Роль субхондральной кости при остеоартрозе
https://doi.org/10.14412/1995-4484-2009-1149
Аннотация
Остеоартроз (ОА) характеризуется прогрессивной потерей суставного хряща и, в противовес этому, усилением процесса костеобразования, склерозированием субхондральной кости (СХК) и пластинки роста и формированием остеофитов. Эти два противоположных процесса составляют основу патогенеза ОА. За последние десятилетия достигнут значительный прогресс в изучении этиологии и патогенеза заболевания, однако многие вопросы до сих пор остаются спорными. В частности, продолжает обсуждаться вопрос о том, какие изменения – в кости или хряще – следует считать первичными и что является пусковым фактором деградации суставного хряща.В настоящее время сформированы 2 основные теории патогенеза ОА. Первая из них получила распространение и была общепризнанной в 70-е годы прошлого века. Согласно этой теории, в основе ОА лежит первичная дегенерация суставного хряща вследствие нарушения обменных процессов. Среди причин, способных приводить к нарушению метаболизма хрящевой ткани, рассматривались генетические, эндокринные и иммунологические факторы, ухудшение кровообращения в тканях сустава и изменение физико-химических свойств синовиальной жидкости.
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Рецензия
Для цитирования:
Alexeeva L.I., Зайцева Е.М. Роль субхондральной кости при остеоартрозе. Научно-практическая ревматология. 2009;47(4):41-48. https://doi.org/10.14412/1995-4484-2009-1149
For citation:
Alexeeva L.I., Zaitseva E.M. Role of subchondral bone in osteoarthritis. Rheumatology Science and Practice. 2009;47(4):41-48. (In Russ.) https://doi.org/10.14412/1995-4484-2009-1149
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