SPECIFIC FEATURES OF THE IMMUNE STATUS IN RHEUMATOID ARTHRITIS IN RELATION TO THE CLIMATIC, GEOGRAPHICAL, AND ENVIRONMENTAL ZONES OF UZBEKISTAN
https://doi.org/10.14412/1995-4484-2016-183-186
Abstract
The feature of rheumatoid arthritis (RA) is the predominant clinical picture of chronic synovial joint inflammation accompanied by progressive cartilage and bone destruction, the pathogenesis of which is greatly due to autoimmune mechanisms. Some investigations demonstrate that a set of poor climatic and geographical factors may influence the development of immune disorders that are a trigger in the development of RA.
Objective: to comparative analyze immunological parameters in RA in dwellers from different regions of Uzbekistan.
Subjects and methods. The study enrolled RA patients from three Uzbekistan zones: 1) Tashkent (n = 25), 2) Xorazm Region (n = 25); 3) Namangan Region (n = 28).
Results and discussion. Comparative analysis of the immune status indicated that the patients living in Zone 2 exhibited a significantly reduced T cell immune response (p < 0.05), a considerably higher count of B lymphocytes (p < 0.001), and significantly lower levels of CD11b+, CD18+, CD25+, and CD95+ cells (p < 0.05) than did those from the two other zones. Examination of the frequency of the monomorphic determinant of histocompatibility Class I (HLA-I) antigens revealed its significant decrease in the patients residing in Zones 1 and 3 (p < 0.05) whereas the RA patients from Zone 2 had a significantly higher frequency of HLA-DR (p < 0.05).
Conclusion. The comparative analysis shows that the immunological parameters differ in the patients from the three zones of Uzbekistan, which may suggest that the climatic and geographical factors of the environment may influence the course of the disease.
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For citations:
Akhmedov Kh.S. SPECIFIC FEATURES OF THE IMMUNE STATUS IN RHEUMATOID ARTHRITIS IN RELATION TO THE CLIMATIC, GEOGRAPHICAL, AND ENVIRONMENTAL ZONES OF UZBEKISTAN. Rheumatology Science and Practice. 2016;54(2):183-186. (In Russ.) https://doi.org/10.14412/1995-4484-2016-183-186
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