rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2005-552rsp-690Research ArticleСтатьиArticlesОценка минеральной плотности костной ткани субхондральных отделов бедренной и большеберцовой костей при гонартрозеAssessment of femur and tibia subchondral parts mineral bone density in gonarthrosisЗайцеваЕ. М.ZaitsevaE M-СмирновА. В.SmirnovA V-AlexeevaL IAlexeevaL I-200515022005431№1 (2005)2730Copyright © Зайцева Е.М., Смирнов А.В., Alexeeva L.I., 20052005Зайцева Е.М., Смирнов А.В., Alexeeva L.I.Zaitseva E.M., Smirnov A.V., Alexeeva L.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/690

Цель.Оценить взаимосвязь МПКТ субхондральных (с/х) отделов бедренной и большеберцовой костей и стадии гонартроза. Материал и методы. 53 жен. с двусторонним гонартрозом. Возраст от 42 до 84 лет, индекс массы тела от 21,2 до 43 кг/м 2. Проведены стандартная рентгенография коленных суставов в 2-х проекциях и 2-х энергетическая рентгеновская денситометрия поясничного отдела позвоночника, шейки бедренной кости и мыщелков бедренной и большеберцовой костей. Оценка МПКТ проводилась в 5 регионах коленного сустава. Результаты. Установлено, что увеличение стадии гонартроза сопровождается повышением значений МПКТ с с/х отделах больше берцовой кости. Увеличение МПКТ в медиальном мыщелке большеберцовой кости ассоциировалось с уменьшением ширины суставной щели тибио-фе- морального сустава, наличием с/х остеосклероза и краевых остеофитов, а также с наличием ва- русной деформации коленного сустава. Значения МПКТ в с/х отделах бедренной кости были связаны только с наличием краевых остеофитов.

Objective. To assess association between bone mineral density (BMD) of parts of femur and tibia gonarthrosis stage. Material and methods. 53 female with bilateral gonarthrosis aged 42 to 84 years with body mass index from 21,2 to 43 kg/m2 were included. Knee joints X-ray examination, densitometry of lumbar spine, femoral neck and condyles of femur and tibia were performed. Subchondral BMD assessment was done in 5 regions of knee. Results. Increase of gonarthrosis stage was accompanied by rise of subchondral tibia BMD values. Increase of medial femur condyles BMD was associated with knee joint space decrease, presence of subchondral osteosclerosis and marginal osteophytes so as knee varus deformity. Subchondral femur BMD values correlated only with the presence of marginal osteophytes.

МПКТ субхондршьных отделов бедренной и большеберцовой костейгонартрозgonarthrosisbone mineral density of subchondral femur and tibiaReferences<div><p>Buckland-Wright С., Macfarlane D., Jasani М.К., Lynch J. Quantitative microfocal radiographic assessment of osteoarthritis of the knee from weight bearing tunnel and semiflexed standing views. J. Rheumatol., 1994, 21,17341741.</p><p>Buckland-Wright C., Lynch J., Macfarlane D. Fractal signature analysis measures cancellous bone organisation in macroradiographs of patients with knee osteoarthritis. Ann. Rheum. Dis., 1996, 55,748-755.</p><p>Billingham M.E.J., Meijers M.H.M., Mahwinney B., Malcolm A. Spontaneous osteoarthritis in guinea pigs: cartilage degeneration is preceded by loss of subchondral trabecular bone [abstract], J. Rheum., 1996, suppl 1,104</p><p>Hutton C.W., Higgs E.R., Jackson P.C. et al. Tc HMDP bone scanning in generalised arthritis. I. Comparison of the standard radiograph and four hour bone scan image of the hand. Ann. Rheum. Dis., 1986,45,617-621</p><p>Hutton C.W., Higgs E.R., Jackson P.C. et al. Tc HMDP bone scanning in generalised arthritis. II. The four hour bone scan image predicts radiographic change. Ann. Rheum. Dis., 1986,45,622-626</p><p>Dieppe P., Cushnaghan J., Young P., Kirwan J. Prediction of the progression of joint space narrowing in osteoarthritis of the knee by bone scintigraphy. Ann. Rheum. Dis., 1993,52,557-563</p><p>Bruyere O., Dardenne C., Lejeune E. et al. Subchondral tibial bone mineral density predicts future joint space narrowing at the medial femoro-tibial compartment in patients with knee osteoarthritis. Bone, 2003,32(5),541-545.</p><p>Genant H.K., Steiger P., Faulkner K.G. et al. Non invasive bone mineral analysis: recent advances and future direc­tions. In: Christiansen C., Overgaard K., eds. Osteoporosis, Vol 2. Denmark: Kobenhaven K., 1990,435.</p><p>Murphy E.t Bresnihan B., FitzGerald O. Validated measurement of periarticular bone mineral density at the knee joint by dual energy X-ray absorptiometry. Ann. Rheum. Dis., 2001,60, 8-13</p><p>Shahid M.S., Gosling J., Shepstone L. et al. Dual energy xray absorptiometry (DXA) of the knee joint. Br. J. Rheumatol., 1995,34(suppl 1),122.</p><p>Hulet C., Sabatier J.P., Schiltz D. et al. Dual x-ray absorptiometry assessment of bone density of the proximal tibia in advanced-stage degenerative disease of the knee. Rev. Chir, Orthop. Reparatrice Appar. Mot., 2001,87(1),50-60</p><p>Hulet C., Sabatier J.P., Souquet D. et al. Distribution of bone mineral density at the proximal tibia in knee osteoarthritis. Calcif. Tissue Int., 2002,71(4),315-322.</p><p>Carlson C.S., Loeser R.F., Purser C.B. et al. Osteoarthritis in cynomolgus macaques. 111. Effects of age, gender, and subchondral bone thickness on the severity of disease. J. Bone Miner. Res., 1996, II, 12091217</p><p>Messner K., Fahlgren A., Ross I., Andersson B. Simultaneous changes in bone mineral density and articular cartilage in a rabbit meniscectomy model of knee osteoarthrosis. Octeoarthr. and Cartil.,2000, 8,197-206</p><p>Mansell J.P., Bailey A.J. Abnormal cancellous bone collagen metabolism in osteoarthritis. J. Clin. Invest., 1998, 101,1596-1603</p><p>Li B., Aspden R.M. Composition and mechanical properties of cancellous bone from the femoral head of patients with osteoporosis or osteoarthritis. J. Bone Miner. Res., 1997,12,641-651</p><p>Karvonen R.L., Miller P.R., Nelson D.A. et al. Periarticular osteoporosis in osteoarthritis of the knee. J. Rheumatol., 1998,25(11),2187-2194.</p></div><br /><div><p>Buckland-Wright С., Macfarlane D., Jasani М.К., Lynch J. Quantitative microfocal radiographic assessment of osteoarthritis of the knee from weight bearing tunnel and semiflexed standing views. J. Rheumatol., 1994, 21,17341741.</p><p>Buckland-Wright C., Lynch J., Macfarlane D. Fractal signature analysis measures cancellous bone organisation in macroradiographs of patients with knee osteoarthritis. Ann. Rheum. Dis., 1996, 55,748-755.</p><p>Billingham M.E.J., Meijers M.H.M., Mahwinney B., Malcolm A. Spontaneous osteoarthritis in guinea pigs: cartilage degeneration is preceded by loss of subchondral trabecular bone [abstract], J. Rheum., 1996, suppl 1,104</p><p>Hutton C.W., Higgs E.R., Jackson P.C. et al. Tc HMDP bone scanning in generalised arthritis. I. Comparison of the standard radiograph and four hour bone scan image of the hand. Ann. Rheum. Dis., 1986,45,617-621</p><p>Hutton C.W., Higgs E.R., Jackson P.C. et al. Tc HMDP bone scanning in generalised arthritis. II. The four hour bone scan image predicts radiographic change. Ann. Rheum. Dis., 1986,45,622-626</p><p>Dieppe P., Cushnaghan J., Young P., Kirwan J. Prediction of the progression of joint space narrowing in osteoarthritis of the knee by bone scintigraphy. Ann. Rheum. Dis., 1993,52,557-563</p><p>Bruyere O., Dardenne C., Lejeune E. et al. Subchondral tibial bone mineral density predicts future joint space narrowing at the medial femoro-tibial compartment in patients with knee osteoarthritis. Bone, 2003,32(5),541-545.</p><p>Genant H.K., Steiger P., Faulkner K.G. et al. Non invasive bone mineral analysis: recent advances and future direc­tions. In: Christiansen C., Overgaard K., eds. Osteoporosis, Vol 2. Denmark: Kobenhaven K., 1990,435.</p><p>Murphy E.t Bresnihan B., FitzGerald O. Validated measurement of periarticular bone mineral density at the knee joint by dual energy X-ray absorptiometry. Ann. Rheum. Dis., 2001,60, 8-13</p><p>Shahid M.S., Gosling J., Shepstone L. et al. Dual energy xray absorptiometry (DXA) of the knee joint. Br. J. Rheumatol., 1995,34(suppl 1),122.</p><p>Hulet C., Sabatier J.P., Schiltz D. et al. Dual x-ray absorptiometry assessment of bone density of the proximal tibia in advanced-stage degenerative disease of the knee. Rev. Chir, Orthop. Reparatrice Appar. Mot., 2001,87(1),50-60</p><p>Hulet C., Sabatier J.P., Souquet D. et al. Distribution of bone mineral density at the proximal tibia in knee osteoarthritis. Calcif. Tissue Int., 2002,71(4),315-322.</p><p>Carlson C.S., Loeser R.F., Purser C.B. et al. Osteoarthritis in cynomolgus macaques. 111. Effects of age, gender, and subchondral bone thickness on the severity of disease. J. Bone Miner. Res., 1996, II, 12091217</p><p>Messner K., Fahlgren A., Ross I., Andersson B. Simultaneous changes in bone mineral density and articular cartilage in a rabbit meniscectomy model of knee osteoarthrosis. Octeoarthr. and Cartil.,2000, 8,197-206</p><p>Mansell J.P., Bailey A.J. Abnormal cancellous bone collagen metabolism in osteoarthritis. J. Clin. Invest., 1998, 101,1596-1603</p><p>Li B., Aspden R.M. Composition and mechanical properties of cancellous bone from the femoral head of patients with osteoporosis or osteoarthritis. J. Bone Miner. Res., 1997,12,641-651</p><p>Karvonen R.L., Miller P.R., Nelson D.A. et al. Periarticular osteoporosis in osteoarthritis of the knee. J. Rheumatol., 1998,25(11),2187-2194.</p></div><br />

The authors declare that there are no conflicts of interest present.