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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rsp</journal-id><journal-title-group><journal-title xml:lang="ru">Научно-практическая ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Rheumatology Science and Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-4484</issn><issn pub-type="epub">1995-4492</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1995-4484-2012-510</article-id><article-id custom-type="elpub" pub-id-type="custom">rsp-648</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Новые подходы к определению органных поражений при AL-амилоидозе</article-title><trans-title-group xml:lang="en"><trans-title>Novye podkhody k opredeleniyu organnykh porazheniy pri AL-amiloidoze</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васильев</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasilyev</surname><given-names>Vladimir Ivanovich</given-names></name></name-alternatives><email xlink:type="simple">oksanalogw@hotmail.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Gorodetskiy</surname><given-names>V R</given-names></name><name name-style="western" xml:lang="en"><surname>Gorodetskiy</surname><given-names>V R</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Radenska-Lopovok1</surname><given-names>S G</given-names></name><name name-style="western" xml:lang="en"><surname>Radenska-Lopovok</surname><given-names>S G</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пробатова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Probatova</surname><given-names>N A</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Павловская</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Pavlovskaya</surname><given-names>A I</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Варламова</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Varlamova</surname><given-names>E Yu</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Седышев</surname><given-names>С. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Sedyshev</surname><given-names>S Kh</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Логвиненко</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Logvinenko</surname><given-names>O A</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Rodionova</surname><given-names>E B</given-names></name><name name-style="western" xml:lang="en"><surname>Rodionova</surname><given-names>E B</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Korsakova</surname><given-names>Yu O</given-names></name><name name-style="western" xml:lang="en"><surname>Korsakova</surname><given-names>Yu O</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Gayduk</surname><given-names>I V</given-names></name><name name-style="western" xml:lang="en"><surname>Gayduk</surname><given-names>I V</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Насонов</surname><given-names>Евгений Львович</given-names></name><name name-style="western" xml:lang="en"><surname>Nasonov</surname><given-names>E L</given-names></name></name-alternatives></contrib></contrib-group><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>15</day><month>02</month><year>2012</year></pub-date><volume>50</volume><issue>1</issue><issue-title>№1 (2012)</issue-title><fpage>83</fpage><lpage>90</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Васильев В.И., Gorodetskiy V.R., Radenska-Lopovok1 S.G., Пробатова Н.А., Павловская А.И., Варламова Е.Ю., Седышев С.Х., Логвиненко О.А., Rodionova E.B., Korsakova Y.O., Gayduk I.V., Насонов Е.Л., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Васильев В.И., Gorodetskiy V.R., Radenska-Lopovok1 S.G., Пробатова Н.А., Павловская А.И., Варламова Е.Ю., Седышев С.Х., Логвиненко О.А., Rodionova E.B., Korsakova Y.O., Gayduk I.V., Насонов Е.Л.</copyright-holder><copyright-holder xml:lang="en">Vasilyev V.I., Gorodetskiy V.R., Radenska-Lopovok S.G., Probatova N.A., Pavlovskaya A.I., Varlamova E.Y., Sedyshev S.K., Logvinenko O.A., Rodionova E.B., Korsakova Y.O., Gayduk I.V., Nasonov E.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://rsp.mediar-press.net/rsp/article/view/648">https://rsp.mediar-press.net/rsp/article/view/648</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">&lt;div&gt;&lt;p&gt;Belly M., Makovitzky J. Sensetivity and specifity of Congo red staining according to Romhanyi comparison with Puchtler's or Bennhved's methods. Acta Histochem 2006;108:175-80.&lt;/p&gt;&lt;p&gt;Rajkumar S.V., Dispenziery A., Kyle R.A. Monoclonal gfmmapathy of undertermined significance, Waldestrеm macroglobulinemia, AL amyloidosis, and related plasma cell disorders: diagnosis and treatment. Mayo Clin Proc 2006;81:693-703.&lt;/p&gt;&lt;p&gt;Merlini G., Bellotti V. Molecular mechanisms of аmyloidosis. N Engl J Med 2003;349:583-96.&lt;/p&gt;&lt;p&gt;Abraham R.S., Ballman K.V., Dispenzieri A. et al. Functional gene expression analysis of clonal plasma cells identifies a unique molecular profile for light chain amyloidosis. Blood 2005;105:794-803.&lt;/p&gt;&lt;p&gt;Gertz M.A., Kyle R.A. Amyloidosis. In: Wiernik P.H., Canellos G.P., Dutcher J.P., Kyle R.A., eds. Neoplastic diseases of the blood. 3rd ed. New York: Churchill Livingstone, 1996;635-77.&lt;/p&gt;&lt;p&gt;Thornton C. Amyloid disease: An autopsy review of the decades 1937-46 and 1961-70. Ulster Med J 1983;52:31-9.&lt;/p&gt;&lt;p&gt;Gertz M.A., Comenzo R., Falk R.H. et al. Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): a consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis. Amer J Hemat 2005;79:319-28.&lt;/p&gt;&lt;p&gt;Gertz M.A., Hayman S.R. Immunoglobulin light chain amyloidosis. In: Treatment of multiple myeloma and related disorders. Eds Rajkumar S.V., Kyle R.A. Cambridge: Cambridge University Press, 2009;112-8.&lt;/p&gt;&lt;p&gt;Cohen A.D., Comenzo R.L. Systemic light chain amyloidosis: advanced in diagnosis, prognosis and therapy. Am Soc Hematol Educ Program 2010;287-94.&lt;/p&gt;&lt;p&gt;Dispenzieri A., Merlini G., Cjmenzo R.L. Amyloidosis: 2008 BMT tandem meetings (February 13-17,San-Diego). Biol Blood Marrow Transpl 2008;14:6-11.&lt;/p&gt;&lt;p&gt;Kyle R.A., Gertz M.A. Primary systemic amyloidosis: clinical and laboratory features in 474 cases. Semin Hematol 1995;32:45-59.&lt;/p&gt;&lt;p&gt;Смирнова А.Г., Смирнов А.В., Цандер А., Афанасьев Б.В. Аутологичная трансплантация гемопоэтических клеток периферической крови при лечении AL-амилоидоза. Тер арх 2010;10:61-4.&lt;/p&gt;&lt;p&gt;Васильев В.И., Седышев С.Х., Городецкий В.Р. и др. Сухой синдром как проявление AL-амилоидоза. Науч-практич ревматол 2011;5:92-7.&lt;/p&gt;&lt;p&gt;Рыжко В.В., Клодзинский А.А., Варламова Е.Ю. и др. Сложности диагностики и лечения AL-амилоидоза: обзор литературы и собственные наблюдения. Клин онкогематол 2009;1:47-55.&lt;/p&gt;&lt;p&gt;Prokaewa T., Spencer B., Kaut M. et al. Soft tissue, joint and bone manifestation of AL amyloidosis. Arthr Rheum 2007;56:3858-68.&lt;/p&gt;&lt;p&gt;Васильев В.И., Городецкий В.Р., Логвиненко О.А. и др. Дифференциальная диагностика плазматических дискразий в ревматологической практике. Совр ревматол 2010;4:16-24.&lt;/p&gt;&lt;p&gt;Васильев В.И., Городецкий В.Р., Седышев С.Х. и др. Клинические проявления васкулита в дебюте множественной миеломы. Науч-практич ревматол 2010;1:81-7.&lt;/p&gt;&lt;p&gt;Андреева Н.Е., Балакирева Т.В. Парапротеинемические гемобластозы (множественная миелома, лимфоплазмоцитарный лейкоз, болезни тяжелых цепей). В кн.: Руководство по гематологии. В 3-х т. Под ред. А.И. Воробьева. М.: Ньюдиамед, 2003;2:151-80.&lt;/p&gt;&lt;p&gt;Вотякова О.М., Демина Е.А. Множественная миелома. Рук-во для врачей. В кн.: Клиническая онкогематология. Под ред.&lt;/p&gt;&lt;p&gt;М.А. Волковой. М.: Медицина, 2001;423-30.&lt;/p&gt;&lt;p&gt;Андреева Н.Е., Балакирева Т.В. Макроглобулинемия Вальденстрема. Болезнь тяжелых цепей. В кн.: Клиническая онкогематология: Рук-во для врачей. Под ред. М. Волковой. М.: Медицина 2001;420-69.&lt;/p&gt;&lt;p&gt;Козловская Л.В., Рамеев В.В. Амилоидоз. Нефрология. Национальное руководство. Подред. Н.А. Мухина. М.: ГЭОТАР-Медиа, 2009;272-87.&lt;/p&gt;&lt;p&gt;Rajkumar S.V., Gertz M.A., Kyle R.A. Primary systemic amyloidosis with delayed progression to multiple myeloma. Cancer 1998;82:1501-5.&lt;/p&gt;&lt;p&gt;Siragusa S., Morice W., Gertz M.A. et al. Asymptomatic immunoglobulin light amyloidosis (AL) at the time diagnostic bone marrow biopsy in newly diagnosed patients with multiple myeloma and smoldering myeloma. A series of 144 cases and review of the literature. Ann Hematol 2010;90:101-6.&lt;/p&gt;&lt;p&gt;Hayman S.R., Bailey R.J., Jalal S.M. et al. Translocation involving the immunoglobulin heavy-chain locus are possible early genetic events in patients with primary systemic amyloidosis. Blood 2001;98:2266-8.&lt;/p&gt;&lt;p&gt;Perfetti V., Casarini S., Palladini G. et al. Analisis of VX-JX expression in plasma cells from primary (AL) amyloidosis and normal bone marrow identifies 3r(XIII) as a new amyloid-associated germline gene segment. Blood 2002;100:948-53.&lt;/p&gt;&lt;p&gt;Comenzo R.I., Zhang Y., Martinez C. et al. The tropism of organ involvement in primary systemic amyloidosis: contributions of Ig Vl germ line gene use and clonal plasma cell burden. Blood 2001;98:714-20.&lt;/p&gt;&lt;/div&gt;&lt;br /&gt;</mixed-citation><mixed-citation xml:lang="en">&lt;div&gt;&lt;p&gt;Belly M., Makovitzky J. Sensetivity and specifity of Congo red staining according to Romhanyi comparison with Puchtler's or Bennhved's methods. Acta Histochem 2006;108:175-80.&lt;/p&gt;&lt;p&gt;Rajkumar S.V., Dispenziery A., Kyle R.A. Monoclonal gfmmapathy of undertermined significance, Waldestrеm macroglobulinemia, AL amyloidosis, and related plasma cell disorders: diagnosis and treatment. Mayo Clin Proc 2006;81:693-703.&lt;/p&gt;&lt;p&gt;Merlini G., Bellotti V. Molecular mechanisms of аmyloidosis. N Engl J Med 2003;349:583-96.&lt;/p&gt;&lt;p&gt;Abraham R.S., Ballman K.V., Dispenzieri A. et al. Functional gene expression analysis of clonal plasma cells identifies a unique molecular profile for light chain amyloidosis. Blood 2005;105:794-803.&lt;/p&gt;&lt;p&gt;Gertz M.A., Kyle R.A. Amyloidosis. In: Wiernik P.H., Canellos G.P., Dutcher J.P., Kyle R.A., eds. Neoplastic diseases of the blood. 3rd ed. New York: Churchill Livingstone, 1996;635-77.&lt;/p&gt;&lt;p&gt;Thornton C. Amyloid disease: An autopsy review of the decades 1937-46 and 1961-70. Ulster Med J 1983;52:31-9.&lt;/p&gt;&lt;p&gt;Gertz M.A., Comenzo R., Falk R.H. et al. Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): a consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis. Amer J Hemat 2005;79:319-28.&lt;/p&gt;&lt;p&gt;Gertz M.A., Hayman S.R. Immunoglobulin light chain amyloidosis. In: Treatment of multiple myeloma and related disorders. Eds Rajkumar S.V., Kyle R.A. Cambridge: Cambridge University Press, 2009;112-8.&lt;/p&gt;&lt;p&gt;Cohen A.D., Comenzo R.L. Systemic light chain amyloidosis: advanced in diagnosis, prognosis and therapy. Am Soc Hematol Educ Program 2010;287-94.&lt;/p&gt;&lt;p&gt;Dispenzieri A., Merlini G., Cjmenzo R.L. Amyloidosis: 2008 BMT tandem meetings (February 13-17,San-Diego). Biol Blood Marrow Transpl 2008;14:6-11.&lt;/p&gt;&lt;p&gt;Kyle R.A., Gertz M.A. Primary systemic amyloidosis: clinical and laboratory features in 474 cases. Semin Hematol 1995;32:45-59.&lt;/p&gt;&lt;p&gt;Смирнова А.Г., Смирнов А.В., Цандер А., Афанасьев Б.В. Аутологичная трансплантация гемопоэтических клеток периферической крови при лечении AL-амилоидоза. Тер арх 2010;10:61-4.&lt;/p&gt;&lt;p&gt;Васильев В.И., Седышев С.Х., Городецкий В.Р. и др. Сухой синдром как проявление AL-амилоидоза. Науч-практич ревматол 2011;5:92-7.&lt;/p&gt;&lt;p&gt;Рыжко В.В., Клодзинский А.А., Варламова Е.Ю. и др. Сложности диагностики и лечения AL-амилоидоза: обзор литературы и собственные наблюдения. Клин онкогематол 2009;1:47-55.&lt;/p&gt;&lt;p&gt;Prokaewa T., Spencer B., Kaut M. et al. Soft tissue, joint and bone manifestation of AL amyloidosis. Arthr Rheum 2007;56:3858-68.&lt;/p&gt;&lt;p&gt;Васильев В.И., Городецкий В.Р., Логвиненко О.А. и др. Дифференциальная диагностика плазматических дискразий в ревматологической практике. Совр ревматол 2010;4:16-24.&lt;/p&gt;&lt;p&gt;Васильев В.И., Городецкий В.Р., Седышев С.Х. и др. Клинические проявления васкулита в дебюте множественной миеломы. Науч-практич ревматол 2010;1:81-7.&lt;/p&gt;&lt;p&gt;Андреева Н.Е., Балакирева Т.В. Парапротеинемические гемобластозы (множественная миелома, лимфоплазмоцитарный лейкоз, болезни тяжелых цепей). В кн.: Руководство по гематологии. В 3-х т. Под ред. А.И. Воробьева. М.: Ньюдиамед, 2003;2:151-80.&lt;/p&gt;&lt;p&gt;Вотякова О.М., Демина Е.А. Множественная миелома. Рук-во для врачей. В кн.: Клиническая онкогематология. Под ред.&lt;/p&gt;&lt;p&gt;М.А. Волковой. М.: Медицина, 2001;423-30.&lt;/p&gt;&lt;p&gt;Андреева Н.Е., Балакирева Т.В. Макроглобулинемия Вальденстрема. Болезнь тяжелых цепей. В кн.: Клиническая онкогематология: Рук-во для врачей. Под ред. М. Волковой. М.: Медицина 2001;420-69.&lt;/p&gt;&lt;p&gt;Козловская Л.В., Рамеев В.В. Амилоидоз. Нефрология. Национальное руководство. Подред. Н.А. Мухина. М.: ГЭОТАР-Медиа, 2009;272-87.&lt;/p&gt;&lt;p&gt;Rajkumar S.V., Gertz M.A., Kyle R.A. Primary systemic amyloidosis with delayed progression to multiple myeloma. Cancer 1998;82:1501-5.&lt;/p&gt;&lt;p&gt;Siragusa S., Morice W., Gertz M.A. et al. Asymptomatic immunoglobulin light amyloidosis (AL) at the time diagnostic bone marrow biopsy in newly diagnosed patients with multiple myeloma and smoldering myeloma. A series of 144 cases and review of the literature. Ann Hematol 2010;90:101-6.&lt;/p&gt;&lt;p&gt;Hayman S.R., Bailey R.J., Jalal S.M. et al. Translocation involving the immunoglobulin heavy-chain locus are possible early genetic events in patients with primary systemic amyloidosis. Blood 2001;98:2266-8.&lt;/p&gt;&lt;p&gt;Perfetti V., Casarini S., Palladini G. et al. Analisis of VX-JX expression in plasma cells from primary (AL) amyloidosis and normal bone marrow identifies 3r(XIII) as a new amyloid-associated germline gene segment. Blood 2002;100:948-53.&lt;/p&gt;&lt;p&gt;Comenzo R.I., Zhang Y., Martinez C. et al. The tropism of organ involvement in primary systemic amyloidosis: contributions of Ig Vl germ line gene use and clonal plasma cell burden. Blood 2001;98:714-20.&lt;/p&gt;&lt;/div&gt;&lt;br /&gt;</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
