Toxic epidermal necrolysis as a variant of severe skin lesions in systemic lupus erythematosus
https://doi.org/10.14412/1995-4484-2018-785-790
Abstract
Toxic epidermal necrolysis (TEN) has been long believed to be the most severe manifestation of drug allergy. However, cutaneous changes as TEN in systemic lupus erythematosus (SLE) were first described in the late 1970s. As of now, the English-language literature published reports of 30 cases of such lesions in SLE. This paper describes a clinical case of TEN as a direct manifestation of SLE; the positive experience has been first depicted in using not only intravenous immunoglobulin, but also rituximab with a good therapeutic effect in Russian clinical practice.
About the Authors
L. D. Vorobyeva
V.A. Nasonova Research Institute of Rheumatology.
Russian Federation
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522.
E. A. Aseeva
V.A. Nasonova Research Institute of Rheumatology.
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522.
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522.
S. K. Solovyev
V.A. Nasonova Research Institute of Rheumatology.
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522.
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522.
T. A. Belousova
Department of Skin and Venereal Diseases, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia.
Russian Federation
Russian Federation
8, Trubetskaya St., Build. 2, Moscow 119991.
N. E. Lopatina
V.A. Nasonova Research Institute of Rheumatology.
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522.
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522.
E. G. Sazhina
V.A. Nasonova Research Institute of Rheumatology.
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522.
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522.
G. V. Serikova
V.A. Nasonova Research Institute of Rheumatology.
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522.
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522.
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Review
For citations:
Vorobyeva L.D., Aseeva E.A., Solovyev S.K., Belousova T.A., Lopatina N.E., Sazhina E.G., Serikova G.V. Toxic epidermal necrolysis as a variant of severe skin lesions in systemic lupus erythematosus. Rheumatology Science and Practice. 2018;56(6):785-790. (In Russ.) https://doi.org/10.14412/1995-4484-2018-785-790
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