Коронавирусная болезнь 2019 (COVID-19) у детей: уроки педиатрической ревматологии
Аннотация
Клиническая картина и исходы коронавирусной болезни 2019 (coronavirus disease – COVID-19) зависят от многих факторов, одним из которых является возраст пациента. Одним из тяжелых жизнеугрожающих проявлений у взрослых является острый респираторный дистресс-синдром (ОРДС), в ряде случаев сопровождающийся развитием полиорганной недостаточности. В течение первых месяцев пандемии COVID-19 сложилось мнение, что у детей это заболевание, как правило, протекает в легкой форме и не приводит к летальному исходу. Однако по мере накопления новых сведений стала очевидной возможность тяжелого течения COVID-19 у детей, приводящего к развитию патологии, получившей название «мультисистемный воспалительный синдром» (Multisystem inflammatory syndrome in children – MIS-C). В статье обсуждаются эпидемиологические, клинические и лабораторные характеристики MIS-C, подходы к дифференциальной диагностике с другими воспалительными заболеваниями у детей, предполагаемые механизмы иммунопатогенеза и перспективы фармакотерапии.
Об авторах
М. И. Каледа
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия
Россия
Каледа Мария Игоревна
115522, Москва, Каширское шоссе, 34а
И. П. Никишина
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия
115522, Москва, Каширское шоссе, 34а
Россия
115522, Москва, Каширское шоссе, 34а
Е. С. Федоров
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия
115522, Москва, Каширское шоссе, 34а
Россия
115522, Москва, Каширское шоссе, 34а
Е. Л. Насонов
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский Университет)
Россия
115522, Москва, Каширское шоссе, 34а
119991, Москва, ул. Трубецкая, 8, стр. 2
Россия
115522, Москва, Каширское шоссе, 34а
119991, Москва, ул. Трубецкая, 8, стр. 2
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Рецензия
Для цитирования:
Каледа М.И., Никишина И.П., Федоров Е.С., Насонов Е.Л. Коронавирусная болезнь 2019 (COVID-19) у детей: уроки педиатрической ревматологии. Научно-практическая ревматология. 2020;58(5):469-479. https://doi.org/10.47360/1995-4484-2020-469-479
For citation:
Kaleda M.I., Nikishina I.P., Fedorov E.S., Nasonov E.L. Coronavirus Desease 2019 (COVID-19) in Children: Lessons from Pediatric Rheumatology. Rheumatology Science and Practice. 2020;58(5):469-479. https://doi.org/10.47360/1995-4484-2020-469-479
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