CELLULAR AND MOLECULAR BIOMARKERS AND POTENTIAL THERAPEUTIC TARGETS IN SYSTEMIC LUPUS ERYTHEMATOSUS
https://doi.org/10.14412/1995-4484-2016-206-218
Abstract
Systemic lupus erythematosus (SLE) is one of the most severe and prognostically poor systemic connective tissue diseases that affect mainly women of childbearing age. The recent researches have provided a deeper insight into its pathogenesis, the identification and definition of a role of cytokines, cells, and intercellular bonds involved in the development of SLE. These data are borne in mind when designing novel biological agents, the action of which is aimed at inhibiting the targets implicated in the development of the disease. This information also may provide better understanding the mechanism of action of drugs, such as belimumab and rituximab, which have already proven their efficacy.
About the Author
A. A. Mesnyankina
V.A. Nasonova Research Institute of Rheumatology, Moscow
Russian Federation
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522
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Mesnyankina A.A. CELLULAR AND MOLECULAR BIOMARKERS AND POTENTIAL THERAPEUTIC TARGETS IN SYSTEMIC LUPUS ERYTHEMATOSUS. Rheumatology Science and Practice. 2016;54(2):206-218. (In Russ.) https://doi.org/10.14412/1995-4484-2016-206-218
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