Therapy for digital ulcers in patients with systemic scleroderma
https://doi.org/10.14412/1995-4484-2018-777-781
Abstract
As of now, there are several pharmacological directions in the treatment and prevention of Raynaud’s syndrome and digital ulcers, including various vasoactive drugs (calcium channel blockers, intravenous prostanoids, endothelin receptor antagonists, phosphodiesterase 5 inhibitors, antiplatelets, and statins). The approach to treating systemic sclerosis-related digital ulcers is multifactorial: prevention of risk factors, local and systemic drug treatment, and surgical treatment if necessary.
About the Authors
M. N. Starovoitova
V.A. Nasonova Research Institute of Rheumatology.
Russian Federation
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522.
O. V. Desinova
V.A. Nasonova Research Institute of Rheumatology.
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522.
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522.
References
1. Bolster MB, Silver RS. Clinical features of systemic sclerosis. In: Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, editors. Rheumatology. 5th ed. Philadelphia: Mosby, Elsevier; 2011. P. 1373-86.
2. Гусева НГ. Системная склеродермия и псевдосклеродермические синдромы. Москва: Медицина; 1993 [Guseva NG. Sistemnaya sklerodermiya i psevdosklerodermicheskie sindromy [Systemic scleroderma and pseudoscleroderma syndromes]. Moscow: Meditsina; 1993 (In Russ.)].
3. Steen V, Deenton CP, Pope JE. Digital ulcer: over vascular disease in systemic sclerosis. Rheumatology (Oxford). 2009;48 Suppl 3:iii, 19-24.
4. Hachulla E, Clerson P, Launay D, et al. Natural history of ischemic digital ulcers in systemic sclerosis. J Rheumatol. 2007;34:2423-30.
5. Mouthon L, Carpenties P, Lok C, et al. Ischemic digital ulcers affect hand disability and pain in systemic sclerosis. J Rheumatol. 2014;41(7):1317-23. doi: 10.3899/jrheum.130900
6. Ingraham KM, Steen VD. Morbidity of digital tip ulcerations in scleroderma. Arthritis Rheum. 2006;54 Suppl 9:578.
7. Veale DJ, Collidge TA, Belch JJF. Increased prevalence of symptomatic macrovascular disease in systemic sclerosis. Ann Rhеum Dis. 1995;54:853-5. doi: 10.1136/ard.54.10.853
8. Ho M, Veale D, Eastmond C, et al. Macrovascular disease and systemic sclerosis. Ann Rhеum Dis. 2000;59:39-43. doi: 10.1136/ard.59.1.39
9. Herrick AL. Management of Raynaud’s phenomenon and digital ischemia. Curr Rhеumatol Rep. 2013;15:303. doi: 10.1007/s11926-012-0303-1
10. Kowal-Bielecka O, Fransen J, Avouac J, et al. EUSTAR Coauthors. Update of EULAR recommendations for the treatment of systemic sclerosis. Ann Rheum Dis. 2017;0:1-12. doi: 10.1136/annrheumdis-2016-209909
11. Ананьева ЛП. Лечение системной склеродермии с учетом национальных рекомендаций и рекомендаций Европейской лиги по борьбе с ревматизмом (EULAR). Фарматека. 2014;10(283):79-86 [Anan'eva LP. Treatment of systemic scleroderma based on national recommendations and recommendations of the European League against Rheumatism (EULAR). Farmateka. 2014;10(283):79-86 (In Russ.)].
12. Matucci-Cerenic M, Denton CP, Furst DE, et al. Bosentan treatment of digital ulsers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial. Ann Rhеum Dis. 2011;70:32-8. doi: 10.1136/ard.2010.130658
13. Allanore Y, Borderie D, Lemorechol H, et al. Acute and sustained effect of dihidropyridine-type calcium channel antagonists on oxidative stress in systemic sclerosis. Am J Med. 2004;116:595-600. doi: 10.1016/j.amjmed.2003.11.022
14. Thompson AE, Pope JE. Calcium-channel blockers for primary Raynaud’s phenomenon: a meta-analysis. Rheumatology. 2005;44:145-50. doi: 10.1093/rheumatology/keh390
15. Rademaker M, Cooke ED, Almond NE, et al. Comparison of intravenous infusions of iloprost and oral nifedipine in treatment of Raynaud’s phenomenon in patients with systemic sclerosis: a double blind randomized study. Brit Med J. 1989;298:561-4. doi: 10.1136/bmj.298.6673.561
16. Wigley FM, Korn JH, Csuka ME, et al. Oral iloprost treatment in patients with Raynaud’s phenomenon secondary to systemic sclerosis: a multi-center, placebo-controlled, double-blind study. Arthritis Rhеum. 1998;41:670-7. doi: 10.1002/1529-0131(199804)41:4<670::AID-ART14>3.0.CO;2-I
17. Chung L, Fiorentino D. Digital ulcers in patients with systemic sclerosis. Autoimmun Rev. 2006;5:125-8. doi: 10.1016/j.autrev.2005.08.004
18. Chung L, Fiorentino D. A pilot trial of treprostinil for the treatment and prevention of digital ulcers in patients with systemic sclerosis. J Am Acad Dermatol. 2006;54:880-2. doi: 10.1016/j.jaad.2006.02.004
19. Wigley FM, Wise RA, Seibold JR, et al. Intravenous iloprost infusion in patients with Raynaud’s phenomenon secondary to systemic sclerosis. A multicenter, placebo-controlled, double-blind study. Ann Intern Med. 1994;120:199-206. doi: 10.7326/0003-4819-120-3-199402010-00004
20. Насонов ЕЛ, редактор. Российские клинические рекомендации. Ревматология. Москва: ГЭОТАР-Медиа; 2017. 464 с. [Nasonov EL, editor. Rossiyskie klinicheskie rekomendatsii. Revmatologiya [Russian clinical guidelines. Rheumatology.]. Moscow: GEOTAR-Media; 2017. 464 p. (In Russ.)].
21. Korn JH, Mayes M, Matucci-Cerenic M. for the RAPIDS-1 study group. Digital ulcers in systemic sclerosis. Prevention by treatment with bosentan, an oral endothelin receptor antagonist. Arthritis Rhеum. 2004;50:3985-93. doi: 10.1002/art.20676
22. Caglayan E, Axmann S, Hellmich M, et al. Vardenafil for the treatment of Raynaud’s phenomenon; a randomized, doubleblind, placebo-controlled crossover study. Arch Intern Med. 2012;172;1182-4. doi: 10.1001/archinternmed.2012.2271
23. Tingey T, Shu J, Smuczek J, et al. A meta-analysis of healing and prevention of digital ulsers (DU) in systemic sclerosis (SSc). Arthritis Care Res (Hoboken). 2013 April 1. doi: 10.1002/acr.22018
24. Denton CP, Howell K, Stratton RJ, et al. Long-term low molecular weight heparin therapy for severe Raynaud’s phenomenon: a pilot study. Clin Exp Rheumatol. 2000;18:499-502.
25. Abou-Raya A, Abou-Raya S, Helmii M Statins: potentially useful in therapy of systemic sclerosis-related Raynaud’s phenomenon and digital ulcers. J Rheumatol. 2008;35:1801-8.
26. Chung L, Shapiro L, Fiorentino D, et al. MQX-503, a novel formulation of nitroglycerin, improves the severity of Raynaud’s phenomenon. Arthritis Rhеum. 2009;60:870-7. doi: 10.1002/art.24351
27. Amanzi L, Braschi F, Fiori G. Digital ulcers in scleroderma: staging, characteristics and sub-setting through observation 0f 1614 digital lesions. Rheumatology (Oxford). 2010;49:1374-82. doi: 10.1093/rheumatology/keq097
28. Fiori G, Galluccio F, Braschi F, et al. Vitamin E gel reduces time of healing of digital ulcers in patients with systemic sclerosis. Clin Exper Rheumatol. 2009;27 Suppl:51-4.
29. Bogoch ER, Gross DK. Surgery of the hand in patients with systemic sclerosis: outcomes and considerations. J Rheumatol. 2005;32:642-8.
30. Herrick A, Muir L. Raynaud’s phenomenon (secondary). Clinical evidence. London: BMJ Publishing Group Ltd; 2015.
31. Fregene A, Ditmars D, Saddiqvi A. Botulinum toxin type A: a treatment option for digital ischemia in patients with Raynaud’s phenomenon. J Hand Surg. 2009;34:446-52. doi: 10.1016/j.jhsa.2008.11.026
32. Iorio ML, Masden DL, Higgins JP. Botulinum toxin A treatment Raynaud’s phenomenon: a review. Semin Arthritis Rheum. 2012;41:599-603. doi: 10.1016/j.semarthrit.2011.07.006
33. Rajendram R, Hayward A. Ultrasound-guided digital sympathectomy using botulinum toxin. Anaestesia. 2013;68(10):1077. doi: 10.1111/anae.12416
Review
For citations:
Starovoitova M.N., Desinova O.V. Therapy for digital ulcers in patients with systemic scleroderma. Rheumatology Science and Practice. 2018;56(6):777-781. (In Russ.) https://doi.org/10.14412/1995-4484-2018-777-781
Views:
1787
Email this article 