Blood coagulation parameters and activity indices in patients with systemic lupus erythematosus

Objective. To assess coagulation parameters and activity indices in pts with systemic lupus erythematosus (SLE). Material and methods . 86 pts with SLE (83 female and 3 male) were examined. 12 of them had antiphospholipid syndrome. Mean age was 35,9±1,5 years (from 18 to 58 years), mean disease duration was 9,8+1,4 years. Control group consisted of 60 healthy volunteers with mean age 37,1+4,1 years. SLE activity assessment was performed with SLAM, SLEDAI and ECLAM indices. Results. SLE pts showed 5-fold (p<0,01) increase of spontaneous platelets aggregation and more than 3-fold increase of factor von Willebrand antigen (FWA) concentration. Platelet activation in pts was accompanied by decrease of platelet aggregation with collagen (on 27%), p<0,01. Characteristic sign of coagulation hemostasis activation was significant increase of soluble fibrin-monomer complexes (SFMC) concentration on 81 % (p<0,01) so as increase D-dimers level in 53,3% of pts. Fibrinogen concentration was increased on 29%, spontaneous fibrinolysis parameters were decreased on 20%, antithrombin (AT) 111 - on 21% in comparison with control. Direct correlation between activity indiccs and SFMC(ECLAM, r=0,5), fibrinogen concentration (SLAM, r=0,34), D- dimers level (ECLAM, r=0,5), spontaneous platelet aggregation (ECLAM, r=0,5) so as inverse correlation with AT III activity (SLEDAI, r-0,73) was revealed. Conclusion. Changes of hemostasis parameters in SLE may serve as predictors of thrombotic disorders development and indication to drug correction of blood coagulation disorders. Direct correlation between blood coagulation system activity and indices of SLE activity.

SLE, antithrombin III, D-dimer, soluble fibrin-monomer complexes, activity indices

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