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Научно-практическая ревматология

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Создание и применение диагностического индекса, основанного на многопараметрическом анализе биомаркеров, для определения активности ревматоидного артрита

https://doi.org/10.14412/1995-4484-2014-72-78

Аннотация

Ревматоидный артрит (РА) – гетерогенное заболевание, в основе патогенеза которого лежит сложное сочетание генетически детерминированных и приобретенных дефектов регуляторных механизмов, ограничивающих gатологическую активацию иммунной системы в ответ на потенциально патогенные и нередко на физиологические стимулы. Современные противоревматические препараты позволяют эффективно подавлять воспалительный процесс и в значительной мере сдерживать прогрессирование болезни. Однако их потенциал может быть реализован в полной мере лишь при использовании соответствующей тактики лечения, при этом регулярный контроль активности заболевания является ключевым компонентом ведения больных РА. Количественная оценка статуса пациента дает возможность разрабатывать стандартизованные показания для применения противоревматической терапии. Применение для оценки активности заболевания клинических индексов не позволяет добиться полной объективности получаемых результатов. Создаются диагностические индексы, основанные на многопараметрическом анализе биомаркеров. Накопление информации об особенностях белкового профиля при РА привело к созданию индекса для определения активности заболевания, основанного на измерении концентраций биомаркеров, ассоциирующихся со значениями как клинических индексов, так и их компонентов (multi-biomarker disease activity, MBDA) – VECTRA DA. В настоящее время MBDA является единственным клинически апробированным лабораторным индексом, который может быть использован для мониторинга активности РА, прогнозирования степени прогрессирования деструктивного поражения суставов, эффективности проводимой терапии.

Об авторах

А. А. Новиков
ФГБУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой» РАМН, Москва, Россия
Россия


Елена Николаевна Александрова
ФГБУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой» РАМН, Москва, Россия
Россия


Евгений Львович Насонов
ФГБУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой» РАМН, Москва, Россия
Россия


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Рецензия

Для цитирования:


Новиков А.А., Александрова Е.Н., Насонов Е.Л. Создание и применение диагностического индекса, основанного на многопараметрическом анализе биомаркеров, для определения активности ревматоидного артрита. Научно-практическая ревматология. 2014;52(1):72-78. https://doi.org/10.14412/1995-4484-2014-72-78

For citation:


Novikov A.A., Aleksandrova E.N., Nasonov E.L. ELABORATION AND APPLICATION OF THE DIAGNOSTIC INDEX BASED ON MULTIVARIATE ANALYSIS OF BIOMARKERS TO DETERMINE THE ACTIVITY OF RHEUMATOID ARTHRITIS. Rheumatology Science and Practice. 2014;52(1):72-78. (In Russ.) https://doi.org/10.14412/1995-4484-2014-72-78

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ISSN 1995-4484 (Print)
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