rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2005-564rsp-702Research ArticleСтатьиArticlesЧастота дефицита витамина D среди подростков московской выборкиFrequency of vitamin D deficiency among teenagers of a Moscow sampleMihailovE. E.MihailovE. E.-КоротковаТ. А.KorotkovaT A-DeminN VDeminN V-БеневоленмкаяЛ. И.BenevolenskayaL I-200515022005431№1 (2005)8590Copyright © Mihailov E.E., Короткова Т.А., Demin N.V., Беневоленмкая Л.И., 20052005Mihailov E.E., Короткова Т.А., Demin N.V., Беневоленмкая Л.И.Mihailov E.E., Korotkova T.A., Demin N.V., Benevolenskaya L.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/702

Цель. Изучить частоту дефицита витамина D среди подростков московской выборки и его возможного влияния на величину МПКТ. Материал и методы. 318 подросткам 14-18 лет ( 139 м и 179 д) проводились клинический осмотр, антропометрия, расчет суточного потреблениякальция, денситометрия, определение суточной концентрации 25 (OH)D, общего и ионизированного кальция. Результаты. Выявлено большее потребление кальция с молочными продуктами мальчиками по сравнению с девочками ( р<0,0001). Сывороточная концентрация общего кальция (р<0,02) и 25(ОН)Д (р < 0,0001) у мальчиков также была достоверно выше. Чпастота дефицита витамина D у девочек составила 53,6%, что было в 10 раз выше, чем у мальчиков. Частота гиповитаминоза и недостаточности витамина D была значительно выше среди девочек, обследованных в феврале-марте, а частота дефицита витамина D значительно преобладала в группе, обследованной в ноябре-декабре ( 58,8%). Корреляции между концентрациями сывороточного 25(OH)D и возрастом, ростом, весом, индексом массы тела, суточным потреблением кальция, уровнем общего и ионизированного кальция, МПКТ не установлено. В группе девочек 14-15 лет с дефицитом витамина D выявлено повышение МПКТ в проксимальных отделах бедренной кости.

Objective. To study frequency of vitamin D deficiency among teenagers of a Moscow sample and its possible influence on bone mineral density (BMD) value. Material and methods. 318 teenagers (139 male, 179 female) aged 14 to 18 years were included. Clinical examination, anthropometry, calculation of daily calcium consumption, densitometry, 25(OH)D serum level, total and ionized calcium level evaluation were performed. Results. Boys consumed more calcium with milky products than girls (p<0,0001). Boys also had significantly higher concentration of total calcium (p<0,02) and 25(OH)D (p<0,0001). Frequency of vitamin D deficiency in girls was 10 times higher than among boys and came to 53,6%. Frequency of vitamin D hypovitaminosis and insufficiency was significantly higher among girls examined in February-March and frequency of vitamin D deficiency significantly prevailed in group examined in November- December (58,8%, p<0,0001). Correlation between serum concentration of 25(OH)D and age, height, weight, body mass index, daily calcium consumption, total and ionized calcium levels, BMD were not found. Girls with vitamin D deficiency aged 14-15 years showed increase of BMD in proximal femur.

подросткидефицит витамина Dпотребление кальцияМПКТteenagersvitamin D deficiencycalcium consumptionbone mineral densityReferences<div><p>Docio S., Riancho J.A., Perez A. et al. Seasonal deficiency of vitamin D in Children: A potential target for osteoporosis- preventing strategies? J. Bone Miner. Res., 1998, 13 (4), 544-548.</p><p>Shaw N.J., Bishop N.J. Mineral accretion in growing bones a framework for future? Arch. Dis. Child., 1995, 72, 177179.</p><p>Matkovic V., Selic Т., Wardlaw G.M. et al. Timing of peak bone mass in Caucasian females and its implication for the prevention of osteoporosis: Inference from a cross-sectional model. J. Clin. Invest., 1994, 93, 799-808.</p><p>Щеплягина Л.А., Моисеева Е.Ю., Богатырева A.O. и др. Возрастные особенности минеральной плотности костной ткани в детском возрасте. Приложение к журналу "Остеопороз и остеопатии", Российский конгресс по остеопорозу, 20-22 октября 2003, Москва, 90.</p><p>Беневоленская Л.И., Михайлов Е.Е., Короткова Т.А, Демин Н.В. Денситометрическая характеристика костной ткани у подростков. Приложение к журналу "Остеопороз и остеопатии", Российский конгресс по остеопорозу, 20-22 октября 2003, Москва, 91.</p><p>Gunnes М., Lehmann Е.Н. Physical activity and dietary constituents as predictors of forearm cortical and trabccular bone gain in healthy children and adolescence: A prospective study. Acta Paediatr., 1996, 85, 19-25.</p><p>Gloth F.M., Gundberg C.M., Hollis B.W. et al. Vitamin D deficiency in homebound elderly persons. JAMA, 1995, 274, 1683-1686.</p><p>LeBoff M.S., Kohlmeier L., Hurwitz S. et al. Occult vitamin D deficiency in postmenopausal US women with acute hip fracture. JAMA, 1999, 281, 1505-1511.</p><p>Haden S.T., El-Hajj Fuleihan G., Angell G.E. et al. Calcidiol and PTG levels in women attending an osteoporosis program. Calcif. Tissue Int., 1999, 64, 275-279.</p><p>Docio S., Riancho J.A., Perez A. et al. Seasonal deficiency of vitamin D in children: a potencial target for osteoporosis preventing strategies. J. Bone Miner. Res. 1998, 13, 544-548.</p><p>Guillemant J., Le Taupin H.T., Taright N. et al. Vitamin D status during puberty in French healthy male adolescents. Osteoporosis Int., 1999, 10, 222-225.</p><p>Lehtonen-Veromaa М., Mottonen Т., Irjala K. et al. Vitamin D intake is low and hypovitaminosis D common in healthy 9- to 15-years-old Finnish girls. Eur. J. Clin. Nutr., 1999, 53, 746-751.</p><p>Bonjour J.P., Carrie A.L., Ferrari S. et al. Calcium enriched foods and bone mass growth in prepubertal girls: a ran domized double-blind, placebo controlled trial. J. Clin. Invest., 1997, 99, 1287-1294.</p><p>Cadogan J., Eastell R., Jones N,, Barker M.E. Milk intake and bone mineral asquisition in adolescent girl: randomized, controlled intervention trial. Br. Med. J., 1997, 315, 1255-1260.</p><p>McKenna M.J., Freaney R. Secondary hyperparathyroidism in elderly: Means to defining hypovitaminosis D. Osteoporosis Int., 1998, 8, (suppl 2),3-6.</p><p>Scharla S.H. Prevalence of subclinical vitamin D deficiency in different European countries. Osteoporosis Int., 1998, 8, (suppl 2),7-12.</p><p>Barger-Lux M.J., Heaney R.P., Lanspa S.J. et al. An investigation of source of variation in calcium absorption efficiency. J. Clin. Endocrinol. Metab. 1995, 80, 406-411</p><p>Villareal D.T., Civitelli R., Chines A., Avioli L.V. Subclinical vitamin D deficiency in postmenopousal women with low vertebral bone mass. J. Clin. Endocrinol. Metab., 1991. 72. 628-634.</p><p>Ooms M.E., Lips P., Roos J.C. et al. Vitamin D status and sex hormone binding globulin: determinants of bone turnover and bone mineral density in elderly women. J. Bone Miner. Res., 1995, 10, 1177-1184.</p><p>Chapuy M.C., Larquier C., Peyron R., Meunier P.J. Comparative effects of a three-month supplement with 25(OH)D or vitamin D in vitamin D-deficient elderly patients. In: Norman A.W., Bouillon R., Thomasset M. editors. Vitamin D. A pluripotent steroid hormone: structural studies, molecular endocrinology and clinical applications. Berlin: Walter de Gruyter, 1994, 877.</p><p>McKenna M.J. Differences in vitamin D status between countries in young adults and elderly. Am. J. Med,, 1992, 93, 69-77.</p><p>Lips P. Deficiency and secondary hyperparathyroidism in the elderly: Consequences for bone loss and fractures and therapeutic implications. Endocrine Rev., 2001, 22(4), 477-501.</p><p>Ovesen L., Andersen R., Jakobsen J. Geographical differences in vitamin D status, with particular reference to European countries. Proceed. Nutr. Society, 2003, 62, 813821.</p><p>van der Wielen R.P.J., Lowik M.R.H., van der Berg H. et al. Serum vitamin D concentrations among elderly people in Europe. Lancet, 1995, 346, 207-210.</p><p>Andersen R., Brot C., Cashman K.D. et al. Hypovitaminosis D in Europe. Osteoporosis Int. 2004, 15 (suppl I), S7.</p><p>Kristinsson J.O., Valdimarsson O., Sigurdsson G. et al. Serum 25-hydroxyvitamin D levels and bone mineral density in 16-20 years-old girls: lack association. J. Intern. Med., 1998, 243(5), 381-388.</p><p>Outila T.A., Karkkainen M.U., Lamberg-Allardt C.J. Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents with forearm bone density. Am. J. Clin. Nutr., 2001, 74, 206-210.</p><p>Lehtonen-Veromaa M.K., Mottonen T.T., Nuotio I.O. et al. Vitamin D and attainment of peak bone mass among peripuberta! Finnish girl: a 3-y prospective study. Am. J. Clin. Nutr., 2002, 76, 1446-1453</p></div><br /><div><p>Docio S., Riancho J.A., Perez A. et al. Seasonal deficiency of vitamin D in Children: A potential target for osteoporosis- preventing strategies? J. Bone Miner. Res., 1998, 13 (4), 544-548.</p><p>Shaw N.J., Bishop N.J. Mineral accretion in growing bones a framework for future? Arch. Dis. Child., 1995, 72, 177179.</p><p>Matkovic V., Selic Т., Wardlaw G.M. et al. Timing of peak bone mass in Caucasian females and its implication for the prevention of osteoporosis: Inference from a cross-sectional model. J. Clin. Invest., 1994, 93, 799-808.</p><p>Щеплягина Л.А., Моисеева Е.Ю., Богатырева A.O. и др. Возрастные особенности минеральной плотности костной ткани в детском возрасте. Приложение к журналу "Остеопороз и остеопатии", Российский конгресс по остеопорозу, 20-22 октября 2003, Москва, 90.</p><p>Беневоленская Л.И., Михайлов Е.Е., Короткова Т.А, Демин Н.В. Денситометрическая характеристика костной ткани у подростков. Приложение к журналу "Остеопороз и остеопатии", Российский конгресс по остеопорозу, 20-22 октября 2003, Москва, 91.</p><p>Gunnes М., Lehmann Е.Н. Physical activity and dietary constituents as predictors of forearm cortical and trabccular bone gain in healthy children and adolescence: A prospective study. Acta Paediatr., 1996, 85, 19-25.</p><p>Gloth F.M., Gundberg C.M., Hollis B.W. et al. Vitamin D deficiency in homebound elderly persons. JAMA, 1995, 274, 1683-1686.</p><p>LeBoff M.S., Kohlmeier L., Hurwitz S. et al. Occult vitamin D deficiency in postmenopausal US women with acute hip fracture. JAMA, 1999, 281, 1505-1511.</p><p>Haden S.T., El-Hajj Fuleihan G., Angell G.E. et al. Calcidiol and PTG levels in women attending an osteoporosis program. Calcif. Tissue Int., 1999, 64, 275-279.</p><p>Docio S., Riancho J.A., Perez A. et al. Seasonal deficiency of vitamin D in children: a potencial target for osteoporosis preventing strategies. J. Bone Miner. Res. 1998, 13, 544-548.</p><p>Guillemant J., Le Taupin H.T., Taright N. et al. Vitamin D status during puberty in French healthy male adolescents. Osteoporosis Int., 1999, 10, 222-225.</p><p>Lehtonen-Veromaa М., Mottonen Т., Irjala K. et al. Vitamin D intake is low and hypovitaminosis D common in healthy 9- to 15-years-old Finnish girls. Eur. J. Clin. Nutr., 1999, 53, 746-751.</p><p>Bonjour J.P., Carrie A.L., Ferrari S. et al. Calcium enriched foods and bone mass growth in prepubertal girls: a ran domized double-blind, placebo controlled trial. J. Clin. Invest., 1997, 99, 1287-1294.</p><p>Cadogan J., Eastell R., Jones N,, Barker M.E. Milk intake and bone mineral asquisition in adolescent girl: randomized, controlled intervention trial. Br. Med. J., 1997, 315, 1255-1260.</p><p>McKenna M.J., Freaney R. Secondary hyperparathyroidism in elderly: Means to defining hypovitaminosis D. Osteoporosis Int., 1998, 8, (suppl 2),3-6.</p><p>Scharla S.H. Prevalence of subclinical vitamin D deficiency in different European countries. Osteoporosis Int., 1998, 8, (suppl 2),7-12.</p><p>Barger-Lux M.J., Heaney R.P., Lanspa S.J. et al. An investigation of source of variation in calcium absorption efficiency. J. Clin. Endocrinol. Metab. 1995, 80, 406-411</p><p>Villareal D.T., Civitelli R., Chines A., Avioli L.V. Subclinical vitamin D deficiency in postmenopousal women with low vertebral bone mass. J. Clin. Endocrinol. Metab., 1991. 72. 628-634.</p><p>Ooms M.E., Lips P., Roos J.C. et al. Vitamin D status and sex hormone binding globulin: determinants of bone turnover and bone mineral density in elderly women. J. Bone Miner. Res., 1995, 10, 1177-1184.</p><p>Chapuy M.C., Larquier C., Peyron R., Meunier P.J. Comparative effects of a three-month supplement with 25(OH)D or vitamin D in vitamin D-deficient elderly patients. In: Norman A.W., Bouillon R., Thomasset M. editors. Vitamin D. A pluripotent steroid hormone: structural studies, molecular endocrinology and clinical applications. Berlin: Walter de Gruyter, 1994, 877.</p><p>McKenna M.J. Differences in vitamin D status between countries in young adults and elderly. Am. J. Med,, 1992, 93, 69-77.</p><p>Lips P. Deficiency and secondary hyperparathyroidism in the elderly: Consequences for bone loss and fractures and therapeutic implications. Endocrine Rev., 2001, 22(4), 477-501.</p><p>Ovesen L., Andersen R., Jakobsen J. Geographical differences in vitamin D status, with particular reference to European countries. Proceed. Nutr. Society, 2003, 62, 813821.</p><p>van der Wielen R.P.J., Lowik M.R.H., van der Berg H. et al. Serum vitamin D concentrations among elderly people in Europe. Lancet, 1995, 346, 207-210.</p><p>Andersen R., Brot C., Cashman K.D. et al. Hypovitaminosis D in Europe. Osteoporosis Int. 2004, 15 (suppl I), S7.</p><p>Kristinsson J.O., Valdimarsson O., Sigurdsson G. et al. Serum 25-hydroxyvitamin D levels and bone mineral density in 16-20 years-old girls: lack association. J. Intern. Med., 1998, 243(5), 381-388.</p><p>Outila T.A., Karkkainen M.U., Lamberg-Allardt C.J. Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents with forearm bone density. Am. J. Clin. Nutr., 2001, 74, 206-210.</p><p>Lehtonen-Veromaa M.K., Mottonen T.T., Nuotio I.O. et al. Vitamin D and attainment of peak bone mass among peripuberta! Finnish girl: a 3-y prospective study. Am. J. Clin. Nutr., 2002, 76, 1446-1453</p></div><br />

The authors declare that there are no conflicts of interest present.