Терапия генно-инженерными биологическими препаратами и инфекции у больных ревматоидным артритом: актуальность и перспективы
Аннотация
В последние десятилетия в ревматологии отмечается явный прогресс, связанный с внедрением в практику генно-инженерных биологических препаратов (ГИБП). В то же время применение этих препаратов ассоции- руется с нарастающим риском развития инфекций разнообразной природы и локализации, включая оппорту- нистические (инвазивные микозы, пневмоцистная пневмония и др.), а также с повышенным риском реакти- вации латентной инфекции, в первую очередь туберкулеза. Помимо этого, регистрируются случаи тяжелых инфекций (пневмония, сепсис, бактериальный артрит, поражение кожи и мягких тканей и др.), в том чис-
ле с летальным исходом. В настоящем обзоре проанализированы данные литературы, преимущественно пос- ледних 3 лет, касающиеся частоты и локализации инфекций при лечении различными ГИБП, полученные
в рамках плацебоконтролируемых и прямых сравнительных исследований у больных ревматоидным артри- том. Охарактеризована значимость различных инфекций (туберкулез, пневмонии, хронические вирусные ге- патиты, герпесвирусные инфекции и др.) в тактике курации указанных больных. Подчеркнута необходимость более широкого применения иммунизации различными вакцинами (в первую очередь, пневмококковой
и противогриппозной) пациентов с аутоиммунными воспалительными ревматическими заболеваниями.
Ключевые слова
Об авторе
Б. С. Белов
ФГБУ «Научно- исследовательский институт ревматологии им. В.А. Насоновой» РАН, Москва, Россия
Россия
Россия
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Для цитирования:
Белов Б.С. Терапия генно-инженерными биологическими препаратами и инфекции у больных ревматоидным артритом: актуальность и перспективы. Научно-практическая ревматология. 2014;52(3):322-330. https://doi.org/10.14412/1995-4484-2014-322-330
For citation:
Belov B.S. BIOLOGICAL THERAPY AND INFECTIONS IN PATIENTS WITH RHEUMATOID ARTHRITIS: RELEVANCE AND PROSPECTS. Rheumatology Science and Practice. 2014;52(3):322-330. (In Russ.) https://doi.org/10.14412/1995-4484-2014-322-330
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