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Научно-практическая ревматология

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Белимумаб в лечении системной красной волчанки: 20 лет фундаментальных исследований, 10 лет клинической практики

https://doi.org/10.47360/1995-4484-2021-367-383

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Аннотация

В настоящее время получены веские доказательства фундаментальной роли патологической активации В-клеток в патогенезе иммуновоспалительных (аутоиммунных) ревматических заболеваний (ИВРЗ), а препараты, специфически модулирующие функцию или вызывающие истощение (depletion) различных субпопуляций В-клеток и плазматических клеток, рассматриваются как перспективное направление фармакотерапии этих заболеваний. Особый интерес представляет белимумаб (БЛМ) – человеческие моноклональные антитела (мАТ) (IgG1λ) к BAFF (B cell activating factor belonging to the TNF family), – который является первым «таргетным» генно-инженерным биологическим препаратом, специально разработанным для лечения системной красной волчанки (СКВ). Эффективность и безопасность БЛМ при СКВ у взрослых и детей, включая волчаночный нефрит, в комбинированной терапии с ритуксимабом, стероид-сберегающее действие, способность предотвращать необратимое поражение внутренних органов диктуют необходимость более широкого его применения в клинической практике.

Об авторах

Е. Л. Насонов
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский Университет)
Россия

115522, Российская Федерация, Москва, Каширское шоссе, 34а

119991, Российская Федерация, Москва, ул. Трубецкая, 8, стр. 2



Т. В. Попкова
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия

115522, Российская Федерация, Москва, Каширское шоссе, 34а



А. М. Лила
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России
Россия

115522, Российская Федерация, Москва, Каширское шоссе, 34а

125993, Российская Федерация, Москва, ул. Баррикадная, 2/1, стр. 1



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Для цитирования:


Насонов Е.Л., Попкова Т.В., Лила А.М. Белимумаб в лечении системной красной волчанки: 20 лет фундаментальных исследований, 10 лет клинической практики. Научно-практическая ревматология. 2021;59(4):367-383. https://doi.org/10.47360/1995-4484-2021-367-383

For citation:


Nasonov E.L., Popkova T.V., Lila A.M. Belimumab in the treatment of systemic lupus erythematosus: 20 years of basic research, 10 years of clinical practice. Rheumatology Science and Practice. 2021;59(4):367-383. (In Russ.) https://doi.org/10.47360/1995-4484-2021-367-383

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ISSN 1995-4484 (Print)
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