Остеоартроз и ожирение
https://doi.org/10.14412/1995-4484-2015-542-552
Аннотация
обзоре освещены проблемы влияния ожирения на развитие, прогрессирование, тяжесть остеоартроза (ОА), обсуждаются методы лечения ожирения при этом заболевании. Показано, что снижение массы тела у пациентов с ожирением и ОА ведет к уменьшению клинических проявлений. Несмотря на множество проведенных исследований по влиянию немедикаментозной терапии ожирения у больных ОА (диета, физическая активность), результаты остаются противоречивыми и требуют дальнейшего изучения.
Об авторах
Е. А. Стребкова
ФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой, Москва, Россия 115522 Москва, Каширское шоссе, 34
Россия
Россия
Л. И. Алексеева
ФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой, Москва, Россия 115522 Москва, Каширское шоссе, 34
Россия
Россия
Список литературы
1. Алексеева ЛИ, Цветкова ЕС. Остеоартроз: из прошлого в будущее. Научно-практическая ревматология. 2009;(прил. 2):31–7 [Alekseeva LI, Tsvetkova ES. Osteoarthritis: from past to future. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2009;(Suppl. 2):31–7 (In Russ.)].
2. Аметов АС, Доскина ЕВ. Ожирение и современные методы лечения: Лекция для врачей. Москва: РМАПО; 2011. 3 c. [Ametov AS, Doskina EV. Ozhirenie i sovremennye metody lecheniya: Lektsiya dlya vrachei [Obesity and modern methods of treatment: A lecture for physicians]. Moscow: RMAPO; 2011. 3 p.].
3. Yusuf E. Metabolic factors in osteoarthritis: obese people do not walk on their hands. Arthritis Res Ther. 2012 Jul 19;14(4):123. doi: 10.1186/ar3894
4. Lementowski PW, Zelicof SB. Obesity and osteoarthritis. Amer J Orthoped. 2008;37(3):148.
5. Насонов ЕЛ, редактор. Ревматология. Клинические рекомендации. Москва; 2010. С. 326 [Nasonov EL, editor. Revmatologiya. Klinicheskie rekomendatsii [Rheumatology. Clinical Recommendations]. Moscow; 2010. P. 326].
6. Алексеева ЛИ. Препараты замедленного действия в лечении остеоартроза. Русский медицинский журнал. 2012;(7):389–93 [Alekseeva LI. Preparations delayed action in the treatment of osteoarthritis. Russkii meditsinskii zhurnal. 2012;(7):389–93 (In Russ.)].
7. Галушко Е.А. Медико-социальная значимость ревматических заболеваний: Дисс. … докт. мед наук. Москва; 2013 [Galushko E.A. Mediko-sotsial'naya znachimost' revmaticheskikh zabolevanii: Diss. … dokt. med nauk [Medical and social significance of rheumatic diseases: Diss. ... Doctor med. sci.]. Moscow; 2013].
8. Фоломеева ОМ, Галушко ЕА, Эрдес ШФ. Распространенность ревматических заболеваний в популяциях взрослого населения России и США. Научно-практическая ревматология. 2008;(4):4–13 [Folomeeva OM, Galushko EA, Erdes ShF. The prevalence of rheumatic diseases in populations of the adult population of Russia and the United States. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2008;(4):4–13 (In Russ.)].
9. Lee R, Kean WF. Obesity and knee osteoarthritis. Inflammopharmacology. 2012 Apr;20(2):53–8. doi: 10.1007/s10787-011-0118-0
10. Goldring MB, Goldring SR. Osteoarthritis. J Cell Physiol. 2007;213:626–34. doi: 10.1002/jcp.21258
11. Reijman M, Pols H, Bergink AP, et al. Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: The Rotterdam Study. Ann Rheum Dis. 2007;66:158–162. doi: 10.1136/ard.2006.053538
12. Родионова ТИ, Тепаева АИ. Ожирение – глобальная проблема современного общества. Медицинские науки. 21 марта 2013 [Rodionova TI, Tepaeva AI. Obesity – a global problem of modern society. Meditsinskie nauki. 21 march 2013]. doi: 10.1155/2013/616193
13. Patel PS, Buras ED, Balasubramanyam A. The role of the immune system in obesity and insulin resistance. J Obes. 2013;2013:616193. doi: 10.1155/2013/616193
14. Badr HE, Shah NM, Shah MA. Obesity among kuwaitis aged 50 years or older: prevalence, correlates and comorbidities. Gerontologist. 2012 Aug;53(4):555–66. doi: 10.1093/geront/gns1082012
15. Шутова ВИ, Данилова ЛИ. Ожирение, или синдром избыточной массы тела. Медицинские новости. 2004;(7):41–7 [Shutova VI, Danilova LI. Obesity or overweight syndrome. Meditsinskie novosti. 2004;(7):41–7 (In Russ.)].
16. Martin-Ramiro JJ, Alvarez-Martin E, Gil-Prieto R. Disability attributable to excess weight in Spain. Med Clin (Barc). 2013 Aug 6. pii: S0025-7753(13)00402–8. doi: 10.1016/j.medcli. 2013.05.028
17. Хамнуева ЛЮ, Андреева ЛС, Кошикова ИН. Ожирение. Классификация, этиология, патогенез, клиника, диагностика, лечение. Учебное пособие. Иркутск: ГОУ ВПО «Иркутский государственный медицинский университет»; 2007 [Khamnueva LYu, Andreeva LS, Koshikova IN. Ozhirenie. Klassifikatsiya, etiologiya, patogenez, klinika, diagnostika, lechenie. Uchebnoe posobie [Obesity. Classification, etiology, pathogenesis,
18. clinical features, diagnosis, treatment. Tutorial]. Irkutsk: GOU VPO «Irkutskii gosudarstvennyi meditsinskii universitet»; 2007].
19. Николаев ДВ, Смирнов АВ, Бобринская ИГ, Руднев СГ. Биоимпедансный анализ состава тела человека. Москва: Наука; 2009 [Nikolaev DV, Smirnov AV, Bobrinskaya IG, Rudnev SG. Bioimpedansnyi analiz sostava tela cheloveka [Bioimpedance analysis of the composition of the human body]. Moscow: Nauka; 2009].
20. Денисов ЛН, Насонова ВА. Ожирение и остеоартроз. Научно-практическая ревматология. 2010;(3):48–51 [Denisov LN, Nasonova VA. Obesity and osteoarthritis. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2010;(3):48–51 (In Russ.)].
21. Jiang L, Tian W, Wang Y, et al. Body mass index and susceptibility to knee osteoarthritis: a systematic review and meta-analysi. Joint Bone Spine. 2012 May;79(3):291–7. doi: 10.1016/j.jbspin.2011.05.015
22. Manek NJ, Hart D, Spector TD, MacGregor AJ. The association of body mass index and osteoarthritis of the knee joint: an examination of genetic and environmental influences. Arthritis Rheum. 2003 Apr;48(4):1024–9. doi: 10.1002/art.10884
23. Lievense AM, Bierma-Zeinstra SM, Verhagen AP, et al. Influence of obesity on the development of osteoarthritis of the hip: a systematic review. Rheumatology (Oxford). 2002 Oct;41(10):1155–62. doi: 10.1093/rheumatology/41.10.1155
24. Marks R, Allegrante JP. Body mass indices in patients with disabling hip osteoarthritis. Arthritis Res. 2002;4:112–6. doi:10.1186/ar387
25. Vingard E. Overweight predisposes to coxarthrosis. Body-mass index studied in 239 males with hip arthroplasty. Acta Orthop Scand. 1991;62:106–9. doi: 10.3109/17453679108999233
26. Tepper S, Hochberg MC. Factors associated with hip osteoarthritis: data from the First National Health and Nutrition Examination Survey (NHANES-I). Am J Epidemiol. 1993 May 15;137(10):1081–8.
27. Grotle M, Hagen KB, Natvig B, et al. Obesity and osteoarthritis in knee, hip and/or hand: An epidemiological study in the general population with 10 years follow-up. BMC Musculoskelet Disord. 2008 Oct 2;9:132. doi: 10.1186/1471-2474-9-132
28. Oliveria SA, Felson DT, Cirillo PA, et al. Body weight, body mass index, and incident symptomatic osteoarthritis of the hand, hip, and knee. Epidemiology. 1999 Mar;10(2):161–6. doi: 10.1097/00001648-199903000-00013
29. Karman WJ, Sowers M, Hotorn BM, Weissfeld LA. Obesity as a risk factor for osteoarthritis of the hand and wrist: a prospective study. Am J Epidemiol. 1994 Jan 15;139(2):119–29.
30. Erlangga Y, Nelissen RG, Andreea I, et al. Association between weight or body mass index and hand osteoarthritis: a systematic review. Ann Rheum Dis. 2010 Apr;69(4):761–5. doi: 10.1136/ard.2008.106930
31. Felson DT, Lawrence RC, Dieppe PA, et al. Osteoarthritis: New Insights. Part 1: The Disease and Its Risk Factors FREE. Ann Intern Med. 2000;133(8):635–46. doi:10.7326/0003-4819-133-8- 200010170-00016
32. Toivanen AT, Heliö vaara M, Impivaara O, et al. Obesity, physically demanding work and traumatic knee injury are major risk factors for knee osteoarthritis – a population-based study with a follow-up of 22 years. Rheumatology (Oxford). 2010 Feb;49(2):308–14. doi: 10.1093/rheumatology/kep388
33. Lohmander LS, Gerhardsson de Verdier M, Rollof J, et al. Incidence of severe knee and hip osteoarthritis in relation to different measures of body mass: a population-based prospective cohort study. Ann Rheum Dis. 2009 Apr;68(4):490–6. doi: 10.1136/ard.2008.089748
34. Cicuttini FM, Baker JR, Spector TD. The association of obesity with osteoarthritis of the hand and knee in women: a twin study. J Rheumatol. 1996;23:1221–6.
35. Coggon D, Reading I, Croft P, et al. Knee osteoarthritis and obesity. Int J Obes Relat Metab Disord. 2001 May;25(5):622–7. doi: 10.1038/sj.ijo.0801585
36. Насонова ВА. Остеоартроз и ожирение: клинико-патогенетические взаимосвязи. Профилактическая медицина. 2011;(1):29–37 [Nasonova VA. Osteoarthritis and obesity: clinical and pathogenetic relationship. Profilakticheskaya meditsina. 2011;(1):29–37 (In Russ.)].
37. Davis MA, Ettinger WH, Neuhaus JM. Obesity and osteoarthritis of the knee: evidence from the National Health and Nutrition Examination Survey (NHANES I). Semin Arthritis Rheum. 1990;20(3 Suppl 1):34–41. doi: 10.1016/0049-0172(90)90045-H
38. Sharma L, Song J, Felson DT, et al. The role of knee alignment in disease progression and functional decline in knee osteoarthritis. JAMA. 2001 Jul 11;286(2):188–95. doi: 10.1001/jama.286.2.188
39. Sharma L, Lou C, Cahue S, Dunlop DD. The mechanism of the effect of obesity in knee osteoarthritis: the mediating role of malalignment. Arthritis Rheum. 2000;43:568–75. doi: 10.1002/1529-0131(200003)43:3<568::AID-ANR13>3.0.CO;2-E
40. Monira Hussain S, Wang Y, Cicuttini FM, et al. Incidence of total knee and hip replacement for osteoarthritis in relation to the metabolic syndrome and its components: A prospective cohort study. Semin Arthritis Rheum. 2013 Sep 5.pii: S0049–0172(13)00161-3. doi: 10.1016/j.semarthrit.2013.07.013
41. Hochberg MC, Lethbridge-Cejku M, Plato CC, et al. Factors associated with osteoarthritis of the hand in males: data from the Baltimore Longitudinal Study of Aging. Am J Epidemiol. 1991 Nov 15;134(10):1121–7.
42. Hochberg MC, Lethbridge-Cejku M, Scott WW Jr, et al. Obesity and osteoarthritis of the hands in women. Osteoarthr Cartilage. 1993 Apr;1(2):129–35. doi: 10.1016/S1063-4584(05)80028-7
43. Wang Y, Simpson JA, Wluka AE, et al. Relationship between body adiposity measures and risk of primary knee and hip replacement for osteoarthritis: a prospective cohort study. Arthritis Res Ther. 2009;11(2):R31. doi: 10.1186/ar2636
44. Karlson EW, Mandl LA, Aweh GN, et al. Total hip replacement due to osteoarthritis: the importance of age, obesity, and other modifiable risk factors. Am J Med. 2003;114:93–8. doi: 10.1016/S0002-9343(02)01447-X
45. Jä msen E, Nevalainen P, Eskelinen A, et al. Obesity, diabetes, and preoperative hyperglycemia as predictors of periprosthetic joint infection: a single-center analysis of 7181 primary hip and knee replacements for osteoarthritis. J Bone Joint Surg Am. 2012 Jul 18;94(14):e1011–9. doi: 10.2106/JBJS.J.01935
46. Cimmino MA, Scarpa R, Caporali R, et al. Body mass and osteoarthritic pain: results from a study in general practice. Clin Exp Rheumatol. 2013 Nov–Dec;31(6):843–9.
47. Marks R. Obesity profiles with knee osteoarthritis: correlation with pain, disability, disease progression. Obesity (Silver Spring). 2007 Jul;15(7):1867–74. doi: 10.1038/oby.2007.221
48. Tanamas SK, Wluka AE. Association of weight gain with incident knee pain, stiffness, and functional difёculties: A longitudinal study. Arthritis Care Res. 2013;65(1):34–43. doi: 10.1002/acr.21745
49. Brennan SL, Cicuttini FM, Pasco JA, et al. Does an increase in body mass index over 10 years affect knee structure in a population-based cohort study of adult women? Arthritis Res Ther. 2010;12(4):R139. doi: 10.1186/ar3078
50. Laberge MA, Baum T, Virayavanich W, et al. Obesity increases the prevalence and severity of focal knee abnormalities diagnosed using 3T MRI in middle-aged subjects – data from the Osteoarthritis Initiative. Skeletal Radiol. 2012 Jun;41(6):633–41. doi: 10.1007/s00256-011-1259-3
51. Trayhurn P. Hypoxia and adipose tissue function and dysfunction in obesity. Physiol Rev. 2013 Jan;93(1):1–21. doi: 10.1152/physrev.00017.2012
52. Fantuzzi G, Mazzone T, editors. Nutrition and Health: Adipose Tissue and Adipokines in Health and Disease. New York: Springer-Verlag; 2007.
53. Symonds ME, editor. Adipose Tissue Biology. New York: Springer-Verlag; 2012. doi: 10.1007/978-1-4614-0965-6
54. Кузнецов СЛ, Мушкамбаров НН. Гистология, цитология, эмбриология. Учебник для медицинских вузов. Москва: ООО «Медицинское информационное агентство»; 2007 [Kuznetsov SL, Mushkambarov NN. Gistologiya, tsitologiya, embriologiya. Uchebnik dlya meditsinskikh vuzov [Histology, cytology, embryology. Textbook for Medical Schools]. Moscow: OOO «Meditsinskoe informatsionnoe agentstvo»; 2007].
55. McNulty AL, Miller MR, O'Connor SK, Guilak F. The effects of adipokines on cartilage and meniscus catabolism. Connect Tissue Res. 2011;52(6):523–33. doi: 10.3109/03008207.2011.597902
56. Santos MJ, Fonseca JE. Metabolic syndrome, Inflammation and atherosclerosis – the role of adipokinesin health and in systemic inflammatory rheumatic diseaseas. Acta Reumatol Port. 2009 Oct–Dec;34(4):590–8.
57. Gualillo O, Gonzalez-Juanatey JR, Lago F. The emerging role of adipokines as mediators of cardiovascular function: physiologic and clinical perspectives. Trends Cardiovasc Med. 2007;17(8):275–83. doi: 10.1016/j.tcm.2007.09.005
58. Boer TN, van Spil WE, Huisman AM, et al. Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage. Osteoarthr Cartilage. 2012 Aug;20(8):846–53 doi: 10.1016/j.joca.2012.05.002
59. Issa RI, Griffin TM. Pathobiology of obesity and osteoarthritis: integrating biomechanics and inflammation. Pathobiol Aging Agerelat Dis. 2012;2:17470. doi: 10.3402/pba.v2i0.17470
60. Ковалева ОН, Амбросова ТН. Адипокины: биологические, патофизиологические и метаболические эффекты. Внутренняя медицина. 2009;3(15) [Kovaleva ON, Ambrosova TN. Adipokines: biological, pathophysiological and metabolic effects. Vnutrennyaya meditsina. 2009;3(15) (In Russ.)].
61. Ahlma RS, Prabakaran D, Mantzoros C, et al. Role of leptin in the neuroendocrine response to fasting, Nature. 1996;382(6588): 250–2. doi: 10.1038/382250a0
62. Toussirot E, Streit G, Wendling D. The contribution of adipose tissue and adipokines to inflammation in joint diseases. Curr Med Chem. 2007;14(10):1095–100. doi: 10.2174/092986707780362826
63. Носков СМ. Консервативное лечение остеоартроза. Москва; 2014. C. 32 [Noskov SM. Konservativnoe lechenie osteoartroza [Conservative treatment of osteoarthritis]. Moscow; 2014. P. 32].
64. Hui W, Litherland GJ. Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases. Ann Rheum Dis. 2012;71:455–62 doi: 10.1136/annrheumdis-2011-20037
65. Mutabaruka MS, Aoulad-Aissa M, Delalandre A, et al. Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression. Arthritis Res Ther. 2010;12(1):R20. doi: 10.1186/ar2925
66. Presle N, Pottie P, Dumond H, et al. Differential distribution of adipokines between serum and synovial fluid in patients with osteoarthritis. Contribution of joint tissues to their articular production. Osteoarthr Cartilage. 2006;14(7):6905. doi: 10.1016/j.joca.2006.01.009
67. Karvonen-Gutierrez CA, Harlow SD, Mancuso P, et al. Leptin levels are associated with radiographic knee osteoarthritis among a cohort of mid-life women. Arthritis Care Res (Hoboken). 2013 Jun;65(6):936–44. doi: 10.1002/acr.21922
68. Kadowaki T, Yamauchi T. Adiponectin and adiponectin receptors. Endocrin Rev. 2005;26(3):439–51. doi: 10.1210/er.2005-0005
69. Matsuzawa Y. Therapy insight: adipocytokines in metabolic syndrome and related cardiovascular disease. Nat Clin Pract Cardiovasc Med. 2006;3(1):35–42. doi: 10.1038/ncpcardio0380
70. Distel E, Cadoudal T, Durant S, et al. The infrapatellar fat pad in knee osteoarthritis: an important source of interleukin-6 and its soluble receptor. Arthritis Rheum. 2009;60(11):3374–7. doi: 10.1002/art.24881
71. Honsawek S, Chayanupatkul M. Correlation of plasma and synovial fluid adiponectin with knee osteoarthritis severity. Arch Med Res. 2010;41(8):593–8. doi: 10.1016/j.arcmed.2010.11.007
72. Choi SH, Hong ES, Lim S. Clinical implications of adipocytokines and newly emerging metabolic factors with relation to insulin resistance and cardiovascular health. Front Endocrinol (Lausanne). 2013 Aug 21;4:97. doi: 10.3389/fendo.2013.00097
73. Degawa-Yamauchi M, Bovenkerk JE, Juliar BE, et al. Serum resistin (FIZZ3) protein is increased in obese humans . J Clin Endocrinol Metabol. 2003;88(11):5452–5. doi: 10.1210/jc.2002-021808
74. Gerber M, Boettner A, Seidel B, et al. Serum resistin levels of obese and lean children and adolescents: biochemical analysis and clinical relevance. J Clin Endocrinol Metab. 2005
75. Aug;90(8):4503–9. doi: 10.1210/jc.2005-0437
76. McTernan PG, Fisher FM, Valsamakis G, et al. Resistin and type 2 diabetes: regulation of resistin expression by insulin and rosiglitazone and the effects of recombinant resistin on lipid and glucose metabolism in human differentiated adipocytes. J Clin Endocrinol Metab. 2003 Dec;88(12):6098–106. doi: 10.1210/jc.2003-030898
77. Friebe D, Neef M, Kratzsch J, et al. Leucocytes are a major source of circulating nicotinamidephosphoribosyltransferase (NAMPT)/pre-B cell colony (PBEF)/visfatin linking obesity and iflammation in humans. Diabetologia. 2011;54(5):1200–11. doi: 10.1007/s00125-010-2042-z
78. Gosset M, Berenbaum F, Salvat C, et al. Crucial role of visfatin/pre-B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: possible inяuence on osteoarthritis. Arthritis Rheum. 2008;58(5):1399–409. doi: 10.1002/art.23431
79. Klein-Wieringa IR, Kloppenburg M, Bastiaansen-Jenniskens YM, et al. The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype. Ann Rheum Dis. 2011;70(5):8517. doi: 10.1136/ard.2010.140046
80. Sokolove J, Lepus MC. Role of inflammation in the pathogenesis of osteoarthritis latest findings and interpretations. Ther Adv Musculoskel Dis. 2013;5(2):77–94. doi: 10.1177/1759720X12467868
81. Hui W, Litherland GJ, Elias MS, et al. Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases. Ann Rheum Dis. 2012;71(3):45562. doi: 10.1136/annrheumdis-2011-200372
82. Rai MF, Sandell LJ. Inflammatory mediators: tracing links between obesity and osteoarthritis. Crit Rev Eukaryot Gene Expr. 2011;21(2):131–42. doi: 10.1615/CritRevEukarGeneExpr.v21.i2.30
83. Centers for Disease Control and Prevention (CDC). Trends in aging – United States and worldwide. MMWR Morb Mortal Wkly Rep. 2003 Feb 14;52(6):101–4, 106.
84. Kawai M, Devlin MJ, Rosen CJ. Fat targets for skeletal health. Nat Rev Rheumatol. 2009 Jul;5(7):365–72. doi: 10.1038/nrrheum.2009.102
85. Zhuo Q, Yang W, Chen J, Wang Y. Metabolic syndrome meets osteoarthritis. Nat Rev Rheumatol. 2012 Dec;8(12):729–37. doi: 10.1038/nrrheum.2012.135
86. Новикова ДС, Попкова ТВ, Насонов ЕЛ. Артериальная гипертензия при ревматоидном артрите. Научно-практическая ревматология. 2011;(3):52–68 [Novikova DS, Popkova TV, Nasonov EL. Hypertension in rheumatoid arthritis. Nauchnoprakticheskaya revmatologiya = Rheumatology Science and Practice. 2011;(3):52–68 (In Russ.)].
87. Yoshimura N, Muraki S, Oka H, et al. Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study. Osteoarthritis Cartilage. 2012 Nov;20(11):1217–26. doi:10.1016/j.joca.2012.06.006
88. Dahaghin S, Bierma-Zeinstra S, Koes B, et al. Do metabolic factors add to the effect of overweight on hand osteoarthritis? The Rotterdam Study. Ann Rheum Dis. 2007;66:916–20. doi: 10.1136/ard.2005.045724
89. Gregory A, Cheng YI, Imperatore G, et al. Diabetes and Arthritis: Is there a Connection? Prevalence of diagnosed artritis and arthritis – attributable activity limitation among adults with and without diagnosed diabetes: United States, 2008–2010. Diabetes Care. 2012 Aug;35(8):1686–91. doi: 10.2337/dc12-0046
90. Красивина ИГ. Особенности гонартроза у больных ожирением и сахарным диабетом. Международный эндокринологический журнал. 2011;(3):113–23 [Krasivina IG. Features of gonartroz in patients with obesity and diabetes. Mezhdunarodnyi endokrinologicheskii zhurnal. 2011;(3):113–23 (In Russ.)].
91. Супрун ЭВ. Коморбидность при остеоартрозе у пожилых пациентов: выбор тактики лечения. Рациональная фармакотерапия. 2013;28(3):47–52 [Suprun EV. Comorbidity in osteoarthritis in elderly patients: treatment selection. Ratsional'naya farmakoterapiya. 2013;28(3):47–52 (In Russ.)].
92. Zhang W, Nuki G, Moskowitz RW, et al. OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthr Cartilage. 2010 Apr;18(4):476–99. doi: 10.1016/j.joca.2010.01.013
93. Bliddal H, Leeds AR, Stigsgaard L, et al. Weight loss as treatment for knee osteoarthritis symptoms in obese patients: 1-year results from a randomised controlled trial. Ann Rheum Dis. 2011 Oct;70(10):1798–803. doi: 10.1136/ard.2010.142018
94. Richette P, Poitou C, Garnero P, et al. Benefits of massive weight loss on symptoms, systemic inflammation and cartilage turnover in obese patients with knee osteoarthritis. Ann Rheum Dis. 2011 Jan;70(1):139–44. doi: 10.1136/ard.2010.134015
95. Colbert CJ, Almagor O, Chmiel JS, et al. Excess body weight and four-year function outcomes: comparison of African Americans and whites in a prospective study of osteoarthritis. Arthritis Care Res (Hoboken). 2013 Jan;65(1):5–14. doi: 10.1002/acr.21811
96. Messier SP, Mihalko SL, Legault C, et al. Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial. JAMA. 2013 Sep 25;310(12):1263–73. doi: 10.1001/jama.2013.277669
97. Riddleand DL, Stratford PW. Body weight changes and corresponding changes in pain and function in persons with symptomatic knee osteoarthritis: A cohort study. Arthritis Care Res. 2013;65(1):15–22. doi 10.1002/acr.21692
98. Harding GT, Hubley-Kozey CL, Dunbar MJ, et al. Body mass index affects knee joint mechanics during gait differently with and without moderate knee osteoarthritis. Osteoarthr Cartilage. 2012 Nov;20(11):1234–42. doi: 10.1016/j.joca.2012.08.004
99. Савельева ЛВ. Современная концепция лечения ожирения: клинические рекомендации для практикующих врачей. Фарматека. 2007;12:33–8 [Savel'eva LV. The modern concept of treatment of obesity: clinical guidelines for medical practitioners. Farmateka. 2007;12:33–8 (In Russ.)].
100. Toplak H, Ziegler O, Keller U, et al. X-PERT: weight reduction with orlistat in obese subjects receiving a mildly or moderately reduced-energy diet. Early response to treatment predicts weight maintenance. Diabet Obesi Metabol. 2005;7:699–708. doi: 10.1111/j.1463-1326.2005.00483
101. Finer N, James WPT, Kopelman PG, et al. One-year treatment of obesity: a randomized, double-blind, placebo-controlled, multicenter study of orlistat, a gastrointestinal lipase inhibitor. Int J Obesity. 2000;24:306–13.
102. Wirth A. Reduction of body weight and co-morbidities by orlistat: The XXL – Primary Health Care Trial. Diabetes Obes Metab. 2005 Jan;7(1):21–7. doi: 10.1111/j.1463-1326.2004.00428.x
103. Torgerson JS, Hauptman J, Boldrin MN, Sjö ström L. XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients. Diabetes Care. 2004 Jan;27(1):155–61. doi: 10.2337/diacare.27.1.155
Рецензия
Для цитирования:
Стребкова Е.А., Алексеева Л.И. Остеоартроз и ожирение. Научно-практическая ревматология. 2015;53(5):542-552. https://doi.org/10.14412/1995-4484-2015-542-552
For citation:
Strebkova E.A., Alekseeva L.I. OSTEOARTHRITIS AND OBESITY. Rheumatology Science and Practice. 2015;53(5):542-552. (In Russ.) https://doi.org/10.14412/1995-4484-2015-542-552
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