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STRONTIUM RANELATE IN THE TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS: IMPACT OF VITAMIN D RECEPTOR AND MONOCYTE CHEMOATTRACTANT PROTEIN-1 GENE POLYMORPHISMS ON BONE MINERAL DENSITY: A PILOT STUDY

https://doi.org/10.14412/1995-4484-2017-267-271

Abstract

Objective: to investigate the impact of VDR and MCP-1 gene polymorphisms on the efficiency of 12-month therapy with strontium ranelate (SR) in women with postmenopausal osteoporosis (OP).

Subjects and methods. The investigation enrolled 34 postmenopausal women (mean age 65±8 years), who was diagnosed with OP by lumbar spine and/or proximal femur examinations using a Hologic QDR 4500W X-ray bone densitometer. The gene polymorphisms of VDR (BsmI) and MCP-1 (-2518A/G) were genotyped by polymerase chain reaction, followed by restriction fragment length polymorphism analysis.

Results and discussion. The carriers of the BB and Вb genotypes of the VDR gene had a statistically significantly lower increase in the bone mineral density (BMD) of the lumbar spine than those of the homozygous recessive bb genotype (p = 0.024 and p = 0.022, respectively) and the bb genotype and the BB+Bb genotype (p = 0.004), and the carriers of the GА genotype of MCP-1 gene had a statistically significantly lower increase in the BMD of the entire proximal femur than those of the homozygous AA genotype (0.2±2.5% and 4.4±4.4%, respectively; p = 0.004) at 12 months after SR treatment.

Conclusion. The findings may suggest that the BB and Bb genotypes of the VDR gene and the GA genotype of the MCP-1 gene may negatively affect the efficacy of SR in patients with OP. However, additional studies on a larger sample of patients, including those with other forms of OP, are required to confirm this assumption. 

About the Authors

M. Yu. Krylov
V.A. Nasonova Research Institute of Rheumatology, Moscow
Russian Federation

34A, Kashirskoe Shosse, Moscow 115522 



O. A. Nikitinskaya
V.A. Nasonova Research Institute of Rheumatology, Moscow
Russian Federation

34A, Kashirskoe Shosse, Moscow 115522 



E. Yu. Samarkina
V.A. Nasonova Research Institute of Rheumatology, Moscow
Russian Federation

34A, Kashirskoe Shosse, Moscow 115522 



N. V. Toroptsova
V.A. Nasonova Research Institute of Rheumatology, Moscow
Russian Federation

34A, Kashirskoe Shosse, Moscow 115522 



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Krylov M.Yu., Nikitinskaya O.A., Samarkina E.Yu., Toroptsova N.V. STRONTIUM RANELATE IN THE TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS: IMPACT OF VITAMIN D RECEPTOR AND MONOCYTE CHEMOATTRACTANT PROTEIN-1 GENE POLYMORPHISMS ON BONE MINERAL DENSITY: A PILOT STUDY. Rheumatology Science and Practice. 2017;55(3):267-271. (In Russ.) https://doi.org/10.14412/1995-4484-2017-267-271

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ISSN 1995-4484 (Print)
ISSN 1995-4492 (Online)