rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2010-822rsp-955Research ArticleСтатьиArticlesОценка параметров артериальной ригидности у больных подагрой и артериальной гипертензиейEstimation of arterial rigidity parameters in patients with gout and essential hypertensionKlinkovaE VKlinkovaE V-OttevaEl'vira NikolaevnaOttevaEl'vira Nikolaevnaelvott@mail.ru <mailto:elvott@mail.ru>GarbuzovaO GGarbuzovaO G-IsakovaV NIsakovaV N-BandurkoE VBandurkoE V-KlinkovaE VKlinkovaE V-OttevaElvira NikolayevnaOttevaElvira Nikolayevnaelvott@mail.ru <mailto:elvott@mail.ru>GarbuzovaO GGarbuzovaO G-IsakovaV NIsakovaV N-BandurkoE VBandurkoE V-201015122010486№6 (2010)4045Copyright © Klinkova E.V., Otteva E.N., Garbuzova O.G., Isakova V.N., Bandurko E.V., Klinkova E.V., Otteva E.N., Garbuzova O.G., Isakova V.N., Bandurko E.V., 20102010Klinkova E.V., Otteva E.N., Garbuzova O.G., Isakova V.N., Bandurko E.V., Klinkova E.V., Otteva E.N., Garbuzova O.G., Isakova V.N., Bandurko E.V.Klinkova E.V., Otteva E.N., Garbuzova O.G., Isakova V.N., Bandurko E.V., Klinkova E.V., Otteva E.N., Garbuzova O.G., Isakova V.N., Bandurko E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/955

Цель. Оценить параметры артериальной ригидности по данным неинвазивной артериографии у больных подагрой и артериальной гипертензией (АГ). Материал и методы. Проведено обследование 128 пациентов с подагрой и АГ методом неинвазивной артериографии (артериограф Tensio Clinic TL1, Tensio Med, Венгрия). Результаты. В группе больных подагрой жесткость центральных артерий выше, чем у здоровых лиц и больных АГ, и характеризуется увеличением скорости пульсовой волны и индекса аугментации. Нарушение артериальной ригидности свидетельствует о важной роли этих изменений в патогенезе кардиоваскулярных расстройств у этих пациентов. Заключение. С учетом полученных данных и возрастающего интереса к исследованию жесткости артерий как надежному предиктору кардиоваскулярного риска необходимы дальнейшие исследования в этом направлении для уточнения механизмов сердечно-сосудистых нарушений при подагре.

Objective. To estimate arterial rigidity parameters from noninvasive arteriographic readings in patients with gout and essential hypertension (EH). Subjects and methods. One hundred and twenty-eight patients with gout and EH were examined by noninvasive arteriography (Tensio Clinic TL1 arteriograph, Tensio Med, Hungary). Results. In patients with gout, central artery stiffness is higher than that in healthy individuals and patients with EH and characterized by the increases in pulse wave velocity and augmentation index. Impaired arterial rigidity suggests that these changes play a prominent role in the pathogenesis of cardiovascular disorders in these patients. Conclusion. By taking into account the findings and an increasing interest in the study of arterial stiffness as a reliable predictor of cardiovascular risk, there is a need for further investigations in this area to specify the mechanisms of cardiovascular disorders in gout.

подаграартериальная гипертензияартериографияригидность сосудовскорость пульсовой волныиндекс аугментацииgoatessential hypertensionarteriographyvascular rigiditypulse wave velocityaugmentation indexReferences<div><p>Emmerson B. Hyperlipidemia in hyperuricemia and gout. Ann Rheum Dis 1998; 57: 509-10.</p><p>Vazguez-Mellado J., Garsia C.G., Vazguez S.G. et al. Metabolic syndrome and ischemic heart disease in gout. J Clin Rheumatol 2004; 10(3): 105-9.</p><p>Ильина А.Е., Барскова В.Г., Насонов Е.Л. Подагра, гиперурикемия и кардиоваскулярный риск. Науч.-практич. ревматол. 2009; 1: 55-8.</p><p>Laurent S., Cockcroft J., van Bortel L. et al. The European Network for Non-invasive Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 2006; 27(21): 2588-605.</p><p>Диагностика и лечение артериальной гипертонии. Рекомендации Российского медицинского общества по артериальной гипертонии и Всероссийского научного общества кардиологов. М., 2008.</p><p>O'Rourke M.F. Arterial function in health and disease. Edinburg: Churchill Livingstone, 1982; 182 p.</p><p>Laurent S., Katsahian S., Fassot C. et al. Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke 2003; 34(5): 1203-6.</p><p>Zieman S.J., Melenovsky V., Kass D.A. Mechanisms, Pathophysiology and Therapy of Arterial Stiffness. Arterioscler Thromb Vasc Biol 2005; 25: 932-43.</p><p>Baulmann J., Schillings U., Rickert S. et al. A new oscillometric method for assessment of arterial stiffness: comparison with tonometric and piezo-electronic methods. J Hypertension 2008; 26(3): 523-8.</p><p>Arteriograph Tensio Clinic and its program Tensio Clinic. User's manual. Early diagnosis of arteriosclerosis. [Электронный ресурс] http://www.tensiomed.com</p><p>Chen С.Н., Nevo E., Fetics B. et al. Estimation of Central Aortic Pressure Waveform by Mathematical Transformation of Radial Tonometry Pressure: Validation of Generalized Transfer Function. Circulation 1997; 95: 1827-36.</p><p>Asmar R., Blacher J., Djane S. et al. Aоrtic pulse wave velocity as a markers of cardiovascular risk hypertensive patients. Hypertension 1999; 33: 1111-7.</p><p>Wallace K.L., Riedel A.A., Joseph-Ridge N., Wortmann R. Increasing prevalence of gout and hyperuricemia over 10 years among older adult in managed care population. J Rheumatol 2004; 31: 1582-7.</p><p>Кочкина М.С., Затейщиков Д.А., Сидоренко Б.А. Измерение жесткости сосудов и ее клиническое значение. Кардиология 2005; 1: 63-71.</p><p>Asmar R., Benetos A., Topouchian J. et al. Assessment of arterial distensibility by automatic pulse wave velocity measurement. Hypertension 1995; 3: 485-90.</p><p>Mitchell G.F., Parise H., Benjamin E.J. et al. Changes in arterial stiffness and wave reflection with advancing age in healthy men and women. The Framingham Heart Study. Hypertension 2004; 43: 1183-90.</p><p>Fang J., Alderman M. Serum uric acid and cardiovascular mortality: The NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey. JAMA 2000; 238: 2404-10.</p><p>Brand F.N., McGee D.L., Kannel W.B. et al. Hyperuricemia as a risk factor of coronary heart disease: The Framingham Study Am J Epidemiol 1985; 121: 11.</p><p>Khaodhiar L., McCowen K.C., Blackburn G.L. Obesity and comorbid conditions. Clin Cornestone 1999; 2(3): 17-31.</p><p>Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med 1999; 340: 115-26.</p><p>Насонов Е.Л., Насонова В.А., Барскова В.Г. Механизмы развития подагрического воспаления. Тер. арх. 2006; 6(78): 77-84.</p><p>Schumacher H.R. Cristal-induced arthritis: an overview. Am J Med 1996; 100: 46-52.</p><p>Simon A.C., Levenson J., Safar M.E., Avolio A.P. Evidence of early degenerative changes in large arteries in human essential hypertension. Hypertension 1985; 7(5): 675-80.</p><p>Van Popele N.M., Grobbee D.E., Bots M.L. et al. Association between arterial stiffness and atherosclerosis: the Rotterdam Study. Stroke 2001; 32: 454-60.</p><p>Liu H., Yambe T., Zhang X. et al. Comparison of brachial-ankle pulse wave velocity in Japanese and Russians. Tohoko J Exp Med 2005; 207: 263-70.</p><p>Tomiyama H., Yamashina A., Arai T. Influence of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement of a survey of 12517 subjects. Atherosclerosis 2003; 166: 303-9.</p><p>Vague J. The degree of masculine differentiation of obesities a factor determining predisposition to diabetes, atherosclerosis, gout and uric calculous disease. Am J Clin Nulr 1956; 4(2): 20-34.</p><p>Myers A., Epstein F.H., Dodge H.J. et al. The relationship of serum uric acid to risk factors in coronary heart disease. Am J Med 1968; 45: 520-8.</p><p>Camus J.P. Goutte, diabete, hyperlipemie: un trisyndtrom metabolique. Rev Rhumatol 1966; 33: 10-4.</p><p>Wyngaarden J.B., Kelley W.N. Gout and hyperuricemia. New York, 1976; 512 р.</p><p>Zhang W., Dohetry M., Bardin T. et al. EULAR evidence based recommendations for gout. Part II: Management. Report of a task forse of the EULAR Standing Committee For International Clinic Studies Including Therapeutics (ESCISIT). Ann Rheum Dis 2005; 65(10): 1312-24.</p><p>Sweet C.S., Brandstreet D.C., Berman R.S. et al. Pharmacodynamic activity of intravenous E-3174, an angiotensin II antagonist, in patients with essential hypertension. Am J Hypertens 1994; 7(12): 1035-40.</p><p>Hoieggen A., Aiderman M.H., Kjeldsen S.E. et al. The impact of serum uric acid on cardiovascular outcomes in the LIFE study. Kidney Int 2004; 65: 1041-9.</p><p>Jones D.W., Hall J.E. Hypertension: pathways to success. Hypertension 2008; 51(5): 1249-51.</p></div><br /><div><p>Emmerson B. Hyperlipidemia in hyperuricemia and gout. Ann Rheum Dis 1998; 57: 509-10.</p><p>Vazguez-Mellado J., Garsia C.G., Vazguez S.G. et al. Metabolic syndrome and ischemic heart disease in gout. J Clin Rheumatol 2004; 10(3): 105-9.</p><p>Ильина А.Е., Барскова В.Г., Насонов Е.Л. Подагра, гиперурикемия и кардиоваскулярный риск. Науч.-практич. ревматол. 2009; 1: 55-8.</p><p>Laurent S., Cockcroft J., van Bortel L. et al. The European Network for Non-invasive Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 2006; 27(21): 2588-605.</p><p>Диагностика и лечение артериальной гипертонии. Рекомендации Российского медицинского общества по артериальной гипертонии и Всероссийского научного общества кардиологов. М., 2008.</p><p>O'Rourke M.F. Arterial function in health and disease. Edinburg: Churchill Livingstone, 1982; 182 p.</p><p>Laurent S., Katsahian S., Fassot C. et al. Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke 2003; 34(5): 1203-6.</p><p>Zieman S.J., Melenovsky V., Kass D.A. Mechanisms, Pathophysiology and Therapy of Arterial Stiffness. Arterioscler Thromb Vasc Biol 2005; 25: 932-43.</p><p>Baulmann J., Schillings U., Rickert S. et al. A new oscillometric method for assessment of arterial stiffness: comparison with tonometric and piezo-electronic methods. J Hypertension 2008; 26(3): 523-8.</p><p>Arteriograph Tensio Clinic and its program Tensio Clinic. User's manual. Early diagnosis of arteriosclerosis. [Электронный ресурс] http://www.tensiomed.com</p><p>Chen С.Н., Nevo E., Fetics B. et al. Estimation of Central Aortic Pressure Waveform by Mathematical Transformation of Radial Tonometry Pressure: Validation of Generalized Transfer Function. Circulation 1997; 95: 1827-36.</p><p>Asmar R., Blacher J., Djane S. et al. Aоrtic pulse wave velocity as a markers of cardiovascular risk hypertensive patients. Hypertension 1999; 33: 1111-7.</p><p>Wallace K.L., Riedel A.A., Joseph-Ridge N., Wortmann R. Increasing prevalence of gout and hyperuricemia over 10 years among older adult in managed care population. J Rheumatol 2004; 31: 1582-7.</p><p>Кочкина М.С., Затейщиков Д.А., Сидоренко Б.А. Измерение жесткости сосудов и ее клиническое значение. Кардиология 2005; 1: 63-71.</p><p>Asmar R., Benetos A., Topouchian J. et al. Assessment of arterial distensibility by automatic pulse wave velocity measurement. Hypertension 1995; 3: 485-90.</p><p>Mitchell G.F., Parise H., Benjamin E.J. et al. Changes in arterial stiffness and wave reflection with advancing age in healthy men and women. The Framingham Heart Study. Hypertension 2004; 43: 1183-90.</p><p>Fang J., Alderman M. Serum uric acid and cardiovascular mortality: The NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey. JAMA 2000; 238: 2404-10.</p><p>Brand F.N., McGee D.L., Kannel W.B. et al. Hyperuricemia as a risk factor of coronary heart disease: The Framingham Study Am J Epidemiol 1985; 121: 11.</p><p>Khaodhiar L., McCowen K.C., Blackburn G.L. Obesity and comorbid conditions. Clin Cornestone 1999; 2(3): 17-31.</p><p>Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med 1999; 340: 115-26.</p><p>Насонов Е.Л., Насонова В.А., Барскова В.Г. Механизмы развития подагрического воспаления. Тер. арх. 2006; 6(78): 77-84.</p><p>Schumacher H.R. Cristal-induced arthritis: an overview. Am J Med 1996; 100: 46-52.</p><p>Simon A.C., Levenson J., Safar M.E., Avolio A.P. Evidence of early degenerative changes in large arteries in human essential hypertension. Hypertension 1985; 7(5): 675-80.</p><p>Van Popele N.M., Grobbee D.E., Bots M.L. et al. Association between arterial stiffness and atherosclerosis: the Rotterdam Study. Stroke 2001; 32: 454-60.</p><p>Liu H., Yambe T., Zhang X. et al. Comparison of brachial-ankle pulse wave velocity in Japanese and Russians. Tohoko J Exp Med 2005; 207: 263-70.</p><p>Tomiyama H., Yamashina A., Arai T. Influence of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement of a survey of 12517 subjects. Atherosclerosis 2003; 166: 303-9.</p><p>Vague J. The degree of masculine differentiation of obesities a factor determining predisposition to diabetes, atherosclerosis, gout and uric calculous disease. Am J Clin Nulr 1956; 4(2): 20-34.</p><p>Myers A., Epstein F.H., Dodge H.J. et al. The relationship of serum uric acid to risk factors in coronary heart disease. Am J Med 1968; 45: 520-8.</p><p>Camus J.P. Goutte, diabete, hyperlipemie: un trisyndtrom metabolique. Rev Rhumatol 1966; 33: 10-4.</p><p>Wyngaarden J.B., Kelley W.N. Gout and hyperuricemia. New York, 1976; 512 р.</p><p>Zhang W., Dohetry M., Bardin T. et al. EULAR evidence based recommendations for gout. Part II: Management. Report of a task forse of the EULAR Standing Committee For International Clinic Studies Including Therapeutics (ESCISIT). Ann Rheum Dis 2005; 65(10): 1312-24.</p><p>Sweet C.S., Brandstreet D.C., Berman R.S. et al. Pharmacodynamic activity of intravenous E-3174, an angiotensin II antagonist, in patients with essential hypertension. Am J Hypertens 1994; 7(12): 1035-40.</p><p>Hoieggen A., Aiderman M.H., Kjeldsen S.E. et al. The impact of serum uric acid on cardiovascular outcomes in the LIFE study. Kidney Int 2004; 65: 1041-9.</p><p>Jones D.W., Hall J.E. Hypertension: pathways to success. Hypertension 2008; 51(5): 1249-51.</p></div><br />

The authors declare that there are no conflicts of interest present.