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Treat-to-target SLE strategy in 10 years: Discussion of current limitations and available options for implementation in real-world clinical practice

https://doi.org/10.47360/1995-4484-2025-229-238

Abstract

In January 2013, at the initiative of the world’s leading rheumatologists Ronald F. van Vollenhoven, Josef Smolen, Marta Mosca and Matthias Schneider, a project was launched to create the “Treat-to-Target” concept for systemic lupus erythematosus (SLE). In 2014, the group published recommendations “Treat-to-Target for SLE”. The article discusses the problems of implementing the strategy in real clinical practice and discusses the proposed ways of its implementation, proposed by international experts in 2025: 5 basic principles and 11 statements.

About the Authors

E. A. Aseeva
V.A. Nasonova Research Institute of Rheumatology
Russian Federation

Elena A. Aseeva.

115522, Moscow, Kashirskoye Highway, 34A


Competing Interests:

None



S. K. Solovyev
V.A. Nasonova Research Institute of Rheumatology
Russian Federation

Sergey K. Solovyev.

115522, Moscow, Kashirskoye Highway, 34A


Competing Interests:

None



E. A. Pletnev
V.A. Nasonova Research Institute of Rheumatology
Russian Federation

Evgenii A. Pletnev.

115522, Moscow, Kashirskoye Highway, 34A


Competing Interests:

None



G. M. Koilubaeva
National Center for Cardiology and Therapy named after Academician Mirsaid Mirrahimov of the Ministry of Health of the Kyrgyz Republic
Kyrgyzstan

Gulazik M. Koilubaeva.

720040, Bishkek, Togoloka Moldo str., 3


Competing Interests:

None



B. G. Issayeva
Kazakh National Medical University named after S.D. Asfendiyarov
Kazakhstan

Bakytsholpan G. Issayeva.

050012, Almaty, Tole bi str., 94


Competing Interests:

None



E. L. Nasonov
V.A. Nasonova Research Institute of Rheumatology
Russian Federation

Evgeny L. Nasonov.

115522, Moscow, Kashirskoye Highway, 34A


Competing Interests:

None



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Aseeva E.A., Solovyev S.K., Pletnev E.A., Koilubaeva G.M., Issayeva B.G., Nasonov E.L. Treat-to-target SLE strategy in 10 years: Discussion of current limitations and available options for implementation in real-world clinical practice. Rheumatology Science and Practice. 2025;63(3):229-238. (In Russ.) https://doi.org/10.47360/1995-4484-2025-229-238

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ISSN 1995-4484 (Print)
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