Antidepressants administration in rheumatoid arthritiswith comorbid depression
https://doi.org/10.14412/1995-4484-2009-141
Abstract
Objective. To study comorbid depression influence on course of rheumatoid arthritis (RA)and antidepressants efficacy in such pts. Material and methods. 70 pts with RA (all women) fulfilled the 1987 ACR criteria with comorbid depression disturbances were included. 30 from them received course of treatment with antidepressants (main group). 20 refused proposed therapy (main control group). 20 RA pts without depression were included in an additional control group which was also followed up. Hamilton scales of depression and anxiety were used. Results. Baseline clinical measures did not significantly differ between study groups. Antidepressants application in main group pts was accompanied by significant improvement of tender and swollen joint count, morning stiffness duration, pain intensity (score),functional disability index (FDI) after 3 months (<0,001,<0,001, <0,01, <0,001,<0,001). This improvement further increased to sixth month of follow up. Comparison of main and additional control groups showed better outcome in the absence of comorbid depression and its negative influence on results of treatment. Conclusion. Effective treatment of depression with modern antidepressants (selective inhibitors of reverse serotonin capture) in pts with RA improves clinical course of the disease, its prognosis and pts quality of life.
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Yaltseva N.V., Grigorjeva E.A., Korshunov N.I. Antidepressants administration in rheumatoid arthritiswith comorbid depression. Rheumatology Science and Practice. 2009;47(1):43-49. (In Russ.) https://doi.org/10.14412/1995-4484-2009-141
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