Интерлейкин 17 – новая мишень для антицитокиновой терапии иммуновоспалительных ревматических заболеваний
https://doi.org/10.14412/1995-4484-2013-1547
Аннотация
В настоящее время достигнуты значительные успехи в лечении иммуновоспалительных ревматических заболеваний, связанные с расшифровкой фундаментальных патогенетических механизмов их развития. Наиболее хорошо изученными терапевтическими «мишенями» являются фактор некроза опухоли α, интерлейкин 6 (ИЛ6) и ИЛ1, однако ингибиция этих цитокинов с использованием генно-инженерных биологических препаратов не всегда клинически эффективна и редко приводит к развитию ремиссии. Новое перспективное направление в лечении ревматоидного артрита (РА) и других воспалительных артритов связывают с ингибицией ИЛ17А, провоспалительного цитокина, участвующего в развитии воспаления и деструкции костной ткани. В статье суммированы новые данные, касающиеся перспектив применения моноклональных антител к ИЛ17 для лечения РА.
Об авторах
Евгений Львович Насонов
ФГБУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
РАМН, Москва
Россия
Россия
L N Denisov
ФГБУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
РАМН, Москва
Россия
Россия
M L Stanislav
ФГБУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
РАМН, Москва
Россия
Россия
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Рецензия
Для цитирования:
Насонов Е.Л., Denisov L.N., Stanislav M.L. Интерлейкин 17 – новая мишень для антицитокиновой терапии иммуновоспалительных ревматических заболеваний. Научно-практическая ревматология. 2013;51(5):545-552. https://doi.org/10.14412/1995-4484-2013-1547
For citation:
Nasonov E.L., Denisov L.N., Stanislav M.L. INTERLEUKIN-17 IS A NEW TARGET FOR ANTI-CYTOKINE THERAPY OF IMMUNE INFLAMMATORY RHEUMATIC DISEASES. Rheumatology Science and Practice. 2013;51(5):545-552. (In Russ.) https://doi.org/10.14412/1995-4484-2013-1547
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