DEVELOPMENTS OF RUSSIAN ORIGINAL BIOLOGICAL AGENTS FOR THE TREATMENT OF IMMUNOINFLAMMATORY RHEUMATIC DISEASES
https://doi.org/10.14412/1995-4484-2017-201-210
Abstract
The paper analyzes the key biological effects of cytokines that play a central role in the pathogenesis of immunoinflammatory rheumatic diseases. Special attention is drawn to major proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and IL-17. There are data from a preclinical study of the innovative original biological agents (BAs) designed by the JSC «BIOCAD»: BCD-085, a humanized anti-IL-17 monoclonal antibody, BCD-089, a humanized anti-IL-6 receptor monoclonal antibody, and BCD-121, a humanized bispecific antiTNF-α and anti-IL-17 monoclonal antibody. The preclinical findings prove the specific activity of the drugs in suppressing the inflammatory process, as well as the low toxicity and good tolerance in animals, which could justify investigation of the the drugs during human clinical trials and open up prospects for effective and affordable treatment in Russian patients.
About the Authors
E. L. Nasonov
V.A. Nasonova Research Institute of Rheumatology, Moscow
Department of Rheumatology, Institute of Professional Education,
I.M. Sechenov First Moscow State Medical University, Ministry of
Health of Russia, Moscow
Russian Federation
Russian Federation
V. I. Mazurov
I.I. Mechnikov NorthWestern State Medical University, Ministry of
Health of Russia, Saint Petersburg
Russian Federation
Russian Federation
Yu. V. Usacheva
JSC «BIOCAD», Saint Petersburg
Russian Federation
Russian Federation
E. V. Chernyaeva
JSC «BIOCAD», Saint Petersburg
Russian Federation
Russian Federation
Ya. Yu. Ustyugov
JSC «BIOCAD», Saint Petersburg
Russian Federation
Russian Federation
A. B. Ulitin
JSC «BIOCAD», Saint Petersburg
Russian Federation
Russian Federation
R. A. Ivanov
JSC «BIOCAD», Saint Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Nasonov E.L., Mazurov V.I., Usacheva Yu.V., Chernyaeva E.V., Ustyugov Ya.Yu., Ulitin A.B., Ivanov R.A. DEVELOPMENTS OF RUSSIAN ORIGINAL BIOLOGICAL AGENTS FOR THE TREATMENT OF IMMUNOINFLAMMATORY RHEUMATIC DISEASES. Rheumatology Science and Practice. 2017;55(2):201-210. (In Russ.) https://doi.org/10.14412/1995-4484-2017-201-210
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