rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2013-644rsp-782Research ArticleСтатьиArticlesЗначение воспаления в развитии жесткости сосудистой стенкиSignificance of inflammation in the development of vascular wall stiffnessNoskovS MNoskovS M-ZavodchikovAndrei AleksandrovichZavodchikovAndrei Aleksandrovichand-zavod-chikov@yandex.ruShirokovaK YuShirokovaK Yu-KrasivinaI GKrasivinaI G-LavrukhinaA ALavrukhinaA A-201315042013512№2 (2013)159162Copyright © Noskov S.M., Zavodchikov A.A., Shirokova K.Y., Krasivina I.G., Lavrukhina A.A., 20132013Noskov S.M., Zavodchikov A.A., Shirokova K.Y., Krasivina I.G., Lavrukhina A.A.Noskov S.M., Zavodchikov A.A., Shirokova K.Y., Krasivina I.G., Lavrukhina A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/782

В статье рассматривается проблема жесткости артериальной стенки при ревматических заболеваниях. Показана роль воспаления в патогенезе увеличения сосудистой жесткости, рассмотрены ее механизмы на уровне изменения клеточных компонентов, клинические признаки ассоциации воспаления и артериальной жесткости и возможности ее уменьшения, поиск новых терапевтических стратегий снижения жесткости артериальных сосудов с помощью применения противоревматических препаратов.

This review deals with arterial wall stiffness in rheumatic diseases. It shows a role of inflammation in the pathogenesis of increased vascular stiffness, considers its mechanisms at the level of altered cell components, the clinical signs of an inflammation-arterial stiffness association and the possibilities of its reduction, and a search for novel therapeutic strategies to diminish the stiffness of arterial vessels with antirheumatic drugs.

воспалениесосудистая жесткостьревматические заболеванияinflammationvascular stiffnessrheumatic diseasesReferences<div><p>Boutouyrie P., Tropeano A.I., Asmar R. et al. Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study. Hypertension 2002;39:10-5.</p><p>Laurent S., Katsahian S., Fassot C. et al. Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke 2003;34:1203-6.</p><p>Sutton-Tyrrell K., Najjar S.S., Boudreau R.M. et al. Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults. Circulation 2005;111:3384-90.</p><p>Scuteri A., Najjar S.S., Muller D.C. et al. Metabolic syndrome amplifies the age-associated increases in vascular thickness and stiffness. J Am Coll Cardiol 2004;43:1388-95.</p><p>Zieman S.J., Melenovsky V., Kass D.A. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol 2005;25:932-43.</p><p>Lakatta E.G., Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises. Part I: aging arteries: a «set up» for vascular disease. Circulation 2003;107:139-46.</p><p>Lakatta E.G. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises. Part III: cellular and molecular clues to heart and arterial aging. Circulation 2003;107:490-7.</p><p>Jacob M.P. Extracellular matrix remodeling and matrix metallo-proteinases in the vascular wall during aging and in pathological conditions. Biomed Pharmacother 2003;57:195-202.</p><p>Wang M., Lakatta E.G. Altered regulation of matrix metallopro-teinase-2 in aortic remodeling during aging. Hypertension 2002;39:865-73.</p><p>Galis Z.S., Khatri J.J. Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly. Circ Res 2002;90:251-62.</p><p>Wang M., Zhang J., Jiang L.Q. et al. Proinflammatory profile within the grossly normal aged human aortic wall. Hypertension 2007;50:219-27.</p><p>Csiszar A., Ungvari Z., Edwards J.G. et al. Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function. Circ Res 2002;90:1159-66.</p><p>Csiszar A., Ungvari Z., Koller A. et al. Aging-induced proinflam-matory shift in cytokine expression profile in coronary arteries. FASEB J 2003;17:1183-5.</p><p>Spinetti G., Wang M., Monticone R. et al. Rat aortic MCP-1 and its receptor CCR2 increase with age and alter vascular smooth muscle cell function. Arterioscler Thromb Vasc Biol 2004;24:1397-402.</p><p>Ishibashi M., Hiasa K., Zhao Q. et al. Critical role of monocyte chemoattractant protein-1 receptor CCR2 on monocytes in hypertension-induced vascular inflammation and remodeling. Circ Res 2004;94:1203-10.</p><p>Viedt C., Vogel J., Athanasiou T. et al. Monocyte chemoattractant protein-1 induces proliferation and interleukin-6 production in human smooth muscle cells by differential activation of nuclear factor-kappaB and activator protein-1. Arterioscler Thromb Vasc Biol 2002;22:914-20.</p><p>Pasceri V., Willerson J.T., Yeh E.T. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation 2000;102:2165-8.</p><p>Venugopal S.K., Devaraj S., Yuhanna I. et al. Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells. Circulation 2002;106:1439-41.</p><p>Mahmud A., Feely J. Arterial stiffness is related to systemic inflammation in essential hypertension. Hypertension 2005;46:1118-22.</p><p>Nagano M., Nakamura M., Sato K. et al. Association between serum C-reactive protein levels and pulse wave velocity: a population-based cross-sectional study in a general population. Atherosclerosis 2005;180:189-95.</p><p>Boos C.J., Lip G.Y. Elevated high-sensitive C-reactive protein, large arterial stiffness and atherosclerosis: a relationship between inflammation and hypertension? J Hum Hypertens 2005;19:511-3.</p><p>Patel R.S., Al Mheid I., Morris A.A. et al. Oxidative stress is associated with impaired arterial elasticity. Atherosclerosis 2011;218:90-5.</p><p>Park S., Lakatta E.G. Role of inflammation in the pathogenesis of arterial stiffness. Yonsei Med J 2012;53:258-61.</p><p>McEniery C.M., Spratt M., Munnery M. et al. An analysis of prospective risk factors for aortic stiffness in men: 20-year follow-up from the Caerphilly prospective study. Hypertension 2010;56:36-43.</p><p>Новикова Д.С., Попкова Т.В., Мач Э.С., Насонов Е.Л. Ригидность артерий — интегральный показатель сердечнососудистого риска у больных ревматоидным артритом. Науч-практич ревматол 2009;5:38-48.</p><p>Ребров А.П., Гайдукова И.З. Повреждение эндотелия и жесткость сосудистой стенки у больных псориатическим артритом. Саратов науч-мед журн 2009;5:544-8.</p><p>Никитина Н.М., Ребров А.П. Определение риска развития сердечно-сосудистых заболеваний у больных ревматоидным артритом. Тер арх 2009;6:29-33.</p><p>Takami T., Shigemasa M. Efficacy of various antihypertensive agents as evaluated by indices of vascular stiffness in elderly hypertensive patients. Hypertens Res 2003;26:609-14.</p><p>Munakata M., Nagasaki A., Nunokawa T. et al. Effects of valsartan and nifedipine coat-core on systemic arterial stiffness in hypertensive patients. Am J Hypertens 2004;17(11 Pt 1):1050—5.</p><p>Lunder M., Janfc M., Jug B., Sabovfc M. The effects of low-dose fluvastatin and valsartan combination on arterial function: A randomized clinical trial. Eur J Intern Med 2012;23:261—6.</p><p>Цома В.В. Возможности медикаментозной коррекции жесткости сосудов при дислипидемии. Междунар эндокринол журн 2008;6:18.</p><p>Maki-Petaja K.M., Hall F.C., Booth A.D. et al. Rheumatoid arthritis is associated with increased aortic pulse-wave velocity, which is reduced by anti-tumor necrosis factor-alpha therapy. Circulation 2006;114:1185—92.</p><p>Angel K., Provan S.A., Fagerhol M.K. et al. Effect of 1-year anti-TNF-a therapy on aortic stiffness, carotid atherosclerosis, and cal-protectin in inflammatory arthropathies: a controlled study. Am J Hypertens 2012;doi:10.1038/ajh.2012.12.</p><p>Mathieu S., Pereira B., Dubost J.J. et al. No significant change in arterial stiffness in RA after 6 months and 1 year of rituximab treatment. Rheumatology (Oxford) 2012;51:1107—11.</p><p>Capkin E., Karkucak M., Kiris A. et al. Anti-TNF-a therapy may not improve arterial stiffness in patients with AS: a 24-week follow-up. Rheumatology (Oxford) 2012;51:910-4.</p><p>Schillaci G., Bartoloni E., Pucci G. et al. Aortic stiffness is increased in polymyalgia rheumatica and improves after steroidtreatment. Ann Rheum Dis 2012;71:1151-6.</p><p>Martinez-Calatrava M.J., Largo R., Herrero-Beaumont G. Improvement of experimental accelerated atherosclerosis by chondroitin sulphate. Osteoarthr Cartilage 2010;18(Suppl 1):S12—S16.</p></div><br /><div><p>Boutouyrie P., Tropeano A.I., Asmar R. et al. Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study. Hypertension 2002;39:10-5.</p><p>Laurent S., Katsahian S., Fassot C. et al. Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke 2003;34:1203-6.</p><p>Sutton-Tyrrell K., Najjar S.S., Boudreau R.M. et al. Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults. Circulation 2005;111:3384-90.</p><p>Scuteri A., Najjar S.S., Muller D.C. et al. Metabolic syndrome amplifies the age-associated increases in vascular thickness and stiffness. J Am Coll Cardiol 2004;43:1388-95.</p><p>Zieman S.J., Melenovsky V., Kass D.A. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol 2005;25:932-43.</p><p>Lakatta E.G., Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises. Part I: aging arteries: a «set up» for vascular disease. Circulation 2003;107:139-46.</p><p>Lakatta E.G. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises. Part III: cellular and molecular clues to heart and arterial aging. Circulation 2003;107:490-7.</p><p>Jacob M.P. Extracellular matrix remodeling and matrix metallo-proteinases in the vascular wall during aging and in pathological conditions. Biomed Pharmacother 2003;57:195-202.</p><p>Wang M., Lakatta E.G. Altered regulation of matrix metallopro-teinase-2 in aortic remodeling during aging. Hypertension 2002;39:865-73.</p><p>Galis Z.S., Khatri J.J. Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly. Circ Res 2002;90:251-62.</p><p>Wang M., Zhang J., Jiang L.Q. et al. Proinflammatory profile within the grossly normal aged human aortic wall. Hypertension 2007;50:219-27.</p><p>Csiszar A., Ungvari Z., Edwards J.G. et al. Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function. Circ Res 2002;90:1159-66.</p><p>Csiszar A., Ungvari Z., Koller A. et al. Aging-induced proinflam-matory shift in cytokine expression profile in coronary arteries. FASEB J 2003;17:1183-5.</p><p>Spinetti G., Wang M., Monticone R. et al. Rat aortic MCP-1 and its receptor CCR2 increase with age and alter vascular smooth muscle cell function. Arterioscler Thromb Vasc Biol 2004;24:1397-402.</p><p>Ishibashi M., Hiasa K., Zhao Q. et al. Critical role of monocyte chemoattractant protein-1 receptor CCR2 on monocytes in hypertension-induced vascular inflammation and remodeling. Circ Res 2004;94:1203-10.</p><p>Viedt C., Vogel J., Athanasiou T. et al. Monocyte chemoattractant protein-1 induces proliferation and interleukin-6 production in human smooth muscle cells by differential activation of nuclear factor-kappaB and activator protein-1. Arterioscler Thromb Vasc Biol 2002;22:914-20.</p><p>Pasceri V., Willerson J.T., Yeh E.T. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation 2000;102:2165-8.</p><p>Venugopal S.K., Devaraj S., Yuhanna I. et al. Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells. Circulation 2002;106:1439-41.</p><p>Mahmud A., Feely J. Arterial stiffness is related to systemic inflammation in essential hypertension. Hypertension 2005;46:1118-22.</p><p>Nagano M., Nakamura M., Sato K. et al. Association between serum C-reactive protein levels and pulse wave velocity: a population-based cross-sectional study in a general population. Atherosclerosis 2005;180:189-95.</p><p>Boos C.J., Lip G.Y. Elevated high-sensitive C-reactive protein, large arterial stiffness and atherosclerosis: a relationship between inflammation and hypertension? J Hum Hypertens 2005;19:511-3.</p><p>Patel R.S., Al Mheid I., Morris A.A. et al. Oxidative stress is associated with impaired arterial elasticity. Atherosclerosis 2011;218:90-5.</p><p>Park S., Lakatta E.G. Role of inflammation in the pathogenesis of arterial stiffness. Yonsei Med J 2012;53:258-61.</p><p>McEniery C.M., Spratt M., Munnery M. et al. An analysis of prospective risk factors for aortic stiffness in men: 20-year follow-up from the Caerphilly prospective study. Hypertension 2010;56:36-43.</p><p>Новикова Д.С., Попкова Т.В., Мач Э.С., Насонов Е.Л. Ригидность артерий — интегральный показатель сердечнососудистого риска у больных ревматоидным артритом. Науч-практич ревматол 2009;5:38-48.</p><p>Ребров А.П., Гайдукова И.З. Повреждение эндотелия и жесткость сосудистой стенки у больных псориатическим артритом. Саратов науч-мед журн 2009;5:544-8.</p><p>Никитина Н.М., Ребров А.П. Определение риска развития сердечно-сосудистых заболеваний у больных ревматоидным артритом. Тер арх 2009;6:29-33.</p><p>Takami T., Shigemasa M. Efficacy of various antihypertensive agents as evaluated by indices of vascular stiffness in elderly hypertensive patients. Hypertens Res 2003;26:609-14.</p><p>Munakata M., Nagasaki A., Nunokawa T. et al. Effects of valsartan and nifedipine coat-core on systemic arterial stiffness in hypertensive patients. Am J Hypertens 2004;17(11 Pt 1):1050—5.</p><p>Lunder M., Janfc M., Jug B., Sabovfc M. The effects of low-dose fluvastatin and valsartan combination on arterial function: A randomized clinical trial. Eur J Intern Med 2012;23:261—6.</p><p>Цома В.В. Возможности медикаментозной коррекции жесткости сосудов при дислипидемии. Междунар эндокринол журн 2008;6:18.</p><p>Maki-Petaja K.M., Hall F.C., Booth A.D. et al. Rheumatoid arthritis is associated with increased aortic pulse-wave velocity, which is reduced by anti-tumor necrosis factor-alpha therapy. Circulation 2006;114:1185—92.</p><p>Angel K., Provan S.A., Fagerhol M.K. et al. Effect of 1-year anti-TNF-a therapy on aortic stiffness, carotid atherosclerosis, and cal-protectin in inflammatory arthropathies: a controlled study. Am J Hypertens 2012;doi:10.1038/ajh.2012.12.</p><p>Mathieu S., Pereira B., Dubost J.J. et al. No significant change in arterial stiffness in RA after 6 months and 1 year of rituximab treatment. Rheumatology (Oxford) 2012;51:1107—11.</p><p>Capkin E., Karkucak M., Kiris A. et al. Anti-TNF-a therapy may not improve arterial stiffness in patients with AS: a 24-week follow-up. Rheumatology (Oxford) 2012;51:910-4.</p><p>Schillaci G., Bartoloni E., Pucci G. et al. Aortic stiffness is increased in polymyalgia rheumatica and improves after steroidtreatment. Ann Rheum Dis 2012;71:1151-6.</p><p>Martinez-Calatrava M.J., Largo R., Herrero-Beaumont G. Improvement of experimental accelerated atherosclerosis by chondroitin sulphate. Osteoarthr Cartilage 2010;18(Suppl 1):S12—S16.</p></div><br />

The authors declare that there are no conflicts of interest present.