Перспективы применения ингибиторов интерлейкина 17 - нового класса препаратов для таргетной терапии псориатического артрита
Аннотация
Парадигма терапии псориатического артрита (ПсА) претерпела в последние годы существенные изменения вследствие разработки и внедрения в клиническую практику высокоэффективных таргетных лекарственных средств на основе моноклональных антител – ингибиторов различных цитокинов. Выполнен анализ данных литературы о возможностях применения ингибиторов интерлейкина 17 (ИЛ17) как перспективного направления терапии ПсА. Показано, что опосредованный ИЛ17 сигнальный путь играет важную роль как в хро- низации синовиального воспаления, так и в возникновении и развитии костных эрозий, костных пролифераций и энтезитов при этом заболевании. Сочетание высокой эффективности и приемлемой безопасности ингибиторов ИЛ17 и ИЛ23 позволило предположить возможность эффективного их использования в качестве средств первой линии для лечения псориаза и ПсА или в качестве терапии второй линии при неэффективности или непереносимости ингибиторов фактора некроза опухоли α. Отмечено, что активная разработка трех новых препаратов, направленных на подавление ИЛ17, только подтверждает ключевую роль этого цитокина в развитии псориатической болезни.
Приведены данные клинических исследований, подтверждающих высокую эффективность секукинумаба в отношении ключевых клинических проявлений ПсА. Отмечено, что важнейшим преимуществом препарата является отсутствие иммуногенности. Указано, что в последней редакции Рекомендаций EULAR (2015) предложено включить данный класс препаратов в алгоритм лечения больных ПсА.
Ключевые слова
Об авторе
Т. В. Коротаева
ФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой
Россия
115522 Москва, Каширское шоссе, 34А
Россия
115522 Москва, Каширское шоссе, 34А
Список литературы
1. Smolen JS, Braun J, Dougados M, et al. Treating spondyloarthritis, including ankylosing spondylitis and psoriatic arthritis, to target: recommendations of an international task force. Ann Rheum Dis. 2014;73:6-16. doi: 10.1136/annrheumdis-2013-203419
2. Coates LC, Moverly AR, McParland L, et al. Effect of tight control of inflammation in early psoriatic arthritis (TICOPA): a UK multicentre, open-label, randomized controlled trial. Lancet. 2015;386(10012):2489-98. doi: 10.1016/s0140-6736(15)00347-5
3. Kavanaugh A, McInnes I, Mease P, et al. Golimumab, a new human tumor necrosis factor alpha antibody, administered every four weeks as a subcutaneous injection in psoriatic arthritis: twenty-four-week eficacy and safety results of a randomized, placebocontrolled study. Arthritis Rheum. 2009;60(4):976-86. doi: 10.1002/art.24403
4. McInnes I, Kavanaugh A, Gottlieb A, et al. Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial. Lancet. 2013;382(9894):780-9. doi: 10.1016/S0140-6736(13)60594-2
5. Vogelzang EH, Kneepkens EL, Nurmohamed MT, et al. Antiadalimumab antibodies and adalimumab concentrations in psoriatic arthritis; an association with disease activity at 28 and 52 weeks of follow-up. Ann Rheum Dis. 2014;73:2178-2182. doi: 10.1136/annrheumdis-2014-205554
6. Glintborg B, Ostergaard M, Dreyer L, et al. Treatment response, drug survival, and predictors thereof in 764 patients with psoriatic arthritis treated with anti-tumor necrosis factor alpha therapy: results from the nationwide Danish DANBIO registry. Arthritis Rheum. 2011;63:382-90. doi: 10.1002/art.30117
7. Finzel S, Kraus S, Schmidt S, et al. Bone anabolic changes progress in psoriatic arthritis patients despite treatment with methotrexate or tumour necrosis factor inhibitors. Ann Rheum Dis. 2012;72(7):1176-81. doi: 10.1136/annrheumdis-2012-20158
8. Menon B, Gullick NJ, Walter GJ, et al. Interleukin-17+CD8+ T cells are enriched in the joints of patients with psoriatic arthritis and correlate with disease activity and joint damage progression. Arthritis Rheum. 2014;66:1272-81. doi: 10.1002/art.38376
9. Miossec P, Kolls JK. Targeting IL-17 and Th17 cells in chronic inflammation. Nat Rev Drug Discov. 2012;11(10):763-76. doi: 10.1038/nrd3794
10. Raychaudhuri SK, Saxena A, Raychaudhuri SP. Role of IL-17 in the pathogenesis of psoriatic arthritis and axial spondyloarthritis. Clin Rheumatol. 2015;34(6):1019-23. doi: 10.1007/s10067-015-2961-7
11. Rouvier E, Luciani MF, Mattei MG, et al. CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. J Immunol. 1993;150:5445-56.
12. Van den Berg WB, McInnes IB. Th17 cells and IL-17 a-focus on immunopathogenesis and immunotherapeutics. Semin Arthritis Rheum. 2013;43:158-70. doi: 10.1016/j.semarthrit.2013.04.006
13. Miossec P, Korn T, Kuchroo VK. Interleukin-17 and type 17 helper T cells. N Engl J Med. 2009;361:888-98. doi: 10.1056/NEJMra0707449
14. Frleta M, Siebert S, McInnes IB. The interleukin-17 pathway in psoriasis and psoriatic arthritis: disease pathogenesis and possibilities of treatment. Curr Rheumatol Rep. 2014;16:414. doi: 10.1007/s11926-014-0414-y
15. Johansen C, Usher PA, Kjellerup RB, et al. Characterization of the interleukin-17 isoform and receptors in lesional psoriatic skin. Br J Dermatol. 2009;160(2):319-24. doi: 10.1111/j.1365-2133.2008.08902.x
16. Jandus C, Bioley G, Rivas JP, et al. Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides. Arthritis Rheum. 2008;58:2307-17. doi: 10.1002/art.23655
17. Kagami S, Rizzo HL, Lee JJ, et al. Circulating Th17, Th22, and Th1 cells are increased in psoriasis. J Invest Dermatol. 2010;130:1373-83. doi: 10.1038/jid.2009.399
18. Lin AM, Rubin CJ, Khandpur R, et al. Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis. J Immunol. 2011;187:490-500. doi: 10.4049/jimmunol.1100123
19. Noordenbos T, Yeremenko N, Gofita I, et al. Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritis. Arthritis Rheum. 2012;64:99-109. doi: 10.1002/art.33396
20. Lubberts E, Koenders MI, Oppers-Walgreen B, et al. Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. Arthritis Rheum. 2004;50:650-9. doi: 10.1002/art.20001
21. Pllinger B, Junt T, Metzler B, et al. Th17 cells, not IL-17+ γδ T cells, drive arthritic bone destruction in mice and humans. J Immunol. 2011;186:2602-12. doi: 10.4049/jimmunol.1003370
22. Nestle FO, Kaplan DH, Barker J. Psoriasis. N Engl J Med. 2009;361:496-509. doi: 10.1056/NEJMra0804595
23. Raychaudhuri SP. Role of IL-17 in psoriasis and psoriatic arthritis. Clin Rev Allergy Immunol. 2013;44:183-93. doi: 10.1007/s12016-012-8307-1
24. Suzuki E, Mellins ED, Gershwin ME, et al. The IL-23/IL-17 axis in psoriatic arthritis. Autoimmun Rev. 2014;13(4-5):496-502. doi: 10.1016/j.autrev.2014.01.050
25. Annunziato F, Cosmi L, Santarlasci V, et al. Phenotypic and functional features of human Th17 cells. J Exp Med. 2007 Aug 6;204(8):1849-61. doi.org/10.1084/jem.20070663
26. Gaffen SL. The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing. Nat Rev Immunol. 2014 Sep;14(9):585-600. doi: 10.1038/nri3707
27. Langley RG, Elewski BE, Lebwohl M, et al. Secukinumab in plaque psoriasis – results of two phase 3 trials. N Engl J Med. 2014;371:326-38. doi: 10.1056/NEJMoa1314258. Epub 2014 Jul 9.
28. McInnes IB, Mease PJ, Kirkham B, et al; on behalf of the FUTURE 2 Study Group. Secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with monoclonal antibody, in patients with psoriatic arthritis (FUTURE 2): a randomised, double-blinded, placebo-controlled, phase 3 trial. Lancet. 2015 Sep 19;386(9999):1137-46. doi: 10.1016/S0140-6736(15)61134-5
29. Van der Heijde D, Aletaha D, Carmona L, et al. 2014 Update of the EULAR standardized operating procedures for EULARendorsed recommendations. Ann Rheum Dis. 2015 Jan;74(1):8-13. doi: 10.1136/annrheumdis-2014-206350
30. Ritchlin C, Rahman P, Kavanaugh A, et al. Efficacy and safety of the anti-IL-12/23 p40 monoclonal antibody, ustekinumab, in patients with active psoriatic arthritis despite conventional nonbiological and biological anti-tumour necrosis factor therapy: 6-month and 1-year results of the phase 3, multicentre, doubleblind, placebo-controlled, randomized PSUMMIT 2 trial. Ann Rheum Dis. 2014;73:990-9. doi: 10.1136/annrheumdis-2013-204655
31. McInnes IB, Sieper J, Braun J, et al. Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-ofconcept trial. Ann Rheum Dis. 2014;73:349-56. doi: 10.1136/annrheumdis-2012-202646. Epub 2013 Jan 29.
32. Griffiths CE, Reich K, Lebwohl M, et al. Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): results from two phase 3 randomised trials. Lancet. 2015;386(9993):541-51. doi: 10.1016/S0140-6736(15)60125-8
33. Han C, Robinson DW, Hackett MV, et al. Cardiovascular disease and risk factors in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. J Rheumatol. 2006;33:2167-72.
34. Gladman DD, Ang M, Su L, et al. Cardiovascular morbidity in psoriatic arthritis. Ann Rheum Dis. 2009;68:1131-5. doi: 10.1136/ard.2008.094839
35. Husted JA, Thavaneswaran A, Chandran V, et al. Cardiovascular and other comorbidities in patients with psoriatic arthritis: a comparison with patients with psoriasis. Arthritis Care Res (Hoboken). 2011;63:1729-35. doi: 10.1002/acr.20627
36. Mease PJ, McInnes IB, Kirkham B, et al. Secukinumab inhibition of interleukin-17A in patients with psoriatic arthritis. N Engl J Med. 2015;373:1329-39. doi: 10.1056/NEJMoa1412679
37. Leonardi C, Matheson R, Zachariae C, et al. Antiinterleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis. N Engl J Med. 2012;366:1190-9. doi: 10.1056/NEJMoa1109997
38. Papp KA, Leonardi C, Menter A, et al. Brodalumab, an antiinterleukin-17-receptor antibody for psoriasis. N Engl J Med. 2012;366:1181-9. doi: 10.1056/NEJMoa1109017
39. Mease PJ, et al. A randomized, double-blind, active- and placebocontrolled phase 3 study of efficacy and safety of ixekizumab, adalimumab, and placebo therapy in patients naive to biologic disease modifying anti-rheumatic drugs with active psoriatic arthritis 2015 ACR/ARHP Annual Meeting. Abstract number 977 Date of first publication: September 29, 2015.
40. Glintborg B, Ostergaard M, Krogh NS, et al. Clinical response, drug survival, and predictors thereof among 548 patients with psoriatic arthritis who switched tumor necrosis factor α inhibitor therapy: results from the Danish Nationwide DANBIO Registry. Arthritis Rheum. 2013;65:1213-23. doi: 10.1002/art.37876
41. Kavanaugh A, Krueger GG, Beutler A, et al. Infliximab maintains a high degree of clinical response in patients with active psoriatic arthritis through 1 year of treatment: results from the IMPACT 2 trial. Ann Rheum Dis. 2007;66:498-505. doi: 10.1136/ard.2006.058339
42. Fagerli KM, Lie E, van der Heijde D, et al. Switching between TNF inhibitors in psoriatic arthritis: data from the NOR-DMARD study. Ann Rheum Dis. 2013;72:1840-4. doi: 10.1136/annrheumdis-2012-203018
43. Gossec L, Smolen J, Ramiro S. European League Against Rheumatism (EULAR) recommendations for the management of psoriatic arthritis with pharmacological therapies: 2015 update. Ann Rheum Dis. 2015;0:1-12. doi: 10.1136/annrheumdis-2015-208337
Для цитирования:
Коротаева Т.В. Перспективы применения ингибиторов интерлейкина 17 - нового класса препаратов для таргетной терапии псориатического артрита. Научно-практическая ревматология. 2016;54(3):346-351. https://doi.org/10.14412/1995-4484-2016-346-351
For citation:
Korotaeva T.V. PROSPECTS FOR USING INTERLEUKIN-17 INHIBITORS, A NEW CLASS OF DRUGS FOR TARGETED THERAPY OF PSORIATIC ARTHRITIS. Rheumatology Science and Practice. 2016;54(3):346-351. (In Russ.) https://doi.org/10.14412/1995-4484-2016-346-351
Просмотров: 627
Послать статью по эл. почте 
