Пародонтит – предвестник ревматоидного артрита?
https://doi.org/10.14412/1995-4484-2018-613-621
Аннотация
В настоящее время в ревматологии все большее внимание уделяется выявлению заболеваний на максимально ранних сроках (преклинических стадиях), что может способствовать более благоприятному ответу на терапию. С этой целью в качестве возможных предикторов их развития изучаются различные клинические, лабораторные (в первую очередь, иммунологические) и инструментальные показатели. В качестве одного из возможных факторов развития ревматических болезней, в частности ревматоидного артрита (РА), могут выступать заболевания пародонта (ЗП). В настоящем обзоре рассмотрены вопросы взаимосвязи между развитием пародонтита и РА, обсуждается участие отдельных микроорганизмов в патогенезе ЗП и РА. Обозначены клеточно-опосредованные механизмы, вызывающие хронический воспалительный процесс и приводящие к резорбции костей. Описана роль ЗП и P. gingivalis в процессах нарушения цитруллинирования аутоантигенов. Рассмотрена возможность использования генно-инженерных биологических препаратов для лечения ревматических заболеваний, сопровождающихся наличием тяжелых форм ЗП.
Об авторах
А. В. Гордеев
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия
Россия
профессор, зав. лабораторией ранних артритов, докт. мед. наук
115522, Москва, Каширское шоссе, 34А
Е. А. Галушко
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия
Россия
ведущий научный сотрудник лаборатории ранних артритов, докт. мед. наук
115522, Москва, Каширское шоссе, 34А
Н. М. Савушкина
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия
Россия
младший научный сотрудник лаборатории ранних артритов, канд. мед. наук
115522, Москва, Каширское шоссе, 34А
А. М. Лила
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия
Россия
профессор, директор ФГБНУ НИИР им. В.А. Насоновой, докт. мед. наук
115522, Москва, Каширское шоссе, 34А
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Рецензия
Для цитирования:
Гордеев А.В., Галушко Е.А., Савушкина Н.М., Лила А.М. Пародонтит – предвестник ревматоидного артрита? Научно-практическая ревматология. 2018;56(5):613-621. https://doi.org/10.14412/1995-4484-2018-613-621
For citation:
Gordeev A.V., Galushko E.A., Savushkina N.M., Lila A.M. IS PERIODONTITIS A HARBINGER OF RHEUMATOID ARTHRITIS? Rheumatology Science and Practice. 2018;56(5):613-621. (In Russ.) https://doi.org/10.14412/1995-4484-2018-613-621
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