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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rsp</journal-id><journal-title-group><journal-title xml:lang="ru">Научно-практическая ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Rheumatology Science and Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-4484</issn><issn pub-type="epub">1995-4492</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1995-4484-2001-464</article-id><article-id custom-type="elpub" pub-id-type="custom">rsp-602</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>НОВЫЕ ПОДХОДЫ К АНАЛИЗУ ПАТОГЕНЕЗА И ПАТОГЕНЕТИЧЕСКОЙ ТЕРАПИИ РЕВМАТОИДНОГО АРТРИТА</article-title><trans-title-group xml:lang="en"><trans-title>NЕW APPROACHES ТО ANALYSE OF PATHOGENESIS AND PATHOGENETIC THIRAPY OF RHEUMATOID ARTHRITIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сигидин</surname><given-names>Я. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sigidin</surname><given-names>Ya A</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Loukina</surname><given-names>G. V.</given-names></name><name name-style="western" xml:lang="en"><surname>Loukina</surname><given-names>G. V.</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib></contrib-group><pub-date pub-type="collection"><year>2001</year></pub-date><pub-date pub-type="epub"><day>15</day><month>10</month><year>2001</year></pub-date><volume>39</volume><issue>5</issue><issue-title>№5 (2001)</issue-title><fpage>4</fpage><lpage>11</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сигидин Я.А., Loukina G.V., 2001</copyright-statement><copyright-year>2001</copyright-year><copyright-holder xml:lang="ru">Сигидин Я.А., Loukina G.V.</copyright-holder><copyright-holder xml:lang="en">Sigidin Y.A., Loukina G.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://rsp.mediar-press.net/rsp/article/view/602">https://rsp.mediar-press.net/rsp/article/view/602</self-uri></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">&lt;div&gt;&lt;p&gt;Гусев Д.Е. Влияние глюкокортикостероидов на прогрессирование ревматоидного артрита. Автореферат канд. дисс. М., 1997,29.&lt;/p&gt;&lt;p&gt;Гусев Д.Е. Сигидин Я.А. К характеристике влияния кортикостероидов на деструкцию суставов при ревматоидном артрите. Клин, ревматол., 1996. 1, 29-32.&lt;/p&gt;&lt;p&gt;Лукина Г.В., Сигидин Я.А., Скуркович С.В., Скурко- вич Б.С. Новые направления в антицигокиновон терапии ревматоидного артрита (первьш опыт использования антиинтерферонов). Клин, ревматол,. 1997, 3.9-16.&lt;/p&gt;&lt;p&gt;Лукина Г.В., Сигидин Я.А. Скуркович С.В., Скуркович Б.С. Новые подходы к биологической иммуно- модулирующен терапии ревматоидного артрита: нейтрализация основных цитокинов. Тер. архив. 1998, 5, 32-37.&lt;/p&gt;&lt;p&gt;Сигидин Я.А., Лукина Г.В., Гусев Д.Е. О базисных свойствах глюкокортнкостероидов при ревматоидном артрите. Клин, фармакол. и тер., 2000, 1, 55-57.&lt;/p&gt;&lt;p&gt;Сигидин Я.А., Лукина Г.В. Базисная (патогенетическая) терапия ревматоидного артрита, М. 2000, 100.&lt;/p&gt;&lt;p&gt;Beighton R., Solomon L., Valkenburg H.A. Rheumatoid arthritis in a rural Soulh African Negro population. Ann.Rheum.Dis., 1975, 34, 136.&lt;/p&gt;&lt;p&gt;Bresnihan B. Treatment of rheumatoid arthritis with interleukin 1 receptor antagonist. Ann. Rheum. Dis. 1999, 58, suppl. 1, 96-98.&lt;/p&gt;&lt;p&gt;Cutolo М., Straub R.H. Recent aspects of gonadal hormone and neurotransmitter interactions with synovial and immune cells: implications in rheumatoid arthritis. Ann. Rheum. Dis., 2000, 59, 657-661.&lt;/p&gt;&lt;p&gt;Elliott M.J., Maini R.N., Feldmann M. el al. Randomised double blind comparison of a chimaeric monoclonal antibody to tumor necrosis factor alfa (cA2) versus placebo in rheumatoid arthritis. Lancet, 1994, 344, 11051110.&lt;/p&gt;&lt;p&gt;Felder М., Ruegsegger P, Bone loss in patients with rheumatoid arthritis. Rheumatol. Internal., 1991, 11, 41-44.&lt;/p&gt;&lt;p&gt;Ferrara N. Molecular aand biological properties of vascular endothelial growth factor. J, Molec. Med., 1999, 77, 527-543.&lt;/p&gt;&lt;p&gt;Garrison L., McDonnell N.D. Etanercept: therapeutic use in patients with rheumatoid arthritis. Ann. Rheum. Dis., 1999, 5S, suppl. 1, 165-169.&lt;/p&gt;&lt;p&gt;Gough A., Lilley J., Eyre S. et al. Generalised bone loss in patients with early rheumatoid arthritis occurs early and relates to disease activity. Lancet, 1994, 344, 23-27.&lt;/p&gt;&lt;p&gt;Harriman G., Harper L.K. Schaible T.F. Summary of clinical trials in rheumatoid arthritis using infliximab, an anti-TNF alfa treatment. Ann. Rheum. Dis., 1999, 58, suppl. 1, 61-64.&lt;/p&gt;&lt;p&gt;Kirwan J.B. and ARC Low Dose Corticosteroid Group. Radiological progression in rheumatoid arthritis during a randomised controlled trial of prednisolone. Rheumatol. in Europe, 1995, 24, suppl. 3, 223.&lt;/p&gt;&lt;p&gt;Koch A.E. The role of angiogenesis in rheumatoid arthritis: recent developments. Ann. Rheum. Dis., 2000, 59, suppl. 1, 65-71.&lt;/p&gt;&lt;p&gt;Leboff M.S., Wade J., Mackowiak S. et al. Low doses prednisone does not affect calcium homeostasis or bone density in postmenopausal women with rheumatoid arthritis. J. Rheumatol., 1991. 18, 339-344.&lt;/p&gt;&lt;p&gt;Lipsky P.E. Rheumatoid arthritis: new approaches for the new century. Ann. Rheum. Dis., 2000,59, suppl. 1, 5.&lt;/p&gt;&lt;p&gt;Maini R.N., Breedveld F.C., Kalden J.R. et al. Therapeutic efficacy of multiple intravenous infusions of antitumor necrosis factor alfa monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis. Arthr. Rheum., 1998, 41, 1552-1563.&lt;/p&gt;&lt;p&gt;Moscow J.A., Cowan K.H. Multidrug resistance. J.Natl. Cancer Inst., 1988,80, 14-20.&lt;/p&gt;&lt;p&gt;Nepom G.T. HLA-DR4 and rheumatoid arthritis. In: Wolfe F., Pincus T. teds). Rheumatoid arthritis. Marcel Dekker, Inc; NY-Basel-Hong Kong, 1994, 115-129.&lt;/p&gt;&lt;p&gt;Paulus H.E. Machleder H.J., Peter J.B. Clinical improvement of rheumatoid arthritis during prolonged thoracic duct lymphocyte drainage. Arthr. Rheum., 1973, 16, 562.&lt;/p&gt;&lt;p&gt;Pearson C.M. Transfer of adjuvant arthritis by means of lymph node or spleen cells. J. Belg. Rheumatol. Med. Phys. 1969.24, 150.&lt;/p&gt;&lt;p&gt;Sekine Т., Masuko-Hongo K., Matsui T. et al. Recognition of YKL-39, a human cartilage related protein, as a target antigen in patients with rheumatoid arthritis. Ann, Rheum. Dis., 2001, 60, 49-54.&lt;/p&gt;&lt;p&gt;Solomon L., Robin C., Valkenburg H.A. Rheumatoid arthritis in an urban South African Negro population, Ann. Rheum. Dis., 1975, 34, 128.&lt;/p&gt;&lt;p&gt;Verstraeten A„ Dequecker J. Vertebral and peripheral bone mineral content and fracture incidence in postmenopausal patients with rheumatoid arthritis. Ann. Rheum. Dis., 1986, 45, 852-S57.&lt;/p&gt;&lt;p&gt;Wegelius O., Laire W., Lindstrom B„ Klockars M. Fistula of thoracic duct as immunosuppressive treatment in rheumatoid arthritis. Acta Med, Scand., 1970, 187, 539.&lt;/p&gt;&lt;p&gt;Whitehouse M.W., Whitehouse D.J., Pearson C.M. Passive transfer of adjuvant-induced arthritis and allergic encephalomyelitis in rats using thoracic duct lymphocytes. Nature, 1969, 224, 1322.&lt;/p&gt;&lt;p&gt;Yarbo J,W. The scientific basis of cancer chemotherapy. In: Perry M.C. (ed.) The chemotherapy source book, 2nd ed, Williams &amp;amp; Wilkins. Baltimore, 1996, 3-18.&lt;/p&gt;&lt;/div&gt;&lt;br /&gt;</mixed-citation><mixed-citation xml:lang="en">&lt;div&gt;&lt;p&gt;Гусев Д.Е. Влияние глюкокортикостероидов на прогрессирование ревматоидного артрита. Автореферат канд. дисс. М., 1997,29.&lt;/p&gt;&lt;p&gt;Гусев Д.Е. Сигидин Я.А. К характеристике влияния кортикостероидов на деструкцию суставов при ревматоидном артрите. Клин, ревматол., 1996. 1, 29-32.&lt;/p&gt;&lt;p&gt;Лукина Г.В., Сигидин Я.А., Скуркович С.В., Скурко- вич Б.С. Новые направления в антицигокиновон терапии ревматоидного артрита (первьш опыт использования антиинтерферонов). Клин, ревматол,. 1997, 3.9-16.&lt;/p&gt;&lt;p&gt;Лукина Г.В., Сигидин Я.А. Скуркович С.В., Скуркович Б.С. Новые подходы к биологической иммуно- модулирующен терапии ревматоидного артрита: нейтрализация основных цитокинов. Тер. архив. 1998, 5, 32-37.&lt;/p&gt;&lt;p&gt;Сигидин Я.А., Лукина Г.В., Гусев Д.Е. О базисных свойствах глюкокортнкостероидов при ревматоидном артрите. Клин, фармакол. и тер., 2000, 1, 55-57.&lt;/p&gt;&lt;p&gt;Сигидин Я.А., Лукина Г.В. Базисная (патогенетическая) терапия ревматоидного артрита, М. 2000, 100.&lt;/p&gt;&lt;p&gt;Beighton R., Solomon L., Valkenburg H.A. Rheumatoid arthritis in a rural Soulh African Negro population. Ann.Rheum.Dis., 1975, 34, 136.&lt;/p&gt;&lt;p&gt;Bresnihan B. Treatment of rheumatoid arthritis with interleukin 1 receptor antagonist. Ann. Rheum. Dis. 1999, 58, suppl. 1, 96-98.&lt;/p&gt;&lt;p&gt;Cutolo М., Straub R.H. Recent aspects of gonadal hormone and neurotransmitter interactions with synovial and immune cells: implications in rheumatoid arthritis. Ann. Rheum. Dis., 2000, 59, 657-661.&lt;/p&gt;&lt;p&gt;Elliott M.J., Maini R.N., Feldmann M. el al. Randomised double blind comparison of a chimaeric monoclonal antibody to tumor necrosis factor alfa (cA2) versus placebo in rheumatoid arthritis. Lancet, 1994, 344, 11051110.&lt;/p&gt;&lt;p&gt;Felder М., Ruegsegger P, Bone loss in patients with rheumatoid arthritis. Rheumatol. Internal., 1991, 11, 41-44.&lt;/p&gt;&lt;p&gt;Ferrara N. Molecular aand biological properties of vascular endothelial growth factor. J, Molec. Med., 1999, 77, 527-543.&lt;/p&gt;&lt;p&gt;Garrison L., McDonnell N.D. Etanercept: therapeutic use in patients with rheumatoid arthritis. Ann. Rheum. Dis., 1999, 5S, suppl. 1, 165-169.&lt;/p&gt;&lt;p&gt;Gough A., Lilley J., Eyre S. et al. Generalised bone loss in patients with early rheumatoid arthritis occurs early and relates to disease activity. Lancet, 1994, 344, 23-27.&lt;/p&gt;&lt;p&gt;Harriman G., Harper L.K. Schaible T.F. Summary of clinical trials in rheumatoid arthritis using infliximab, an anti-TNF alfa treatment. Ann. Rheum. Dis., 1999, 58, suppl. 1, 61-64.&lt;/p&gt;&lt;p&gt;Kirwan J.B. and ARC Low Dose Corticosteroid Group. Radiological progression in rheumatoid arthritis during a randomised controlled trial of prednisolone. Rheumatol. in Europe, 1995, 24, suppl. 3, 223.&lt;/p&gt;&lt;p&gt;Koch A.E. The role of angiogenesis in rheumatoid arthritis: recent developments. Ann. Rheum. Dis., 2000, 59, suppl. 1, 65-71.&lt;/p&gt;&lt;p&gt;Leboff M.S., Wade J., Mackowiak S. et al. Low doses prednisone does not affect calcium homeostasis or bone density in postmenopausal women with rheumatoid arthritis. J. Rheumatol., 1991. 18, 339-344.&lt;/p&gt;&lt;p&gt;Lipsky P.E. Rheumatoid arthritis: new approaches for the new century. Ann. Rheum. Dis., 2000,59, suppl. 1, 5.&lt;/p&gt;&lt;p&gt;Maini R.N., Breedveld F.C., Kalden J.R. et al. Therapeutic efficacy of multiple intravenous infusions of antitumor necrosis factor alfa monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis. Arthr. Rheum., 1998, 41, 1552-1563.&lt;/p&gt;&lt;p&gt;Moscow J.A., Cowan K.H. Multidrug resistance. J.Natl. Cancer Inst., 1988,80, 14-20.&lt;/p&gt;&lt;p&gt;Nepom G.T. HLA-DR4 and rheumatoid arthritis. In: Wolfe F., Pincus T. teds). Rheumatoid arthritis. Marcel Dekker, Inc; NY-Basel-Hong Kong, 1994, 115-129.&lt;/p&gt;&lt;p&gt;Paulus H.E. Machleder H.J., Peter J.B. Clinical improvement of rheumatoid arthritis during prolonged thoracic duct lymphocyte drainage. Arthr. Rheum., 1973, 16, 562.&lt;/p&gt;&lt;p&gt;Pearson C.M. Transfer of adjuvant arthritis by means of lymph node or spleen cells. J. Belg. Rheumatol. Med. Phys. 1969.24, 150.&lt;/p&gt;&lt;p&gt;Sekine Т., Masuko-Hongo K., Matsui T. et al. Recognition of YKL-39, a human cartilage related protein, as a target antigen in patients with rheumatoid arthritis. Ann, Rheum. Dis., 2001, 60, 49-54.&lt;/p&gt;&lt;p&gt;Solomon L., Robin C., Valkenburg H.A. Rheumatoid arthritis in an urban South African Negro population, Ann. Rheum. Dis., 1975, 34, 128.&lt;/p&gt;&lt;p&gt;Verstraeten A„ Dequecker J. Vertebral and peripheral bone mineral content and fracture incidence in postmenopausal patients with rheumatoid arthritis. Ann. Rheum. Dis., 1986, 45, 852-S57.&lt;/p&gt;&lt;p&gt;Wegelius O., Laire W., Lindstrom B„ Klockars M. Fistula of thoracic duct as immunosuppressive treatment in rheumatoid arthritis. Acta Med, Scand., 1970, 187, 539.&lt;/p&gt;&lt;p&gt;Whitehouse M.W., Whitehouse D.J., Pearson C.M. Passive transfer of adjuvant-induced arthritis and allergic encephalomyelitis in rats using thoracic duct lymphocytes. Nature, 1969, 224, 1322.&lt;/p&gt;&lt;p&gt;Yarbo J,W. The scientific basis of cancer chemotherapy. In: Perry M.C. (ed.) The chemotherapy source book, 2nd ed, Williams &amp;amp; Wilkins. Baltimore, 1996, 3-18.&lt;/p&gt;&lt;/div&gt;&lt;br /&gt;</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
