rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2008-417rsp-555Research ArticleСтатьиArticlesРитуксимаб в лечении нодальной В-клеточной лимфомы маргинальной зоны, болезни Шёгрена и аутоиммунного гепатитаRituximab in the treatment of nodal Bcell marginal zone lymphoma, primary Sjogren’s syndrome and autoimmune hepatitisЛогвиненкоО. А.LogvinenkoO A-VasiljevVIVasiljevVI-KovriginaA MKovriginaA M-KokosadseN. V.KokosadseN. V.-GaidukI. V.GaidukI. V.-MitrikovB. V.MitrikovB. V.-MaevskayaM. V.MaevskayaM. V.-НасоновЕвгений ЛьвовичNasonovE L-200815102008465№5 (2008)6471Copyright © Логвиненко О.А., Vasiljev V., Kovrigina A.M., Kokosadse N.V., Gaiduk I.V., Mitrikov B.V., Maevskaya M.V., Насонов Е.Л., 20082008Логвиненко О.А., Vasiljev V., Kovrigina A.M., Kokosadse N.V., Gaiduk I.V., Mitrikov B.V., Maevskaya M.V., Насонов Е.Л.Logvinenko O.A., Vasiljev V., Kovrigina A.M., Kokosadse N.V., Gaiduk I.V., Mitrikov B.V., Maevskaya M.V., Nasonov E.L.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/555

Представлен случай применения ритуксимаба в терапии нодальной В-клеточной лимфомы маргинальной зоны, болезни Шёгрена и аутоиммунного гепатита.

Rituximab in the treatment of nodal B- cell marginal zone lymphoma, primary Sjogren’s syndrome and autoimmune hepatitis A case of nodal B- cell marginal zone lymphoma, primary Sjogren’s syndrome and autoimmune hepatitis treated with rituximab is presented.

болезнь Шёгреналимфомааутоиммунный гепатитритуксимабprimary Sjogren’ssyndromelymphomaautoimmune hepatitisrituximabReferences<div><p>Поддубная И.В., Москаленко О.А., Балакирева Ю.Н. Неходжкинские лимфомы маргинальной зоны. Соврем, онкол., 2006, 1, online.</p><p>Подымова С.Д. Болезни печени. Рук. для врачей. М., Медицина, 2005, 767.</p><p>Шерлок Ш., Дули Дж. Заболевания печени и жёлчных путей. Практич. рук., пер. с англ, под ред. Апросиной З.Г., Мухина Н.А. М., Гэотар Медицина, 1999, 864.</p><p>Czaja A., Manns М., McFarlane I. et al. Autoimmune hepatitis: the investigational and clinical challenges. Hepatology, 2000, 31, 1194-1200.</p><p>Eggink H., Houthoff H., Huitema S. et al. Cellular and humoral immune reactions in chronic active liver disease. Lymphocyte subsets in liver biopsies of patients with untreated idiopathic autoimmune hepatitis, chronic active hepatitis В and primary biliary cirrhosis. Clin. Exp. Immunol., 1982, 50, 17-24.</p><p>Fargion S., Sangalli G., Ronchi G. et al. Evaluation of T and В lymphocytes in liver infiltrates of patients with chronic active hepatitis. J. Clin. Pathol., 1979, 32, 344-350.</p><p>Ferrari R., Pappas G., Agostinelli D. et al. Type 1 autoimmune hepatitis: patterns of clinical presentation and differential diagnosis of the acute type. Q. J. Med., 2004, 97, 407-412.</p><p>Heneghan М., McFarlane I. Current and novel immunosuppressive therapv for autoimmune hepatitis. Hepatology, 2002, 35, 7-13.</p><p>Johnson P., McFarlane I., Williams R. Azathioprine for long-term maintence of remission in autoimmune hepatitis. N. Engl. J. Med., 1995, 333, 958-963.</p><p>Larsen F., Vainer B., Eefsen M. et al. Low-dose tacrolimus ameliorates liver inflammation and fibrosis in steroid refractory autoimmune hepatitis. World J.Gastroenterol., 2007, 13, 3232-3236.</p><p>Loddenkemper К., Longerich Т., Hummel М. et al. Frequency and diagnostic patterns of lymphomas in liver biopsies with respect to the WHO classification. Virchows Arch., 2007, 450, 493-502.</p><p>Lohr H., Manns М., Kyriatsoulis A. et al. Clonal analysis of liver-infiltrating T cells in patients with LKM-1 antibody-positive autoimmune chronic active hepatitis. Clin. Exp. Immunol., 1991, 84, 297-302.</p><p>Manns М., Vogel A. Autoimmune hepatitis, from mechanisms to therapy. Hepatology, 2006, 43, S132-S144.</p><p>Migita K., Abiru S., Maeda Y., et al. Elevated semm BAFF levels in patients with autoimmune hepatitis. Hum. Immunol., 2007, 68, 586-591.</p><p>Santos E., Arosemena L., Raez L. et al. Successful treatment of autoimmune hepatitis and idiopathic thrombocytopenic purpura with the monoclonal antibody, rituximab: case report and review of literature. Liver Int., 2006, 26, 625-629.</p><p>Skopouli F., Barbatis C., Moutsopoulos H. Liver involvement in primary Sjogren’s syndrome. Rheumatology, 1994, 33, 745- 748.</p><p>Voulgarelis М., Dafni U., IsenbergD. et al. Malignant lymphoma in primary Sjogren’s syndrome. A multicenter, retrospective, clinical study by the European Concerted Action on Sjogren’s syndrome. Art hr. Rheum., 1999, 42, 1765-1772.</p><p>Wada М., Kamimoto H., Park S. et al. Autoimmune hepatitis concomitant with hypergammaglobulinemic purpura, immune thrombocytopenia, and Sjogren’s syndrome. Intern. Med., 2001, 40, 308-311.</p><p>Yamaike N. Saigo K., Imoto S. et al. Autoimmune hepatitis accompanied by idiopathic thwmbocytopenic purpura and Sjogren’s svndrome. Intern. Med., 2002, 41, 72.</p><p>Zachou К., Rigopoulou Dalekos G. Autoantibodies tools in clinical practice and to study pathogenesis of and autoantigens in autoimmune hepatitis: important the disease. J. Autoimmune Dis., 2004, 1, 2-19.</p></div><br /><div><p>Поддубная И.В., Москаленко О.А., Балакирева Ю.Н. Неходжкинские лимфомы маргинальной зоны. Соврем, онкол., 2006, 1, online.</p><p>Подымова С.Д. Болезни печени. Рук. для врачей. М., Медицина, 2005, 767.</p><p>Шерлок Ш., Дули Дж. Заболевания печени и жёлчных путей. Практич. рук., пер. с англ, под ред. Апросиной З.Г., Мухина Н.А. М., Гэотар Медицина, 1999, 864.</p><p>Czaja A., Manns М., McFarlane I. et al. Autoimmune hepatitis: the investigational and clinical challenges. Hepatology, 2000, 31, 1194-1200.</p><p>Eggink H., Houthoff H., Huitema S. et al. Cellular and humoral immune reactions in chronic active liver disease. Lymphocyte subsets in liver biopsies of patients with untreated idiopathic autoimmune hepatitis, chronic active hepatitis В and primary biliary cirrhosis. Clin. Exp. Immunol., 1982, 50, 17-24.</p><p>Fargion S., Sangalli G., Ronchi G. et al. Evaluation of T and В lymphocytes in liver infiltrates of patients with chronic active hepatitis. J. Clin. Pathol., 1979, 32, 344-350.</p><p>Ferrari R., Pappas G., Agostinelli D. et al. Type 1 autoimmune hepatitis: patterns of clinical presentation and differential diagnosis of the acute type. Q. J. Med., 2004, 97, 407-412.</p><p>Heneghan М., McFarlane I. Current and novel immunosuppressive therapv for autoimmune hepatitis. Hepatology, 2002, 35, 7-13.</p><p>Johnson P., McFarlane I., Williams R. Azathioprine for long-term maintence of remission in autoimmune hepatitis. N. Engl. J. Med., 1995, 333, 958-963.</p><p>Larsen F., Vainer B., Eefsen M. et al. Low-dose tacrolimus ameliorates liver inflammation and fibrosis in steroid refractory autoimmune hepatitis. World J.Gastroenterol., 2007, 13, 3232-3236.</p><p>Loddenkemper К., Longerich Т., Hummel М. et al. Frequency and diagnostic patterns of lymphomas in liver biopsies with respect to the WHO classification. Virchows Arch., 2007, 450, 493-502.</p><p>Lohr H., Manns М., Kyriatsoulis A. et al. Clonal analysis of liver-infiltrating T cells in patients with LKM-1 antibody-positive autoimmune chronic active hepatitis. Clin. Exp. Immunol., 1991, 84, 297-302.</p><p>Manns М., Vogel A. Autoimmune hepatitis, from mechanisms to therapy. Hepatology, 2006, 43, S132-S144.</p><p>Migita K., Abiru S., Maeda Y., et al. Elevated semm BAFF levels in patients with autoimmune hepatitis. Hum. Immunol., 2007, 68, 586-591.</p><p>Santos E., Arosemena L., Raez L. et al. Successful treatment of autoimmune hepatitis and idiopathic thrombocytopenic purpura with the monoclonal antibody, rituximab: case report and review of literature. Liver Int., 2006, 26, 625-629.</p><p>Skopouli F., Barbatis C., Moutsopoulos H. Liver involvement in primary Sjogren’s syndrome. Rheumatology, 1994, 33, 745- 748.</p><p>Voulgarelis М., Dafni U., IsenbergD. et al. Malignant lymphoma in primary Sjogren’s syndrome. A multicenter, retrospective, clinical study by the European Concerted Action on Sjogren’s syndrome. Art hr. Rheum., 1999, 42, 1765-1772.</p><p>Wada М., Kamimoto H., Park S. et al. Autoimmune hepatitis concomitant with hypergammaglobulinemic purpura, immune thrombocytopenia, and Sjogren’s syndrome. Intern. Med., 2001, 40, 308-311.</p><p>Yamaike N. Saigo K., Imoto S. et al. Autoimmune hepatitis accompanied by idiopathic thwmbocytopenic purpura and Sjogren’s svndrome. Intern. Med., 2002, 41, 72.</p><p>Zachou К., Rigopoulou Dalekos G. Autoantibodies tools in clinical practice and to study pathogenesis of and autoantigens in autoimmune hepatitis: important the disease. J. Autoimmune Dis., 2004, 1, 2-19.</p></div><br />

The authors declare that there are no conflicts of interest present.