rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2005-550rsp-688Research ArticleСтатьиArticlesИзучение взаимосвязи между минеральной плотностью костной ткани и клинико-лабораторными показателями активности ревматоидного артритаStudy of correlation between bone mineral density and clinical and laboratory indices of rheumatoid arthritis activityGukasyanD. A.GukasyanD. A.-БалабановаРимма МихайловнаBalabanovaR M-СмирновА. В.SmirnovA V-NassonovE. L.NassonovE. L.-200515022005431№1 (2005)1821Copyright © Gukasyan D.A., Балабанова Р.М., Смирнов А.В., Nassonov E.L., 20052005Gukasyan D.A., Балабанова Р.М., Смирнов А.В., Nassonov E.L.Gukasyan D.A., Balabanova R.M., Smirnov A.V., Nassonov E.L.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/688

Цель. Изучить взаимосвязь между минеральной плотностью костной ткани (МПКТ) и клинико-лабораторными показателями активности ревматоидного артрита (РА). Материал и методы. Обследовано 60 больных РА жен., не получавших ранее глюкокортикоид- ную и антиостеопоротическую терапию, 30 с сохраненным менструальным циклом и 30 - в постменопаузе. Для изучения МПКТ поясничного отдела позвоночника и проксимального отдела бедренной кости был использован метод двойной рентгеновской абсорбциометри аппаратом QDR 1000 (Hologic). Для характеристики активности и тяжести РА были использованы индексы W.Wilke. Уровень СРБ (мг/л) в сыворотке крови определялся количественным иммуно- ферментным методом. Результаты. Установлена достоверная отрицательная взаимосвязь между МПКТ исследуемых отделов скелета и индексом тяжести РА, а также между МПКТ шейки бедра и концентрацией СРБ в группе больных женщин с сохраненным менструальным циклом и в постменопаузе.

Objective. To study association between bone mineral density (BMD) and clinical and laboratory indices of rheumatoid arthritis (RA) activity Material and methods. 60 women with RA who had not received glucocorticoid and anti-osteoporotic therapy were included. 30 had unchanged menstrual cycle and 30 were postmenopausal. Lumbar spine BMD and proximal femur was studied with double radiological absorptiometry (QDR 1000 Hologic apparatus). W.Wilke indices were used to characterize activity and severity of RA. CRP level was evaluated with quantitative immunoenzyme method. Results. Significant negative association was revealed between spine and femoral neck BMD and RA severity so as between femoral neck BMD and CRP level in pts with unchanged menstrual cycle and in postmenopausal pts.

ревматоидный артритминеральная плотность костной тканиостеопорозиндекс тяжестиС - реактивный белокrheumatoid arthritisbone mineral densityosteoporosisactivityseverityseverity indexC- reactive proteinReferences<div><p>Беневоленская Л.И. Руководство по остеопорозу, М.,Бином 2003, 523 ст.</p><p>Насонов Е.Л., Скрипникова И.А., Насонова В.А. П роблема остеопороза в ревматологии. М., "Стин", 1997.</p><p>Насонов Е.Л., Скрипникова И.А., Насонова В.А. Остеопороз:ревматологические перспективы. Тер. архив,1997, 5, 5-9.</p><p>Star V.L., Hochberg М.С. Osteoporosis in patients with rheumatic diseases. Rheum. Dis. North. Amer., 1994, 20, 561-576.</p><p>Haugeberg G, Lodder М. C, Lems W. F. T. et. al. Hand cortical bone mass and its association with radiographic joint damage and fractures in 50-70 year old- femal patiens with rheumatoid arthritis: cross sectional Oslo - Truro - Amsterdam (OSTRA) collaboratorial study. Ann. Rheum.Dis., 2004, 63, 1331-1334</p><p>Насонов ЕЛ., Скрипникова И.А., Беневоленская Л.И., Насонова В.А. Патогенез остеопороза: анализ иммунологических механизмов. Клин, ревматол. 1996, 3, 2-9.</p><p>Cortet В., Flipo R-M., Pigny P., et al. Is bone turnover a determinant of bone mass in rheumatoid arthritis? J. Rheumatol., 1998, 25, 2339-2344.</p><p>Rifas L. Bone and cytokines: beyond IL-1, IL-6 and TNF-a. Calcif. Tiss, Res., 1998, 64,1-7.</p><p>Насонов E. Л. Остеопороз при ревматических заболеваниях. Рук. по остеопорзу. Ред. Беневоленская Л.И. М., 2003, 346-363.</p><p>Towheed Т.Е., Brouillard D., Yendt E., Anastassiades T. Osteoporosis in rheumatoid arthritis: findings in the metacarpal, spine, and hip and a study of the determinations of both localized and generalized osteopenia. J. Rheumatol., 1995, 22, 440-443.</p><p>Kroger Н., Honkanan R„ Saarikoski S., Alhava E. Decreased axial bone mineral density in perimenopausal women with rheumatoid arthritis. A population based study. Ann. Rheum. Dis.,1994,53,18-23.</p><p>Lems W.F., Dijkmans B.A. Should we look for osteoporosis in patients with rheumatoid arthritis ? Ann. Rheum. Dis.,1998, 57, 325-337.</p><p>Laan R.F., Buijs J.M. et al. Bone mineral density in patients with recent onset rheumatoid arthritis: influence of disease activity and functional capacity. Ann. Rheum. Dis., 1993,52, 21-26.</p><p>Lems W.F, Jahangier Z.N, Gacobs J.W.G J. et al. Vertebral fractures in patients with rheumatoid arthritis with corticosteroids. Clin. Exper. Rheumat., 1995,13, 293297.</p><p>Arend W.P., Dayer J.M. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis. Arthr. Rheum. 1995, 38, 151-160.</p><p>Suzuki Y., Tanihara М., Ichikawa Y. et al. Periarticular osteopenia in adjuvant induced arthritis: role of interleukin-1 in decreased osteogenic and increased resorbtive potential of bone marrow cells. Ann. Rheum. Dis., 1995, 54, 484-490.</p><p>Combe B., Eliaou J-F., Daurs J-P. et al. Prognostic factors in rheumatoid arthritis. Comparative study of two subsets of patients according to severety of articular damage. Br. J. Rheumatol., 1995, 34, 529-534.</p><p>Насонов Е.Л., Чичасова H.B., Баранов и соавт. Клиническое значение С -реактивного белка при ревматоидном артрите. Клин, мед., 1997,7, 26-31.</p><p>Ottemess l.G. The value of C-reactive protein measurement in rheumatoid arthritis. Semin. Arthr. Rheum., 1994, 24, 91-104.</p><p>Eggelmcijer F., Papapoulos S.E., Westedt M.L. et al. Bone metabolism in rheumatoid arthritis; relationship to disease activity. Br. J. Rheumatol., 1993, 32, 387-391.</p><p>Gough A.K.S., Peel N.F.A., Easteell R. et al. Excretion of pyridinium cross - links correlates with disease activity and appendicular bone loss in early rheumatoid arthritis. Ann. Rheum. Dis., 1994, 53. 14-17.</p><p>Sambrook P.N., Jones G. Corticosteroid osteoporosis. Br. J. Rheumatol., 1995, 34, 8-12.</p><p>Wilke W.S., Sweeney T.J., Calabrese L.H. Models of combination therapy with disease-modifying antirheumatic drugs. Early, aggressive therapy for rheumatoid artritis: concerns, descriptions, and estimate of outcome. Semin. Arthr. Rheum., 1993, 23, 26-41.</p><p>Frieis J.S., Spitz P.U., Kraines R.S. et al. Measurement of patient outcome in arthritis. Arthr. Rheum., 1980, 23,137145.</p></div><br /><div><p>Беневоленская Л.И. Руководство по остеопорозу, М.,Бином 2003, 523 ст.</p><p>Насонов Е.Л., Скрипникова И.А., Насонова В.А. П роблема остеопороза в ревматологии. М., "Стин", 1997.</p><p>Насонов Е.Л., Скрипникова И.А., Насонова В.А. Остеопороз:ревматологические перспективы. Тер. архив,1997, 5, 5-9.</p><p>Star V.L., Hochberg М.С. Osteoporosis in patients with rheumatic diseases. Rheum. Dis. North. Amer., 1994, 20, 561-576.</p><p>Haugeberg G, Lodder М. C, Lems W. F. T. et. al. Hand cortical bone mass and its association with radiographic joint damage and fractures in 50-70 year old- femal patiens with rheumatoid arthritis: cross sectional Oslo - Truro - Amsterdam (OSTRA) collaboratorial study. Ann. Rheum.Dis., 2004, 63, 1331-1334</p><p>Насонов ЕЛ., Скрипникова И.А., Беневоленская Л.И., Насонова В.А. Патогенез остеопороза: анализ иммунологических механизмов. Клин, ревматол. 1996, 3, 2-9.</p><p>Cortet В., Flipo R-M., Pigny P., et al. Is bone turnover a determinant of bone mass in rheumatoid arthritis? J. Rheumatol., 1998, 25, 2339-2344.</p><p>Rifas L. Bone and cytokines: beyond IL-1, IL-6 and TNF-a. Calcif. Tiss, Res., 1998, 64,1-7.</p><p>Насонов E. Л. Остеопороз при ревматических заболеваниях. Рук. по остеопорзу. Ред. Беневоленская Л.И. М., 2003, 346-363.</p><p>Towheed Т.Е., Brouillard D., Yendt E., Anastassiades T. Osteoporosis in rheumatoid arthritis: findings in the metacarpal, spine, and hip and a study of the determinations of both localized and generalized osteopenia. J. Rheumatol., 1995, 22, 440-443.</p><p>Kroger Н., Honkanan R„ Saarikoski S., Alhava E. Decreased axial bone mineral density in perimenopausal women with rheumatoid arthritis. A population based study. Ann. Rheum. Dis.,1994,53,18-23.</p><p>Lems W.F., Dijkmans B.A. Should we look for osteoporosis in patients with rheumatoid arthritis ? Ann. Rheum. Dis.,1998, 57, 325-337.</p><p>Laan R.F., Buijs J.M. et al. Bone mineral density in patients with recent onset rheumatoid arthritis: influence of disease activity and functional capacity. Ann. Rheum. Dis., 1993,52, 21-26.</p><p>Lems W.F, Jahangier Z.N, Gacobs J.W.G J. et al. Vertebral fractures in patients with rheumatoid arthritis with corticosteroids. Clin. Exper. Rheumat., 1995,13, 293297.</p><p>Arend W.P., Dayer J.M. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis. Arthr. Rheum. 1995, 38, 151-160.</p><p>Suzuki Y., Tanihara М., Ichikawa Y. et al. Periarticular osteopenia in adjuvant induced arthritis: role of interleukin-1 in decreased osteogenic and increased resorbtive potential of bone marrow cells. Ann. Rheum. Dis., 1995, 54, 484-490.</p><p>Combe B., Eliaou J-F., Daurs J-P. et al. Prognostic factors in rheumatoid arthritis. Comparative study of two subsets of patients according to severety of articular damage. Br. J. Rheumatol., 1995, 34, 529-534.</p><p>Насонов Е.Л., Чичасова H.B., Баранов и соавт. Клиническое значение С -реактивного белка при ревматоидном артрите. Клин, мед., 1997,7, 26-31.</p><p>Ottemess l.G. The value of C-reactive protein measurement in rheumatoid arthritis. Semin. Arthr. Rheum., 1994, 24, 91-104.</p><p>Eggelmcijer F., Papapoulos S.E., Westedt M.L. et al. Bone metabolism in rheumatoid arthritis; relationship to disease activity. Br. J. Rheumatol., 1993, 32, 387-391.</p><p>Gough A.K.S., Peel N.F.A., Easteell R. et al. Excretion of pyridinium cross - links correlates with disease activity and appendicular bone loss in early rheumatoid arthritis. Ann. Rheum. Dis., 1994, 53. 14-17.</p><p>Sambrook P.N., Jones G. Corticosteroid osteoporosis. Br. J. Rheumatol., 1995, 34, 8-12.</p><p>Wilke W.S., Sweeney T.J., Calabrese L.H. Models of combination therapy with disease-modifying antirheumatic drugs. Early, aggressive therapy for rheumatoid artritis: concerns, descriptions, and estimate of outcome. Semin. Arthr. Rheum., 1993, 23, 26-41.</p><p>Frieis J.S., Spitz P.U., Kraines R.S. et al. Measurement of patient outcome in arthritis. Arthr. Rheum., 1980, 23,137145.</p></div><br />

The authors declare that there are no conflicts of interest present.