence. Nat Rev Rheumatol. 2020;16(4):239-246. doi: 10.1038/s41584-020-0370-zHardy RS, Raza K, Cooper MS. Therapeutic glucocorticoids: Mechanisms of actions in rheumatic disease. Nat Rev Rheumatol. 2020;16(3):133-144. doi: 10.1038/s41584-020-0371-yHardy RS, Raza K, Cooper MS. Therapeutic glucocorticoids: Mechanisms of actions in rheumatic disease. Nat Rev Rheumatol. 2020;16(3):133-144. doi: 10.1038/s41584-020-0371-yНасонов ЕЛ. Коронавирусная болезнь 2019 (COVID-19) и аутоиммунитет. Научно-практическая ревматология. 2021;59(1):5-30. doi: 10.47360/1995-4484-2021-5-30Nasonov E.L. Coronavirus disease 2019 (COVID-19) and autoimmunity. Nauchno-Prakticheskaya Revmatologia = Rheumatology Science and Practice. 2021;59(1):5-30 (In Russ.). doi: 10.47360/1995-4484-2021-5-30Franco LM, Gadkari M, Howe KN, Sun J, Kardava L, Kumar P, et al. Immune regulation by glucocorticoids can be linked to cell type-dependent transcriptional responses. J Exp Med. 2019;216(2):384-406. doi: 10.1084/jem.20180595Franco LM, Gadkari M, Howe KN, Sun J, Kardava L, Kumar P, et al. Immune regulation by glucocorticoids can be linked to cell type-dependent transcriptional responses. J Exp Med. 2019;216(2):384-406. doi: 10.1084/jem.20180595Buttgereit F, Elling C, Jakob F. Design and development of glucocorticoid receptor modulators. Trends Pharmacol Sci. 2025;46(8):771-791. doi: 10.1016/j.tips.2025.06.005Buttgereit F, Elling C, Jakob F. Design and development of glucocorticoid receptor modulators. Trends Pharmacol Sci. 2025;46(8):771-791. doi: 10.1016/j.tips.2025.06.005Cummins CL, Goldstein I. New anti-inflammatory mechanism of glucocorticoids uncovered. Trends Endocrinol Metab. 2025;36(2):99-101. doi: 10.1016/j.tem.2024.08.003Cummins CL, Goldstein I. New anti-inflammatory mechanism of glucocorticoids uncovered. Trends Endocrinol Metab. 2025;36(2):99-101. doi: 10.1016/j.tem.2024.08.003Auger JP, Zimmermann M, Faas M, Stifel U, Chambers D, Krishnacoumar B, et al. Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids. Nature. 2024;629(8010):184-192. doi: 10.1038/s41586-024-07282-7Auger JP, Zimmermann M, Faas M, Stifel U, Chambers D, Krishnacoumar B, et al. Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids. Nature. 2024;629(8010):184-192. doi: 10.1038/s41586-024-07282-7Xie Y, Cheng Q, Xu ML, Xue J, Wu H, Du Y. Itaconate: A potential therapeutic strategy for autoimmune disease. Scand J Immunol. 2025;101(5):e70026. doi: 10.1111/sji.70026Xie Y, Cheng Q, Xu ML, Xue J, Wu H, Du Y. Itaconate: A potential therapeutic strategy for autoimmune disease. Scand J Immunol. 2025;101(5):e70026. doi: 10.1111/sji.70026Liu Y, Jiang X, Zhuang S, Zhu L, Zhu B, Rui K, et al. Itaconate: A key regulator of immune responses and potential therapeutic target for autoimmune and inflammatory diseases. Autoimmun Rev. 2025;24(10):103885. doi: 10.1016/j.autrev.2025.103885Liu Y, Jiang X, Zhuang S, Zhu L, Zhu B, Rui K, et al. Itaconate: A key regulator of immune responses and potential therapeutic target for autoimmune and inflammatory diseases. Autoimmun Rev. 2025;24(10):103885. doi: 10.1016/j.autrev.2025.103885

The authors declare that there are no conflicts of interest present.