Influence of combined therapy with prospidin and methotrexate on radiological progression, functional status and quality of life in pts with rheumatoid arthritis
https://doi.org/10.14412/1995-4484-2004-1479
Abstract
Objective. To evaluate influence of combination therapy with prospidin (P) and methotrexate (MTX) on X-ray progression, functional status (FS) and quality of life (QL) in patients with rheumatoid arthritis (RA) in comparison with MTX monotherapy. Material and methods. 143 RA pts (129 female and 14 male) were studied. Of them, there were. Mean age was 45.5±5.l years. Average duration of the disease was 4.5 years. 20 pts had II and 123 - 111 degree of RA activity. The second X-ray stage according to Steinbroker dominated. 72 pts of group I received P+MTX combination therapy. The therapy included intravenous drip-feed of P 200-300 mg per week in 200ml of 5% glucose and MTX 10 mg per week 1M. The maintaining therapy included P 100-200 mg per week IM and MTX 10 mg per week. 71 patients of group II received MTX monotherapy 10 mg per week. X-ray progression assessment was performed according to Sharp method. FS was evaluated with the HAQ questionnaire, Lee test. QL was evaluated with SF-36 scale. Pts were examined before and after I, 2, 3, 6 and 12 months of treatment. Results. There was no increase of X-ray progression of the disease in case of P+MTX therapy as compared with MTX monotherapy. Both methods resulted in improvement of FS parameters and physical health. Combination therapy significantly improved psychological health as well.
References
1. <div><p>Амирджанова В.Н., Койлубаева Г.М. Методология оценки качества жизни в практике ревматолога. Науч- но-практич. ревматол., 2003, 2, 72-76</p><p>Амирджанова В.Н., Койлубаева Г.М., Горячев Д.В. Изучение качества жизни больных ревматоидным артритом. Матер, конф. PROCEEDINGS. Санкт-Петербург, 2002, 107-108</p><p>Григорьева АЛ., Маслянский А.Л., Зоткнн Е.Г. Качество жизни больных ревматоидным артритом. Научно- практич. ревматол., 2003, 2, 23-25</p><p>Иванова М.М., Каратеев Д.Е., Акимова Т.Ф. и др. Клинические варианты течения ревматоидного артрита и прогноз болезни. Клинич. ревматол., 1994, 2, 5-9</p><p>Койлубаева Г.М., Амирджанова В.Н., Эрдес К.111. и др. Изучение качества жизни больных ревматоидным артритом. Научно-практич. ревматол., 2002, 4, 98-102</p><p>Крель А.А., Болотин Е.В., Каневская М.З. и др. Объективизация проявлений ревматоидного артрита, характеризующих его эволюцию. I. Метод количественной оценки выраженности эрозивного артрита и темпов его прогрессирования в суставах кистей и стоп. Во- пр. ревмат., 1981, 3, 11-15</p><p>Новик А.А, Ионова Т.Н., Кайнд П. Концепция исследования качества жизни в медицине. Санкт-Петербург, 1999, 140 с.</p><p>Новик А.А., Ионова Т.И., Шемеровская Т.Г. и др. Качество жизни больных ревматоидным артритом. Научно-практич. ревматол., 2001, 3, 81</p><p>Новик А.А., Ионова Т.И., Шемеровская Т.Г. и др. Динамика показателей качества жизни больных ревматоидным артритом в процессе лечения. Научно-практич. ревматол., 2001, 3, 81-84</p><p>Новик А.А., Ионова Т.И. Руководство по исследованию качества жизни в медицине. Санкт-Петербург.: "ОЛМА-ПРЕСС", 2002, 169-177</p><p>Сизова Л.В. Оценка качества жизни в современной медицине. Научно-практич. ревматол., 2003, 2, 38-46</p><p>Эрдес 111., Эрдес К.Ш. Вопросник SF-36 и использование его при ревматоидном артрите. Научно-практич. ревматол., 2003, 2, 47-52</p><p>Dougados М., Combe В., Caniagrel A et al. Combination therapy in early rheumatoid arthritis: a randomized, controlled, double blind 52 week clinical trial of sulphasalazine and methotrexate compared with the single components. Ann. Rheum. Dis., 1999, 58, 220-225</p><p>Kremer J.M. Concomitant leflunomide therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate. Ann. Int. Medicine, 2002, 137, 9, 726-733</p><p>Sokka Т., Mottonen T. Hannonen P. Disease-modifying anti-rheumatic drug use according to the 'sawtooth' treatment strategy improves the functional outcome in rheumatoid arthritis? results of a long-term follow-up study with review of the literature. Rheumatology, 2000, 39, 34-42</p><p>Ware J. E., Sherbourne C.D. The MOS 36-Item Ssort- Form Health Survey (SF-36). I. Conceptual framework and item selection. Medical Care, 1992,30, 473-483</p><p>Welsing P. M. J., van Gestel A. M. The relationship between disease activity, joint destruction, and functional capacity over the course of rheumatoid arthritis. Arthr. Rheum., 2001, 44, 9, 2009-2017</p><p>Wiles N.J., Scott D.G.I., Barrett E.M. et al. Benchmarcking the five year outcome of rheumatoid arthritis assessed using a pain score, the Health Assessment Questionnaire, and the Short Form-36 (SF-36) in a community and a clinic based sample. Ann. Rheum. Dis., 2001, 60, 956-96</p></div><br />
Review
For citations:
Simonova O.V., Nemtsov B.F., Politova N.N. Influence of combined therapy with prospidin and methotrexate on radiological progression, functional status and quality of life in pts with rheumatoid arthritis. Rheumatology Science and Practice. 2004;42(3):45-49. (In Russ.) https://doi.org/10.14412/1995-4484-2004-1479
Views:
874
Email this article 