RUSVISK: DOMESTICALLY DEVELOPED PRODUCT OF HYALURONIC ACID: ASSESSMENT OF EFFICACY AND SAFETY IN EARLY STAGES OF THE KNEE OSTEOARTHRITIS
https://doi.org/10.14412/1995-4484-2014-538-544
Abstract
Objective: to compare the efficacy and safety of intra-articular therapy with Rusvisk (hyaluronic acid product) and Ostenil in early stages of knee osteoarthritis.
Subjects and methods. 50 patients with II–III stage of the knee osteoarthritis were included in the randomized double blinded controlled study. They had pain at movement of more than 40 mm by visual analogue scale (VAS) and Lequesne index of 4–12. All patients received a course of three intra-articular injections with products of hyaluronic acid at the interval of 7 days. Rusvisk (molecular weight 3500 kDa) was administered to 25 patients, whereas other 25 received Ostenil (molecular weight 1200–1400 kDa). In 1, 2, 3 weeks after the first injection following criteria were registered: changes of WOMAC index, pain at movement and at rest by VAS, general assessment of therapy efficacy by doctor and patient, assessment of efficacy according to OMERACTOARSI.
Results. In three weeks after the first injection a significant decrease of pain at movement (by 69% in Rusvisk group and by 55% in Ostenil group) and of WOMAC index (by 63% in Rusvsik group and by 60% in Ostenil group) was achieved in both groups without any differences between them. Significant decrease of pain at rest was observed at all visits only in Rusvisk group. When assessing the general efficacy, patients found more advantagesin the domestic product, whereas the therapist did not see the differences between groups. Response to the therapy by OMERACT-OARSI criteria was observed in 88% of patients in Rusvisk group and in 64% in Ostenil group. Short-term pain in the site of injection was mentioned by 64% of patients from Rusvisk group and by 72% from Ostenil group.
Conclusion. Intra-articular therapy with the products of hyaluronic acid «Rusvisk», «Ostenil» provides comparable decrease of pain and improvement of functional parameters in patients with knee osteoarthritis.
About the Authors
N. V. Vas'kova
Ural State Medicine University, Yekaterinburg, Russia
Russian Federation
Russian Federation
O. M. Lesnyak
Ural State Medicine University, Yekaterinburg, Russia
Russian Federation
Russian Federation
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Review
For citations:
Vas'kova N.V., Lesnyak O.M. RUSVISK: DOMESTICALLY DEVELOPED PRODUCT OF HYALURONIC ACID: ASSESSMENT OF EFFICACY AND SAFETY IN EARLY STAGES OF THE KNEE OSTEOARTHRITIS. Rheumatology Science and Practice. 2014;52(5):538-544. (In Russ.) https://doi.org/10.14412/1995-4484-2014-538-544
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