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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rsp</journal-id><journal-title-group><journal-title xml:lang="ru">Научно-практическая ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Rheumatology Science and Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-4484</issn><issn pub-type="epub">1995-4492</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1995-4484-2005-623</article-id><article-id custom-type="elpub" pub-id-type="custom">rsp-761</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Роль дефектов иммуносупрессии в развитии аутоиммунных заболеваний</article-title><trans-title-group xml:lang="en"><trans-title>Role of immunosupression defects in the development of autoimmune diseases</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Bykovskaya</surname><given-names>S N</given-names></name><name name-style="western" xml:lang="en"><surname>Bykovskaya</surname><given-names>S N</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Nassonov</surname><given-names>E L</given-names></name><name name-style="western" xml:lang="en"><surname>Nassonov</surname><given-names>E L</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib></contrib-group><pub-date pub-type="collection"><year>2005</year></pub-date><pub-date pub-type="epub"><day>15</day><month>08</month><year>2005</year></pub-date><volume>43</volume><issue>4</issue><issue-title>№4 (2005)</issue-title><fpage>81</fpage><lpage>84</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Bykovskaya S.N., Nassonov E.L., 2005</copyright-statement><copyright-year>2005</copyright-year><copyright-holder xml:lang="ru">Bykovskaya S.N., Nassonov E.L.</copyright-holder><copyright-holder xml:lang="en">Bykovskaya S.N., Nassonov E.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://rsp.mediar-press.net/rsp/article/view/761">https://rsp.mediar-press.net/rsp/article/view/761</self-uri></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">&lt;div&gt;&lt;p&gt;Davidson A., Diamond В. 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Immunol., 2001,167, 107-113&lt;/p&gt;&lt;p&gt;Gilliet М., Liu Y.J. Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells. J. Exp Med., 2002, 195, 695-704&lt;/p&gt;&lt;p&gt;Ciubotariu R., Colovai A.I., Pennesi G. et al. Specific suppression of human CD4+ Th cell responses to pig MHC antigens by CD8+CD28- regulatory T cells. J. Immunol., 1998, 161, 51932024&lt;/p&gt;&lt;p&gt;Zhang Z.X., Yang L., Young K.J. et al. Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat. Med., 2000, 6, 782-789&lt;/p&gt;&lt;p&gt;Seino K., Taniguchi M. Functional roles of NKT cell in the immune system. Front. Biosci., 2005, 10, 38-48&lt;/p&gt;&lt;p&gt;Groux Н., O'Garra A., Bigler М. et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature, 1997, 389, 737-742&lt;/p&gt;&lt;p&gt;Roncarolo M.G., Bacchetta R., Bordignon C. et al. Type I T regulatory cells. Immunol. Rev., 2001, 182, 68-79&lt;/p&gt;&lt;p&gt;Sundstedt A., O'Neill E.J., Nicolson K.S., Wraith D.C. Role for IL-10 in suppression mediated by peptide-induced regulatory T cells in vivo. J. Immunol., 2003, 170, 1240-1248&lt;/p&gt;&lt;p&gt;Wakkach A., Fournier N., Brun V. et al. Characterization of dendritic cells that induce tolerance and T regulatory I cell differentiation in vivo. Immunity, 2003, 18, 605-617&lt;/p&gt;&lt;p&gt;Buckner J.H., Ziegler S.F. Regulating the immune system: the induction of regulatory T cells in the periphery. Arthr.Res.Ther., 2004. 6,215-222&lt;/p&gt;&lt;p&gt;Hall B.M., Pearce N.W., Gurley K.E., Dorsch S.E. Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action. J. Exp. Med., 1990, 171. 141-157&lt;/p&gt;&lt;p&gt;Sakaguchi S., Sakaguchi N., Asano M. et al. 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