PRIMARY SJOGREN'S SYNDROME ASSOCIATED WITH ANTICENTROMERE ANTIBODIES
https://doi.org/10.14412/1995-4484-2018-235-238
Abstract
Anti-centromere antibody (ANCA) seropositivity is generally regarded by rheumatologists as a sign of systemic sclerosis (SS) in clinical practice. However, the literature describes many cases of ANCA-associated primary Sjogren's syndrome (PSS) that is the subtype of this disease, which differs from the classic type in a number of laboratory and clinical manifestations. According to the literature, even a long-term follow-up indicates that only one quarter of patients with ANCA-positive PSS develop documented SS. This fact raises the question of whether it is necessary to include ANCA into the list of autoantibodies pathogenetically related to PSS.
About the Author
B. D. Chaltsev
V.A.Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
Bogdan Chaltsev.
34A, Kashirskoe Shosse, Moscow 115522
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Review
For citations:
Chaltsev B.D. PRIMARY SJOGREN'S SYNDROME ASSOCIATED WITH ANTICENTROMERE ANTIBODIES. Rheumatology Science and Practice. 2018;56(2):235-238. (In Russ.) https://doi.org/10.14412/1995-4484-2018-235-238
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