ANALYSIS OF DISEASE MODIFYING DRUGS ADMINISTRATION FREGUENCY AND CAUSES OF THEIR WITHDRAWAL IN RHEUMATOID ARTHRITIS

Aim of studdy: To assess the frequency of practical application of different basic drugs in rheumatoid arthritis (RA). Material and methods: Tlxe study was conducted basing of questionner of pts and analysis of ycases by randomized sampling among 103 consequent pts (M:F= 13:90) with reliable RA (ARA, 1987) in rheumatologic department of Clinical Hospital Nol in Ekaterinburg. 74% of pts under study demonstrated systemic manifestations: anemia (in 47 pts), lymphadenopathy (in 34), rheumatoid nodules (in 15), Sjogren s syndrome (in 4), nephropathy (in 4), vascular disturbances including Raynaud s phenomenon, capillarites (by 1 pt). Results: In the course of disease basic therapy was prescribed to 88 out of103 (85.4%) pts and one and the same patient could take different basic drugs. Aminochinoline drugs prevailed, after them more frequent were immunodepressants and gold preparations. More rarely pts had sulfasalazin, cuprenil and wobenzym. In general, in 133 out of 184 cases of prescribing basic drugs they were canceled. The reason for cancellation were: prevalently absence of the drug in the pharmaceutical stores (in 48 cases) averagely in 8 months of taking the drug; then they insufficient efficacy (44 cases) averagely in 1.3 year. In 18 cases pts themselves stopped treatment averagely in 3.5 months of drug taking. Conclusion: In the majority of cases of basic drugs cancellation in RA the cause is their absence in sail especially on free of charge prescription. Cases ofself-cancellation of the drug demonstrate the need of explaining to pts the necessity> of long-term taking disease-modifying drugs.

Rheumatoid arthritis, basic drugs, aminocholine drugs, Sulfosalazin, immunodepressants, gold preparations, Cuprenil

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