Остеопороз и кардиоваскулярные заболевания
https://doi.org/10.14412/1995-4484-2009-1148
Аннотация
Цель. Изучить возможную связь между остеопорозом (ОП) и кардиоваскулярными заболеваниями (КВЗ) у женщин в постменопаузальном периоде. Материал и методы. В исследовании приняли участие 98 жен. в возрасте от 45 до 70 лет с менопаузой. Группа ОП- 50 чел. и группа сравнения 48 чел. Диагноз ОП ставился на основании данных денситометрии (показатели денситометрии в области позвоночника и проксимального отдела бедра меньше -2,5 SD и больше -1 SD по Т критерию, соответственно). Проводилось анкетирование по основным факторам риска (ФР) развития ОП и КВЗ, оценивались биохимические показатели липидного и минерального обменов, данные функциональных обследований (ЭКГ, Эхо-КГ, УЗДГ сонных артерий и сосудов нижних конечностей, денситометрия). Результаты. По большинству показателей не было выявлено значимых различий между группами сравнения. В группе жен. без ОП отмечалось более позднее начало менопаузы (50 vs 47 лет, р=0,005), большее число детей в семье (2 vs 1, р=0,01). Различия по другим ФР не выявлены. Не отмечено различий между группами по показателям минерального и липидного обменов, данным ЭКГ обследования, показателям Эхо-КГ (уплотнение аорты и клапанного аппарата сердца). При УЗДГ обследовании (сравнение толщины комплекса интима/медиа) получены различия между группой нормы и ОП только в области луковицы правой общ. сонной арте- рии (0,96мм vs 1,03мм, р=0,02). Результаты. В данном одномоментном когортном исследовании не было выявлено определенной связи между ОП и КВЗ. Необходимы дальнейшие крупные комплексные исследования с использованием клинических, инструментальных и биохимических методов.
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Рецензия
Для цитирования:
Аникин С.Г., Беневоленмкая Л.И., Demin N.V., Mach E.S., Korsakova Y.O. Остеопороз и кардиоваскулярные заболевания. Научно-практическая ревматология. 2009;47(4):32-40. https://doi.org/10.14412/1995-4484-2009-1148
For citation:
Anikin S.G., Benevolenskaya L.I., Demin N.V., Mach E.S., Korsakova Y.O. Osteoporosis and cardiovascular diseases. Rheumatology Science and Practice. 2009;47(4):32-40. (In Russ.) https://doi.org/10.14412/1995-4484-2009-1148
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