Ингибиторы Янус-киназ при иммуновоспалительных заболеваниях: 10 лет клинической практики в ревматологии
https://doi.org/10.47360/1995-4484-2022-131-148
Аннотация
Несмотря на большие успехи в диагностике и лечении иммуновоспалительных ревматических заболеваний (ИВРЗ), приведшие к существенному улучшению прогноза у многих пациентов, центральные медицинские проблемы этой патологии – восстановление качества жизни и снижение летальности до популяционного уровня – далеки от разрешения. Это послужило мощным стимулом к изучению новых подходов к фармакотерапии ИВРЗ, один из которых связан с использованием низкомолекулярных химически синтезированных препаратов, ингибирующих внутриклеточные «сигнальные» молекулы – Янус-киназ (JAK, Janus kinase). Рассмотрены современные достижения, тенденции и рекомендации, касающиеся применения ингибиторов JAK в лечении ИВРЗ и COVID-19.
Об авторах
Е. Л. НасоновРоссия
Насонов Евгений Львович
115522, Москва, Каширское шоссе, 34а; 119991, Москва, ул. Трубецкая, 8, стр. 2
Конфликт интересов:
Авторы подтверждают, что получают гонорары за консультационные услуги в области научной и педагогической деятельности (образовательные услуги, научные статьи, участие в экспертных советах, участие в исследованиях и др.)
Т. В. Коротаева
Россия
115522, Москва, Каширское шоссе, 34а
Конфликт интересов:
Авторы подтверждают, что получают гонорары за консультационные услуги в области научной и педагогической деятельности (образовательные услуги, научные статьи, участие в экспертных советах, участие в исследованиях и др.)
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Рецензия
Для цитирования:
Насонов Е.Л., Коротаева Т.В. Ингибиторы Янус-киназ при иммуновоспалительных заболеваниях: 10 лет клинической практики в ревматологии. Научно-практическая ревматология. 2022;60(2):131-148. https://doi.org/10.47360/1995-4484-2022-131-148
For citation:
Nasonov E.L., Korotaeva T.V. Janus kinase inhibitors in immunoinflammatory diseases: 10 years of clinical practice in rheumatology. Rheumatology Science and Practice. 2022;60(2):131-148. (In Russ.) https://doi.org/10.47360/1995-4484-2022-131-148