TREATMENT OF IgG4-RELATED DISEASE
https://doi.org/10.14412/1995-4484-2016-352-360
Abstract
IgG4-related disease (IgG4-RD) is a fibroinflammatory condition characterized by the occurrence of tumor-like foci in different organs with a unique histological pattern (moirо-like fibrosis, obvious lymphoplasmacytic infiltration with large numbers of IgG4+ plasma cells, and obliterating phlebitis) and elevated serum IgG4 levels in the majority of patients. Its first-line therapy is glucocorticoids at a starting dose of 0.6 mg/kg/day (equivalent to prednisolone); however, this treatment entails a great number of adverse events and high recurrence rates. The paper provides a review of today's literature on the treatment of IgG4-RD; particular emphasis is laid on the description of therapy with glucocorticoids and rituximab.
About the Authors
E. V. Sokol
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522
V. I. Vasilyev
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522
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Sokol E.V., Vasilyev V.I. TREATMENT OF IgG4-RELATED DISEASE. Rheumatology Science and Practice. 2016;54(3):352-360. (In Russ.) https://doi.org/10.14412/1995-4484-2016-352-360
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