Эффективность цертолизумаба пэгола в лечении псориатического артрита
https://doi.org/10.14412/1995-4484-2015-553-557
Аннотация
Выполнен анализ данных литературы о механизмах действия цертолизумаба пэгола (ЦЗП) – нового ингибитора фактора некроза опухоли α (ФНОα) для лечения активного псориатического артрита (ПсА). Описаны уникальная молекулярная структура препарата, механизм действия, показано, что ЦЗП эффективно ингибирует ФНОα, не вызывая клеточный апоптоз, а также обладает низкой иммуногенностью. Рассмотрены результаты клинического исследования ЦЗП – RAPID-PsA. Отмечена быстрая клиническая эффективность лечения ЦЗП в разных дозах в отношении проявлений как артрита, так и псориаза. Приведены данные о том, что терапия ЦЗП препятствует образованию эрозий в суставах, особенно у пациентов с активным заболеванием. Сделан вывод, что ЦЗП – перспективный препарат для лечения активного ПсА, однако необходимо проведение дальнейших фундаментальных и клинических исследований этого класса лекарственных средств, направленных против определенных цитокинов.
Об авторах
Т. В. Коротаева
ФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой, Москва, Россия 115522 Москва, Каширское шоссе, 34А
Россия
Россия
Е. Ю. Логинова
ФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой, Москва, Россия 115522 Москва, Каширское шоссе, 34А
Россия
Россия
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Рецензия
Для цитирования:
Коротаева Т.В., Логинова Е.Ю. Эффективность цертолизумаба пэгола в лечении псориатического артрита. Научно-практическая ревматология. 2015;53(5):553-557. https://doi.org/10.14412/1995-4484-2015-553-557
For citation:
Korotaeva T.V., Loginova E.Yu. EFFICACY OF CERTOLIZUMAB PEGOL IN THE TREATMENT OF PSORIATIC ARTHRITIS. Rheumatology Science and Practice. 2015;53(5):553-557. (In Russ.) https://doi.org/10.14412/1995-4484-2015-553-557
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